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P53779 | MK10_HUMAN | Mitogen-activated protein kinase 10 (MAPK10)

3D structures mapped by conservation among orthologs

[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4859660 OBDepict NH 2 N F + N O NH O _ O IC50 = -24200.0 nM 378.36 Nc1ncc(-c2cccc([N+](=O)[O-])c2F)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804402 cell-based format
CHEMBL4860979 OBDepict F S N O O CH 3 N H 2 N O N H IC50 = -12900.0 nM 466.54 CN(C1CC1)S(=O)(=O)c1ccc(-c2cnc(N)c(-c3ccc4c(c3)CCNC4=O)c2)c(F)c1 Homo sapiens CHEMBL4804402 cell-based format
CHEMBL4546504 OBDepict CH 3 N CH 3 O O N H CH 3 H N N F F F O N H H Cl H 3 C HO IC50 = 0.107 nM 555.99 C[C@@H](Oc1cc(C(=O)N(C)C)ccc1Nc1nc(O[C@H]2CC[C@@](C)(O)CC2)c2c(Cl)c[nH]c2n1)C(F)(F)F Homo sapiens CHEMBL4349107 assay format
CHEMBL3220502 OBDepict O N N H N N N H Cl O H 2 N IC50 = 0.16 nM 422.88 NC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCCC3=O)cc2)ncc1Cl Homo sapiens CHEMBL3226836 single protein format
CHEMBL3220499 OBDepict Cl N N NH N H O NH 2 F N O IC50 = 0.25 nM 442.88 NC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)c(F)c2)ncc1Cl Homo sapiens CHEMBL3226836 single protein format
CHEMBL3220497 OBDepict CH 3 O N N H N N O NH Cl O NH 2 IC50 = 0.28 nM 454.92 COc1cc(Nc2ncc(Cl)c(Nc3ccccc3C(N)=O)n2)ccc1N1CCOCC1 Homo sapiens CHEMBL3226836 single protein format
CHEMBL3220493 OBDepict Cl N N NH N H O NH 2 N O IC50 = 0.28 nM 424.89 NC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2)ncc1Cl Homo sapiens CHEMBL3226836 single protein format
CHEMBL4077018 OBDepict CH 2 NH O N H O N H N N N H 3 C S H 3 C F IC50 = 0.3 nM 578.67 C=CC(=O)Nc1cccc(C(=O)Nc2ccc(Nc3cc(-c4c(-c5ccc(F)cc5)nc(SC)n4C)ccn3)cc2)c1 Homo sapiens CHEMBL4003427 assay format
CHEMBL3220496 OBDepict F N H N N N O NH Cl O NH 2 IC50 = 0.3 nM 442.88 NC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2F)ncc1Cl Homo sapiens CHEMBL3226836 single protein format
CHEMBL3220498 OBDepict Cl N N NH N H O NH 2 CH 3 N O IC50 = 0.31 nM 438.92 Cc1cc(Nc2ncc(Cl)c(Nc3ccccc3C(N)=O)n2)ccc1N1CCOCC1 Homo sapiens CHEMBL3226836 single protein format
CHEMBL3220494 OBDepict CH 3 O N H N N N H Cl O H 2 N IC50 = 0.42 nM 369.81 COc1ccc(Nc2ncc(Cl)c(Nc3ccccc3C(N)=O)n2)cc1 Homo sapiens CHEMBL3226836 single protein format
