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P50579 | MAP2_HUMAN | Methionine aminopeptidase 2 (METAP2)

3D structures mapped by conservation among orthologs

[ Domain: "winged" // crvDNA_42K ]

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[ Domain: "Creatinase/aminopeptidase" // Peptidase_M24 ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4475680 OBDepict O N H N O HO N H O F Cl Ki = 0.16 nM 431.85 O=C1CCc2cc(N3CC[C@](O)(C(=O)NCc4cc(F)cc(Cl)c4)C3=O)ccc2N1 Homo sapiens CHEMBL4417041 cell-based format
CHEMBL176975 OBDepict CH 3 O H H O H O H 3 C O O H 2 N H CH 3 CH 3 IC50 = 0.39 nM 325.41 CO[C@H]1[C@H]([C@@]2(C)O[C@@H]2CC=C(C)C)[C@]2(CC[C@H]1OC(N)=O)CO2 Homo sapiens CHEMBL716777 single protein format
CHEMBL562231 OBDepict CH 3 O H O HO O CH 3 O H CH 3 H 3 C IC50 = 0.4 nM 296.36 CO[C@@H]1C(=O)CC[C@]2(CO2)[C@@]1(O)[C@@]1(C)O[C@@H]1CC=C(C)C Homo sapiens CHEMBL1027137 single protein format
CHEMBL368349 OBDepict CH 3 O H H O H O H 3 C O N H O H O Cl CH 3 CH 3 IC50 = 0.43 nM 387.86 CO[C@H]1[C@H]([C@@]2(C)O[C@@H]2CC=C(C)C)[C@]2(CC[C@H]1OC(=O)NC(=O)Cl)CO2 Homo sapiens CHEMBL716777 single protein format
CHEMBL172123 OBDepict CH 3 O H H O H O H 3 C O O H 3 C H CH 3 CH 3 IC50 = 0.51 nM 324.42 CO[C@H]1[C@H]([C@@]2(C)O[C@@H]2CC=C(C)C)[C@]2(CC[C@H]1OC(C)=O)CO2 Homo sapiens CHEMBL716777 single protein format
CHEMBL367938 OBDepict H 3 C N N O O H H O CH 3 H O N CH 3 O IC50 = 0.8 nM 451.61 CCN1CCN(C(=O)O[C@@H]2CC[C@]3(CO3)[C@@H](/C(C)=N/OCC3CCCCC3)[C@@H]2OC)CC1 Homo sapiens CHEMBL716777 single protein format
CHEMBL4451402 OBDepict F F HN O OH O N N N H Ki = 0.9 nM 386.36 O=C(NCc1cc(F)cc(F)c1)[C@@]1(O)CCN(c2cnc3[nH]ccc3c2)C1=O Homo sapiens CHEMBL4417041 cell-based format
CHEMBL137766 OBDepict CH 3 O H H O H O H 3 C O O H H 3 C H 3 C O O CH 3 O H 3 C CH 3 IC50 = 0.96 nM 502.6 COc1cc(/C=C/C(=O)O[C@@H]2CC[C@]3(CO3)[C@@H]([C@@]3(C)O[C@@H]3CC=C(C)C)[C@@H]2OC)cc(OC)c1OC Homo sapiens CHEMBL4349223 single protein format
CHEMBL32838 OBDepict CH 3 O H H O H O H 3 C O O H CH 3 H 3 C O OH IC50 = 1.0 nM 458.55 CO[C@H]1[C@H]([C@@]2(C)O[C@@H]2CC=C(C)C)[C@]2(CC[C@H]1OC(=O)/C=C/C=C/C=C/C=C/C(=O)O)CO2 Homo sapiens CHEMBL709685 single protein format
CHEMBL424278 OBDepict Cl N H O O O H H O H 3 C H O H 3 C O H CH 3 CH 3 IC50 = 1.0 nM 401.89 CO[C@H]1[C@H]([C@@]2(C)O[C@@H]2CC=C(C)C)[C@]2(CC[C@H]1OC(=O)NC(=O)CCl)CO2 Homo sapiens CHEMBL910328 single protein format
CHEMBL174250 OBDepict CH 3 O H H O H N CH 3 O O CH 3 O IC50 = 1.2 nM 347.41 CO[C@H]1[C@H](/C(C)=N/OCc2ccccc2)[C@]2(CC[C@H]1OC(C)=O)CO2 Homo sapiens CHEMBL716777 single protein format
