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Q05513 | KPCZ_HUMAN | Protein kinase C zeta type (PRKCZ)

3D structures mapped by conservation among orthologs



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4868141 OBDepict H 2 N N O O HN NH S O O IC50 = -12400.0 nM 532.67 Nc1ncc(-c2ccc(NS(=O)(=O)C3CC3)cc2OC2CCCCC2)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804474 cell-based format
CHEMBL4635482 OBDepict H 2 N F NH N H NH IC50 = 0.1 nM 350.44 Nc1ccc(-c2cc(N[C@H]3CCCCNC3)c3ccncc3c2)c(F)c1 Homo sapiens CHEMBL4619369 single protein format
CHEMBL4636488 OBDepict H NH N H N IC50 = 0.2 nM 303.41 c1ccc(-c2cc(N[C@H]3CCCNC3)c3ccncc3c2)cc1 Homo sapiens CHEMBL4619369 single protein format
CHEMBL4646995 OBDepict NH 2 N H N HN IC50 = 0.5 nM 318.42 Nc1ccc(-c2cc(NC3CCCNC3)c3ccncc3c2)cc1 Homo sapiens CHEMBL4619369 single protein format
CHEMBL4644939 OBDepict OH N H N HN IC50 = 0.6 nM 319.41 Oc1ccc(-c2cc(NC3CCCNC3)c3ccncc3c2)cc1 Homo sapiens CHEMBL4619369 single protein format
CHEMBL4636337 OBDepict NH 2 F F HN N H HN IC50 = 0.8 nM 368.43 Nc1ccc(-c2cc(N[C@H]3CCCCNC3)c3ccncc3c2)c(F)c1F Homo sapiens CHEMBL4619369 single protein format
CHEMBL4632523 OBDepict NH 2 N HN N H HN IC50 = 0.9 nM 333.44 Nc1ccc(-c2cc(N[C@H]3CCCCNC3)c3ccncc3c2)cn1 Homo sapiens CHEMBL4619369 single protein format
CHEMBL4643553 OBDepict H 2 N N F NH N H NH IC50 = 1.1 nM 351.43 Nc1ccc(-c2cc(N[C@H]3CCCCNC3)c3ccncc3c2)c(F)n1 Homo sapiens CHEMBL4619369 single protein format
CHEMBL4637452 OBDepict F NH 2 F N H N H HN IC50 = 1.4 nM 368.43 Nc1cc(F)c(-c2cc(N[C@H]3CCCCNC3)c3ccncc3c2)cc1F Homo sapiens CHEMBL4619369 single protein format
CHEMBL4642166 OBDepict NH 2 HN N H HN IC50 = 1.4 nM 332.45 Nc1ccc(-c2cc(N[C@H]3CCCCNC3)c3ccncc3c2)cc1 Homo sapiens CHEMBL4619369 single protein format
CHEMBL514197 OBDepict H 3 C O HO N H N N N H N N CH 3 IC50 = 2.26 nM 454.53 COc1cc(-c2ccc3c(-c4nc5c(N6CCN(C)CC6)cccc5[nH]4)n[nH]c3c2)ccc1O Homo sapiens CHEMBL942589 single protein format
CHEMBL4647780 OBDepict NH 2 N F HN N H HN IC50 = 3.4 nM 351.43 Nc1cc(F)c(-c2cc(N[C@H]3CCCCNC3)c3ccncc3c2)cn1 Homo sapiens CHEMBL4619369 single protein format
CHEMBL4643470 OBDepict H 2 N HN N IC50 = 4.1 nM 263.34 NCCNc1cc(-c2ccccc2)cc2cnccc12 Homo sapiens CHEMBL4619369 single protein format
CHEMBL480391 OBDepict CH 3 N N N N H N N H H 2 N IC50 = 5.18 nM 423.52 CN1CCN(c2cccc3nc(-c4n[nH]c5cc(-c6ccc(N)cc6)ccc45)[nH]c23)CC1 Homo sapiens CHEMBL942589 single protein format
CHEMBL473631 OBDepict CH 3 N N N N H N N H OH IC50 = 5.6 nM 424.51 CN1CCN(c2cccc3[nH]c(-c4n[nH]c5cc(-c6ccc(O)cc6)ccc45)nc23)CC1 Homo sapiens CHEMBL942589 single protein format
CHEMBL4641918 OBDepict HN N H N IC50 = 6.4 nM 303.41 c1ccc(-c2cc(NC3CCCNC3)c3ccncc3c2)cc1 Homo sapiens CHEMBL4619369 single protein format