CHEMBL4062023 OBDepict CH 2 HN O N H O N H N N N H S CH 3 F IC50 = 0.6 nM 564.65 C=CC(=O)Nc1cccc(C(=O)Nc2ccc(Nc3cc(-c4[nH]c(SC)nc4-c4ccc(F)cc4)ccn3)cc2)c1 Homo sapiens CHEMBL4003427 assay format
CHEMBL3220500 OBDepict N N H N N N H Cl O H 2 N IC50 = 0.77 nM 364.8 N#Cc1ccc(Nc2ncc(Cl)c(Nc3ccccc3C(N)=O)n2)cc1 Homo sapiens CHEMBL3226836 single protein format
CHEMBL3220495 OBDepict CH 3 O N H N N N O HN Cl O H 2 N IC50 = 0.78 nM 454.92 COc1cc(N2CCOCC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2C(N)=O)n1 Homo sapiens CHEMBL3226836 single protein format
CHEMBL2216824 OBDepict H 3 C N CH 3 N H O N H O CH 3 N H N N N IC50 = 0.98 nM 507.6 Cc1cc(NC(=O)c2cccc(NC(=O)/C=C/CN(C)C)c2)ccc1Nc1nccc(-c2cccnc2)n1 Homo sapiens CHEMBL2217257 single protein format
CHEMBL4875508 OBDepict O N H S H N N N D D D N H Cl IC50 = 1.0 nM 455.0 [2H]C([2H])([2H])N1CC[C@H](NC(=O)c2cc(-n3ncc4cc(Nc5ccccc5Cl)ccc43)cs2)C1 Homo sapiens CHEMBL4840117 single protein format
CHEMBL4861739 OBDepict F N H N N Cl S N H O IC50 = 1.0 nM 426.9 O=C(NC1CC1)c1cc(-n2ncc3cc(Nc4ccccc4Cl)c(F)cc32)cs1 Homo sapiens CHEMBL4840117 single protein format
CHEMBL3099975 OBDepict F OH O N N N H N O IC50 = 1.0 nM 432.46 Oc1onc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)c2)c1-c1ccc(F)cc1 Homo sapiens CHEMBL3102587 assay format
CHEMBL3355178 OBDepict O NH N H Cl N N NH O N N N H IC50 < 1.0 nM 490.96 O=C(Nc1cnn(-c2cccc(C(=O)Nc3cnn(C4CCNC4)c3)c2)c1)Nc1ccccc1Cl Homo sapiens CHEMBL3372265 single protein format
CHEMBL3217784 OBDepict F HN N N N H Cl O H 2 N IC50 = 1.2 nM 357.78 NC(=O)c1ccccc1Nc1nc(Nc2ccc(F)cc2)ncc1Cl Homo sapiens CHEMBL3226836 single protein format
CHEMBL194806 OBDepict O HN N NH N H N H Cl IC50 = 1.4 nM 445.95 O=C(NC1CCNCC1)c1cccc(-c2n[nH]c3cc(Nc4ccccc4Cl)ccc23)c1 Homo sapiens CHEMBL881401 single protein format
CHEMBL252967 OBDepict CH 3 N N N N N N H CH 3 Cl Cl IC50 = 1.6 nM 485.46 CCCn1c(C2CCN(C)CC2)nc(-c2ccc(Cl)c(Cl)c2)c1-c1ccnc(NC2CC2)n1 Homo sapiens CHEMBL925133 single protein format
CHEMBL3356001 OBDepict CH 3 O N H N N N H N N NH H H H 2 N IC50 = 1.9 nM 556.67 Cc1cc(Nc2nc3ccccc3[nH]2)c2ccccc2c1Oc1ncccc1-c1ccnc(N[C@H]2CC[C@H](N)CC2)n1 Homo sapiens CHEMBL3375438 single protein format
