P50336 | PPOX_HUMAN | Protoporphyrinogen oxidase (PPOX)
3D structures mapped by conservation among orthologs
[ Domain: "FAD/NAD(P)-binding domain" // Amino_oxidase_1st ]
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[ Domain: "FAD-linked reductases-C" // Amino_oxidase_2nd_3 ]
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[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Ki table
| molecule_chembl_id | structure | assay_type | relation | values | units | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1926835 | Ki | = | 40.0 | nM | 413.52 | CCOC(=O)Sc1nc2cc(-n3nc(C(C)(C)C)sc3=O)c(F)cc2s1 | Homo sapiens | CHEMBL1929737 | single protein format | |
| CHEMBL2252322 | Ki | = | 95.0 | nM | 323.8 | CCCOc1cc(N2CC3=C(CCCC3)C2=O)c(F)cc1Cl | Homo sapiens | CHEMBL3066844 | single protein format | |
| CHEMBL2252323 | Ki | = | 120.0 | nM | 321.78 | C=CCOc1cc(N2CC3=C(CCCC3)C2=O)c(F)cc1Cl | Homo sapiens | CHEMBL3066844 | single protein format | |
| CHEMBL1926845 | Ki | = | 200.0 | nM | 429.98 | CCOC(=O)Sc1nc2cc(-n3nc(C(C)(C)C)sc3=O)c(Cl)cc2s1 | Homo sapiens | CHEMBL1929737 | single protein format | |
| CHEMBL2252320 | Ki | = | 200.0 | nM | 309.77 | CCOc1cc(N2CC3=C(CCCC3)C2=O)c(F)cc1Cl | Homo sapiens | CHEMBL3066844 | single protein format | |
| CHEMBL1926967 | Ki | = | 250.0 | nM | 441.96 | CCOC(=O)CCSc1nc2cc(-n3nc(C(C)(C)C)oc3=O)c(Cl)cc2s1 | Homo sapiens | CHEMBL1929737 | single protein format | |
| CHEMBL2252321 | Ki | = | 300.0 | nM | 340.25 | CCCOc1cc(N2CC3=C(CCCC3)C2=O)c(Cl)cc1Cl | Homo sapiens | CHEMBL3066844 | single protein format | |
| CHEMBL1926960 | Ki | = | 320.0 | nM | 425.51 | CCOC(=O)CCSc1nc2cc(-n3nc(C(C)(C)C)oc3=O)c(F)cc2s1 | Homo sapiens | CHEMBL1929737 | single protein format | |
| CHEMBL1926963 | Ki | = | 330.0 | nM | 413.91 | CCOC(=O)Sc1nc2cc(-n3nc(C(C)(C)C)oc3=O)c(Cl)cc2s1 | Homo sapiens | CHEMBL1929737 | single protein format | |
| CHEMBL1926837 | Ki | = | 340.0 | nM | 427.55 | CCOC(=O)CSc1nc2cc(-n3nc(C(C)(C)C)sc3=O)c(F)cc2s1 | Homo sapiens | CHEMBL1929737 | single protein format | |
| CHEMBL1926961 | Ki | = | 360.0 | nM | 439.53 | CCOC(=O)CCCSc1nc2cc(-n3nc(C(C)(C)C)oc3=O)c(F)cc2s1 | Homo sapiens | CHEMBL1929737 | single protein format | |
| CHEMBL2252326 | Ki | = | 530.0 | nM | 422.28 | O=C1C2=C(CCCC2)C(O)N1c1cc(OCc2cccc(Cl)c2)c(Cl)cc1F | Homo sapiens | CHEMBL3066844 | single protein format | |
| CHEMBL2252319 | Ki | = | 670.0 | nM | 326.22 | CCOc1cc(N2CC3=C(CCCC3)C2=O)c(Cl)cc1Cl | Homo sapiens | CHEMBL3066844 | single protein format | |
| CHEMBL2252347 | Ki | = | 690.0 | nM | 323.8 | CC(C)Oc1cc(N2CC3=C(CCCC3)C2=O)c(F)cc1Cl | Homo sapiens | CHEMBL3066844 | single protein format | |
| CHEMBL1926863 | Ki | = | 700.0 | nM | 425.51 | CCCOC(=O)CSc1nc2cc(-n3nc(C(C)(C)C)oc3=O)c(F)cc2s1 | Homo sapiens | CHEMBL1929737 | single protein format | |
| CHEMBL1884669 | Ki | = | 720.0 | nM | 387.2 | Cc1nn(-c2cc(NS(C)(=O)=O)c(Cl)cc2Cl)c(=O)n1C(F)F | Homo sapiens | CHEMBL3049525 | assay format | |
| CHEMBL1926857 | Ki | = | 720.0 | nM | 397.45 | CCOC(=O)Sc1nc2cc(-n3nc(C(C)(C)C)oc3=O)c(F)cc2s1 | Homo sapiens | CHEMBL1929737 | single protein format | |
| CHEMBL2230219 | Ki | = | 720.0 | nM | 383.43 | COC(=O)Sc1nc2cc(-n3nc(C(C)(C)C)oc3=O)c(F)cc2s1 | Homo sapiens | CHEMBL3049525 | assay format | |
| CHEMBL2252325 | Ki | = | 780.0 | nM | 405.83 | O=C1C2=C(CCCC2)C(O)N1c1cc(OCc2cccc(F)c2)c(Cl)cc1F | Homo sapiens | CHEMBL3066844 | single protein format | |
| CHEMBL2230215 | Ki | = | 840.0 | nM | 455.99 | CC(C)(C)OC(=O)CSc1nc2cc(-n3nc(C(C)(C)C)oc3=O)c(Cl)cc2s1 | Homo sapiens | CHEMBL3049525 | assay format | |
| CHEMBL2230211 | Ki | = | 980.0 | nM | 441.96 | CCCOC(=O)CSc1nc2cc(-n3nc(C(C)(C)C)oc3=O)c(Cl)cc2s1 | Homo sapiens | CHEMBL3049525 | assay format |