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P49768 | PSN1_HUMAN | Presenilin-1 (PSEN1)

3D structures mapped by conservation among orthologs

[ Domain: "Presenilin family intramembrane aspartate proteases" // Presenilin ]

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[ Domain: "Presenilin family intramembrane aspartate proteases" // UNK_F_TYPE ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL3942982 OBDepict CH 3 N N O N O N CH 3 H H O H F F F F F IC50 = 3.34 nM 522.47 Cc1cn(-c2ccc3n(c2=O)CCN([C@@H](C)[C@@H]2CC[C@H](c4cc(F)c(C(F)(F)F)c(F)c4)O2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL2159510 OBDepict H 3 C S O O H O H O S O O F Cl F IC50 = 5.0 nM 521.0 CCS(=O)(=O)CC[C@@H]1OCC[C@@]2(S(=O)(=O)c3ccc(Cl)cc3)c3c(F)ccc(F)c3OC[C@@H]12 Homo sapiens CHEMBL2160914 cell-based format
CHEMBL3893460 OBDepict CH 3 N N O N O N CH 3 H H O H F F Cl IC50 = 5.48 nM 488.92 Cc1cn(-c2ccc3n(c2=O)CCN([C@@H](C)[C@@H]2CC[C@H](c4cc(F)c(Cl)c(F)c4)O2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3890783 OBDepict CH 3 N N O N O N CH 3 H H O H F Cl Cl IC50 = 5.78 nM 505.38 Cc1cn(-c2ccc3n(c2=O)CCN([C@@H](C)[C@@H]2CC[C@H](c4cc(F)c(Cl)c(Cl)c4)O2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3951810 OBDepict H 3 C N N O N O N H 3 C H H O H F F F F Cl IC50 = 7.84 nM 538.93 Cc1cn(-c2ccc3n(c2=O)CCN([C@@H](C)[C@@H]2CC[C@H](c4cc(F)c(Cl)cc4C(F)(F)F)O2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL2159689 OBDepict CH 3 N H O O H O H O S O O Cl F F IC50 = 8.0 nM 501.94 CNC(=O)OCC[C@@H]1OCC[C@@]2(S(=O)(=O)c3ccc(Cl)cc3)c3c(F)ccc(F)c3OC[C@@H]12 Homo sapiens CHEMBL2160914 cell-based format
CHEMBL2159509 OBDepict Cl S O O H O F O H F S O O CH 3 H 3 C IC50 = 8.0 nM 535.03 CC(C)S(=O)(=O)CC[C@@H]1OCC[C@@]2(S(=O)(=O)c3ccc(Cl)cc3)c3c(F)ccc(F)c3OC[C@@H]12 Homo sapiens CHEMBL2160914 cell-based format
CHEMBL3959250 OBDepict CH 3 N N O N O N CH 3 H H O H F F F F IC50 = 8.35 nM 504.48 Cc1cn(-c2ccc3n(c2=O)CCN([C@@H](C)[C@@H]2CC[C@H](c4ccc(C(F)(F)F)c(F)c4)O2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3980608 OBDepict Cl F F F H O H N H 3 C H O N O N N CH 3 IC50 = 9.1 nM 520.94 Cc1cn(-c2ccc3n(c2=O)CCN([C@@H](C)[C@@H]2CC[C@H](c4ccc(Cl)cc4C(F)(F)F)O2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3929506 OBDepict CH 3 N N O N O N CH 3 H H O H F F F F Cl IC50 = 10.0 nM 538.93 Cc1cn(-c2ccc3n(c2=O)CCN([C@@H](C)[C@@H]2CC[C@H](c4ccc(Cl)c(F)c4C(F)(F)F)O2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3948397 OBDepict CH 3 N N O N O N CH 3 H H O H F F F F F IC50 = 11.0 nM 522.47 Cc1cn(-c2ccc3n(c2=O)CCN([C@@H](C)[C@@H]2CC[C@H](c4ccc(C(F)(F)F)c(F)c4F)O2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3978667 OBDepict H 3 C O Cl H O F H N CH 3 H O N O N N H 3 C IC50 = 11.1 nM 500.96 COc1cc(Cl)c(F)cc1[C@H]1CC[C@@H]([C@H](C)N2CCn3c(ccc(-n4cnc(C)c4)c3=O)C2=O)O1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3962470 OBDepict CH 3 N N O N O N CH 3 H H O H F F Cl IC50 = 11.4 nM 488.92 Cc1cn(-c2ccc3n(c2=O)CCN([C@@H](C)[C@@H]2CC[C@H](c4cc(F)c(Cl)cc4F)O2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3906008 