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P62993 | GRB2_HUMAN | Growth factor receptor-bound protein 2 (GRB2)

3D structures mapped by conservation among orthologs

[ Domain: "SH2" // SH2 ]

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[ Domain: "SH3" // SH3_1 ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL3144403 OBDepict NH 2 O N H H O H 2 N O N H O H 2 N H NH 2 O P O OH HO IC50 = 1.0 nM 514.48 NC(=O)C[C@H](NC(=O)C1(NC(=O)[C@@H](N)Cc2ccc(OP(=O)(O)O)c(N)c2)CCCCC1)C(N)=O Homo sapiens CHEMBL686598 single protein format
CHEMBL2372811 OBDepict H 2 N O HN H O NH 2 O NH O H 2 N H NH 2 O P O OH HO IC50 = 23.0 nM 500.45 NC(=O)C[C@H](NC(=O)C1(NC(=O)[C@@H](N)Cc2ccc(OP(=O)(O)O)c(N)c2)CCCC1)C(N)=O Homo sapiens CHEMBL686598 single protein format
CHEMBL2372812 OBDepict CH 3 CH 3 H N H H N H O O H NH 2 H O NH 2 O NH 2 NH 2 O P O HO OH IC50 = 65.0 nM 502.47 CC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1ccc(OP(=O)(O)O)c(N)c1)C(=O)N[C@@H](CC(N)=O)C(N)=O Homo sapiens CHEMBL686598 single protein format
CHEMBL2372814 OBDepict NH 2 O N H H O NH 2 O N H O H 2 N H H 2 N O P O OH OH IC50 = 124.0 nM 472.4 NC(=O)C[C@H](NC(=O)C1(NC(=O)[C@@H](N)Cc2ccc(OP(=O)(O)O)c(N)c2)CC1)C(N)=O Homo sapiens CHEMBL686598 single protein format
CHEMBL3144402 OBDepict H 2 N O HN H O NH 2 O NH O H 2 N H NH 2 O P O OH HO IC50 = 140.0 nM 548.49 NC(=O)C[C@H](NC(=O)C1(NC(=O)[C@@H](N)Cc2ccc(OP(=O)(O)O)c(N)c2)Cc2ccccc2C1)C(N)=O Homo sapiens CHEMBL686598 single protein format
CHEMBL2372813 OBDepict H 2 N O NH H O NH 2 O N H H 3 C CH 3 O H 2 N H NH 2 O P O OH HO IC50 = 206.0 nM 474.41 CC(C)(NC(=O)[C@@H](N)Cc1ccc(OP(=O)(O)O)c(N)c1)C(=O)N[C@@H](CC(N)=O)C(N)=O Homo sapiens CHEMBL686598 single protein format
CHEMBL3142740 OBDepict H 3 C NH O H N H O NH O O P H O HO OH O NH 2 O H 2 N IC50 = 210.0 nM 527.47 CC(=O)N[C@H](C(=O)NC1(C(=O)N[C@@H](CC(N)=O)C(N)=O)CCCCC1)c1ccc(OP(=O)(O)O)cc1 Homo sapiens CHEMBL674102 cell-based format
CHEMBL78242 OBDepict H 3 C NH O H N H O N H O H P H O OH HO O NH 2 IC50 = 700.0 nM 550.59 CC(=O)N[C@@H](Cc1ccc(CP(=O)(O)O)cc1)C(=O)NC1(C(=O)N[C@@H]2CCCC[C@@H]2C(N)=O)CCCCC1 Homo sapiens CHEMBL677219 cell-based format