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Q04912 | RON_HUMAN | Macrophage-stimulating protein receptor (MST1R)

3D structures mapped by conservation among orthologs

[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // TIG_3 ]

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[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Domain: "Trefoil/Plexin domain-like" // PSI_1 ]

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[ Domain: "7-bladed" // Sema_2 ]

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[ Domain: pdbs with more than 2 multi-domains ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL2031893 OBDepict CH 3 O O CH 3 O N F N H O CH 3 N O N H 3 C Ki = 1.0 nM 528.54 COc1cc2nccc(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)cc3F)c2cc1OC Homo sapiens CHEMBL2032459 single protein format
CHEMBL3545307 OBDepict F N CH 3 O N H O F O N N N N H 3 C H IC50 = 1.2 nM 552.54 Cc1ccc(C(=O)Nc2ccc(Oc3cc4cnn(C)c4cc3-c3cn[nH]c3)c(F)c2)c(=O)n1-c1ccc(F)cc1 Homo sapiens CHEMBL4330214 single protein format
CHEMBL460702 OBDepict CH 3 O N N H O O F F O Cl N NH 2 IC50 = 1.8 nM 512.9 CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc(N)c2Cl)c(F)c1 Homo sapiens CHEMBL957100 single protein format
CHEMBL4753082 OBDepict H 3 C O N N H O O F F O Cl N NH 2 IC50 = 1.8 nM 498.87 COc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc(N)c2Cl)c(F)c1 Homo sapiens CHEMBL4686622 single protein format
CHEMBL2143592 OBDepict H N NH O O F F O Cl N NH 2 IC50 < 3.0 nM 468.85 Nc1nccc(Oc2ccc(NC(=O)c3c[nH]cc(-c4ccc(F)cc4)c3=O)cc2F)c1Cl Homo sapiens CHEMBL3767453 single protein format
CHEMBL3899652 OBDepict O NH N H N O F N H O N N F F F IC50 = 4.3 nM 512.42 O=C1NCc2c(Oc3ccc(NC(=O)c4cnn(-c5ccccc5)c4C(F)(F)F)cc3F)ccnc2N1 Homo sapiens CHEMBL3888135 single protein format
CHEMBL1802829 OBDepict H 3 C N N N O N H S N O O H 3 C CH 3 IC50 = 7.0 nM 409.47 CN(C)S(=O)(=O)Nc1ccc2ccc3ncc(-c4cnn(C)c4)cc3c(=O)c2c1 Homo sapiens CHEMBL2327589 single protein format
CHEMBL2323775 OBDepict H 3 C N N N O S N H O O N IC50 = 7.0 nM 471.54 Cn1cc(-c2cnc3ccc4ccc(CS(=O)(=O)NCc5ccccn5)cc4c(=O)c3c2)cn1 Homo sapiens CHEMBL2327589 single protein format
CHEMBL1822792 OBDepict H 3 C N N N O N H S N O O CH 3 H O O IC50 = 7.0 nM 495.56 CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(-c4cnn(C)c4)cc3c(=O)c2c1 Homo sapiens CHEMBL1804190 single protein format