CHEMBL172883 OBDepict CH 3 O H H O H N CH 3 O O NH 2 O IC50 = 1.2 nM 348.4 CO[C@H]1[C@H](/C(C)=N/OCc2ccccc2)[C@]2(CC[C@H]1OC(N)=O)CO2 Homo sapiens CHEMBL716777 single protein format
CHEMBL3973816 OBDepict HO N N N N O H N F F F IC50 = 1.46 nM 429.4 O=c1c2cn[nH]c2c2ccc(-c3cccnc3N3CCC(O)C3)cc2n1CC(F)(F)F Homo sapiens CHEMBL3887429 single protein format
CHEMBL369152 OBDepict CH 3 O H H O H CH 3 O O NH 2 H 3 C H 3 C IC50 = 1.7 nM 309.41 CO[C@H]1[C@H](/C(C)=C/CC=C(C)C)[C@]2(CC[C@H]1OC(N)=O)CO2 Homo sapiens CHEMBL716777 single protein format
CHEMBL3930227 OBDepict H N N N O F F F N HN IC50 = 2.13 nM 427.43 O=c1c2cn[nH]c2c2ccc(-c3ccc(N4CCNCC4)cc3)cc2n1CC(F)(F)F Homo sapiens CHEMBL3887429 single protein format
CHEMBL3798615 OBDepict N N N N F F F H IC50 = 3.0 nM 288.23 N#Cc1cncc(-c2cc(C(F)(F)F)cc3[nH]ncc23)c1 Homo sapiens CHEMBL3802682 cell-based format
CHEMBL3935543 OBDepict H N N N O F F F N N HN IC50 = 3.06 nM 428.42 O=c1c2cn[nH]c2c2ccc(-c3ccc(N4CCNCC4)nc3)cc2n1CC(F)(F)F Homo sapiens CHEMBL3887429 single protein format
CHEMBL4448724 OBDepict F Cl HN O OH O N N N H Ki = 3.36 nM 402.81 O=C(NCc1cc(F)cc(Cl)c1)[C@@]1(O)CCN(c2cnc3[nH]ccc3c2)C1=O Homo sapiens CHEMBL4417041 cell-based format
CHEMBL3917406 OBDepict F N N N N O H N F F F IC50 = 3.45 nM 445.42 O=c1c2cn[nH]c2c2ccc(-c3cccnc3N3CCC(F)CC3)cc2n1CC(F)(F)F Homo sapiens CHEMBL3887429 single protein format
CHEMBL3958170 OBDepict H 3 C N CH 3 N N N O H N F F F IC50 = 3.87 nM 387.37 CN(C)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 Homo sapiens CHEMBL3887429 single protein format
CHEMBL3944602 OBDepict CH 3 N N N N O H N F F F IC50 = 3.94 nM 441.46 CN1CCN(c2ccc(-c3ccc4c5[nH]ncc5c(=O)n(CC(F)(F)F)c4c3)cc2)CC1 Homo sapiens CHEMBL3887429 single protein format
CHEMBL3798871 OBDepict OH N H O F N N F F F H IC50 = 4.0 nM 367.3 O=C(NCCO)c1ccc(-c2cc(C(F)(F)F)cc3[nH]ncc23)c(F)c1 Homo sapiens CHEMBL3802682 cell-based format
CHEMBL3798727 OBDepict H N N F F F N N IC50 = 4.0 nM 302.26 FC(F)(F)c1cc(-c2ccc3nccn3c2)c2cn[nH]c2c1 Homo sapiens CHEMBL3802682 cell-based format
CHEMBL3904411 OBDepict H 3 C N N N N N O H N F F F IC50 = 4.12 nM 442.45 CN1CCN(c2cc(-c3ccc4c5[nH]ncc5c(=O)n(CC(F)(F)F)c4c3)ccn2)CC1 Homo sapiens CHEMBL3887429 single protein format
CHEMBL3941661 OBDepict CH 3 N H 3 C N N N O H N F F F IC50 = 4.19 nM 401.39 CCN(C)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 Homo sapiens CHEMBL3887429 single protein format
CHEMBL193610 OBDepict CH 3 N N N H Ki = 4.2 nM 159.19 Cc1ccc(-c2c[nH]nn2)cc1 Homo sapiens CHEMBL884774 single protein format