OBDepict CH 3 N N O N O N H O H F F Cl IC50 = 13.3 nM 474.9 Cc1cn(-c2ccc3n(c2=O)CCN(C[C@@H]2CC[C@H](c4cc(F)c(Cl)c(F)c4)O2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3955146 OBDepict CH 3 N N O N O N CH 3 H H O H F F F IC50 = 14.3 nM 486.49 Cc1cn(-c2ccc3n(c2=O)CCN([C@@H](C)[C@@H]2CC[C@H](c4ccc(C(F)(F)F)cc4)O2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3917064 OBDepict Cl O H O F F F H N H 3 C H O N O N N CH 3 IC50 = 14.5 nM 536.94 Cc1cn(-c2ccc3n(c2=O)CCN([C@@H](C)[C@@H]2CC[C@H](c4ccc(Cl)cc4OC(F)(F)F)O2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3976595 OBDepict H 3 C O H O F F F H N CH 3 H O N O N N H 3 C IC50 = 15.0 nM 516.52 COc1cc(C(F)(F)F)ccc1[C@H]1CC[C@@H]([C@H](C)N2CCn3c(ccc(-n4cnc(C)c4)c3=O)C2=O)O1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3925476 OBDepict CH 3 N N O N O N H O H F F F F IC50 = 15.7 nM 490.46 Cc1cn(-c2ccc3n(c2=O)CCN(C[C@@H]2CC[C@H](c4ccc(C(F)(F)F)c(F)c4)O2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3979115 OBDepict CH 3 N N O N O N H O H F F F F F IC50 = 16.0 nM 508.45 Cc1cn(-c2ccc3n(c2=O)CCN(C[C@@H]2CC[C@H](c4cc(F)c(C(F)(F)F)c(F)c4)O2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL2159687 OBDepict OH H O H O S O O Cl F F IC50 = 18.0 nM 444.88 O=S(=O)(c1ccc(Cl)cc1)[C@@]12CCO[C@@H](CCO)[C@@H]1COc1c(F)ccc(F)c12 Homo sapiens CHEMBL2160914 cell-based format
CHEMBL3968096 OBDepict CH 3 N N O N O N H H 3 C H O H F F F IC50 = 19.8 nM 486.49 Cc1cn(-c2ccc3n(c2=O)C[C@H](C)N(C[C@H]2CC[C@@H](c4ccc(C(F)(F)F)cc4)O2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3985730 OBDepict H 3 C O Cl H O H N O N O N N H 3 C IC50 = 21.6 nM 468.94 COc1cc(Cl)ccc1[C@H]1CC[C@@H](CN2CCn3c(ccc(-n4cnc(C)c4)c3=O)C2=O)O1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3924102 OBDepict F F F F H O H N H 3 C H O N O N N CH 3 IC50 = 24.2 nM 504.48 Cc1cn(-c2ccc3n(c2=O)CCN([C@@H](C)[C@@H]2CC[C@H](c4ccc(F)cc4C(F)(F)F)O2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3918666 OBDepict F O F Cl H O H N H 3 C H O N O N N CH 3 IC50 = 24.6 nM 518.95 Cc1cn(-c2ccc3n(c2=O)CCN([C@@H](C)[C@@H]2CC[C@H](c4ccc(Cl)cc4OC(F)F)O2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3906428 OBDepict CH 3 N N O N O N H O H CH 3 H F F F IC50 = 25.0 nM 486.49 Cc1cn(-c2ccc3n(c2=O)CCN(C[C@H]2O[C@@H](c4ccc(C(F)(F)F)cc4)C[C@@H]2C)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3910627 OBDepict Cl F F F H O H N O N O N N CH 3 IC50 = 26.8 nM 506.91 Cc1cn(-c2ccc3n(c2=O)CCN(C[C@@H]2CC[C@H](c4ccc(Cl)cc4C(F)(F)F)O2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3911070 OBDepict CH 3 N N O N O N H O H F F F IC50 = 27.6 nM 472.47 Cc1cn(-c2ccc3n(c2=O)CCN(C[C@@H]2CC[C@H](c4ccc(C(F)(F)F)cc4)O2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3908938 OBDepict CH 3 N N O N O N CH 3 H H O H Cl F F F IC50 = 29.1 nM 520.94 Cc1cn(-c2ccc3n(c2=O)CCN([C@@H](C)[C@@H]2CC[C@H](c4ccc(C(F)(F)F)cc4Cl)O2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3902117 OBDepict CH 3 N N O N O N H O H F F F IC50 = 29.9 nM 486.49 Cc1cn(-c2ccc3n(c2=O)CCN(C[C@H]2CCC[C@H](c4ccc(C(F)(F)F)cc4)O2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3918851 OBDepict H 3 C N N O N O N H 3 C H H O H F F F F F IC50 = 33.5 nM 522.47 Cc1cn(-c2ccc3n(c2=O)CCN([C@@H](C)[C@@H]2CC[C@H](c4cc(F)c(F)cc4C(F)(F)F)O2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL2159691 OBDepict N H O H O S O O Cl F F IC50 = 37.0 nM 453.89 N#CCC[C@@H]1OCC[C@@]2(S(=O)(=O)c3ccc(Cl)cc3)c3c(F)ccc(F)c3OC[C@@H]12 Homo sapiens CHEMBL2160914 cell-based format