CHEMBL3355999 OBDepict H N N H N O N N N NH H H H 2 N IC50 = 1.9 nM 542.65 N[C@H]1CC[C@H](Nc2nccc(-c3cccnc3Oc3ccc(Nc4nc5ccccc5[nH]4)c4ccccc34)n2)CC1 Homo sapiens CHEMBL3375438 single protein format
CHEMBL399167 OBDepict CH 3 N CH 3 N H O N N H N H Cl IC50 = 1.9 nM 433.94 CN(C)CCNC(=O)c1ccc(-c2n[nH]c3cc(Nc4ccccc4Cl)ccc23)cc1 Homo sapiens CHEMBL881401 single protein format
CHEMBL4874575 OBDepict O NH S H N O N F N H Cl IC50 = 2.0 nM 456.93 O=C(N[C@H]1CCOC1)c1cc(-n2ncc3cc(Nc4ccccc4Cl)c(F)cc32)cs1 Homo sapiens CHEMBL4840117 single protein format
CHEMBL1822152 OBDepict N N O N H O S Br N N H N IC50 = 2.0 nM 455.3 N#Cc1ccc2ccc(=O)n(CC(=O)Nc3scc(Br)c3-c3ncn[nH]3)c2c1 Homo sapiens CHEMBL1825596 single protein format
CHEMBL437747 OBDepict H 3 C N N N N H N N H Cl Cl IC50 = 2.0 nM 513.52 CCCn1c(C2CCNCC2)nc(-c2ccc(Cl)c(Cl)c2)c1-c1ccnc(NC2CCCCC2)n1 Homo sapiens CHEMBL902313 single protein format
CHEMBL4086457 OBDepict CH 2 NH O CH 3 N H O N H N N N H 3 C S H 3 C F IC50 = 2.0 nM 592.7 C=CC(=O)Nc1cccc(C(=O)Nc2ccc(Nc3cc(-c4c(-c5ccc(F)cc5)nc(SC)n4C)ccn3)cc2)c1C Homo sapiens CHEMBL4003427 assay format
CHEMBL4857979 OBDepict CH 3 HN O S N N N N H F Cl IC50 = 2.0 nM 401.85 CNC(=O)c1cc(-n2ncc3cc(Nc4c(F)cccc4Cl)cnc32)cs1 Homo sapiens CHEMBL4840117 single protein format
CHEMBL4867426 OBDepict O N H S N N O F N H Cl IC50 = 2.0 nM 470.96 O=C(NC1CCOCC1)c1cc(-n2ncc3cc(Nc4ccccc4Cl)c(F)cc32)cs1 Homo sapiens CHEMBL4840117 single protein format
CHEMBL4874573 OBDepict H 3 C N H O S N N F N H F Cl IC50 = 2.0 nM 418.86 CNC(=O)c1cc(-n2ncc3cc(Nc4c(F)cccc4Cl)c(F)cc32)cs1 Homo sapiens CHEMBL4840117 single protein format
CHEMBL4069805 OBDepict CH 3 HN O N H O N H N N N H S CH 3 F IC50 = 2.0 nM 566.66 CCC(=O)Nc1cccc(C(=O)Nc2ccc(Nc3cc(-c4[nH]c(SC)nc4-c4ccc(F)cc4)ccn3)cc2)c1 Homo sapiens CHEMBL4003427 assay format
CHEMBL1822151 OBDepict N N O N H O S Br N N H N IC50 = 2.0 nM 455.3 N#Cc1ccc2c(ccc(=O)n2CC(=O)Nc2scc(Br)c2-c2ncn[nH]2)c1 Homo sapiens CHEMBL1825596 single protein format
CHEMBL4082278 OBDepict CH 2 NH O N H O N H N N H 3 C N H S H 3 C IC50 = 2.0 nM 484.59 C=CC(=O)Nc1cccc(C(=O)Nc2ccc(Nc3cc(-c4[nH]c(SC)nc4C)ccn3)cc2)c1 Homo sapiens CHEMBL4003427 assay format
CHEMBL4865870 OBDepict H 3 C NH CH 3 O S N N F N H Cl IC50 = 2.0 nM 428.92 CC(C)NC(=O)c1cc(-n2ncc3cc(Nc4ccccc4Cl)c(F)cc32)cs1 Homo sapiens CHEMBL4840117 single protein format