CHEMBL3950368 OBDepict CH 3 NH O CH 3 N N O H N F F F IC50 = 4.29 nM 428.41 CCC(=O)Nc1ccc(C)cc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 Homo sapiens CHEMBL3887429 single protein format
CHEMBL4464946 OBDepict F F HN O OH O N N H Ki = 4.33 nM 385.37 O=C(NCc1cc(F)cc(F)c1)[C@@]1(O)CCN(c2ccc3[nH]ccc3c2)C1=O Homo sapiens CHEMBL4417041 cell-based format
CHEMBL3945374 OBDepict OH N H 3 C N N N O H N F F F IC50 = 4.41 nM 417.39 CN(CCO)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 Homo sapiens CHEMBL3887429 single protein format
CHEMBL3960287 OBDepict H 3 C NH O N N N O H N F F F IC50 = 4.68 nM 401.35 CC(=O)Nc1cnccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 Homo sapiens CHEMBL3887429 single protein format
CHEMBL3908559 OBDepict Cl N N Cl N H N O F F F IC50 = 4.9 nM 413.19 O=c1c2cn[nH]c2c2cc(Cl)c(-c3cccnc3Cl)cc2n1CC(F)(F)F Homo sapiens CHEMBL3887429 single protein format
CHEMBL3979948 OBDepict H 3 C N CH 3 S N H O O N N O H N F F F IC50 = 4.99 nM 493.51 CN(C)CCS(=O)(=O)Nc1ccccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 Homo sapiens CHEMBL3887429 single protein format
CHEMBL3799242 OBDepict H 3 C N N N N H OH F F F H IC50 = 5.0 nM 362.36 Cc1nc(N2CC[C@H](O)C2)ccc1-c1cc(C(F)(F)F)cc2[nH]ncc12 Homo sapiens CHEMBL3802682 cell-based format
CHEMBL3797286 OBDepict CH 3 O N O CH 3 N N F F F H IC50 = 5.0 nM 323.27 COc1ccc(-c2cc(C(F)(F)F)cc3[nH]ncc23)c(OC)n1 Homo sapiens CHEMBL3802682 cell-based format
CHEMBL3798702 OBDepict H 3 C N N N N H OH F F F H IC50 = 5.0 nM 362.36 Cc1nc(N2CC[C@@H](O)C2)ccc1-c1cc(C(F)(F)F)cc2[nH]ncc12 Homo sapiens CHEMBL3802682 cell-based format
CHEMBL3799512 OBDepict H 3 C N N N N N H OH F F F H IC50 = 5.0 nM 363.34 Cc1nc(N2CC[C@@H](O)C2)ncc1-c1cc(C(F)(F)F)cc2[nH]ncc12 Homo sapiens CHEMBL3802682 cell-based format
CHEMBL3891524 OBDepict H N N O N F F F N H S O O CH 3 IC50 = 5.33 nM 436.42 CS(=O)(=O)Nc1ccccc1-c1ccc2c3n[nH]cc3c(=O)n(CC(F)(F)F)c2c1 Homo sapiens CHEMBL3887429 single protein format
CHEMBL3913956 OBDepict H N N N O F F F N N IC50 = 5.34 nM 413.4 O=c1c2cn[nH]c2c2ccc(-c3cccnc3N3CCCC3)cc2n1CC(F)(F)F Homo sapiens CHEMBL3887429 single protein format
CHEMBL3934094 OBDepict O N N N F F F H N N HN IC50 = 5.62 nM 428.42 O=c1c2cn[nH]c2c2ccc(-c3ccnc(N4CCNCC4)c3)cc2n1CC(F)(F)F Homo sapiens CHEMBL3887429 single protein format
CHEMBL3901247 OBDepict CH 3 N N N N N O H N F F F IC50 = 6.0 nM 456.47 CN1CCCN(c2ncccc2-c2ccc3c4[nH]ncc4c(=O)n(CC(F)(F)F)c3c2)CC1 Homo sapiens CHEMBL3887429 single protein format
CHEMBL3800596 OBDepict H 3 C N N N N N H OH F F F H IC50 = 6.0 nM 363.34 Cc1nc(N2CC[C@H](O)C2)ncc1-c1cc(C(F)(F)F)cc2[nH]ncc12 Homo sapiens CHEMBL3802682 cell-based format