CHEMBL460472 OBDepict CH 3 O N O N N H O CH 3 N O N OH CH 3 H 3 C IC50 = 10.0 nM 539.59 COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)(C)O)n(-c5ccccc5)c4=O)nc3)ccnc2c1 Homo sapiens CHEMBL2032459 single protein format
CHEMBL3931180 OBDepict O N H HN N O F N H O N CH 3 N IC50 = 10.0 nM 458.45 Cc1c(C(=O)Nc2ccc(Oc3ccnc4c3CNC(=O)N4)c(F)c2)cnn1-c1ccccc1 Homo sapiens CHEMBL3888135 single protein format
CHEMBL3582033 OBDepict CH 3 N N S N O F HN O N F F F IC50 = 10.0 nM 577.56 Cn1cnc(-c2cc3nccc(Oc4ccc(NC(=O)c5ccn(-c6ccccc6)c5C(F)(F)F)cc4F)c3s2)c1 Homo sapiens CHEMBL3585031 cell-based format
CHEMBL2031893 OBDepict CH 3 O O CH 3 O N F N H O CH 3 N O N H 3 C IC50 = 10.0 nM 528.54 COc1cc2nccc(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)cc3F)c2cc1OC Homo sapiens CHEMBL2032459 single protein format
CHEMBL3582034 OBDepict CH 3 N N S N O F HN O N N F F F IC50 = 13.0 nM 578.55 Cn1cnc(-c2cc3nccc(Oc4ccc(NC(=O)c5ncn(-c6ccccc6)c5C(F)(F)F)cc4F)c3s2)c1 Homo sapiens CHEMBL3585031 cell-based format
CHEMBL3608551 OBDepict H 3 C N N S N O F NH O N N N IC50 = 14.0 nM 587.64 Cn1cnc(-c2cc3nccc(Oc4ccc(NC(=O)c5cnn(-c6ccccc6)c5-c5cccnc5)cc4F)c3s2)c1 Homo sapiens CHEMBL3610848 single protein format
CHEMBL2032274 OBDepict OH O F F F OH O N NH 2 N N N HN IC50 = 14.0 nM 490.44 Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1-c1nc2ccc(O)cc2o1.O=C(O)C(F)(F)F Homo sapiens CHEMBL2034273 single protein format
CHEMBL3582035 OBDepict CH 3 N N S N O F HN O N N N F F F IC50 = 17.0 nM 579.54 Cn1cnc(-c2cc3nccc(Oc4ccc(NC(=O)c5nnn(-c6ccccc6)c5C(F)(F)F)cc4F)c3s2)c1 Homo sapiens CHEMBL3585031 cell-based format
CHEMBL4779315 OBDepict H 3 C O O H 3 C O N F N H O O CH 3 CH 3 H 3 C O F IC50 = 18.64 nM 550.56 COc1cc2nccc(Oc3ccc(NC(=O)C(OC(=O)c4ccc(F)cc4)C(C)(C)C)cc3F)c2cc1OC Homo sapiens CHEMBL4686391 single protein format
CHEMBL3608549 OBDepict H 3 C N N S N O F NH O N N N IC50 = 23.0 nM 587.64 Cn1cnc(-c2cc3nccc(Oc4ccc(NC(=O)c5cnn(-c6ccccc6)c5-c5ccccn5)cc4F)c3s2)c1 Homo sapiens CHEMBL3610848 single protein format
CHEMBL3608544 OBDepict H 3 C N N S N O F NH O N N IC50 = 23.0 nM 586.65 Cn1cnc(-c2cc3nccc(Oc4ccc(NC(=O)c5cnn(-c6ccccc6)c5-c5ccccc5)cc4F)c3s2)c1 Homo sapiens CHEMBL3610848 single protein format
CHEMBL3919424 OBDepict H 3 C N N N H O N N F O N O CH 3 O CH 3 IC50 = 30.0 nM 514.52 CCc1c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)c(F)c2)cnn1-c1cncnc1 Homo sapiens CHEMBL3889184 single protein format
