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Q04756 | HGFA_HUMAN | Hepatocyte growth factor activator (HGFAC)

3D structures mapped by conservation among orthologs

[ Domain: "FMN-binding split barrel 2" // Trypsin_1 ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL273264 OBDepict NH 2 HN NH O O NH H 2 N Ki = 25.0 nM 347.38 N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1 Homo sapiens CHEMBL3389934 single protein format
CHEMBL273264 OBDepict NH 2 HN NH O O NH H 2 N IC50 = 150.0 nM 347.38 N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1 Homo sapiens CHEMBL3404294 cell-based format
CHEMBL3780434 OBDepict H 3 C O N N O N NH NH 2 Ki = 160.0 nM 449.6 COCC1CN(CC2CCN(Cc3ccccc3)CC2)C(=O)N(c2cccc(C(=N)N)c2)C1 Homo sapiens CHEMBL3782552 cell-based format
CHEMBL191881 OBDepict O NH H O N H H N H O H 3 C CH 3 HN H 2 N HN H O CH 3 CH 3 H 3 C Ki = 188.0 nM 426.56 CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C=O)CCCNC(=N)N Homo sapiens CHEMBL3389934 single protein format
CHEMBL3781354 OBDepict OH N N O N HN NH 2 Ki = 230.0 nM 435.57 N=C(N)c1cccc(N2CC(CO)CN(CC3CCN(Cc4ccccc4)CC3)C2=O)c1 Homo sapiens CHEMBL3782552 cell-based format
CHEMBL3403524 OBDepict NH 2 N H NH O O Cl + N O _ O IC50 = 300.0 nM 334.72 N=C(N)Nc1ccc(C(=O)Oc2ccc([N+](=O)[O-])cc2Cl)cc1 Homo sapiens CHEMBL3404294 cell-based format
CHEMBL3780273 OBDepict O N N N H S N O O CH 3 HN NH 2 Ki = 350.0 nM 498.65 CS(=O)(=O)NC1CN(CC2CCN(Cc3ccccc3)CC2)C(=O)N(c2cccc(C(=N)N)c2)C1 Homo sapiens CHEMBL3782552 cell-based format
CHEMBL3780548 OBDepict O HN N N O N NH NH 2 Ki = 380.0 nM 538.7 N=C(N)c1cccc(N2CC(NC(=O)Cc3ccccc3)CN(CC3CCN(Cc4ccccc4)CC3)C2=O)c1 Homo sapiens CHEMBL3782552 cell-based format
CHEMBL3780036 OBDepict O N N O N NH NH 2 Ki = 430.0 nM 525.7 N=C(N)c1cccc(N2CC(COCc3ccccc3)CN(CC3CCN(Cc4ccccc4)CC3)C2=O)c1 Homo sapiens CHEMBL3782552 cell-based format
CHEMBL3781673 OBDepict O N N HN S N O O NH NH 2 Ki = 440.0 nM 574.75 N=C(N)c1cccc(N2CC(NS(=O)(=O)Cc3ccccc3)CN(CC3CCN(Cc4ccccc4)CC3)C2=O)c1 Homo sapiens CHEMBL3782552 cell-based format
CHEMBL3781349 OBDepict CH 3 N N O N NH H 2 N Ki = 480.0 nM 419.57 CC1CN(CC2CCN(Cc3ccccc3)CC2)C(=O)N(c2cccc(C(=N)N)c2)C1 Homo sapiens CHEMBL3782552 cell-based format
CHEMBL3780005 OBDepict NH 2 NH N O N HN S O O N Ki = 520.0 nM 560.72 N=C(N)c1cccc(N2CC(NS(=O)(=O)c3ccccc3)CN(CC3CCN(Cc4ccccc4)CC3)C2=O)c1 Homo sapiens CHEMBL3782552 cell-based format
CHEMBL3403520 OBDepict H 3 C O NH H H 3 C HN O S O O N N H 3 C HN NH 2 Ki = 590.0 nM 494.58 CCc1cc([C@@H](Nc2ccc(C(=N)N)cc2)C(=O)NS(=O)(=O)c2cn(C)cn2)cc2c(C)coc12 Homo sapiens CHEMBL3404299 single protein format
CHEMBL3403525 OBDepict H 3 C O O O O HN NH NH 2 IC50 = 600.0 nM 363.37 COC(=O)c1ccc2cc(OC(=O)c3ccc(NC(=N)N)cc3)ccc2c1 Homo sapiens CHEMBL3404294 cell-based format
CHEMBL550687 OBDepict NH 2 NH HN O O + N O _ O IC50 = 820.0 nM 300.27 N=C(N)Nc1ccc(C(=O)Oc2ccc([N+](=O)[O-])cc2)cc1 Homo sapiens CHEMBL3404294 cell-based format
CHEMBL3781784 OBDepict OH N N O N NH NH 2 Ki = 880.0 nM 421.55 N=C(N)c1cccc(N2CC(O)CN(CC3CCN(Cc4ccccc4)CC3)C2=O)c1 Homo sapiens CHEMBL3782552 cell-based format