CHEMBL3797663 OBDepict H N N F F F N N IC50 = 6.0 nM 264.21 FC(F)(F)c1cc(-c2cncnc2)c2cn[nH]c2c1 Homo sapiens CHEMBL3802682 cell-based format
CHEMBL3925571 OBDepict O N N N F F F H N N N H IC50 = 6.08 nM 442.45 O=c1c2cn[nH]c2c2ccc(-c3cccnc3N3CCCNCC3)cc2n1CC(F)(F)F Homo sapiens CHEMBL3887429 single protein format
CHEMBL3895483 OBDepict OH N HO N N N O N F F F H IC50 = 6.41 nM 445.4 O=c1c2c[nH]nc2c2ccc(-c3cccnc3N3CC(O)C(O)C3)cc2n1CC(F)(F)F Homo sapiens CHEMBL3887429 single protein format
CHEMBL3901734 OBDepict NH 2 N N N O H N F F F IC50 = 7.06 nM 359.31 Nc1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 Homo sapiens CHEMBL3887429 single protein format
CHEMBL3928567 OBDepict F N N N H N O F F F IC50 = 7.1 nM 362.29 O=c1c2cn[nH]c2c2cc(F)c(-c3ccccn3)cc2n1CC(F)(F)F Homo sapiens CHEMBL3887429 single protein format
CHEMBL3930411 OBDepict CH 3 N N N N N O H N F F F IC50 = 7.24 nM 442.45 CN1CCN(c2ncccc2-c2ccc3c4[nH]ncc4c(=O)n(CC(F)(F)F)c3c2)CC1 Homo sapiens CHEMBL3887429 single protein format
CHEMBL3943061 OBDepict CH 3 N N N O H N F F F IC50 = 7.38 nM 358.32 Cc1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 Homo sapiens CHEMBL3887429 single protein format
CHEMBL3923146 OBDepict Cl N N N O H N F F F IC50 = 7.42 nM 378.74 O=c1c2cn[nH]c2c2ccc(-c3cccnc3Cl)cc2n1CC(F)(F)F Homo sapiens CHEMBL3887429 single protein format
CHEMBL3972816 OBDepict H N N N O N F F F IC50 = 7.53 nM 344.3 O=c1c2cn[nH]c2c2ccc(-c3ccccn3)cc2n1CC(F)(F)F Homo sapiens CHEMBL3887429 single protein format
CHEMBL3957907 OBDepict NH 2 N N N O H N F F F IC50 = 7.64 nM 359.31 Nc1cnccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 Homo sapiens CHEMBL3887429 single protein format
CHEMBL3938818 OBDepict Cl N N H N N O F F F IC50 = 7.77 nM 378.74 O=c1c2cn[nH]c2c2cc(Cl)c(-c3ccncc3)cc2n1CC(F)(F)F Homo sapiens CHEMBL3887429 single protein format
CHEMBL388245 OBDepict CH 3 O O HO HN S O O O F IC50 = 8.0 nM 391.38 COc1c(-c2ccoc2)ccc(NS(=O)(=O)c2ccc(F)cc2)c1C(=O)O Homo sapiens CHEMBL887601 single protein format
CHEMBL3799449 OBDepict CH 3 O N N N F F F H IC50 = 8.0 nM 293.25 COc1cnccc1-c1cc(C(F)(F)F)cc2[nH]ncc12 Homo sapiens CHEMBL3802682 cell-based format
CHEMBL3800546 OBDepict F N N N F F F H IC50 = 8.0 nM 281.21 Fc1cnccc1-c1cc(C(F)(F)F)cc2[nH]ncc12 Homo sapiens CHEMBL3802682 cell-based format
CHEMBL3800534 OBDepict CH 3 O N O N CH 3 N N F F F H IC50 = 8.0 nM 324.26 COc1ncc(-c2cc(C(F)(F)F)cc3[nH]ncc23)c(OC)n1 Homo sapiens CHEMBL3802682 cell-based format
