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P49862 | KLK7_HUMAN | Kallikrein-7 (KLK7)

3D structures mapped by conservation among orthologs

[ Domain: "FMN-binding split barrel 2" // Trypsin_1 ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL1413622 OBDepict CH 3 N O N NH 2 N N IC50 = 40.0 nM 279.3 Cc1ccc(C(=O)n2nc(-c3cccnc3)nc2N)cc1 Homo sapiens CHEMBL2412649 single protein format
CHEMBL4575974 OBDepict H 3 C O O CH 3 N O O O CH 3 IC50 = 48.0 nM 327.34 CCOc1cc2c(=O)oc(-c3ccccc3OC)nc2cc1OC Homo sapiens CHEMBL4424186 single protein format
CHEMBL4228441 OBDepict CH 3 N H N H O O NH N H N CH 3 H 3 C O Cl H 3 C N N H 3 C IC50 = 48.0 nM 580.13 CCC[C@@H](C(=O)Nc1cccc(-c2cnn(C)c2)c1)N1C/C(=N/N(C)C)NC[C@@H](Cc2cc(Cl)ccc2OC)C1=O Homo sapiens CHEMBL4222616 single protein format
CHEMBL4126936 OBDepict H 3 C O Cl H NH O N N H 3 C H N N H O CH 3 CH 3 N N H 3 C IC50 = 58.0 nM 552.08 COc1ccc(Cl)cc1C[C@@H]1CN/C(=NN(C)C)CN([C@@H](C)C(=O)Nc2cccc(-c3cnn(C)c3)c2)C1=O Homo sapiens CHEMBL4125121 single protein format
CHEMBL4228178 OBDepict CH 3 N H N H O O NH N H N CH 3 H 3 C O Cl H 3 C N N H 3 C IC50 = 110.0 nM 594.16 CCCC[C@@H](C(=O)Nc1cccc(-c2cnn(C)c2)c1)N1C/C(=N/N(C)C)NC[C@@H](Cc2cc(Cl)ccc2OC)C1=O Homo sapiens CHEMBL4222616 single protein format
CHEMBL1464269 OBDepict Cl N O N NH 2 N N IC50 = 220.0 nM 299.72 Nc1nc(-c2cccnc2)nn1C(=O)c1ccc(Cl)cc1 Homo sapiens CHEMBL2412649 single protein format
CHEMBL1471674 OBDepict CH 3 O O H 3 C N O N NH 2 N IC50 = 230.0 nM 324.34 COc1ccc(C(=O)n2nc(-c3ccccc3)nc2N)cc1OC Homo sapiens CHEMBL2412649 single protein format
CHEMBL4554224 OBDepict CH 3 N S N O O Br NH CH 3 IC50 = 390.0 nM 432.34 CC1=NC(c2cn(S(=O)(=O)c3ccccc3Br)c3ccc(C)cc23)CN1 Homo sapiens CHEMBL4372250 single protein format
CHEMBL4227658 OBDepict CH 3 N H N H O O NH N H N CH 3 H 3 C O Cl H 3 C N N H 3 C IC50 = 450.0 nM 566.11 CC[C@@H](C(=O)Nc1cccc(-c2cnn(C)c2)c1)N1C/C(=N/N(C)C)NC[C@@H](Cc2cc(Cl)ccc2OC)C1=O Homo sapiens CHEMBL4222616 single protein format
CHEMBL4130204 OBDepict CH 3 O Cl H HN O N N N N H O CH 3 H 3 C N N H 3 C IC50 = 520.0 nM 538.05 COc1ccc(Cl)cc1C[C@@H]1CN/C(=NN(C)C)CN(CC(=O)Nc2cccc(-c3cnn(C)c3)c2)C1=O Homo sapiens CHEMBL4125121 single protein format
