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P57059 | SIK1_HUMAN | Serine/threonine-protein kinase SIK1 (SIK1)

3D structures mapped by conservation among orthologs



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL1421 OBDepict HO N N N N N H CH 3 N S N H O H 3 C Cl IC50 = 1.0 nM 488.02 Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1 Homo sapiens CHEMBL4807587 single protein format
CHEMBL388978 OBDepict CH 3 HN H H O H O N H 3 C H 3 C N O N H IC50 = 1.34 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL4328603 single protein format
CHEMBL2151321 OBDepict CH 3 O H 3 C N H N N N N NH CH 3 H N F IC50 = 5.5 nM 381.42 CC(C)Oc1cc(-n2cnc3ccc(N[C@@H](C)c4ccc(F)cn4)nc32)n[nH]1 Homo sapiens CHEMBL2154706 single protein format
CHEMBL1421 OBDepict HO N N N N N H CH 3 N S N H O H 3 C Cl Ki < 10.0 nM 488.02 Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1 Homo sapiens CHEMBL4312065 assay format
CHEMBL4875238 OBDepict H 3 C N N N N N H CH 3 N S N H O Cl S H 3 C IC50 = 10.0 nM 464.02 Cc1nc(Nc2ncc(C(=O)Nc3c(C)csc3Cl)s2)cc(N2CCN(C)CC2)n1 Homo sapiens CHEMBL4807587 single protein format
CHEMBL4867844 OBDepict OH N N N N N H CH 3 N S N H O Cl S CH 3 IC50 = 13.4 nM 494.05 Cc1nc(Nc2ncc(C(=O)Nc3c(C)csc3Cl)s2)cc(N2CCN(CCO)CC2)n1 Homo sapiens CHEMBL4807587 single protein format
CHEMBL4865466 OBDepict CH 3 N O N N N NH H 3 C N S N H O Cl S CH 3 IC50 = 20.0 nM 492.03 CC(=O)N1CCN(c2cc(Nc3ncc(C(=O)Nc4c(C)csc4Cl)s3)nc(C)n2)CC1 Homo sapiens CHEMBL4807587 single protein format
CHEMBL4855726 OBDepict OH N N HN N N N H CH 3 N S NH O Cl H 3 C N IC50 = 30.0 nM 504.02 Cc1nc(Nc2ncc(C(=O)Nc3c(Cl)ccnc3C)s2)cc(NN2CCN(CCO)CC2)n1 Homo sapiens CHEMBL4807587 single protein format
CHEMBL4857583 OBDepict HO N N N N N H CH 3 N S N H O H 3 C H 3 C N IC50 = 30.6 nM 468.59 Cc1nc(Nc2ncc(C(=O)Nc3c(C)cncc3C)s2)cc(N2CCN(CCO)CC2)n1 Homo sapiens CHEMBL4807587 single protein format
CHEMBL4869199 OBDepict HO N N N N N H CH 3 N S N H O H 3 C Cl N IC50 = 32.7 nM 489.01 Cc1nc(Nc2ncc(C(=O)Nc3c(C)cncc3Cl)s2)cc(N2CCN(CCO)CC2)n1 Homo sapiens CHEMBL4807587 single protein format
CHEMBL1090479 OBDepict H 3 C N N N N HN H N O H 3 C CH 3 N CH 3 CH 3 IC50 = 70.0 nM 507.64 CCn1cc(-c2ccnc3[nH]c(-c4cccc(CN(C)C)c4)cc23)c(-c2ccc(NC(=O)N(C)C)cc2)n1 Homo sapiens CHEMBL1104802 single protein format
CHEMBL4878274 OBDepict HO N N N N N H CH 3 N S N H O H 3 C H 3 C N IC50 = 132.0 nM 468.59 Cc1nc(Nc2ncc(C(=O)Nc3c(C)ccnc3C)s2)cc(N2CCN(CCO)CC2)n1 Homo sapiens CHEMBL4807587 single protein format
CHEMBL4850733 OBDepict HO N N N N N H CH 3 N S N H O H 3 C N H 3 C O IC50 = 169.0 nM 458.55 Cc1nc(Nc2ncc(C(=O)Nc3c(C)noc3C)s2)cc(N2CCN(CCO)CC2)n1 Homo sapiens CHEMBL4807587 single protein format
CHEMBL4865214 OBDepict OH N N N N N H CH 3 N S N H O N CH 3 IC50 = 177.0 nM 454.56 Cc1nc(Nc2ncc(C(=O)Nc3ncccc3C)s2)cc(N2CCN(CCO)CC2)n1 Homo sapiens CHEMBL4807587 single protein format
CHEMBL3116050 OBDepict F N N N H CH 3 H N N HN N H N N CH 3 IC50 = 190.0 nM 353.37 C[C@H](Nc1nc(Nc2cn(C)cn2)c2cc[nH]c2n1)c1ncc(F)cn1 Homo sapiens CHEMBL3117033 single protein format
CHEMBL2380845 OBDepict O N H N H N N H O IC50 = 211.0 nM 406.45 O=C(Nc1ccc(Nc2ccnc3[nH]c(=O)c4ccccc4c23)cc1)c1ccccc1 Homo sapiens CHEMBL2382834 single protein format
CHEMBL4851745 OBDepict CH 3 N N N N N H CH 3 N S N H O Cl CH 3 N IC50 = 302.0 nM 458.98 Cc1nc(Nc2ncc(C(=O)Nc3c(Cl)ccnc3C)s2)cc(N2CCN(C)CC2)n1 Homo sapiens CHEMBL4807587 single protein format
CHEMBL4857318 OBDepict OH HN N N N H CH 3 N S NH O Cl CH 3 N IC50 = 302.0 nM 419.9 Cc1nc(NCCO)cc(Nc2ncc(C(=O)Nc3c(Cl)ccnc3C)s2)n1 Homo sapiens CHEMBL4807587 single protein format
CHEMBL4872654 OBDepict OH N N N N N H CH 3 N S N H O CH 3 N IC50 = 336.0 nM 454.56 Cc1nc(Nc2ncc(C(=O)Nc3cccnc3C)s2)cc(N2CCN(CCO)CC2)n1 Homo sapiens CHEMBL4807587 single protein format
CHEMBL4865345 OBDepict HO N N N N N H CH 3 N S N H O Br H 3 C N IC50 = 571.0 nM 533.46 Cc1nc(Nc2ncc(C(=O)Nc3c(Br)ccnc3C)s2)cc(N2CCN(CCO)CC2)n1 Homo sapiens CHEMBL4807587 single protein format