CHEMBL4632384 OBDepict H HN N H N IC50 = 9.7 nM 317.44 c1ccc(-c2cc(N[C@H]3CCCCNC3)c3ccncc3c2)cc1 Homo sapiens CHEMBL4619369 single protein format
CHEMBL4213984 OBDepict H 3 C O N N H N N N H IC50 = 10.0 nM 381.44 COc1cc2c(cc1-n1cnc3ccc(-c4ccnc5[nH]ccc45)cc31)CNC2 Homo sapiens CHEMBL4189554 assay format
CHEMBL3732444 OBDepict N H N N N S N IC50 = 12.0 nM 351.48 c1cc(-c2nc(N3CCNCC3)c3c4c(sc3n2)CCCC4)ccn1 Homo sapiens CHEMBL4623319 cell-based format
CHEMBL4642061 OBDepict CH 3 NH O N H N N H IC50 = 13.0 nM 360.46 CC(=O)Nc1ccc(-c2cc(NC3CCCNC3)c3ccncc3c2)cc1 Homo sapiens CHEMBL4619369 single protein format
CHEMBL4644763 OBDepict H N N N O H N H IC50 = 13.0 nM 330.39 c1cc2cc(-c3cncc4ccc(O[C@H]5CCNC5)cc34)cnc2[nH]1 Homo sapiens CHEMBL4619369 single protein format
CHEMBL4634517 OBDepict F F N H N H NH IC50 = 15.2 nM 353.42 Fc1cccc(F)c1-c1cc(N[C@H]2CCCCNC2)c2ccncc2c1 Homo sapiens CHEMBL4619369 single protein format
CHEMBL474619 OBDepict H 3 C O HO N H N N N H N N CH 3 IC50 = 22.0 nM 454.53 COc1cc(O)ccc1-c1ccc2c(-c3nc4c(N5CCN(C)CC5)cccc4[nH]3)n[nH]c2c1 Homo sapiens CHEMBL942589 single protein format
CHEMBL471790 OBDepict H 3 C O H 2 N N H N N N H N N CH 3 IC50 = 23.3 nM 453.55 COc1cc(N)ccc1-c1ccc2c(-c3nc4c(N5CCN(C)CC5)cccc4[nH]3)n[nH]c2c1 Homo sapiens CHEMBL942589 single protein format
CHEMBL4645728 OBDepict NH 2 N O H HN IC50 = 33.0 nM 305.38 Nc1ccc(-c2cncc3ccc(O[C@H]4CCNC4)cc23)cc1 Homo sapiens CHEMBL4619369 single protein format
CHEMBL4641607 OBDepict H NH N H N IC50 = 35.0 nM 303.41 c1ccc(-c2cc(N[C@@H]3CCCNC3)c3ccncc3c2)cc1 Homo sapiens CHEMBL4619369 single protein format
CHEMBL4568087 OBDepict H 3 C N N N N N S N H O H H H 2 N IC50 = 40.0 nM 421.53 Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 Homo sapiens CHEMBL4479771 assay format
CHEMBL482368 OBDepict H 3 C O H 2 N N H N N N H N N CH 3 IC50 = 51.3 nM 453.55 COc1cc(-c2ccc3c(-c4nc5c(N6CCN(C)CC6)cccc5[nH]4)n[nH]c3c2)ccc1N Homo sapiens CHEMBL942589 single protein format
CHEMBL4648006 OBDepict OH N H N N H IC50 = 54.0 nM 319.41 Oc1ccccc1-c1cc(NC2CCCNC2)c2ccncc2c1 Homo sapiens CHEMBL4619369 single protein format
CHEMBL519795 OBDepict CH 3 N N N N H N N H F NH 2 IC50 = 55.5 nM 441.51 CN1CCN(c2cccc3[nH]c(-c4n[nH]c5cc(-c6ccc(N)c(F)c6)ccc45)nc23)CC1 Homo sapiens CHEMBL942589 single protein format
CHEMBL3323359 OBDepict Cl N N OH OH OH IC50 < 100.0 nM 380.83 Oc1ccc(C2CC(c3ccccc3O)=NN2c2ccc(Cl)cc2)cc1O Homo sapiens CHEMBL3368438 single protein format
CHEMBL3323361 OBDepict Cl N N HO F HO OH IC50 < 100.0 nM 398.82 Oc1ccc(C2=NN(c3cccc(Cl)c3)C(c3ccc(O)c(F)c3)C2)c(O)c1 Homo sapiens CHEMBL3368438 single protein format
CHEMBL4290181 OBDepict Cl N N Cl OH IC50 < 100.0 nM 383.28 Oc1ccc(C2=NN(c3cccc(Cl)c3)C(c3ccc(Cl)cc3)C2)cc1 Homo sapiens CHEMBL4259277 cell-based format
CHEMBL4282313 OBDepict Cl N N Cl OH IC50 < 100.0 nM 383.28 Oc1ccc(C2=NN(c3ccc(Cl)cc3)C(c3cccc(Cl)c3)C2)cc1 Homo sapiens CHEMBL4259277 cell-based format
