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P51160 | PDE6C_HUMAN | "Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'" (PDE6C)

3D structures mapped by conservation among orthologs

[ Domain: "HD-domain/PDEase-like" // PDEase_I ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL3936651 OBDepict CH 3 O N N O H O N N H 3 C CH 3 N N N HN O OH IC50 = 0.13 nM 534.58 CCOc1ccc(OC2CCN(c3ncc(C(=O)NO)cn3)CC2)cc1-c1nc2c(CC)nn(C)c2c(=O)[nH]1 Homo sapiens CHEMBL3861027 cell-based format
CHEMBL377168 OBDepict H 3 C N N N CH 3 N OH O O CH 3 H 3 C IC50 = 0.9 nM 354.41 CCCc1nn(C)c2c(O)nc(-c3cc(C(C)=O)ccc3OCC)nc12 Homo sapiens CHEMBL860111 single protein format
CHEMBL4217054 OBDepict CH 3 S H N N N N H O N IC50 = 1.2 nM 451.56 CCc1ccc([C@@H]2c3[nH]c4ccccc4c(=O)c3CN2c2ncc(-c3ccccn3)cn2)s1 Homo sapiens CHEMBL4198222 cell-based format
CHEMBL4218772 OBDepict CH 3 O N H HO O O N H N S O O IC50 = 1.2 nM 491.53 COCCNc1cc(O)c2c(=O)c3c(-c4nccs4)[nH]c(Cc4ccc5c(c4)OCO5)c3oc2c1 Homo sapiens CHEMBL4200912 assay format
CHEMBL209460 OBDepict H 3 C N N N CH 3 N OH O O CH 3 N O IC50 = 1.4 nM 439.52 CCCc1nn(C)c2c(O)nc(-c3cc(C(=O)CN4CCOCC4)ccc3OCC)nc12 Homo sapiens CHEMBL860111 single protein format
CHEMBL4212186 OBDepict H 3 C N N N CH 3 N O H O CH 3 S NH O HO IC50 = 1.4 nM 467.55 CCCc1nn(C)c2c(=O)[nH]c(-c3cc(Cc4ccc(C(=O)NO)s4)ccc3OCC)nc12 Homo sapiens CHEMBL4198940 single protein format
CHEMBL4217579 OBDepict CH 3 O H N N N N H O N IC50 = 1.5 nM 435.49 CCc1ccc([C@@H]2c3[nH]c4ccccc4c(=O)c3CN2c2ncc(-c3ccccn3)cn2)o1 Homo sapiens CHEMBL4198222 cell-based format
CHEMBL4212630 OBDepict H 3 C O N N N N H O N IC50 = 2.3 nM 435.49 CCc1ccc(C2c3[nH]c4ccccc4c(=O)c3CN2c2ncc(-c3ccccn3)cn2)o1 Homo sapiens CHEMBL4198222 cell-based format
CHEMBL3900593 OBDepict CH 3 O N N H O N N H 3 C H 3 C N H O OH IC50 = 2.6 nM 425.49 CCOc1ccc(CC2CC(C(=O)NO)C2)cc1-c1nc2c(CC)nn(C)c2c(=O)[nH]1 Homo sapiens CHEMBL3861027 cell-based format
CHEMBL4218398 OBDepict H 3 C S N N N N H O IC50 = 3.7 nM 374.47 CCc1ccc(C2c3[nH]c4ccccc4c(=O)c3CN2c2ncccn2)s1 Homo sapiens CHEMBL4198222 cell-based format
CHEMBL4208249 OBDepict CH 3 O H N N N N H O N IC50 = 3.8 nM 435.49 CCc1ccc([C@H]2c3[nH]c4ccccc4c(=O)c3CN2c2ncc(-c3ccccn3)cn2)o1 Homo sapiens CHEMBL4198222 cell-based format
CHEMBL4209716 OBDepict H 3 C S N N N N H O N IC50 = 4.8 nM 451.56 CCc1ccc(C2c3[nH]c4ccccc4c(=O)c3CN2c2ncc(-c3ccccn3)cn2)s1 Homo sapiens CHEMBL4198222 cell-based format
CHEMBL3401745 OBDepict H 3 C N N N CH 3 N O H O S N H O O HO CH 3 IC50 = 5.2 nM 491.61 CCCc1nn(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)NCCCCCCO)ccc3OCC)nc12 Homo sapiens CHEMBL3405817 single protein format
CHEMBL4204725 OBDepict H 3 C O N N N N H O IC50 = 6.2 nM 358.4 CCc1ccc(C2c3[nH]c4ccccc4c(=O)c3CN2c2ncccn2)o1 Homo sapiens CHEMBL4198222 cell-based format
CHEMBL4072903 OBDepict H 3 C N O N N H N Cl O CH 3 IC50 = 6.6 nM 406.87 CCN1Cc2nc3ccc(C#N)cc3c(NCc3ccc(OC)c(Cl)c3)c2C1=O Homo sapiens CHEMBL4020496 single protein format
