HOME LIGAND hPROTEOME OTHERS DOCUMENT

P78540 | ARGI2_HUMAN | "Arginase-2, mitochondrial" (ARG2)

3D structures mapped by conservation among orthologs

[ Domain: "Arginase/deacetylase" // Arginase ]

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[ Domain: pdbs with more than 2 multi-domains ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4764455 OBDepict NH 2 N H S N O O NH 2 H O HO B HO OH IC50 = 0.1 nM 338.2 NCCNS(=O)(=O)N1C[C@H](CCCB(O)O)[C@](N)(C(=O)O)C1 Homo sapiens CHEMBL4729733 single protein format
CHEMBL4745275 OBDepict HO B OH HN O HO H NH 2 IC50 = 4.0 nM 244.1 N[C@H]1CCN[C@@](CCCCB(O)O)(C(=O)O)C1 Homo sapiens CHEMBL4672977 assay format
CHEMBL1812661 OBDepict HO B OH NH 2 H O OH Ki = 8.5 nM 174.99 N[C@@H](CCCCB(O)O)C(=O)O Homo sapiens CHEMBL1816206 single protein format
CHEMBL4758805 OBDepict HO B OH H 2 N O OH N HO Cl Ki < 10.0 nM 426.75 NC(CCCCB(O)O)(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)C(=O)O Homo sapiens CHEMBL4729731 single protein format
CHEMBL4790798 OBDepict OH B HO NH 2 O HO NH Ki < 10.0 nM 336.24 NC(CCCCB(O)O)(CCCNCCc1ccccc1)C(=O)O Homo sapiens CHEMBL4729731 single protein format
CHEMBL4749355 OBDepict CH 3 HN H N H O OH B HO HO IC50 = 10.0 nM 244.1 CN[C@H]1CN[C@@](CCCCB(O)O)(C(=O)O)C1 Homo sapiens CHEMBL4729736 single protein format
CHEMBL4757930 OBDepict H 3 C CH 3 NH 2 H NH O H N H O HO B OH OH IC50 = 15.0 nM 357.26 CC(C)C[C@H](N)C(=O)N[C@H]1CCN[C@@](CCCCB(O)O)(C(=O)O)C1 Homo sapiens CHEMBL4672977 assay format
CHEMBL4752307 OBDepict HO B OH N H O HO H NH 2 IC50 = 20.0 nM 230.07 N[C@H]1CN[C@@](CCCCB(O)O)(C(=O)O)C1 Homo sapiens CHEMBL4729736 single protein format
CHEMBL4752391 OBDepict H 3 C H 2 N H HN O H N H O OH B HO HO IC50 = 21.0 nM 329.21 CC[C@H](N)C(=O)N[C@H]1CCN[C@@](CCCCB(O)O)(C(=O)O)C1 Homo sapiens CHEMBL4672977 assay format
CHEMBL4753285 OBDepict H 3 C CH 3 H NH 2 H NH O H N H O HO B OH OH IC50 = 21.0 nM 357.26 CC[C@H](C)[C@H](N)C(=O)N[C@H]1CCN[C@@](CCCCB(O)O)(C(=O)O)C1 Homo sapiens CHEMBL4672977 assay format
CHEMBL2418831 OBDepict OH B HO H 2 N O HO N Cl Cl IC50 = 23.0 nM 443.18 NC(CCCCB(O)O)(C(=O)O)C1CC2CCC(C1)N2Cc1ccc(Cl)c(Cl)c1 Homo sapiens CHEMBL2423683 single protein format
CHEMBL4750174 OBDepict HO B OH N H O HO H HN O NH 2 H CH 3 CH 3 H 3 C IC50 = 24.0 nM 357.26 CC(C)(C)[C@H](N)C(=O)N[C@H]1CCN[C@@](CCCCB(O)O)(C(=O)O)C1 Homo sapiens CHEMBL4672977 assay format
CHEMBL4778086 OBDepict OH B HO N H O OH H NH O NH 2 H CH 3 H 3 C IC50 = 24.0 nM 343.23 CC(C)[C@H](N)C(=O)N[C@H]1CCN[C@@](CCCCB(O)O)(C(=O)O)C1 Homo sapiens CHEMBL4672977 assay format
CHEMBL2418830 OBDepict OH B HO H 2 N O HO N Cl IC50 = 30.0 nM 408.74 NC(CCCCB(O)O)(C(=O)O)C1CC2CCC(C1)N2Cc1ccc(Cl)cc1 Homo sapiens CHEMBL2423683 single protein format