CHEMBL3609808 OBDepict H 3 C N N S N O F N O N N IC50 = 30.0 nM 536.59 Cn1cnc(-c2cc3nccc(Oc4ccc(N5CCc6c(cnn6-c6ccccc6)C5=O)cc4F)c3s2)c1 Homo sapiens CHEMBL3611224 single protein format
CHEMBL3608545 OBDepict CH 3 N N S N O F N H O N N IC50 = 32.0 nM 586.65 Cn1cnc(-c2cc3nccc(Oc4ccc(NC(=O)c5cn(-c6ccccc6)nc5-c5ccccc5)cc4F)c3s2)c1 Homo sapiens CHEMBL3610848 single protein format
CHEMBL3609807 OBDepict CH 3 N N S N O F N O N N IC50 = 34.0 nM 550.62 Cn1cnc(-c2cc3nccc(Oc4ccc(N5CCCc6c(cnn6-c6ccccc6)C5=O)cc4F)c3s2)c1 Homo sapiens CHEMBL3611224 single protein format
CHEMBL3582037 OBDepict F N N F F F N H O F O S N N N CH 3 IC50 = 44.0 nM 596.54 Cn1cnc(-c2cc3nccc(Oc4ccc(NC(=O)c5cnn(-c6ccc(F)cc6)c5C(F)(F)F)cc4F)c3s2)c1 Homo sapiens CHEMBL3585031 cell-based format
CHEMBL3609805 OBDepict CH 3 N N S N O F N O N N IC50 = 49.0 nM 548.6 Cn1cnc(-c2cc3nccc(Oc4ccc(N5CC=Cc6c(cnn6-c6ccccc6)C5=O)cc4F)c3s2)c1 Homo sapiens CHEMBL3611224 single protein format
CHEMBL1094718 OBDepict CH 3 N N S N O F HN O N N F F F IC50 = 50.0 nM 578.55 Cn1cnc(-c2cc3nccc(Oc4ccc(NC(=O)c5cnn(-c6ccccc6)c5C(F)(F)F)cc4F)c3s2)c1 Homo sapiens CHEMBL1103914 cell-based format
CHEMBL1813632 OBDepict F N O HN O F O N N S IC50 = 50.4 nM 552.56 O=C(Nc1ccc(Oc2ncnc3scc(-c4ccccc4)c23)c(F)c1)c1cccn(-c2ccc(F)cc2)c1=O Homo sapiens CHEMBL1816199 single protein format
CHEMBL1095034 OBDepict F O HN O S N N N F F F N N H 3 C IC50 = 60.0 nM 578.55 Cn1ccnc1-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(-c5ccccc5)c4C(F)(F)F)cc3F)c2s1 Homo sapiens CHEMBL1103914 cell-based format
CHEMBL2105717 OBDepict CH 3 O O CH 3 O N N H O HN O F IC50 = 69.0 nM 501.51 COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC Homo sapiens CHEMBL4147638 single protein format
CHEMBL460772 OBDepict CH 3 O O CH 3 O N F N N Ki = 79.0 nM 467.5 COc1cc2nccc(Oc3ccc(-c4ccc(Cc5ccccc5)nn4)cc3F)c2cc1OC Homo sapiens CHEMBL971822 single protein format
CHEMBL1087984 OBDepict CH 3 O O CH 3 O N F N H O N N F F F IC50 = 80.0 nM 552.48 COc1cc2nccc(Oc3ccc(NC(=O)c4cnn(-c5ccccc5)c4C(F)(F)F)cc3F)c2cc1OC Homo sapiens CHEMBL1103914 cell-based format
CHEMBL461831 OBDepict CH 3 O O CH 3 O N F N O N H 3 C N H F Ki = 80.0 nM 516.5 COc1cc2nccc(Oc3ccc(-c4cnc(Nc5ccc(F)cc5)n(C)c4=O)cc3F)c2cc1OC Homo sapiens CHEMBL971822 single protein format
CHEMBL4794496 OBDepict H 3 C O O H 3 C N O N F N H N N O H F IC50 = 90.1 nM 553.53 COc1cc2ncnc(Oc3ccc(Nc4nccc5[nH]cc(-c6ccc(F)cc6)c(=O)c45)cc3F)c2cc1OC Homo sapiens CHEMBL4774508 single protein format
