HOME LIGAND hPROTEOME OTHERS DOCUMENT

P51512 | MMP16_HUMAN | Matrix metalloproteinase-16 (MMP16)

3D structures mapped by conservation among orthologs

[ Domain: "Metalloproteases ("zincins") catalytic domain" // Peptidase_M10 ]

download pymol session



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL234530 OBDepict OH HN O N S O O O HN O S O O NH 2 IC50 = 1.0 nM 562.63 NS(=O)(=O)c1ccc(CCNC(=O)CN(CC(=O)NO)S(=O)(=O)c2ccc(Oc3ccccc3)cc2)cc1 Homo sapiens CHEMBL1010054 single protein format
CHEMBL515980 OBDepict OH N H O N H S H 3 C CH 3 O O O O OH IC50 = 1.56 nM 422.46 CC(C)[C@H](C(=O)NO)N(CC(=O)O)S(=O)(=O)c1ccc(Oc2ccccc2)cc1 Homo sapiens CHEMBL1010054 single protein format
CHEMBL514138 OBDepict HO N H O N H S CH 3 H 3 C O O O CH 3 N ClH IC50 = 6.8 nM 429.93 COc1ccc(S(=O)(=O)N(Cc2cccnc2)[C@@H](C(=O)NO)C(C)C)cc1.Cl Homo sapiens CHEMBL1010054 single protein format
CHEMBL19611 OBDepict OH HN O H N H O CH 3 CH 3 H NH O H 3 C N H IC50 = 8.0 nM 388.47 CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CC(=O)NO)CC(C)C Homo sapiens CHEMBL718405 single protein format
CHEMBL472899 OBDepict OH HN O N S O O O O OH IC50 = 11.4 nM 380.38 O=C(O)CN(CC(=O)NO)S(=O)(=O)c1ccc(Oc2ccccc2)cc1 Homo sapiens CHEMBL1010054 single protein format
CHEMBL148214 OBDepict CH 3 O S N O O HN O OH O OH H 3 C IC50 = 16.0 nM 408.43 COc1ccc(S(=O)(=O)N2CCc3cc(O)c(OC)cc3C2C(=O)NO)cc1 Homo sapiens CHEMBL718405 single protein format
CHEMBL147882 OBDepict OH N H O N S O O H 3 C OH IC50 = 21.0 nM 362.41 Cc1ccc(S(=O)(=O)N2CCc3cc(O)ccc3C2C(=O)NO)cc1 Homo sapiens CHEMBL718405 single protein format
CHEMBL358539 OBDepict OH HN O N S O O O CH 3 O IC50 = 22.0 nM 468.53 COc1ccc(S(=O)(=O)N2CCc3cc(OCc4ccccc4)ccc3C2C(=O)NO)cc1 Homo sapiens CHEMBL718405 single protein format
CHEMBL573715 OBDepict OH NH O S O O O O H 3 C IC50 = 32.0 nM 413.45 COc1ccc(Oc2ccc(S(=O)(=O)c3ccccc3CC(=O)NO)cc2)cc1 Homo sapiens CHEMBL1042359 single protein format
CHEMBL88520 OBDepict CH 3 HN O N H O H N H O H H O H 3 C H 3 C HN O OH Ki = 35.0 nM 462.55 CNC(=O)CNC(=O)[C@@H]1Cc2ccc(cc2)OCCC[C@H](C(=O)NO)[C@@H](CC(C)C)C(=O)N1 Homo sapiens CHEMBL718403 single protein format
CHEMBL147881 OBDepict OH N H O N S O O O IC50 = 35.0 nM 438.51 O=C(NO)C1c2ccc(OCc3ccccc3)cc2CCN1S(=O)(=O)c1ccccc1 Homo sapiens CHEMBL718405 single protein format
CHEMBL1939846 OBDepict OH N O O N H S CH 3 CH 3 O O O IC50 = 39.0 nM 404.44 CC(C)[C@@H]1C(=O)N(O)C(=O)CN1S(=O)(=O)c1ccc(Oc2ccccc2)cc1 Homo sapiens CHEMBL1942113 single protein format
CHEMBL148171 OBDepict HO N H O N S O O O CH 3 OH IC50 = 40.0 nM 378.41 COc1cc2c(cc1O)CCN(S(=O)(=O)c1ccccc1)C2C(=O)NO Homo sapiens CHEMBL718405 single protein format
CHEMBL234529 OBDepict OH HN O N S O O O H 3 C HN O S O O NH 2 IC50 = 44.0 nM 500.56 COc1ccc(S(=O)(=O)N(CC(=O)NO)CC(=O)NCCc2ccc(S(N)(=O)=O)cc2)cc1 Homo sapiens CHEMBL1010054 single protein format