CHEMBL3890183 OBDepict CH 3 N N O N O N H O H H H 3 C F F F IC50 = 38.4 nM 486.49 Cc1cn(-c2ccc3n(c2=O)CCN(C[C@@H]2C[C@H](C)[C@H](c4ccc(C(F)(F)F)cc4)O2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3972571 OBDepict CH 3 N N O N O N H O H 3 C F F F IC50 = 40.5 nM 486.49 Cc1cn(-c2ccc3n(c2=O)CCN(C[C@@H]2CC[C@](C)(c4ccc(C(F)(F)F)cc4)O2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL2159511 OBDepict Cl S O O H O F O H F S O O CH 3 IC50 = 46.0 nM 506.98 CS(=O)(=O)CC[C@@H]1OCC[C@@]2(S(=O)(=O)c3ccc(Cl)cc3)c3c(F)ccc(F)c3OC[C@@H]12 Homo sapiens CHEMBL2163035 cell-based format
CHEMBL3938538 OBDepict CH 3 N N O N O N H H 3 C H O H F F F IC50 = 46.4 nM 486.49 Cc1cn(-c2ccc3n(c2=O)C[C@@H](C)N(C[C@H]2CC[C@@H](c4ccc(C(F)(F)F)cc4)O2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL2159690 OBDepict CH 3 HN O O H O H O S O O Cl F F IC50 = 48.0 nM 515.96 CCNC(=O)OCC[C@@H]1OCC[C@@]2(S(=O)(=O)c3ccc(Cl)cc3)c3c(F)ccc(F)c3OC[C@@H]12 Homo sapiens CHEMBL2160914 cell-based format
CHEMBL3926551 OBDepict Cl H O H N O N O N N CH 3 IC50 = 52.1 nM 438.92 Cc1cn(-c2ccc3n(c2=O)CCN(C[C@@H]2CC[C@H](c4ccc(Cl)cc4)O2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3960512 OBDepict CH 3 N N O N O N CH 3 H H O H S F F F IC50 = 52.4 nM 492.52 Cc1cn(-c2ccc3n(c2=O)CCN([C@@H](C)[C@@H]2CC[C@H](c4ccc(C(F)(F)F)s4)O2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3928795 OBDepict CH 3 N N O N O N H O H O F F F IC50 = 60.3 nM 488.47 Cc1cn(-c2ccc3n(c2=O)CCN(C[C@@H]2CC[C@H](c4ccc(OC(F)(F)F)cc4)O2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3896372 OBDepict H 3 C N N O N O N H H O F F IC50 = 60.6 nM 476.48 Cc1cn(-c2ccc3n(c2=O)CCN([C@@H]2CC[C@H]2Oc2cccc4cc(F)c(F)cc24)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3953711 OBDepict CH 3 N N O N O N H O H IC50 = 63.8 nM 444.54 Cc1cn(-c2ccc3n(c2=O)CCN(C[C@@H]2CC[C@H](c4ccc(C5CC5)cc4)O2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3935522 OBDepict CH 3 N N O N O N H O H F F H 3 C IC50 = 73.3 nM 468.5 Cc1cn(-c2ccc3n(c2=O)CCN(C[C@@H]2CC[C@H](c4ccc(C(C)(F)F)cc4)O2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3913030 OBDepict H 3 C N N O N O N H O H F F F IC50 = 73.3 nM 472.47 Cc1cn(-c2ccc3n(c2=O)CCN(C[C@@H]2CC[C@H](c4ccccc4C(F)(F)F)O2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3980167 OBDepict CH 3 N N O N O N H O H H F F F F IC50 = 73.5 nM 490.46 Cc1cn(-c2ccc3n(c2=O)CCN(C[C@@H]2C[C@@H](F)[C@H](c4ccc(C(F)(F)F)cc4)O2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3949792 OBDepict CH 3 N N O N O N H O H H H 3 C F F F IC50 = 73.5 nM 486.49 Cc1cn(-c2ccc3n(c2=O)CCN(C[C@@H]2C[C@@H](C)[C@H](c4ccc(C(F)(F)F)cc4)O2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3900856 