CHEMBL3735648 OBDepict N N H O H 3 C CH 3 N O IC50 = 93.4 nM 467.61 CC1(C)c2cc(C3CCN(CC4CCOCC4)CC3)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21 Homo sapiens CHEMBL3830313 cell-based format
CHEMBL3582036 OBDepict CH 3 N N S N O F N H O N N F F F IC50 = 95.0 nM 578.55 Cn1cnc(-c2cc3nccc(Oc4ccc(NC(=O)c5cn(-c6ccccc6)nc5C(F)(F)F)cc4F)c3s2)c1 Homo sapiens CHEMBL3585031 cell-based format
CHEMBL3608546 OBDepict CH 3 N N S N O F N H O N IC50 = 101.0 nM 585.66 Cn1cnc(-c2cc3nccc(Oc4ccc(NC(=O)c5cc(-c6ccccc6)n(-c6ccccc6)c5)cc4F)c3s2)c1 Homo sapiens CHEMBL3610848 single protein format
CHEMBL2401834 OBDepict CH 3 O Cl Cl F H 2 N N O N N NH IC50 = 130.0 nM 490.37 CC(Oc1c(N)ncc2c(-c3cnn(C4CCNCC4)c3)coc12)c1c(Cl)ccc(F)c1Cl Homo sapiens CHEMBL2406498 cell-based format
CHEMBL1086932 OBDepict CH 3 N N S N O F N H O N H 3 C N IC50 = 150.0 nM 524.58 Cc1c(C(=O)Nc2ccc(Oc3ccnc4cc(-c5cn(C)cn5)sc34)c(F)c2)cnn1-c1ccccc1 Homo sapiens CHEMBL1103914 cell-based format
CHEMBL462232 OBDepict CH 3 N N S N O F HN N O O N IC50 = 170.0 nM 528.57 Cn1cnc(-c2cc3nccc(Oc4ccc(NC(=O)N5CCN(c6ccccc6)C5=O)cc4F)c3s2)c1 Homo sapiens CHEMBL1103914 cell-based format
CHEMBL2401832 OBDepict H 2 N N O O N O NH 2 CH 3 H Cl Cl F IC50 = 200.0 nM 465.31 C[C@@H](Oc1c(N)ncc2c(C3=CCN(C(N)=O)CC3)coc12)c1c(Cl)ccc(F)c1Cl Homo sapiens CHEMBL2406498 cell-based format
CHEMBL1098158 OBDepict CH 3 N N S N O F HN O N N F F F H 3 C H 3 C H 3 C IC50 = 200.0 nM 558.56 Cn1cnc(-c2cc3nccc(Oc4ccc(NC(=O)c5cnn(C(C)(C)C)c5C(F)(F)F)cc4F)c3s2)c1 Homo sapiens CHEMBL1103914 cell-based format
CHEMBL1086675 OBDepict CH 3 N N N H O F O S N N N H 3 C IC50 = 210.0 nM 552.64 CCCc1c(C(=O)Nc2ccc(Oc3ccnc4cc(-c5cn(C)cn5)sc34)c(F)c2)cnn1-c1ccccc1 Homo sapiens CHEMBL1103914 cell-based format
CHEMBL602472 OBDepict H 2 N O N O CH 3 H Cl Cl F IC50 = 230.0 nM 419.28 C[C@@H](Oc1ccc2ncc(C3CC3C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl Homo sapiens CHEMBL1066398 single protein format
CHEMBL1684800 OBDepict H 3 C O N N NH 2 N H O CH 3 N H NH O Cl F F F IC50 = 277.1 nM 572.98 COc1ccc(Cn2ncc(NC(=O)c3cc(NC(=O)Nc4ccc(Cl)c(C(F)(F)F)c4)ccc3C)c2N)cc1 Homo sapiens CHEMBL1687374 single protein format
CHEMBL601719 OBDepict NH 2 N O CH 3 H N N Cl Cl F HN IC50 = 300.0 nM 450.35 C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl Homo sapiens CHEMBL976904 single protein format
CHEMBL2442124 OBDepict NH 2 N S CH 3 H N N Cl Cl F HN IC50 = 336.4 nM 466.41 C[C@@H](Sc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl Homo sapiens CHEMBL2447157 single protein format
