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Q02779 | M3K10_HUMAN | Mitogen-activated protein kinase kinase kinase 10 (MAP3K10)

3D structures mapped by conservation among orthologs

[ Domain: "SH3" // SH3_1 ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL388978 OBDepict CH 3 HN H H O H O N H 3 C H 3 C N O N H IC50 = 2.69 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL4328503 single protein format
CHEMBL288817 OBDepict CH 3 O N H O O N H N OH H 3 C O O CH 3 O H 3 C IC50 = 16.0 nM 555.59 COCc1ccc2c(c1)c1c3c(c4c5cc(COC)ccc5n5c4c1n2[C@H]1C[C@](O)(C(=O)OC)[C@]5(C)O1)CNC3=O Homo sapiens CHEMBL732489 single protein format
CHEMBL277817 OBDepict CH 3 O N H O O N H N H 3 C OH O O CH 3 O H 3 C IC50 = 20.0 nM 583.64 CCOCc1ccc2c(c1)c1c3c(c4c5cc(COCC)ccc5n5c4c1n2[C@H]1C[C@](O)(C(=O)OC)[C@]5(C)O1)CNC3=O Homo sapiens CHEMBL732489 single protein format
CHEMBL288229 OBDepict CH 3 S N CH 3 O N H N HO O H O O CH 3 IC50 = 28.0 nM 541.63 CCSCc1ccc2c(c1)c1c3c(c4c5ccccc5n5c4c1n2[C@@]1(C)O[C@@H]5C[C@]1(O)C(=O)OC)C(=O)NC3 Homo sapiens CHEMBL732489 single protein format
CHEMBL2436978 OBDepict CH 3 N N N N H N H IC50 = 42.0 nM 421.55 CN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5ccc6[nH]ccc6c5)c4c3)cc2)CC1 Homo sapiens CHEMBL2439776 single protein format
CHEMBL416056 OBDepict CH 3 O O HO CH 3 O N H N N H O IC50 = 45.0 nM 467.48 COC(=O)[C@]1(O)C[C@@H]2O[C@@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL911980 single protein format
CHEMBL4218417 OBDepict OH N N H O N H O H 3 C CH 3 IC50 = 46.0 nM 427.5 CC(C)OCc1ccc2c(c1)c1c3c(c4c5ccccc5[nH]c4c1n2CCO)CNC3=O Homo sapiens CHEMBL4199316 assay format
CHEMBL4281823 OBDepict CH 3 N N N NH 2 N O O F F F IC50 = 50.0 nM 481.48 CCn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 Homo sapiens CHEMBL4261427 single protein format
CHEMBL36891 OBDepict H 3 C S N H O O N H N HO H 3 C O O H 3 C IC50 = 140.0 nM 541.63 CCSCc1ccc2c(c1)c1c3c(c4c5ccccc5n5c4c1n2[C@H]1C[C@](O)(C(=O)OC)[C@]5(C)O1)CNC3=O Homo sapiens CHEMBL732489 single protein format
CHEMBL386636 OBDepict O N H O N H IC50 = 339.0 nM 338.37 O=C1NC(=O)c2c1c1c(c3[nH]c4ccccc4c23)CCc2ccccc2-1 Homo sapiens CHEMBL911980 single protein format
CHEMBL357490 OBDepict O N H N H IC50 = 364.0 nM 310.36 O=C1NCc2c1c1c(c3[nH]c4ccccc4c23)Cc2ccccc2-1 Homo sapiens CHEMBL911980 single protein format
CHEMBL2171124 OBDepict O N F F F N CH 3 H 2 N N N IC50 = 452.0 nM 451.45 Cn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(C(F)(F)F)c2)c2c(N)ncnc21 Homo sapiens CHEMBL2172947 single protein format
CHEMBL3393333 OBDepict N N N H N N N F F O IC50 = 767.0 nM 440.5 N#Cc1ccnc(Nc2cc(C3CCN(C4COC4)CC3)cc(N3CCC(F)(F)C3)n2)c1 Homo sapiens CHEMBL3395596 single protein format