OBDepict Cl H H N O N O N N CH 3 IC50 = 80.0 nM 450.97 Cc1cn(-c2ccc3n(c2=O)CCN(C[C@@H]2CCC[C@H](c4ccc(Cl)cc4)C2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3946187 OBDepict CH 3 N N O N O N H O H F F F IC50 = 81.2 nM 472.47 Cc1cn(-c2ccc3n(c2=O)CCN(C[C@@H]2CC[C@H](c4cccc(C(F)(F)F)c4)O2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3965573 OBDepict CH 3 N N O N O N H O H F F F IC50 = 96.6 nM 486.49 Cc1cn(-c2ccc3n(c2=O)CCN(C[C@H]2CCC[C@@H](c4ccc(C(F)(F)F)cc4)O2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3935854 OBDepict Cl N O N O N N CH 3 IC50 = 98.0 nM 450.97 Cc1cn(-c2ccc3n(c2=O)CCN(CC2CCCC(c4ccc(Cl)cc4)C2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3889603 OBDepict F O H H N O N O N N CH 3 IC50 = 112.0 nM 458.49 Cc1cn(-c2ccc3n(c2=O)CCN([C@@H]2CC[C@H]2Oc2cccc4ccc(F)cc24)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3935477 OBDepict CH 3 N N O N O N O Cl Cl IC50 = 117.0 nM 473.36 Cc1cn(-c2ccc3n(c2=O)CCN(CC2CCC(c4ccc(Cl)c(Cl)c4)O2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3935655 OBDepict Cl O F F F H H N O N O N N CH 3 IC50 = 120.0 nM 492.89 Cc1cn(-c2ccc3n(c2=O)CCN([C@@H]2CC[C@H]2Oc2ccc(Cl)cc2C(F)(F)F)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3890892 OBDepict F O F F F H H N O N O N N CH 3 IC50 = 140.0 nM 490.46 Cc1cn(-c2ccc3n(c2=O)CCN([C@@H]2CCC[C@@H]2Oc2ccc(F)cc2C(F)(F)F)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3956978 OBDepict H 3 C N N O N O N H H O H 3 C Cl F IC50 = 146.0 nM 456.91 Cc1cn(-c2ccc3n(c2=O)CCN([C@@H]2CC[C@H]2Oc2ccc(F)c(Cl)c2C)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3912132 OBDepict H 3 C N N O N O N H H O H 3 C CH 3 F IC50 = 153.0 nM 450.51 Cc1cn(-c2ccc3n(c2=O)CCN([C@@H]2CC[C@H]2Oc2cccc(F)c2C(C)C)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3898549 OBDepict CH 3 N N O N O N H O H F F F F F IC50 = 157.0 nM 522.47 Cc1cn(-c2ccc3n(c2=O)CCN(C[C@H]2CC[C@@H](c4ccc(C(F)(F)C(F)(F)F)cc4)O2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3982082 OBDepict H 3 C N N O N O N H H O Cl F F F IC50 = 157.0 nM 492.89 Cc1cn(-c2ccc3n(c2=O)CCN([C@@H]2CC[C@H]2Oc2cccc(C(F)(F)F)c2Cl)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3966656 OBDepict H 3 C N N O N O N H H O Cl H 3 C CH 3 IC50 = 158.0 nM 466.97 Cc1cn(-c2ccc3n(c2=O)CCN([C@@H]2CC[C@H]2Oc2ccc(Cl)c(C(C)C)c2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3968767 OBDepict H 3 C N N O N O N H H O F IC50 = 162.0 nM 448.5 Cc1cn(-c2ccc3n(c2=O)CCN([C@@H]2CC[C@H]2Oc2ccc(F)c4c2CCC4)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3905374 OBDepict H 3 C N N O N O N H H O IC50 = 164.0 nM 440.5 Cc1cn(-c2ccc3n(c2=O)CCN([C@@H]2CC[C@H]2Oc2cccc4ccccc24)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3939251 OBDepict CH 3 N N O N O N O F F F IC50 = 188.0 nM 486.49 Cc1cn(-c2ccc3n(c2=O)CCN(CC2CCCC2Oc2cccc(C(F)(F)F)c2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3975978 OBDepict H 3 C N N O N O N H H O F F F IC50 = 211.0 nM 458.44 Cc1cn(-c2ccc3n(c2=O)CCN([C@@H]2CC[C@H]2Oc2ccccc2C(F)(F)F)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3957731 