CHEMBL4877727 OBDepict CH 3 HN O S N N N N H F Cl IC50 = 2.0 nM 401.85 CNC(=O)c1cc(-n2ncc3cc(Nc4c(F)cccc4Cl)ncc32)cs1 Homo sapiens CHEMBL4840117 single protein format
CHEMBL4092555 OBDepict CH 2 HN O N H O CH 3 N H N N N CH 3 S CH 3 F IC50 = 2.0 nM 592.7 C=CC(=O)Nc1cccc(C(=O)Nc2ccc(Nc3cc(-c4c(-c5ccc(F)cc5)nc(SC)n4C)ccn3)c(C)c2)c1 Homo sapiens CHEMBL4003427 assay format
CHEMBL3220501 OBDepict Cl HN N N N H Cl O H 2 N IC50 = 2.5 nM 374.23 NC(=O)c1ccccc1Nc1nc(Nc2ccc(Cl)cc2)ncc1Cl Homo sapiens CHEMBL3226836 single protein format
CHEMBL198756 OBDepict H 3 C NH N N N N H OH F IC50 = 2.5 nM 367.43 CCCNc1nccc(-c2c(-c3ccc(F)cc3)nc3n2[C@H](CO)CC3)n1 Homo sapiens CHEMBL881495 single protein format
CHEMBL203839 OBDepict O NH O N N N H F IC50 = 3.0 nM 378.41 O=C(Nc1cc(-c2ccnc(Nc3ccc(F)cc3)c2)ccn1)C1CCOC1 Homo sapiens CHEMBL862176 single protein format
CHEMBL4071770 OBDepict CH 2 N H O CH 3 HN O N H N N N H 3 C S H 3 C F IC50 = 3.0 nM 592.7 C=CC(=O)Nc1cccc(C(=O)Nc2cccc(Nc3cc(-c4c(-c5ccc(F)cc5)nc(SC)n4C)ccn3)c2)c1C Homo sapiens CHEMBL4003427 assay format
CHEMBL4876387 OBDepict H 3 C O NH O S N N F N H Cl IC50 = 3.0 nM 444.92 COCCNC(=O)c1cc(-n2ncc3cc(Nc4ccccc4Cl)c(F)cc32)cs1 Homo sapiens CHEMBL4840117 single protein format
CHEMBL383799 OBDepict H 3 C NH N N N N H OH F IC50 = 3.0 nM 367.43 CCCNc1nccc(-c2c(-c3ccc(F)cc3)nc3n2[C@@H](CO)CC3)n1 Homo sapiens CHEMBL881495 single protein format
CHEMBL252763 OBDepict O N H H O N N N H F IC50 = 3.0 nM 378.41 O=C(Nc1cc(-c2ccnc(Nc3ccc(F)cc3)c2)ccn1)[C@H]1CCOC1 Homo sapiens CHEMBL925133 single protein format
CHEMBL4094220 OBDepict CH 2 N H O HN O N H N N N H 3 C S H 3 C F IC50 = 3.0 nM 578.67 C=CC(=O)Nc1cccc(C(=O)Nc2cccc(Nc3cc(-c4c(-c5ccc(F)cc5)nc(SC)n4C)ccn3)c2)c1 Homo sapiens CHEMBL4003427 assay format
CHEMBL4082212 OBDepict H 2 C NH O N H O N H N N N H S CH 3 F IC50 = 3.0 nM 564.65 C=CC(=O)Nc1ccc(C(=O)Nc2ccc(Nc3cc(-c4[nH]c(SC)nc4-c4ccc(F)cc4)ccn3)cc2)cc1 Homo sapiens CHEMBL4003427 assay format
CHEMBL1822305 OBDepict O HN N S O N Br N N N H 3 C IC50 = 3.0 nM 447.32 Cn1cnc(-c2c(Br)csc2NC(=O)CN2C(=O)CCc3ncccc32)n1 Homo sapiens CHEMBL1825596 single protein format
