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P53582 | MAP11_HUMAN | Methionine aminopeptidase 1 (METAP1)

3D structures mapped by conservation among orthologs

[ Domain: "Creatinase/aminopeptidase" // Peptidase_M24 ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL271696 OBDepict O HN N H O O N CH 3 CH 3 Ki = 10.0 nM 285.3 CN(C)c1ccc(/C=C/C=C2C(=O)NC(=O)NC2=O)cc1 Homo sapiens CHEMBL951176 single protein format
CHEMBL4079583 OBDepict CH 3 O N N N N N IC50 = 100.0 nM 397.48 COc1ccc(N2CCN(c3nc(-c4ccccn4)nc4ccccc34)CC2)cc1 Homo sapiens CHEMBL4053556 single protein format
CHEMBL2392772 OBDepict Cl N N F F F N H N Cl N CH 3 N IC50 = 360.0 nM 483.33 Cc1nc(-c2ccccn2)nc(NC2CCN(c3ncc(C(F)(F)F)cc3Cl)CC2)c1Cl Homo sapiens CHEMBL2394384 assay format
CHEMBL352943 OBDepict H 3 C S H 2 N H HO H HN O CH 3 H IC50 = 370.0 nM 346.5 CCSCC[C@@H](N)[C@H](O)C(=O)N[C@@H](C)c1cccc2ccccc12 Homo sapiens CHEMBL715020 single protein format
CHEMBL327579 OBDepict O O HN CH 3 H 3 C CH 3 N HN O N S IC50 = 400.0 nM 320.37 CC(C)(C)OC(=O)Nc1cccnc1C(=O)Nc1nccs1 Homo sapiens CHEMBL4053556 single protein format
CHEMBL2392900 OBDepict OH N N S HN O O H HN N Cl N CH 3 N IC50 = 600.0 nM 560.12 Cc1nc(-c2ccccn2)nc(NC[C@H](NS(=O)(=O)CCN2CCN(CCO)CC2)c2ccccc2)c1Cl Homo sapiens CHEMBL2394384 assay format
CHEMBL2392893 OBDepict O N H H N N H N N H Cl N CH 3 N IC50 = 600.0 nM 480.02 Cc1nc(-c2ccccn2)nc(NC[C@H](NC(=O)CCN2CCNCC2)c2ccccc2)c1Cl Homo sapiens CHEMBL2394384 assay format
CHEMBL256279 OBDepict CH 3 O O H NH H N H O O O H OH H H 3 C HO H HO H CH 3 CH 3 IC50 = 700.0 nM 584.8 CCCCCCCCCCCCCC(=O)O[C@H]1CC[C@H](NC(=O)[C@H](OC)[C@H](O)[C@@H](O)[C@H](O)/C=C/C(C)C)C(=O)NC1 Homo sapiens CHEMBL4053556 single protein format
CHEMBL4078211 OBDepict H 3 C O H OH H NH O OH H HO H H O N H H 3 C H 3 C CH 3 H O O IC50 = 700.0 nM 498.62 CO[C@@H](C(=O)N[C@H]1CC[C@@H](OC(=O)C2CCCCC2)CNC1=O)[C@H](O)[C@@H](O)[C@H](O)/C=C/C(C)(C)C Homo sapiens CHEMBL4053556 single protein format
CHEMBL2392891 OBDepict OH N N N H O H N H N Cl N CH 3 N IC50 = 800.0 nM 524.07 Cc1nc(-c2ccccn2)nc(NC[C@H](NC(=O)CCN2CCN(CCO)CC2)c2ccccc2)c1Cl Homo sapiens CHEMBL2394384 assay format
CHEMBL2392899 OBDepict H 3 C N Cl N N H N N H H S O O N NH IC50 = 800.0 nM 516.07 Cc1nc(-c2ccccn2)nc(NC[C@H](NS(=O)(=O)CCN2CCNCC2)c2ccccc2)c1Cl Homo sapiens CHEMBL2394384 assay format
CHEMBL2392898 OBDepict OH N N N H H N H N Cl N CH 3 N IC50 = 800.0 nM 524.11 Cc1nc(-c2ccccn2)nc(NC[C@H](NCCCCN2CCN(CCO)CC2)c2ccccc2)c1Cl Homo sapiens CHEMBL2394384 assay format
CHEMBL472879 OBDepict CH 3 N Cl N NH N IC50 = 860.0 nM 324.81 Cc1nc(-c2ccccn2)nc(NCCc2ccccc2)c1Cl Homo sapiens CHEMBL2394384 assay format
CHEMBL2392771 OBDepict H 3 C N Cl N N H N N H N F F F IC50 = 1000.0 nM 408.81 Cc1nc(-c2ccccn2)nc(NCCNc2cccc(C(F)(F)F)n2)c1Cl Homo sapiens CHEMBL2394384 assay format
CHEMBL3337748 OBDepict Cl O CH 2 IC50 = 1000.0 nM 178.62 C=C1Cc2cc(Cl)ccc2C1=O Homo sapiens CHEMBL3384241 assay format
CHEMBL257930 OBDepict S HN N H O O N CH 3 CH 3 Ki = 1000.0 nM 301.37 CN(C)c1ccc(/C=C/C=C2C(=O)NC(=S)NC2=O)cc1 Homo sapiens CHEMBL951176 single protein format