OBDepict H 3 C N N O N O N H H O F F F IC50 = 217.0 nM 458.44 Cc1cn(-c2ccc3n(c2=O)CCN([C@@H]2CC[C@H]2Oc2cccc(C(F)(F)F)c2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3967275 OBDepict CH 3 N N O N O N CH 3 O F F F IC50 = 236.0 nM 486.49 Cc1cn(-c2ccc3n(c2=O)CCN(CC2(C)CCC(c4ccc(C(F)(F)F)cc4)O2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3899746 OBDepict CH 3 N N O N O N H H O F F F IC50 = 300.0 nM 472.47 Cc1cn(-c2ccc3n(c2=O)CCN([C@@H]2CCC[C@H]2Oc2ccccc2C(F)(F)F)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3981756 OBDepict F O F F F H H N O N O N N CH 3 IC50 = 303.0 nM 490.46 Cc1cn(-c2ccc3n(c2=O)CCN([C@H]2C[C@H](COc4ccc(F)cc4C(F)(F)F)C2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL2159688 OBDepict OH H O H O S O O Cl F F IC50 = 320.0 nM 444.88 O=S(=O)(c1ccc(Cl)cc1)[C@]12CCO[C@H](CCO)[C@H]1COc1c(F)ccc(F)c12 Homo sapiens CHEMBL2160915 assay format
CHEMBL3982060 OBDepict H 3 C N N O N O N O N F Cl F F F IC50 = 353.0 nM 523.87 Cc1cn(-c2ccc3n(c2=O)CCN(CC2CC(c4cc(C(F)(F)F)cc(Cl)c4F)=NO2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL2159686 OBDepict Cl S O O H O F O H F S O O CH 3 IC50 = 377.0 nM 506.98 CS(=O)(=O)CC[C@H]1OCC[C@]2(S(=O)(=O)c3ccc(Cl)cc3)c3c(F)ccc(F)c3OC[C@H]12 Homo sapiens CHEMBL2160915 assay format
CHEMBL3930235 OBDepict CH 3 N N O N O N O N Cl F F F IC50 = 429.0 nM 505.88 Cc1cn(-c2ccc3n(c2=O)CCN(CC2CC(c4cccc(C(F)(F)F)c4Cl)=NO2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3957582 OBDepict H 3 C N N O N O N H H O F F F IC50 = 469.0 nM 458.44 Cc1cn(-c2ccc3n(c2=O)CCN([C@@H]2CC[C@@H]2Oc2ccccc2C(F)(F)F)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3918962 OBDepict CH 3 N N O N O N O N Cl F F F IC50 = 483.0 nM 505.88 Cc1cn(-c2ccc3n(c2=O)CCN(CC2CC(c4ccc(Cl)c(C(F)(F)F)c4)=NO2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3941322 OBDepict F F H H N O N O N N CH 3 IC50 = 561.0 nM 438.48 Cc1cn(-c2ccc3n(c2=O)CCN([C@@H]2CCC[C@@H]2Cc2cc(F)cc(F)c2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3974235 OBDepict F F H H N O N O N N CH 3 IC50 = 563.0 nM 424.45 Cc1cn(-c2ccc3n(c2=O)CCN([C@@H]2CCC[C@@H]2c2cc(F)cc(F)c2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3944609 OBDepict Cl O N O N O N N CH 3 IC50 = 591.0 nM 452.94 Cc1cn(-c2ccc3n(c2=O)CCN(C2CCCCC2Oc2ccc(Cl)cc2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3956668 OBDepict CH 3 N N O N O N O N Cl F F F IC50 = 711.0 nM 505.88 Cc1cn(-c2ccc3n(c2=O)CCN(CC2CC(c4cc(C(F)(F)F)ccc4Cl)=NO2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3934015 OBDepict CH 3 N N O N O N H O H 3 C F F F IC50 = 725.0 nM 486.49 Cc1cn(-c2ccc3n(c2=O)CCN(C[C@H]2CC[C@@](C)(c4ccc(C(F)(F)F)cc4)O2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3965759 OBDepict H 3 C N N O N O N H H O F F F IC50 = 789.0 nM 458.44 Cc1cn(-c2ccc3n(c2=O)CCN([C@H]2C[C@H](Oc4ccccc4C(F)(F)F)C2)C3=O)cn1 Homo sapiens CHEMBL3887616 cell-based format
CHEMBL3397727 OBDepict CH 3 O OH O O F F F F F F IC50 = 1000.0 nM 558.56 CCCC/C(=Cc1cc(OCC2CCC(C(F)(F)F)CC2)ccc1OCc1ccc(C(F)(F)F)cc1)C(=O)O Homo sapiens CHEMBL3398675 cell-based format