CHEMBL482708 OBDepict CH 3 N N N N N IC50 = 3.0 nM 307.4 CN(c1nccc(-c2cnc3ccccn23)n1)C1CCCCC1 Homo sapiens CHEMBL956507 single protein format
CHEMBL1092764 OBDepict CH 3 N CH 3 N H O O OH N N H N H Cl IC50 = 3.0 nM 491.98 CN(C)CCCC(=O)Nc1cc(C(=O)O)cc(-c2n[nH]c3cc(Nc4ccccc4Cl)ccc23)c1 Homo sapiens CHEMBL1116946 single protein format
CHEMBL370516 OBDepict CH 3 O N H N N S N H N IC50 = 3.1 nM 401.5 COc1ccc(CCNc2nccc(/C(C#N)=C3Nc4ccccc4S3)n2)cc1 Homo sapiens CHEMBL925133 single protein format
CHEMBL199136 OBDepict H N N N H O H 2 N Cl IC50 = 3.3 nM 362.82 NC(=O)c1cccc(-c2[nH]nc3cc(Nc4ccccc4Cl)ccc23)c1 Homo sapiens CHEMBL881401 single protein format
CHEMBL198687 OBDepict O NH N N H N O NH Cl IC50 = 3.4 nM 490.01 O=C(NCCCN1CCOCC1)c1cccc(-c2[nH]nc3cc(Nc4ccccc4Cl)ccc23)c1 Homo sapiens CHEMBL881401 single protein format
CHEMBL571626 OBDepict H 3 C S NH O O N N NH N N N IC50 = 4.0 nM 407.46 CS(=O)(=O)Nc1ccc(-c2ccnc(Nc3ccc(-n4ccnn4)cc3)n2)cc1 Homo sapiens CHEMBL1042602 single protein format
CHEMBL4879188 OBDepict F F N H O S N N F N H Cl IC50 = 4.0 nM 450.87 O=C(NCC(F)F)c1cc(-n2ncc3cc(Nc4ccccc4Cl)c(F)cc32)cs1 Homo sapiens CHEMBL4840117 single protein format
CHEMBL4862656 OBDepict H 3 C N O H NH O S N N F N H Cl IC50 = 4.0 nM 497.98 CC(=O)N1CC[C@H](NC(=O)c2cc(-n3ncc4cc(Nc5ccccc5Cl)c(F)cc43)cs2)C1 Homo sapiens CHEMBL4840117 single protein format
CHEMBL1761584 OBDepict CH 3 O N N N N N H H 3 C N N N N O IC50 = 4.0 nM 483.54 COc1c(-c2cnn(C)c2)ccc2cnc(Nc3ccc(-n4cnc(N5CCOCC5)n4)cc3)nc12 Homo sapiens CHEMBL1763331 single protein format
CHEMBL4072555 OBDepict CH 2 NH O HN O N H N N N H 3 C S H 3 C F IC50 = 4.0 nM 578.67 C=CC(=O)Nc1ccc(C(=O)Nc2cccc(Nc3cc(-c4c(-c5ccc(F)cc5)nc(SC)n4C)ccn3)c2)cc1 Homo sapiens CHEMBL4003427 assay format
CHEMBL1094014 OBDepict CH 3 N H 3 C N N N N HN H H OH Ki = 5.0 nM 392.51 CN(C)c1c(-c2ccnc(N[C@H]3CC[C@H](O)CC3)n2)cnn1Cc1ccccc1 Homo sapiens CHEMBL1116946 single protein format
CHEMBL245936 OBDepict CH 3 N H N O N H N N N H IC50 = 5.0 nM 440.55 CCNC(=O)N1CCC(Nc2nccc(-c3c(-c4ccccc4)[nH]c4ccccc34)n2)CC1 Homo sapiens CHEMBL886372 single protein format
CHEMBL4845770 OBDepict O HN S N O N N CH 3 N H F Cl IC50 = 5.0 nM 457.92 Cc1nc2c(cnn2-c2csc(C(=O)NC3COC3)c2)cc1Nc1c(F)cccc1Cl Homo sapiens CHEMBL4840117 single protein format