CHEMBL4284224 OBDepict CH 3 O H N N H O N H O CH 3 IC50 = 10.0 nM 363.42 CCc1ccc([C@H]2c3[nH]c4ccccc4c3C[C@@H]3C(=O)N(CC)C(=O)N32)o1 Homo sapiens CHEMBL4268480 cell-based format
CHEMBL4285199 OBDepict CH 3 N O N O H H S N H 3 C H IC50 = 13.0 nM 365.46 CCN1C(=O)[C@@H]2Cc3c([nH]c4ccccc34)[C@@H](c3sccc3C)N2C1=O Homo sapiens CHEMBL4268480 cell-based format
CHEMBL4062273 OBDepict CH 3 O Cl N H N N O H 3 C N IC50 = 30.1 nM 420.9 COc1ccc(CNc2c3c(nc4ccc(C#N)cc24)CCN(C(C)=O)C3)cc1Cl Homo sapiens CHEMBL4020496 single protein format
CHEMBL4205338 OBDepict CH 3 S H N N N N H O N IC50 = 34.1 nM 451.56 CCc1ccc([C@H]2c3[nH]c4ccccc4c(=O)c3CN2c2ncc(-c3ccccn3)cn2)s1 Homo sapiens CHEMBL4198222 cell-based format
CHEMBL2180945 OBDepict H 3 C O N N S H N O O N CH 3 O CH 3 CH 3 IC50 = 45.6 nM 448.59 CCCOc1ccc(S(=O)(=O)N2CCN(C)CC2)cc1-c1nc(CC)c(CC)c(=O)[nH]1 Homo sapiens CHEMBL2184506 single protein format
CHEMBL4277243 OBDepict CH 3 S H N N H O N H O CH 3 IC50 = 56.0 nM 379.49 CCc1ccc([C@@H]2c3[nH]c4ccccc4c3C[C@H]3C(=O)N(CC)C(=O)N32)s1 Homo sapiens CHEMBL4268480 cell-based format
CHEMBL4292389 OBDepict CH 3 N O N O H H O N H CH 3 IC50 = 62.0 nM 349.39 CCN1C(=O)[C@@H]2Cc3c([nH]c4ccccc34)[C@@H](c3ccc(C)o3)N2C1=O Homo sapiens CHEMBL4268480 cell-based format
CHEMBL4280648 OBDepict CH 3 N O N O H H S N H H 3 C IC50 = 107.0 nM 407.54 CCCCN1C(=O)[C@@H]2Cc3c([nH]c4ccccc34)[C@@H](c3ccc(CC)s3)N2C1=O Homo sapiens CHEMBL4268480 cell-based format
CHEMBL4281766 OBDepict CH 3 O H N N H O N H O CH 3 IC50 = 127.0 nM 363.42 CCc1ccc([C@@H]2c3[nH]c4ccccc4c3C[C@H]3C(=O)N(CC)C(=O)N32)o1 Homo sapiens CHEMBL4268480 cell-based format
CHEMBL4289471 OBDepict Br S H N N H O H N O CH 3 IC50 = 136.0 nM 430.33 CN1CC(=O)N2[C@H](c3ccc(Br)s3)c3[nH]c4ccccc4c3C[C@@H]2C1=O Homo sapiens CHEMBL4268480 cell-based format
CHEMBL192 OBDepict H 3 C N N N CH 3 N O H O S N O O N H 3 C CH 3 IC50 = 160.0 nM 474.59 CCCc1nn(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(C)CC4)ccc3OCC)nc12 Homo sapiens CHEMBL998838 single protein format
CHEMBL210603 OBDepict H 3 C N N N N N OH O N O CH 3 CH 3 IC50 = 183.0 nM 460.54 CCCCOc1ncc(C(C)=O)cc1-c1nc(O)c2nn(Cc3ccccn3)c(CCC)c2n1 Homo sapiens CHEMBL860111 single protein format
CHEMBL4287438 OBDepict H 3 C S N N N N H O O O CH 3 H 3 C IC50 = 253.0 nM 510.62 CCc1ccc(C2c3[nH]c4ccccc4c3C(=O)CN2c2ncc(-c3ccc(OC)c(OC)c3)cn2)s1 Homo sapiens CHEMBL4268480 cell-based format
CHEMBL4292970 OBDepict H 3 C O N N N N H O O O CH 3 H 3 C IC50 = 288.0 nM 494.55 CCc1ccc(C2c3[nH]c4ccccc4c3C(=O)CN2c2ncc(-c3ccc(OC)c(OC)c3)cn2)o1 Homo sapiens CHEMBL4268480 cell-based format
CHEMBL209157 OBDepict H 3 C O O N N N S H N O O N H 3 C O N N H 3 C N IC50 = 386.0 nM 582.69 CCc1c2nc(-c3cc(S(=O)(=O)N4CCN(CC)CC4)cnc3OCCOC)[nH]c(=O)c2nn1Cc1ccccn1 Homo sapiens CHEMBL860111 single protein format
CHEMBL1463540 OBDepict Cl N O N S N N IC50 = 460.0 nM 370.87 O=c1n(Cc2ccc(Cl)cc2)c2sc3c(c2c2ncnn12)CCCC3 Homo sapiens CHEMBL4011527 cell-based format
CHEMBL210930 OBDepict CH 3 O N N N O CH 3 HO N N H 3 C N CH 3 IC50 = 840.0 nM 438.53 CCCCOc1ncc(C(C)=O)cc1-c1nc(O)c2nn(C3CN(CC)C3)c(CC)c2n1 Homo sapiens CHEMBL860111 single protein format