CHEMBL4646074 OBDepict NH 2 N O HN IC50 = 109.0 nM 319.41 Nc1ccc(-c2cncc3ccc(OC4CCNCC4)cc23)cc1 Homo sapiens CHEMBL4619369 single protein format
CHEMBL4639268 OBDepict H O HN N S IC50 = 141.0 nM 296.39 c1cc(-c2cncc3ccc(O[C@H]4CCNC4)cc23)cs1 Homo sapiens CHEMBL4619369 single protein format
CHEMBL4641149 OBDepict OH N O H HN IC50 = 142.0 nM 306.36 Oc1cccc(-c2cncc3ccc(O[C@H]4CCNC4)cc23)c1 Homo sapiens CHEMBL4619369 single protein format
CHEMBL4633764 OBDepict H O HN N S IC50 = 147.0 nM 296.39 c1csc(-c2cncc3ccc(O[C@H]4CCNC4)cc23)c1 Homo sapiens CHEMBL4619369 single protein format
CHEMBL4645229 OBDepict NH 2 N H N N H IC50 = 153.0 nM 318.42 Nc1ccccc1-c1cc(NC2CCCNC2)c2ccncc2c1 Homo sapiens CHEMBL4619369 single protein format
CHEMBL4640042 OBDepict NH 2 N H N N H IC50 = 162.0 nM 318.42 Nc1cccc(-c2cc(NC3CCCNC3)c3ccncc3c2)c1 Homo sapiens CHEMBL4619369 single protein format
CHEMBL3116050 OBDepict F N N N H CH 3 H N N HN N H N N CH 3 IC50 = 200.0 nM 353.37 C[C@H](Nc1nc(Nc2cn(C)cn2)c2cc[nH]c2n1)c1ncc(F)cn1 Homo sapiens CHEMBL3117032 single protein format
CHEMBL3975634 OBDepict CH 3 O H O N H N H H 3 C N N HO IC50 = 204.2 nM 452.51 CN[C@H]1CC2OC([C@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(O)=NC4 Homo sapiens CHEMBL3707543 single protein format
CHEMBL388978 OBDepict CH 3 HN H H O H O N H 3 C H 3 C N O N H IC50 = 216.8 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL3820667 single protein format
CHEMBL3732675 OBDepict H NH 2 N H N N S N IC50 = 270.0 nM 415.57 N[C@H](CNc1nc(-c2ccncc2)nc2sc3c(c12)CCCC3)Cc1ccccc1 Homo sapiens CHEMBL4623318 single protein format
CHEMBL474807 OBDepict HO N H N N N H N N CH 3 IC50 = 290.0 nM 438.54 CN1CCN(c2cccc3[nH]c(-c4n[nH]c5cc(-c6ccc(CO)cc6)ccc45)nc23)CC1 Homo sapiens CHEMBL942589 single protein format
CHEMBL3323358 OBDepict Cl N N H 3 C H 3 C CH 3 HO F IC50 = 300.0 nM 346.83 CC(C)(C)C1=NN(c2cccc(Cl)c2)C(c2ccc(F)c(O)c2)C1 Homo sapiens CHEMBL3368438 single protein format
CHEMBL4638383 OBDepict NH 2 N O H N H IC50 = 321.0 nM 319.41 Nc1ccc(-c2cncc3ccc(OC[C@@H]4CCCN4)cc23)cc1 Homo sapiens CHEMBL4619369 single protein format
CHEMBL4641174 OBDepict H O N H N IC50 = 356.0 nM 340.43 c1ccc2cc(-c3cncc4ccc(O[C@H]5CCNC5)cc34)ccc2c1 Homo sapiens CHEMBL4619369 single protein format
CHEMBL4645321 OBDepict H 3 C NH N N N S N IC50 = 360.0 nM 379.53 CNC1CCN(c2nc(-c3ccncc3)nc3sc4c(c23)CCCC4)CC1 Homo sapiens CHEMBL4623317 single protein format
CHEMBL4647507 OBDepict H 2 N N N N S N IC50 = 380.0 nM 365.51 NC1CCN(c2nc(-c3ccncc3)nc3sc4c(c23)CCCC4)CC1 Homo sapiens CHEMBL4623317 single protein format
CHEMBL3323344 OBDepict OH N N S F F F IC50 = 400.0 nM 388.41 Oc1ccc(C2CC(c3cccs3)=NN2c2ccc(C(F)(F)F)cc2)cc1 Homo sapiens CHEMBL3368438 single protein format