CHEMBL3929804 OBDepict Cl N N N H N O F F F IC50 = 8.22 nM 378.74 O=c1c2cn[nH]c2c2cc(Cl)c(-c3ccccn3)cc2n1CC(F)(F)F Homo sapiens CHEMBL3887429 single protein format
CHEMBL3946517 OBDepict O N N N F F F H N N O IC50 = 8.35 nM 443.43 O=c1c2cn[nH]c2c2ccc(-c3cccnc3N3CCCOCC3)cc2n1CC(F)(F)F Homo sapiens CHEMBL3887429 single protein format
CHEMBL3984809 OBDepict CH 3 N H 3 C N N O H N F F F IC50 = 8.81 nM 372.35 Cc1cc(-c2ccc3c4[nH]ncc4c(=O)n(CC(F)(F)F)c3c2)cc(C)n1 Homo sapiens CHEMBL3887429 single protein format
CHEMBL3952819 OBDepict Cl N N N O H N F F F IC50 = 8.83 nM 378.74 O=c1c2cn[nH]c2c2ccc(-c3ncccc3Cl)cc2n1CC(F)(F)F Homo sapiens CHEMBL3887429 single protein format
CHEMBL172948 OBDepict CH 3 O H H O H CH 3 O O CH 3 CH 3 H 3 C IC50 = 8.9 nM 308.42 CO[C@H]1[C@H](/C(C)=C/CC=C(C)C)[C@]2(CC[C@H]1OC(C)=O)CO2 Homo sapiens CHEMBL716777 single protein format
CHEMBL3919632 OBDepict CH 3 N N O N N O H N F F F IC50 = 8.98 nM 483.49 CN1CCCN(C(=O)c2ccccc2-c2ccc3c4[nH]ncc4c(=O)n(CC(F)(F)F)c3c2)CC1 Homo sapiens CHEMBL3887429 single protein format
CHEMBL2407597 OBDepict CH 3 S NH O O O HO Br IC50 = 9.0 nM 370.22 Cc1ccc(S(=O)(=O)Nc2ccc(Br)cc2C(=O)O)cc1 Homo sapiens CHEMBL2412833 single protein format
CHEMBL3799467 OBDepict H 3 C N N N N F F F H IC50 = 9.0 nM 266.23 Cn1nccc1-c1cc(C(F)(F)F)cc2[nH]ncc12 Homo sapiens CHEMBL3802682 cell-based format
CHEMBL380394 OBDepict OH O HN S O O IC50 = 9.0 nM 331.39 O=C(O)c1c(NS(=O)(=O)c2ccccc2)ccc2c1CCCC2 Homo sapiens CHEMBL853527 single protein format
CHEMBL3901263 OBDepict H 3 C NH O N N N O H N F F F IC50 = 9.01 nM 401.35 CC(=O)Nc1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 Homo sapiens CHEMBL3887429 single protein format
CHEMBL3908228 OBDepict O N N N F F F H N N H IC50 = 9.22 nM 455.48 O=c1c2cn[nH]c2c2ccc(-c3ccccc3CN3CCCNCC3)cc2n1CC(F)(F)F Homo sapiens CHEMBL3887429 single protein format
CHEMBL3976726 OBDepict CH 3 O O N N N O H N F F F IC50 = 9.36 nM 402.33 COC(=O)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 Homo sapiens CHEMBL3887429 single protein format
CHEMBL3975808 OBDepict O N H N N N N O H N F F F IC50 = 9.44 nM 442.4 O=C1CN(c2ncccc2-c2ccc3c4[nH]ncc4c(=O)n(CC(F)(F)F)c3c2)CCN1 Homo sapiens CHEMBL3887429 single protein format
CHEMBL3907107 OBDepict CH 3 N H 3 C N CH 3 O N N O H N F F F IC50 = 9.53 nM 471.48 CN(C)CCN(C)C(=O)c1ccccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 Homo sapiens CHEMBL3887429 single protein format
CHEMBL3924037 OBDepict H N N N O F F F N H N S O O CH 3 IC50 = 9.66 nM 437.4 CS(=O)(=O)Nc1cnccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 Homo sapiens CHEMBL3887429 single protein format
