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P54577 | SYYC_HUMAN | "Tyrosine--tRNA ligase, cytoplasmic" (YARS1)

3D structures mapped by conservation among orthologs

[ Domain: "HUP domains" // tRNA-synt_1b_1 ]

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[ Domain: "Nucleic acid-binding proteins" // tRNA_bind ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL310012 OBDepict O NH H 2 N H H H N O HO HO H HO H O OH HO H OH IC50 = 0.6 nM 413.38 N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)O)[C@H]1[C@H](O)[C@]2(O)CO[C@@H]([C@@H]2O)N1O Homo sapiens CHEMBL811413 single protein format
CHEMBL163375 OBDepict CH 3 O O N H H H O H HO O H CH 3 H HO H 2 N H H OH HO IC50 = 0.8 nM 440.49 CCCCOC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H]1O[C@H](C)[C@H](O)[C@H](O)[C@H]1O Homo sapiens CHEMBL811414 single protein format
CHEMBL51499 OBDepict O N H H 2 N H H H N O OH HO H OH H OH HO H OH IC50 = 1.2 nM 385.37 N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)O)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)CN1O Homo sapiens CHEMBL811416 single protein format
CHEMBL1789974 OBDepict O NH H 2 N H H N O HO HO H HO H O OH OH H OH IC50 = 1.4 nM 413.38 N[C@@H](Cc1ccc(O)cc1)C(=O)NC(C(=O)O)[C@H]1[C@H](O)[C@]2(O)CO[C@@H]([C@@H]2O)N1O Homo sapiens CHEMBL811416 single protein format
CHEMBL161302 OBDepict O NH H 2 N H H N O HO HO HO OH H O OH H OH IC50 = 2.0 nM 413.38 N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)O)C1C(O)[C@]2(O)CO[C@H]([C@H]2O)N1O Homo sapiens CHEMBL842143 single protein format
CHEMBL84867 OBDepict CH 3 O O HN H H H OH O H HO NH 2 H H HO OH IC50 = 3.4 nM 394.42 CCOC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H]1C=C[C@H](O)[C@H](O)[C@H]1O Homo sapiens CHEMBL811413 single protein format
CHEMBL351127 OBDepict H 3 C O O N H H O O H OH H CH 3 H 2 N H H OH HO IC50 = 3.6 nM 424.49 CCCCOC(=O)C(NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@H]1C[C@@H](O)[C@@H](O)[C@@H](C)O1 Homo sapiens CHEMBL811414 single protein format
CHEMBL163022 OBDepict HO H 2 N H NH O H H O O HO H HO H CH 3 H OH H OH IC50 = 4.0 nM 384.39 C[C@H]1O[C@@H]([C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)O)[C@H](O)[C@@H](O)[C@H]1O Homo sapiens CHEMBL811414 single protein format
CHEMBL52779 OBDepict O N H H 2 N H H H N O OH HO H OH H OH HO H OH IC50 = 21.3 nM 385.37 N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C(=O)O)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)CN1O Homo sapiens CHEMBL811416 single protein format
CHEMBL422362 OBDepict O NH NH 2 H H H O O HO H HO H OH HO H OH IC50 = 100.0 nM 370.36 N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)O)[C@@H]1OC[C@H](O)[C@H](O)[C@H]1O Homo sapiens CHEMBL811414 single protein format
CHEMBL82579 OBDepict CH 3 O O HN H H H OH O H HO NH 2 H H HO OH IC50 = 124.0 nM 394.42 CCOC(=O)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H]1C=C[C@H](O)[C@H](O)[C@H]1O Homo sapiens CHEMBL811413 single protein format
CHEMBL162552 OBDepict HO H O H HO H H OH HN H OH O OH O NH 2 H OH IC50 = 190.0 nM 400.38 N[C@@H](Cc1ccc(O)cc1)C(=O)NC(C(=O)O)[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O Homo sapiens CHEMBL811414 single protein format
CHEMBL85201 OBDepict CH 3 O O HN H H H OH O H HO NH 2 H H HO OH IC50 = 245.0 nM 396.44 CCOC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H]1CC[C@H](O)[C@H](O)[C@H]1O Homo sapiens CHEMBL811413 single protein format
CHEMBL159436 OBDepict O NH NH 2 H H H O O HO H HO H OH HO H OH IC50 = 260.0 nM 370.36 N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C(=O)O)[C@@H]1OC[C@H](O)[C@H](O)[C@H]1O Homo sapiens CHEMBL842143 single protein format
CHEMBL318019 OBDepict HO NH 2 H N H O O HO HO OH OH IC50 = 510.0 nM 362.34 N[C@@H](Cc1ccc(O)cc1)C(=O)NC(C(=O)O)c1ccc(O)c(O)c1O Homo sapiens CHEMBL811411 single protein format
CHEMBL98455 OBDepict O N H NH 2 H O OH OH OH IC50 = 800.0 nM 330.34 N[C@@H](Cc1ccc(O)cc1)C(=O)NC(C(=O)O)c1ccccc1O Homo sapiens CHEMBL811411 single protein format
CHEMBL98622 OBDepict O N H NH 2 H H O HO HO IC50 = 900.0 nM 314.34 N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)O)c1ccccc1 Homo sapiens CHEMBL811411 single protein format