CHEMBL4584949 OBDepict O N H N O F NH N N O CH 3 F IC50 = 346.0 nM 539.54 Cn1cc(-c2ccc(F)cc2)c(=O)c2c(Nc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)c(F)c3)nccc21 Homo sapiens CHEMBL4376518 assay format
CHEMBL3609806 OBDepict O N H N N O N F O S N N N H 3 C IC50 = 361.0 nM 565.59 Cn1cnc(-c2cc3nccc(Oc4ccc(N5CC(=O)Nc6c(cnn6-c6ccccc6)C5=O)cc4F)c3s2)c1 Homo sapiens CHEMBL3611224 single protein format
CHEMBL2324117 OBDepict NH 2 O HO O N N N CH 3 IC50 = 403.0 nM 360.37 Cn1cc(-c2cnc3ccc4ccc(C(O)C(N)=O)cc4c(=O)c3c2)cn1 Homo sapiens CHEMBL2327589 single protein format
CHEMBL600632 OBDepict O N H HN F F F F O S N N N CH 3 IC50 = 410.0 nM 555.56 Cn1cnc(-c2cc3nccc(Oc4ccc(NC(=O)CC(Nc5ccccc5)C(F)(F)F)cc4F)c3s2)c1 Homo sapiens CHEMBL1103914 cell-based format
CHEMBL388978 OBDepict CH 3 HN H H O H O N H 3 C H 3 C N O N H IC50 = 442.5 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL1919770 single protein format
CHEMBL2376650 OBDepict CH 3 N N N H O O N O H H 3 C H Cl Cl F IC50 = 446.0 nM 519.4 C[C@@H](Oc1c[nH]c(=O)c(C(=O)Nc2ccc(N3CCN(C)CC3)cc2)c1)c1c(Cl)ccc(F)c1Cl Homo sapiens CHEMBL2379876 single protein format
CHEMBL602471 OBDepict H 2 N O N O CH 3 H Cl Cl F IC50 = 450.0 nM 405.26 C[C@@H](Oc1ccc2ncc(/C=C/C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl Homo sapiens CHEMBL1066398 single protein format
CHEMBL3580678 OBDepict H 3 C N N S N O F N CH 3 O N N F F F IC50 = 580.0 nM 592.58 CN(C(=O)c1cnn(-c2ccccc2)c1C(F)(F)F)c1ccc(Oc2ccnc3cc(-c4cn(C)cn4)sc23)c(F)c1 Homo sapiens CHEMBL3585031 cell-based format
CHEMBL461648 OBDepict H 3 C O O H 3 C O N F N O N CH 3 Ki = 581.0 nM 497.53 COc1cc2nccc(Oc3ccc(-c4cnc(Cc5ccccc5)n(C)c4=O)cc3F)c2cc1OC Homo sapiens CHEMBL971822 single protein format
CHEMBL1086676 OBDepict CH 3 N N S N O F N H O N N IC50 = 590.0 nM 510.55 Cn1cnc(-c2cc3nccc(Oc4ccc(NC(=O)c5cnn(-c6ccccc6)c5)cc4F)c3s2)c1 Homo sapiens CHEMBL1103914 cell-based format
CHEMBL4074262 OBDepict OH N N N N N N N CH 3 F N N N H 3 C IC50 = 731.0 nM 484.5 CC(c1cc2cc(-c3cnn(C)c3)cnc2cc1F)n1nnc2ncc(-c3cnn(CCO)c3)nc21 Homo sapiens CHEMBL4021221 single protein format
CHEMBL2324129 OBDepict NH 2 O O N N N CH 3 IC50 = 861.0 nM 344.37 Cn1cc(-c2cnc3ccc4ccc(CC(N)=O)cc4c(=O)c3c2)cn1 Homo sapiens CHEMBL2327589 single protein format
CHEMBL2324116 OBDepict NH 2 O H 3 C O N N N H 3 C IC50 = 912.0 nM 358.4 CC(C(N)=O)c1ccc2ccc3ncc(-c4cnn(C)c4)cc3c(=O)c2c1 Homo sapiens CHEMBL2327589 single protein format