CHEMBL1682014 OBDepict O NH N S O Cl N N H N IC50 = 5.0 nM 387.85 O=C(CN1C(=O)CCc2ccccc21)Nc1scc(Cl)c1-c1ncn[nH]1 Homo sapiens CHEMBL1686758 single protein format
CHEMBL1822145 OBDepict O NH N S O Br N N F H N F IC50 = 5.0 nM 466.27 O=C(Cn1c(=O)ccc2cc(F)c(F)cc21)Nc1scc(Br)c1-c1ncn[nH]1 Homo sapiens CHEMBL1825596 single protein format
CHEMBL4872832 OBDepict O N H S N O N N N H Cl IC50 = 5.0 nM 425.9 O=C(NC1COC1)c1cc(-n2ncc3cc(Nc4ccccc4Cl)ncc32)cs1 Homo sapiens CHEMBL4840117 single protein format
CHEMBL4875476 OBDepict H 3 C N H O S N N F N H F O CH 3 IC50 = 5.0 nM 414.44 CNC(=O)c1cc(-n2ncc3cc(Nc4c(F)cccc4OC)c(F)cc32)cs1 Homo sapiens CHEMBL4840117 single protein format
CHEMBL4874134 OBDepict CH 3 N H O S N N F N H Cl IC50 = 5.0 nM 400.87 CNC(=O)c1cc(-n2ncc3cc(Nc4ccccc4Cl)c(F)cc32)cs1 Homo sapiens CHEMBL4840117 single protein format
CHEMBL4847175 OBDepict O HN S H N N N D D D F N H Cl IC50 = 5.0 nM 472.99 [2H]C([2H])([2H])N1CC[C@H](NC(=O)c2cc(-n3ncc4cc(Nc5ccccc5Cl)c(F)cc43)cs2)C1 Homo sapiens CHEMBL4840117 single protein format
CHEMBL202639 OBDepict O N H H N N O H 3 C N N H F IC50 = 5.0 nM 433.49 CC(=O)N1CCC[C@@H](C(=O)Nc2cc(-c3ccnc(Nc4ccc(F)cc4)c3)ccn2)C1 Homo sapiens CHEMBL862176 single protein format
CHEMBL197613 OBDepict H N N N H O HO Cl IC50 = 5.3 nM 363.8 O=C(O)c1cccc(-c2[nH]nc3cc(Nc4ccccc4Cl)ccc23)c1 Homo sapiens CHEMBL881401 single protein format
CHEMBL3355996 OBDepict CH 3 N HN N N N O N H N N H IC50 = 5.5 nM 542.65 CN1CCCC(Nc2nccc(-c3cccnc3Oc3ccc(Nc4nc5ccccc5[nH]4)c4ccccc34)n2)C1 Homo sapiens CHEMBL3375438 single protein format
CHEMBL1822141 OBDepict O NH N S O Br N N N H N F F F IC50 = 6.0 nM 499.27 O=C(Cn1c(=O)ccc2cnc(C(F)(F)F)cc21)Nc1scc(Br)c1-c1ncn[nH]1 Homo sapiens CHEMBL1825596 single protein format
CHEMBL1822139 OBDepict N S HN N N H N O N O N IC50 = 6.0 nM 379.4 N#Cc1csc(NC(=O)CN2C(=O)CCc3ncccc32)c1-c1ncn[nH]1 Homo sapiens CHEMBL1825596 single protein format
CHEMBL1822149 OBDepict O NH N S O Br N N H N O F F F IC50 = 6.0 nM 514.28 O=C(Cn1c(=O)ccc2cc(OC(F)(F)F)ccc21)Nc1scc(Br)c1-c1ncn[nH]1 Homo sapiens CHEMBL1825596 single protein format
CHEMBL1822153 OBDepict O NH N S O Br N O N IC50 = 6.0 nM 433.29 O=C(CN1C(=O)CCc2ncccc21)Nc1scc(Br)c1-c1ncco1 Homo sapiens CHEMBL1825596 single protein format