CHEMBL4290590 OBDepict OH N N Cl Cl IC50 = 400.0 nM 383.28 Oc1ccc(C2=NN(c3cccc(Cl)c3)C(c3cccc(Cl)c3)C2)cc1 Homo sapiens CHEMBL4259277 cell-based format
CHEMBL4635556 OBDepict H 2 N N N N N S N IC50 = 420.0 nM 394.55 NCCN1CCN(c2nc(-c3ccncc3)nc3sc4c(c23)CCCC4)CC1 Homo sapiens CHEMBL4623317 single protein format
CHEMBL3323346 OBDepict OH N N N H Cl IC50 = 500.0 nM 337.81 Oc1ccc(C2CC(c3ccc[nH]3)=NN2c2cccc(Cl)c2)cc1 Homo sapiens CHEMBL3368438 single protein format
CHEMBL4637651 OBDepict H 2 N N N N S N IC50 = 520.0 nM 379.53 NCC1CCN(c2nc(-c3ccncc3)nc3sc4c(c23)CCCC4)CC1 Homo sapiens CHEMBL4623317 single protein format
CHEMBL4640268 OBDepict H 3 C N CH 3 N N N S N IC50 = 560.0 nM 393.56 CN(C)C1CCN(c2nc(-c3ccncc3)nc3sc4c(c23)CCCC4)CC1 Homo sapiens CHEMBL4623317 single protein format
CHEMBL474441 OBDepict CH 3 N H N H N N N H N N CH 3 IC50 = 585.0 nM 437.55 CNc1ccc(-c2ccc3c(-c4nc5c(N6CCN(C)CC6)cccc5[nH]4)n[nH]c3c2)cc1 Homo sapiens CHEMBL942589 single protein format
CHEMBL3323342 OBDepict OH N N S Cl IC50 = 600.0 nM 354.86 Oc1ccc(C2CC(c3cccs3)=NN2c2ccc(Cl)cc2)cc1 Homo sapiens CHEMBL3368438 single protein format
CHEMBL4644160 OBDepict NH 2 N O H HN IC50 = 604.0 nM 319.41 Nc1ccc(-c2cncc3ccc(OC[C@@H]4CCNC4)cc23)cc1 Homo sapiens CHEMBL4619369 single protein format
CHEMBL4644798 OBDepict H O N H N N S IC50 = 631.0 nM 347.44 c1ccc2sc(-c3cncc4ccc(O[C@H]5CCNC5)cc34)nc2c1 Homo sapiens CHEMBL4619369 single protein format
CHEMBL4633210 OBDepict HN N H N N S N IC50 = 700.0 nM 365.51 c1cc(-c2nc(NC3CCNCC3)c3c4c(sc3n2)CCCC4)ccn1 Homo sapiens CHEMBL4623317 single protein format
CHEMBL3323334 OBDepict OH N N CH 3 CH 3 H 3 C F F F IC50 = 700.0 nM 348.37 CC(C)(C)C1=NN(c2ccc(F)c(F)c2F)C(c2ccc(O)cc2)C1 Homo sapiens CHEMBL3368438 single protein format
CHEMBL3323357 OBDepict Cl N N H 3 C H 3 C CH 3 Cl OH IC50 = 700.0 nM 363.29 CC(C)(C)C1=NN(c2ccc(Cl)cc2)C(c2ccc(O)c(Cl)c2)C1 Homo sapiens CHEMBL3368438 single protein format
CHEMBL3323364 OBDepict Cl N N H 3 C OH F OH IC50 = 720.0 nM 396.85 CC1C(c2ccccc2O)=NN(c2cccc(Cl)c2)C1c1ccc(O)c(F)c1 Homo sapiens CHEMBL3368438 single protein format
CHEMBL4283413 OBDepict Cl N N OH Cl HO IC50 = 800.0 nM 399.28 Oc1ccc(C2=NN(c3ccc(Cl)cc3)C(c3ccc(Cl)cc3)C2)cc1O Homo sapiens CHEMBL4259296 cell-based format
CHEMBL2393448 OBDepict H 3 C O O NH 2 S N H 3 C CH 3 IC50 = 800.0 nM 290.39 CCOC(=O)c1c(-c2ccc(N(C)C)cc2)csc1N Homo sapiens CHEMBL2393915 single protein format
CHEMBL3323330 OBDepict HO N N H 3 C H 3 C CH 3 Cl F IC50 = 900.0 nM 346.83 CC(C)(C)C1=NN(c2ccc(F)c(Cl)c2)C(c2ccc(O)cc2)C1 Homo sapiens CHEMBL3368438 single protein format
CHEMBL3323331 OBDepict HO N N H 3 C H 3 C CH 3 F F IC50 = 900.0 nM 330.38 CC(C)(C)C1=NN(c2ccc(F)c(F)c2)C(c2ccc(O)cc2)C1 Homo sapiens CHEMBL3368443 cell-based format
CHEMBL3323343 OBDepict OH N N S Br IC50 = 1000.0 nM 399.31 Oc1ccc(C2CC(c3cccs3)=NN2c2ccc(Br)cc2)cc1 Homo sapiens CHEMBL3368445 assay format