P52788 | SPSY_HUMAN | Spermine synthase (SMS)

3D structures mapped by conservation among orthologs

[ Domain: "S-adenosyl-L-methionine-dependent methyltransferases" // Spermine_synth ]

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[ Domain: "Bacterial S-adenosylmethionine decarboxylase" // KOG1562 ]

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[ Domain: "Bacterial S-adenosylmethionine decarboxylase" // KOG1562 ]

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[ Domain: "Spermidine synthase tetramerisation domain" // Spermine_synt_N_1 ]

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[ Domain: pdbs with more than 2 multi-domains ]

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[ Alpha Fold Model ] (go)

Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id	structure	assay_type	relation	values	units	mol_wt	smiles	organism	assay_chembl_id	bao_label
CHEMBL315995		IC50	=	20.0	nM	482.66	NCCCNCCCCCC(CCN)SC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	Homo sapiens	CHEMBL845254	single protein format
CHEMBL330673		IC50	=	50.0	nM	425.56	NCCCCCC(CCN)SC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	Homo sapiens	CHEMBL845254	single protein format