CHEMBL4872493 OBDepict O N H S N O N N N H Cl IC50 = 6.0 nM 425.9 O=C(NC1COC1)c1cc(-n2ncc3cc(Nc4ccccc4Cl)cnc32)cs1 Homo sapiens CHEMBL4840117 single protein format
CHEMBL205078 OBDepict F HN N N HN O O IC50 = 6.0 nM 392.43 O=C(Nc1cc(-c2ccnc(Nc3ccc(F)cc3)c2)ccn1)C1CCOCC1 Homo sapiens CHEMBL862176 single protein format
CHEMBL1950289 OBDepict F F F N H N N N H N O N H H H HO IC50 = 6.0 nM 448.45 O[C@H]1CC[C@H](Nc2ncc3nc(Nc4c(F)cc(F)cc4F)n([C@H]4CCOC4)c3n2)CC1 Homo sapiens CHEMBL1952893 assay format
CHEMBL1682015 OBDepict N S HN N N H N O N O IC50 = 6.0 nM 378.42 N#Cc1csc(NC(=O)CN2C(=O)CCc3ccccc32)c1-c1ncn[nH]1 Homo sapiens CHEMBL1686758 single protein format
CHEMBL3099962 OBDepict F N N H N N H N O IC50 = 7.0 nM 415.47 Fc1ccc(-c2n[nH]cc2-c2ccnc(Nc3ccc(N4CCOCC4)cc3)c2)cc1 Homo sapiens CHEMBL3102587 assay format
CHEMBL1682018 OBDepict N S NH N N H N O N IC50 = 7.0 nM 360.4 N#Cc1csc(NC(=O)Cc2cccc3cnccc23)c1-c1ncn[nH]1 Homo sapiens CHEMBL1686758 single protein format
CHEMBL3356003 OBDepict CH 3 O N H N N O N N HN H H NH 2 IC50 = 7.0 nM 557.66 Cc1cc(Nc2nc3ccccc3o2)c2ccccc2c1Oc1ncccc1-c1ccnc(N[C@H]2CC[C@H](N)CC2)n1 Homo sapiens CHEMBL3375438 single protein format
CHEMBL1771718 OBDepict F N N H 3 C N N H N N H 3 C N CH 3 IC50 = 7.0 nM 439.5 Cc1nc(C)n(-c2ccc(Nc3cc(-c4nn(C)cc4-c4ccc(F)cc4)ccn3)cc2)n1 Homo sapiens CHEMBL1772668 single protein format
CHEMBL3393599 OBDepict CH 3 O O N H CH 3 O CH 3 O N N N H NH O CH 3 IC50 = 7.0 nM 501.54 COc1cc(NC(=O)c2cccc(-n3cc(NC(=O)Nc4cccc(C)c4)cn3)c2)cc(OC)c1OC Homo sapiens CHEMBL3395898 single protein format
CHEMBL252762 OBDepict F N N N H N NH N N IC50 = 7.0 nM 429.5 Fc1ccc(-c2nc3n(c2-c2ccnc(NC4CCC4)n2)[C@H](Cn2ccnc2)CC3)cc1 Homo sapiens CHEMBL925133 single protein format
CHEMBL1761566 OBDepict O N N N N NH N N N S IC50 = 7.0 nM 456.54 c1cc(-c2nccs2)c2nc(Nc3ccc(-n4cnc(N5CCOCC5)n4)cc3)ncc2c1 Homo sapiens CHEMBL1763331 single protein format
CHEMBL1822140 OBDepict O NH N S O Br N N N H N IC50 = 7.0 nM 431.27 O=C(Cn1c(=O)ccc2cnccc21)Nc1scc(Br)c1-c1ncn[nH]1 Homo sapiens CHEMBL1825596 single protein format
CHEMBL1923217 OBDepict CH 3 O O N N N H Cl O H 2 N IC50 = 7.0 nM 370.8 COc1ccc(Oc2ncc(Cl)c(Nc3ccccc3C(N)=O)n2)cc1 Homo sapiens CHEMBL1925289 single protein format
