P54764 | EPHA4_HUMAN | Ephrin type-A receptor 4 (EPHA4)

3D structures mapped by conservation among orthologs

[ Domain: "Galactose-binding domain-like" // KOG0196,Ephrin_lbd ]

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[ Domain: "Galactose-binding domain-like" // Ephrin_lbd ]

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[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // fn3 ]

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[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // fn3_9 ]

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[ Domain: "EGF/Laminin" // KOG0196 ]

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[ Domain: "EGF/Laminin" // TNFR_c6 ]

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[ Domain: "Complement control module/SCR domain" // KOG0196 ]

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[ Domain: "TNF receptor-like" // UNK_F_TYPE ]

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[ Domain: pdbs with more than 2 multi-domains ]

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[ Alpha Fold Model ] (go)

Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id	structure	assay_type	relation	values	units	mol_wt	smiles	organism	assay_chembl_id	bao_label
CHEMBL566515		IC50	=	3.3	nM	417.43	COc1ccccc1-n1c(-c2cc(O)ccc2C)cn2c3c(=O)[nH]c(=O)n(C)c3nc12	Homo sapiens	CHEMBL1046773	single protein format
CHEMBL3787112		IC50	=	9.0	nM	349.44	Nc1ncnc2c1c(-c1cccc(O)c1)cn2[C@H]1C[C@@H](CN2CCC2)C1	Homo sapiens	CHEMBL3789981	single protein format
CHEMBL388978		IC50	=	12.5	nM	466.54	CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4	Homo sapiens	CHEMBL4328399	single protein format
CHEMBL103667		IC50	=	70.0	nM	527.67	Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1	Homo sapiens	CHEMBL1932845	single protein format
CHEMBL4216073		IC50	=	74.0	nM	452.44	CC(=O)Nc1cn2cc(-c3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3C)ccc2n1	Homo sapiens	CHEMBL4181665	single protein format
CHEMBL4798527		IC50	=	227.0	nM	548.57	Cc1ccc(NC(=O)c2ccc(C)c(C(F)(F)F)c2)cc1C#Cc1nn([C@H]2CC[C@H](O)CC2)c2ncnc(N)c12	Homo sapiens	CHEMBL4766184	single protein format