CHEMBL376940 OBDepict F S N H O O O OH N CH 3 IC50 = 10.0 nM 472.58 CC(/C=Cc1cc(F)ccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2)N1CCCC1 Homo sapiens CHEMBL852974 single protein format
CHEMBL379124 OBDepict F S HN O O O OH IC50 = 10.0 nM 349.38 O=C(O)c1c(NS(=O)(=O)c2ccc(F)cc2)ccc2c1CCCC2 Homo sapiens CHEMBL853527 single protein format
CHEMBL230407 OBDepict CH 3 O H 3 C O HO N H S O O N H N CH 3 CH 3 IC50 = 10.0 nM 449.57 CCc1ccc(NS(=O)(=O)c2ccccc2NCCCCN(C)C)c(C(=O)O)c1OC Homo sapiens CHEMBL887601 single protein format
CHEMBL3797707 OBDepict CH 3 O N H 2 N N N N F F F H IC50 = 10.0 nM 309.25 COc1nc(N)ncc1-c1cc(C(F)(F)F)cc2[nH]ncc12 Homo sapiens CHEMBL3802682 cell-based format
CHEMBL209206 OBDepict OH O N H S O O NH N N IC50 = 10.0 nM 454.55 O=C(O)c1c(NS(=O)(=O)c2ccccc2NCCCn2ccnc2)ccc2c1CCCC2 Homo sapiens CHEMBL852974 single protein format
CHEMBL193610 OBDepict CH 3 N N N H IC50 = 10.0 nM 159.19 Cc1ccc(-c2c[nH]nn2)cc1 Homo sapiens CHEMBL881950 single protein format
CHEMBL3945936 OBDepict H N N N O F F F N H N S O O IC50 = 10.2 nM 513.5 O=c1c2cn[nH]c2c2ccc(-c3ccncc3NS(=O)(=O)Cc3ccccc3)cc2n1CC(F)(F)F Homo sapiens CHEMBL3887429 single protein format
CHEMBL3913665 OBDepict H N N O N F F F H 2 N IC50 = 10.4 nM 358.32 Nc1ccccc1-c1ccc2c3n[nH]cc3c(=O)n(CC(F)(F)F)c2c1 Homo sapiens CHEMBL3887429 single protein format
CHEMBL3985583 OBDepict CH 3 HN N N N O H N F F F IC50 = 10.6 nM 373.34 CNc1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 Homo sapiens CHEMBL3887429 single protein format
CHEMBL3800090 OBDepict OH N H O CH 3 N N F F F H IC50 = 11.0 nM 363.34 Cc1cc(C(=O)NCCO)ccc1-c1cc(C(F)(F)F)cc2[nH]ncc12 Homo sapiens CHEMBL3802682 cell-based format
CHEMBL230280 OBDepict CH 3 O CH 3 O HO HN S O O F IC50 = 11.0 nM 353.37 CCc1ccc(NS(=O)(=O)c2ccc(F)cc2)c(C(=O)O)c1OC Homo sapiens CHEMBL887601 single protein format
CHEMBL3798034 OBDepict CH 3 N N N F F F H IC50 = 11.0 nM 277.25 Cc1cnccc1-c1cc(C(F)(F)F)cc2[nH]ncc12 Homo sapiens CHEMBL3802682 cell-based format
CHEMBL3927634 OBDepict CH 3 N N Cl N H N O F F F IC50 = 11.1 nM 392.77 Cc1cc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2cc1-c1cccnc1Cl Homo sapiens CHEMBL3887429 single protein format
CHEMBL3978845 OBDepict OH N N N O H N F F F IC50 = 11.3 nM 360.3 O=c1c2cn[nH]c2c2ccc(-c3cccnc3O)cc2n1CC(F)(F)F Homo sapiens CHEMBL3887429 single protein format
CHEMBL3930908 OBDepict CH 3 O NH O N N O H N F F F IC50 = 11.8 nM 430.39 COCC(=O)Nc1ccccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 Homo sapiens CHEMBL3887429 single protein format