CHEMBL203535 OBDepict O NH O N N N H IC50 = 7.0 nM 360.42 O=C(Nc1cc(-c2ccnc(Nc3ccccc3)c2)ccn1)C1CCOC1 Homo sapiens CHEMBL862176 single protein format
CHEMBL1950304 OBDepict H 3 C N H O H H N H N N N N N H H O F F F IC50 = 7.0 nM 489.5 CNC(=O)[C@H]1CC[C@H](Nc2ncc3nc(Nc4c(F)cc(F)cc4F)n([C@H]4CCOC4)c3n2)CC1 Homo sapiens CHEMBL1952893 assay format
CHEMBL585916 OBDepict CH 3 S HN O O N N NH S O O NH 2 IC50 = 7.0 nM 419.49 CS(=O)(=O)Nc1ccc(-c2ccnc(Nc3ccc(S(N)(=O)=O)cc3)n2)cc1 Homo sapiens CHEMBL1042602 single protein format
CHEMBL3356000 OBDepict H N N H N O N N N HN H H NH 2 IC50 = 7.5 nM 542.65 N[C@H]1CC[C@@H](Nc2nccc(-c3cccnc3Oc3ccc(Nc4nc5ccccc5[nH]4)c4ccccc34)n2)CC1 Homo sapiens CHEMBL3375438 single protein format
CHEMBL4753310 OBDepict O NH N H Cl N N S NH O H O IC50 = 8.0 nM 431.91 O=C(Nc1cnn(-c2csc(C(=O)N[C@@H]3CCOC3)c2)c1)Nc1ccccc1Cl Homo sapiens CHEMBL4724650 single protein format
CHEMBL1822143 OBDepict O NH N S O N N Br N N H N IC50 = 8.0 nM 420.25 O=C(Cn1c(=O)ccn2nccc12)Nc1scc(Br)c1-c1ncn[nH]1 Homo sapiens CHEMBL1825596 single protein format
CHEMBL4063964 OBDepict H 2 C NH O N H O CH 3 N H N N N CH 3 S CH 3 F IC50 = 8.0 nM 592.7 C=CC(=O)Nc1ccc(C(=O)Nc2ccc(Nc3cc(-c4c(-c5ccc(F)cc5)nc(SC)n4C)ccn3)c(C)c2)cc1 Homo sapiens CHEMBL4003427 assay format
CHEMBL1822309 OBDepict N S N HN S O N O F F F IC50 = 8.0 nM 460.46 N#Cc1csc(NC(=O)Cn2c(=O)ccc3cc(C(F)(F)F)ccc32)c1-c1cscn1 Homo sapiens CHEMBL1825596 single protein format
CHEMBL203059 OBDepict O N H N O N N H IC50 = 8.0 nM 374.44 O=C(Nc1cc(-c2ccnc(Nc3ccccc3)c2)ccn1)C1CCOCC1 Homo sapiens CHEMBL862176 single protein format
CHEMBL1822307 OBDepict N S N O HN O N O F F F IC50 = 8.0 nM 444.39 N#Cc1csc(NC(=O)Cn2c(=O)ccc3cc(C(F)(F)F)ccc32)c1-c1ncco1 Homo sapiens CHEMBL1825596 single protein format
CHEMBL1822147 OBDepict O NH N S O Br N N H N F F F IC50 = 9.0 nM 498.28 O=C(Cn1c(=O)ccc2ccc(C(F)(F)F)cc21)Nc1scc(Br)c1-c1ncn[nH]1 Homo sapiens CHEMBL1825596 single protein format
CHEMBL203225 OBDepict O N H N N O CH 3 N N H IC50 = 9.0 nM 415.5 CC(=O)N1CCCC(C(=O)Nc2cc(-c3ccnc(Nc4ccccc4)c3)ccn2)C1 Homo sapiens CHEMBL862176 single protein format
CHEMBL1761582 OBDepict CH 3 N N N N N N N H CH 3 N N N N O IC50 = 9.0 nM 533.6 Cn1cc(-c2ccc3cnc(Nc4ccc(-n5cnc(N6CCOCC6)n5)cc4)nc3c2-c2cnn(C)c2)cn1 Homo sapiens CHEMBL1763331 single protein format