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P60842 | IF4A1_HUMAN | Eukaryotic initiation factor 4A-I (EIF4A1)

3D structures mapped by conservation among orthologs

[ Domain: "P-loop containing nucleoside triphosphate hydrolases" // DEAD ]

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[ Domain: "P-loop containing nucleoside triphosphate hydrolases" // Helicase_C_1 ]

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[ Domain: pdbs with more than 2 multi-domains ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4857096 OBDepict H 3 C O N O HO H H N H H OH Br O IC50 = 2.3 nM 553.45 COc1cncc2c1[C@]1(O)[C@@H](CNC3COC3)[C@H](CO)[C@@H](c3ccccc3)[C@]1(c1ccc(Br)cc1)O2 Homo sapiens CHEMBL4837021 single protein format
CHEMBL438139 OBDepict CH 3 O O OH H H HO H O N O O CH 3 CH 3 H 3 C CH 3 IC50 = 4.7 nM 505.57 COc1ccc([C@@]23Oc4cc(OC)cc(OC)c4[C@]2(O)[C@H](O)[C@H](C(=O)N(C)C)[C@H]3c2ccccc2)cc1 Homo sapiens CHEMBL4616486 cell-based format
CHEMBL4864162 OBDepict NH 2 H OH H O O N CH 3 Br IC50 = 5.0 nM 467.36 COc1cncc2c1[C@]1(O)[C@@H](CN)C[C@@H](c3ccccc3)[C@]1(c1ccc(Br)cc1)O2 Homo sapiens CHEMBL4837021 single protein format
CHEMBL4855528 OBDepict NH 2 H OH H O O N CH 3 N IC50 = 5.6 nM 413.48 COc1cncc2c1[C@]1(O)[C@@H](CN)C[C@@H](c3ccccc3)[C@]1(c1ccc(C#N)cc1)O2 Homo sapiens CHEMBL4837021 single protein format
CHEMBL4303782 OBDepict CH 3 O N O O CH 3 OH H H HO H N H 3 C CH 3 N IC50 = 6.3 nM 487.56 COc1cc2c(c(OC)n1)[C@]1(O)[C@H](O)[C@H](CN(C)C)[C@@H](c3ccccc3)[C@]1(c1ccc(C#N)cc1)O2 Homo sapiens CHEMBL4616497 cell-based format
CHEMBL4849769 OBDepict CH 3 O N O OH H H N H OH Br O IC50 = 10.0 nM 567.48 COc1cncc2c1[C@]1(O)[C@@H](CN3CCOCC3)[C@H](CO)[C@@H](c3ccccc3)[C@]1(c1ccc(Br)cc1)O2 Homo sapiens CHEMBL4837021 single protein format
CHEMBL2058177 OBDepict CH 3 O NH O H H H OH O HO O H 3 C O O H 3 C H 3 C IC50 = 20.0 nM 507.54 CONC(=O)[C@@H]1[C@@H](c2ccccc2)[C@]2(c3ccc(OC)cc3)Oc3cc(OC)cc(OC)c3[C@]2(O)[C@@H]1O Homo sapiens CHEMBL2060259 cell-based format
CHEMBL4875109 OBDepict CH 3 O N O OH H H NH 2 H OH Br IC50 = 25.0 nM 497.39 COc1cncc2c1[C@]1(O)[C@@H](CN)[C@H](CO)[C@@H](c3ccccc3)[C@]1(c1ccc(Br)cc1)O2 Homo sapiens CHEMBL4837021 single protein format
CHEMBL123292 OBDepict O HN O HO H H O H CH 3 H CH 3 IC50 = 226.0 nM 281.35 C[C@H]1C[C@H](C)C(=O)[C@H]([C@H](O)CC2CC(=O)NC(=O)C2)C1 Homo sapiens CHEMBL4616486 cell-based format
CHEMBL1098427 OBDepict H OH H CH 3 H H OH H H CH 3 H H O CH 3 HO O H H 3 C CH 3 H 3 C IC50 = 426.0 nM 462.67 C[C@H]1C[C@@]2(O[C@H]3C[C@H]4[C@@H]5CC[C@H]6C[C@H](O)CC[C@]6(C)[C@H]5[C@@H](O)C[C@]4(C)[C@H]3[C@@]2(C)O)OC1(C)C Homo sapiens CHEMBL4616486 cell-based format