P51692 | STA5B_HUMAN | Signal transducer and activator of transcription 5B (STAT5B)

3D structures mapped by conservation among orthologs

[ Domain: "EF-hand" // STAT_bind_C ]

download pymol session

[ Domain: "Common fold of diphtheria toxin/transcription factors/cytochrome f" // STAT_bind_N ]

download pymol session

[ Domain: "SH2" // SH2 ]

download pymol session

[ Domain: "STAT" // STAT_alpha ]

download pymol session

[ Domain: pdbs with more than 2 multi-domains ]

download pymol session

[ Alpha Fold Model ] (go)

Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id	structure	assay_type	relation	values	units	mol_wt	smiles	organism	assay_chembl_id	bao_label
CHEMBL4066274		IC50	=	280.0	nM	552.37	O=C(COc1ccc(C(=O)Nc2ccccc2)cc1)NCc1ccc(OP(=O)(O)O)c(OP(=O)(O)O)c1	Homo sapiens	CHEMBL4055339	single protein format
CHEMBL4077592		IC50	=	330.0	nM	586.81	O=C(COc1ccc(C(=O)Nc2ccc(Cl)cc2)cc1)NCc1ccc(OP(=O)(O)O)c(OP(=O)(O)O)c1	Homo sapiens	CHEMBL4055339	single protein format
CHEMBL4093849		IC50	=	350.0	nM	570.36	O=C(COc1ccc(C(=O)Nc2ccc(F)cc2)cc1)NCc1ccc(OP(=O)(O)O)c(OP(=O)(O)O)c1	Homo sapiens	CHEMBL4055339	single protein format
CHEMBL4075745		IC50	=	460.0	nM	586.81	O=C(COc1ccc(C(=O)Nc2cccc(Cl)c2)cc1)NCc1ccc(OP(=O)(O)O)c(OP(=O)(O)O)c1	Homo sapiens	CHEMBL4055339	single protein format
CHEMBL4549938		Ki	=	600.0	nM	305.23	O=C(O)c1nonc1NCn1nnnc1-c1ccc(F)cc1	Homo sapiens	CHEMBL4357304	single protein format
CHEMBL4062751		IC50	=	620.0	nM	570.36	O=C(COc1ccc(C(=O)Nc2cccc(F)c2)cc1)NCc1ccc(OP(=O)(O)O)c(OP(=O)(O)O)c1	Homo sapiens	CHEMBL4055339	single protein format