Q02880 | TOP2B_HUMAN | DNA topoisomerase 2-beta (TOP2B)

3D structures mapped by conservation among orthologs

[ Domain: "winged" // DNA_topoisoIV_1st ]

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[ Domain: "Toprim domain" // DNA_gyraseB_C ]

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[ Domain: "SSHS domain in type II DNA topoisomerase" // TOPRIM_C ]

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[ Domain: "a+b domain in type II DNA topoisomerase" // DNA_topoisoIV_2nd_1 ]

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[ Domain: "a+b domain in type II DNA topoisomerase" // DNA_topoisoIV_2nd_1 ]

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[ Domain: "alpha-helical domain in type II DNA topoisomerase" // DNA_topoisoIV_3rd ]

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[ Domain: pdbs with more than 2 multi-domains ]

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[ Alpha Fold Model ] (go)

Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id	structure	assay_type	relation	values	units	mol_wt	smiles	organism	assay_chembl_id	bao_label
CHEMBL49442		IC50	=	30.0	nM	412.49	O=C1c2ccccc2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	Homo sapiens	CHEMBL4382900	single protein format
CHEMBL44657		IC50	=	69.8	nM	588.56	COc1cc([C@@H]2c3cc4c(cc3[C@@H](O[C@@H]3O[C@@H]5CO[C@@H](C)O[C@H]5[C@H](O)[C@H]3O)[C@H]3COC(=O)[C@H]23)OCO4)cc(OC)c1O	Homo sapiens	CHEMBL4156659	single protein format
CHEMBL4751362		IC50	=	130.0	nM	385.45	Cc1cc(NC2=NC(=O)/C(=Cc3c4ccccc4cc4ccccc34)S2)no1	Homo sapiens	CHEMBL4672266	single protein format
CHEMBL4213218		IC50	=	580.0	nM	507.52	O=C(CN1CCN(c2cc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)CC1)N/N=C/c1ccccc1O	Homo sapiens	CHEMBL4198805	single protein format
CHEMBL53463		IC50	=	727.0	nM	543.53	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	Homo sapiens	CHEMBL4672266	single protein format
CHEMBL4205327		IC50	=	860.0	nM	530.56	O=C(CN1CCN(c2cc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)CC1)N/N=C/c1cc2ccccc2[nH]1	Homo sapiens	CHEMBL4198805	single protein format