CHEMBL4227495 OBDepict CH 3 O Cl H HN O N N N N H O CH 3 H 3 C O IC50 = 590.0 nM 524.02 COc1ccc(Cl)cc1C[C@@H]1CN/C(=NN(C)C)CN(CC(=O)Nc2cccc(-c3ccco3)c2)C1=O Homo sapiens CHEMBL4222616 single protein format
CHEMBL1580446 OBDepict CH 3 O N O N NH 2 N IC50 = 610.0 nM 218.22 COc1ccc(C(=O)n2cnnc2N)cc1 Homo sapiens CHEMBL2412649 single protein format
CHEMBL1580091 OBDepict CH 3 S N N N O Cl IC50 = 660.0 nM 329.81 CSc1nc(-c2ccc(Cl)cc2)nn1C(=O)c1ccccc1 Homo sapiens CHEMBL2412649 single protein format
CHEMBL4227724 OBDepict CH 3 O Cl H HN O N N N N H O CH 3 H 3 C O IC50 = 670.0 nM 524.02 COc1ccc(Cl)cc1C[C@@H]1CN/C(=NN(C)C)CN(CC(=O)Nc2cccc(-c3ccoc3)c2)C1=O Homo sapiens CHEMBL4222616 single protein format
CHEMBL4126785 OBDepict O N H N O N H N N CH 3 CH 3 N N Cl Cl H 3 C IC50 = 790.0 nM 542.47 CN(C)/N=C1/CN(CC(=O)Nc2cccc(-c3cnn(C)c3)c2)C(=O)C(Cc2c(Cl)cccc2Cl)CN1 Homo sapiens CHEMBL4125121 single protein format
CHEMBL4216497 OBDepict CH 3 O Cl H NH O N N N NH O CH 3 CH 3 S O O H 3 C IC50 = 820.0 nM 536.05 COc1ccc(Cl)cc1C[C@@H]1CN/C(=NN(C)C)CN(CC(=O)Nc2cccc(S(C)(=O)=O)c2)C1=O Homo sapiens CHEMBL4181449 single protein format
CHEMBL4227375 OBDepict CH 3 O Cl H HN O N N N N H O CH 3 H 3 C S IC50 = 870.0 nM 540.09 COc1ccc(Cl)cc1C[C@@H]1CN/C(=NN(C)C)CN(CC(=O)Nc2cccc(-c3cccs3)c2)C1=O Homo sapiens CHEMBL4222616 single protein format
CHEMBL4226810 OBDepict H 3 C O Cl H NH O N N H 3 C H N N H O CH 3 CH 3 N N H 3 C IC50 = 920.0 nM 552.08 COc1ccc(Cl)cc1C[C@@H]1CN/C(=NN(C)C)CN([C@H](C)C(=O)Nc2cccc(-c3cnn(C)c3)c2)C1=O Homo sapiens CHEMBL4222616 single protein format
CHEMBL4127430 OBDepict CH 3 N N H 3 C HN N O N H O F Cl N N H 3 C IC50 = 940.0 nM 526.02 CN(C)/N=C1/CN(CC(=O)Nc2cccc(-c3cnn(C)c3)c2)C(=O)C(Cc2c(F)cccc2Cl)CN1 Homo sapiens CHEMBL4125121 single protein format
CHEMBL4226469 OBDepict H 3 C N H O NH O N O HN N H N H 3 C CH 3 O Cl H 3 C IC50 = 940.0 nM 515.01 CNC(=O)c1cccc(NC(=O)CN2C/C(=N/N(C)C)NC[C@@H](Cc3cc(Cl)ccc3OC)C2=O)c1 Homo sapiens CHEMBL4222616 single protein format
CHEMBL4225621 OBDepict CH 3 O Cl H HN O N N N N H O H 3 C H 3 C S N O O H 3 C H 3 C IC50 = 990.0 nM 565.1 COc1ccc(Cl)cc1C[C@@H]1CN/C(=NN(C)C)CN(CC(=O)Nc2cccc(S(=O)(=O)N(C)C)c2)C1=O Homo sapiens CHEMBL4222616 single protein format
CHEMBL4517387 OBDepict CH 3 NH N N S O O H 3 C CH 3 IC50 = 1000.0 nM 367.47 CC1=NC(c2cn(S(=O)(=O)c3ccccc3C)c3ccc(C)cc23)CN1 Homo sapiens CHEMBL4372250 single protein format