CHEMBL3896253 OBDepict O N O N N O H N F F F IC50 = 12.1 nM 456.42 O=C(c1ccccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1)N1CCOCC1 Homo sapiens CHEMBL3887429 single protein format
CHEMBL3933046 OBDepict CH 3 N Cl N N O H N F F F IC50 = 12.3 nM 392.77 Cc1ccc(-c2ccc3c4[nH]ncc4c(=O)n(CC(F)(F)F)c3c2)c(Cl)n1 Homo sapiens CHEMBL3887429 single protein format
CHEMBL3978127 OBDepict H 3 C N CH 3 O N N N O H N F F F IC50 = 12.5 nM 415.38 CN(C)C(=O)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 Homo sapiens CHEMBL3887429 single protein format
CHEMBL3902138 OBDepict O HN N N N O H N F F F IC50 = 12.9 nM 491.47 O=C(NCCc1ccncc1)c1ccccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 Homo sapiens CHEMBL3887429 single protein format
CHEMBL3798047 OBDepict OH N H O O CH 3 N N F F F H IC50 = 13.0 nM 379.34 COc1cc(C(=O)NCCO)ccc1-c1cc(C(F)(F)F)cc2[nH]ncc12 Homo sapiens CHEMBL3802682 cell-based format
CHEMBL377888 OBDepict OH O HN S O O NH 2 IC50 = 13.0 nM 346.41 Nc1ccccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)CCCC2 Homo sapiens CHEMBL852974 single protein format
CHEMBL3930974 OBDepict H N N N O F F F N N IC50 = 13.0 nM 399.38 O=c1c2cn[nH]c2c2ccc(-c3cccnc3N3CCC3)cc2n1CC(F)(F)F Homo sapiens CHEMBL3887429 single protein format
CHEMBL3980759 OBDepict O N N O N N O H N F F F IC50 = 14.1 nM 457.41 O=C(c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1)N1CCOCC1 Homo sapiens CHEMBL3887429 single protein format
CHEMBL3969775 OBDepict CH 3 N H 3 C N CH 3 O N N N O H N F F F IC50 = 14.5 nM 472.47 CN(C)CCN(C)C(=O)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 Homo sapiens CHEMBL3887429 single protein format
CHEMBL3893168 OBDepict O N N O N N O H N F F F IC50 = 14.7 nM 471.44 O=C(c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1)N1CCCOCC1 Homo sapiens CHEMBL3887429 single protein format
CHEMBL3957068 OBDepict Cl N N N O H N F F F IC50 = 14.9 nM 378.74 O=c1c2cn[nH]c2c2ccc(-c3ccnc(Cl)c3)cc2n1CC(F)(F)F Homo sapiens CHEMBL3887429 single protein format
CHEMBL210557 OBDepict CH 3 N HN S NH O O O OH IC50 = 15.0 nM 457.6 CN1CCC(CNc2ccccc2S(=O)(=O)Nc2ccc3c(c2C(=O)O)CCCC3)CC1 Homo sapiens CHEMBL852974 single protein format
CHEMBL388898 OBDepict CH 3 O CH 3 O HO N H S O O N H N H 3 C IC50 = 15.0 nM 461.58 CCc1ccc(NS(=O)(=O)c2ccccc2NCCC2CCCN2C)c(C(=O)O)c1OC Homo sapiens CHEMBL887601 single protein format
CHEMBL230838 OBDepict CH 3 N CH 3 S F N H O O O HO O H 3 C O IC50 = 15.0 nM 502.56 CCN(CC)C/C=Cc1cc(F)ccc1S(=O)(=O)Nc1ccc(-c2ccoc2)c(OC)c1C(=O)O Homo sapiens CHEMBL887601 single protein format