CHEMBL179288 OBDepict HO NH O N H S O H 3 C CH 3 O O H 3 C CH 3 IC50 = 51.0 nM 406.5 CC(C)ON([C@@H](C(=O)NO)C(C)C)S(=O)(=O)c1ccc(-c2ccccc2)cc1 Homo sapiens CHEMBL1042359 single protein format
CHEMBL561963 OBDepict OH HN O N S O CH 3 CH 3 O O H 3 C H 3 C CH 3 H 3 C IC50 = 51.0 nM 448.59 CC(C)ON(C(C(=O)NO)C(C)C)S(=O)(=O)c1ccc(-c2ccc(C(C)C)cc2)cc1 Homo sapiens CHEMBL816872 single protein format
CHEMBL146718 OBDepict OH HN O N S O O CH 3 O IC50 = 56.0 nM 452.53 Cc1ccc(S(=O)(=O)N2CCc3cc(OCc4ccccc4)ccc3C2C(=O)NO)cc1 Homo sapiens CHEMBL718405 single protein format
CHEMBL91636 OBDepict HO NH O H H O HN O H 3 C H 3 C H O N H NH O N O O Ki = 107.0 nM 527.62 CC(C)C[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N2CCOCC2)CCCCNC(=O)OCCC[C@@H]1C(=O)NO Homo sapiens CHEMBL718403 single protein format
CHEMBL573714 OBDepict OH NH O S O O O H 3 C IC50 = 130.0 nM 321.35 COc1ccc(S(=O)(=O)c2ccccc2CC(=O)NO)cc1 Homo sapiens CHEMBL1042359 single protein format
CHEMBL584365 OBDepict OH NH O S O O O H 3 C IC50 = 130.0 nM 397.45 COc1ccc(-c2ccc(S(=O)(=O)c3ccccc3CC(=O)NO)cc2)cc1 Homo sapiens CHEMBL1042359 single protein format
CHEMBL572780 OBDepict OH HN O CH 3 S O O O H 3 C IC50 = 150.0 nM 411.48 COc1ccc(-c2ccc(S(=O)(=O)c3ccccc3C(C)C(=O)NO)cc2)cc1 Homo sapiens CHEMBL1042359 single protein format
CHEMBL147489 OBDepict HO NH O N S O O + N O _ O OH IC50 = 177.0 nM 393.38 O=C(NO)C1c2ccc(O)cc2CCN1S(=O)(=O)c1ccc([N+](=O)[O-])cc1 Homo sapiens CHEMBL718405 single protein format
CHEMBL146289 OBDepict OH N H O N S O O HO IC50 = 184.0 nM 348.38 O=C(NO)C1c2ccc(O)cc2CCN1S(=O)(=O)c1ccccc1 Homo sapiens CHEMBL718405 single protein format
CHEMBL234735 OBDepict OH HN O N S O O HN O S O O NH 2 IC50 = 186.0 nM 546.63 NS(=O)(=O)c1ccc(CCNC(=O)CN(CC(=O)NO)S(=O)(=O)c2ccc(-c3ccccc3)cc2)cc1 Homo sapiens CHEMBL1010054 single protein format
CHEMBL148406 OBDepict OH N H O N S O O H 2 N OH IC50 = 202.0 nM 363.4 Nc1ccc(S(=O)(=O)N2CCc3cc(O)ccc3C2C(=O)NO)cc1 Homo sapiens CHEMBL718405 single protein format
CHEMBL574370 OBDepict OH N H O S O O IC50 = 220.0 nM 367.43 O=C(Cc1ccccc1S(=O)(=O)c1ccc(-c2ccccc2)cc1)NO Homo sapiens CHEMBL1042359 single protein format
CHEMBL574605 OBDepict OH HN O CH 3 S O O IC50 = 470.0 nM 381.45 CC(C(=O)NO)c1ccccc1S(=O)(=O)c1ccc(-c2ccccc2)cc1 Homo sapiens CHEMBL1042359 single protein format
CHEMBL573936 OBDepict CH 3 O S O O O HO IC50 = 730.0 nM 382.44 COc1ccc(-c2ccc(S(=O)(=O)c3ccccc3CC(=O)O)cc2)cc1 Homo sapiens CHEMBL1042359 single protein format
CHEMBL181244 OBDepict OH HN O N S O O O CH 3 CH 3 IC50 = 900.0 nM 364.42 CC(C)ON(CC(=O)NO)S(=O)(=O)c1ccc(-c2ccccc2)cc1 Homo sapiens CHEMBL816872 single protein format
CHEMBL515083 OBDepict OH HN O N S O O O H 3 C O OH IC50 = 996.0 nM 318.31 COc1ccc(S(=O)(=O)N(CC(=O)O)CC(=O)NO)cc1 Homo sapiens CHEMBL1010054 single protein format