CHEMBL4244287 OBDepict HO B OH S NH 2 H O OH Ki = 30.0 nM 193.03 N[C@@H](CSCCB(O)O)C(=O)O Homo sapiens CHEMBL4729728 single protein format
CHEMBL2418991 OBDepict OH B HO H 2 N O HO N F F IC50 = 33.0 nM 410.27 NC(CCCCB(O)O)(C(=O)O)C1CC2CCC(C1)N2Cc1ccc(F)c(F)c1 Homo sapiens CHEMBL2423683 single protein format
CHEMBL2418829 OBDepict OH B HO H 2 N O HO N IC50 = 47.0 nM 374.29 NC(CCCCB(O)O)(C(=O)O)C1CC2CCC(C1)N2Cc1ccccc1 Homo sapiens CHEMBL2423683 single protein format
CHEMBL2418998 OBDepict OH B OH NH 2 O OH N Cl Cl IC50 = 50.0 nM 445.2 NC(CCCCB(O)O)(C(=O)O)C1CCN(CCCc2ccc(Cl)cc2Cl)CC1 Homo sapiens CHEMBL2423683 single protein format
CHEMBL1234777 OBDepict HO N H N H NH H 2 N H O OH Ki = 51.0 nM 176.18 N=C(NO)NCC[C@H](N)C(=O)O Homo sapiens CHEMBL4184940 single protein format
CHEMBL2326090 OBDepict CH 3 N H O HO N B HO OH IC50 = 67.0 nM 300.21 CN[C@](CCCCB(O)O)(CCN1CCCCC1)C(=O)O Homo sapiens CHEMBL2330668 assay format
CHEMBL2418999 OBDepict OH B HO H 2 N O HO N F F F IC50 = 70.0 nM 444.3 NC(CCCCB(O)O)(C(=O)O)C1CCN(CCCc2ccc(C(F)(F)F)cc2)CC1 Homo sapiens CHEMBL2423683 single protein format
CHEMBL2418828 OBDepict HO B OH NH 2 O OH NH IC50 = 85.0 nM 284.17 NC(CCCCB(O)O)(C(=O)O)C1CC2CCC(C1)N2 Homo sapiens CHEMBL2423683 single protein format
CHEMBL4793482 OBDepict HO B OH H NH 2 H O HO N IC50 = 100.0 nM 312.22 N[C@]1(C(=O)O)C[C@H](CCB(O)O)CC[C@H]1CN1CCCCC1 Homo sapiens CHEMBL4729733 single protein format
CHEMBL2326087 OBDepict OH B OH NH 2 O OH N H CH 3 CH 3 IC50 = 190.0 nM 260.14 CC(C)NCC[C@](N)(CCCCB(O)O)C(=O)O Homo sapiens CHEMBL2330668 assay format
CHEMBL2418993 OBDepict CH 3 CH 3 N NH 2 O HO B HO OH IC50 = 230.0 nM 328.26 CC(C)CCN1CCC(C(N)(CCCCB(O)O)C(=O)O)CC1 Homo sapiens CHEMBL2423683 single protein format
CHEMBL2418994 OBDepict OH B OH NH 2 O OH N IC50 = 230.0 nM 348.25 NC(CCCCB(O)O)(C(=O)O)C1CCN(Cc2ccccc2)CC1 Homo sapiens CHEMBL2423683 single protein format
CHEMBL2418995 OBDepict OH B OH NH 2 O OH N Cl IC50 = 240.0 nM 382.7 NC(CCCCB(O)O)(C(=O)O)C1CCN(Cc2ccc(Cl)cc2)CC1 Homo sapiens CHEMBL2423683 single protein format
CHEMBL2326085 OBDepict CH 3 N H 3 C NH 2 O HO B HO OH IC50 = 270.0 nM 274.17 CCN(CC)CC[C@](N)(CCCCB(O)O)C(=O)O Homo sapiens CHEMBL2330668 assay format
CHEMBL2418996 OBDepict OH B OH NH 2 O OH N Cl Cl IC50 = 290.0 nM 417.14 NC(CCCCB(O)O)(C(=O)O)C1CCN(Cc2ccc(Cl)c(Cl)c2)CC1 Homo sapiens CHEMBL2423683 single protein format
CHEMBL4218271 OBDepict HO B OH H N H 2 N O OH O H 2 N CH 3 H IC50 = 296.0 nM 287.12 C[C@H](N)C(=O)N1C[C@H](CCCB(O)O)[C@](N)(C(=O)O)C1 Homo sapiens CHEMBL4729733 single protein format
CHEMBL2326095 OBDepict OH B OH NH 2 O HO N IC50 = 310.0 nM 272.15 N[C@](CCCCB(O)O)(CCN1CCCC1)C(=O)O Homo sapiens CHEMBL2330668 assay format
CHEMBL2326086 OBDepict CH 3 N CH 3 H 2 N O HO B OH HO IC50 = 320.0 nM 274.17 CCCN(C)CC[C@](N)(CCCCB(O)O)C(=O)O Homo sapiens CHEMBL2330668 assay format
CHEMBL2418997 OBDepict OH B OH NH 2 O OH N Cl Cl IC50 = 330.0 nM 431.17 NC(CCCCB(O)O)(C(=O)O)C1CCN(CCc2ccc(Cl)cc2Cl)CC1 Homo sapiens CHEMBL2423683 single protein format
CHEMBL4746323 OBDepict OH B OH NH O OH H HN O NH 2 H H 3 C H 3 C IC50 = 330.0 nM 329.21 CC(C)[C@H](N)C(=O)N[C@H]1CN[C@@](CCCCB(O)O)(C(=O)O)C1 Homo sapiens CHEMBL4729736 single protein format
CHEMBL2326097 OBDepict H 3 C O H N H 2 N O HO B OH HO IC50 = 340.0 nM 316.21 COC[C@@H]1CCCN1CC[C@](N)(CCCCB(O)O)C(=O)O Homo sapiens CHEMBL2330668 assay format
CHEMBL2326084 OBDepict OH N CH 3 NH 2 O OH B OH OH IC50 = 390.0 nM 290.17 CCN(CCO)CC[C@](N)(CCCCB(O)O)C(=O)O Homo sapiens CHEMBL2330668 assay format
CHEMBL2326093 OBDepict HO B OH H 2 N O OH N OH IC50 = 420.0 nM 302.18 N[C@](CCCCB(O)O)(CCN1CCC(O)CC1)C(=O)O Homo sapiens CHEMBL2330668 assay format
CHEMBL4755855 OBDepict NH 2 N O H CH 3 H H 2 N O OH B HO HO IC50 = 500.0 nM 287.12 C[C@@H]1N(C(=O)CN)C[C@@H](CCB(O)O)C[C@]1(N)C(=O)O Homo sapiens CHEMBL4729733 single protein format
CHEMBL4750602 OBDepict OH B HO H N NH 2 O H H 3 C O HO NH 2 H N N H IC50 = 500.0 nM 367.22 C[C@@H]1N(C(=O)[C@@H](N)Cc2c[nH]cn2)C[C@@H](CCB(O)O)C[C@]1(N)C(=O)O Homo sapiens CHEMBL4729733 single protein format
CHEMBL4749434 OBDepict HO B OH H N H 2 N O H CH 3 O OH NH 2 CH 3 H IC50 = 500.0 nM 301.15 C[C@H](N)C(=O)N1C[C@@H](CCB(O)O)C[C@](N)(C(=O)O)[C@@H]1C Homo sapiens CHEMBL4729733 single protein format
CHEMBL2326089 OBDepict OH B HO NH 2 O HO N IC50 = 509.0 nM 286.18 N[C@](CCCCB(O)O)(CCN1CCCCC1)C(=O)O Homo sapiens CHEMBL2330668 assay format
CHEMBL4743587 OBDepict HO B OH N H O HO H N H O H 2 N H HO CH 3 CH 3 IC50 = 520.0 nM 345.21 CC(C)(O)[C@H](N)C(=O)N[C@H]1CN[C@@](CCCCB(O)O)(C(=O)O)C1 Homo sapiens CHEMBL4729736 single protein format
CHEMBL2326099 OBDepict HO B OH NH 2 O OH N IC50 = 550.0 nM 320.2 N[C@](CCCCB(O)O)(CCN1Cc2ccccc2C1)C(=O)O Homo sapiens CHEMBL2330668 assay format
CHEMBL2326096 OBDepict HO H N NH 2 O OH B HO OH IC50 = 600.0 nM 302.18 N[C@](CCCCB(O)O)(CCN1CC[C@@H](CO)C1)C(=O)O Homo sapiens CHEMBL2330668 assay format
CHEMBL2348486 OBDepict OH B OH NH 2 O HO N IC50 = 620.0 nM 272.15 NC(CCCCB(O)O)(CCN1CCCC1)C(=O)O Homo sapiens CHEMBL2351680 single protein format
CHEMBL2418992 OBDepict OH B HO NH 2 O HO HN IC50 = 640.0 nM 258.13 NC(CCCCB(O)O)(C(=O)O)C1CCNCC1 Homo sapiens CHEMBL2423683 single protein format
CHEMBL2348488 OBDepict CH 3 N H 3 C NH 2 O HO B HO OH IC50 = 934.0 nM 274.17 CCN(CC)CCC(N)(CCCCB(O)O)C(=O)O Homo sapiens CHEMBL2351680 single protein format
CHEMBL2348487 OBDepict HO B OH H 2 N O OH N OH IC50 = 980.0 nM 302.18 NC(CCCCB(O)O)(CCN1CCC(O)CC1)C(=O)O Homo sapiens CHEMBL2351680 single protein format
CHEMBL4748105 OBDepict HO B OH NH 2 CH 3 OH O OH IC50 < 1000.0 nM 245.08 CC1(O)CCC(CCB(O)O)CC1(N)C(=O)O Homo sapiens CHEMBL4729733 single protein format