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Q05932 | FOLC_HUMAN | "Folylpolyglutamate synthase, mitochondrial" (FPGS)

3D structures mapped by conservation among orthologs



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL38937 OBDepict H 2 N N H O OH O NH Cl N NH 2 N H 2 N Ki = 1.7 nM 457.92 NCCCC(NC(=O)c1ccc(NCc2ccc3nc(N)nc(N)c3c2Cl)cc1)C(=O)O Homo sapiens CHEMBL678792 assay format
CHEMBL288142 OBDepict H 2 N N H O OH O NH Cl N OH N H 2 N Ki = 8.3 nM 458.91 NCCCC(NC(=O)c1ccc(NCc2ccc3nc(N)nc(O)c3c2Cl)cc1)C(=O)O Homo sapiens CHEMBL679521 assay format
CHEMBL130518 OBDepict H 2 N N H O OH O NH F F F N OH N H 2 N Ki = 8.8 nM 492.46 NCCCC(NC(=O)c1ccc(NCc2ccc3nc(N)nc(O)c3c2C(F)(F)F)cc1)C(=O)O Homo sapiens CHEMBL679521 assay format
CHEMBL133637 OBDepict H 2 N N H O OH O N H F F F N OH N H 2 N Ki = 11.0 nM 492.46 NCCCC(NC(=O)c1ccc(CNc2ccc3nc(N)nc(O)c3c2C(F)(F)F)cc1)C(=O)O Homo sapiens CHEMBL679521 assay format
CHEMBL289923 OBDepict H 2 N N H O OH O NH N H N OH N H 2 N Ki = 64.0 nM 429.48 NCCCC(NC(=O)c1ccc(NCC2CNc3nc(N)nc(O)c3C2)cc1)C(=O)O Homo sapiens CHEMBL682447 single protein format
CHEMBL339240 OBDepict H 2 N HN O OH O N H F N OH N CH 3 Ki = 150.0 nM 441.46 Cc1nc(O)c2c(F)c(NCc3ccc(C(=O)NC(CCCN)C(=O)O)cc3)ccc2n1 Homo sapiens CHEMBL679521 assay format
CHEMBL83868 OBDepict H 2 N N H O OH O NH N H N H N OH N H 2 N Ki = 200.0 nM 430.47 NCCCC(NC(=O)c1ccc(NCC2CNc3nc(N)nc(O)c3N2)cc1)C(=O)O Homo sapiens CHEMBL676945 single protein format
CHEMBL331279 OBDepict H 2 N N H O OH O NH HN N OH N H 2 N Ki = 200.0 nM 441.49 NCCC[C@@H](C(=O)O)N1Cc2cc(NCC3CNc4nc(N)nc(O)c4C3)ccc2C1=O Homo sapiens CHEMBL676944 single protein format
CHEMBL281656 OBDepict NH 2 N H H O HO O N H N N N NH 2 N H 2 N Ki = 300.0 nM 425.45 NCCC[C@H](NC(=O)c1ccc(NCc2cnc3nc(N)nc(N)c3n2)cc1)C(=O)O Homo sapiens CHEMBL676946 single protein format
CHEMBL43288 OBDepict H 2 N N H O OH O S N OH N Ki = 420.0 nM 426.5 NCCCC(NC(=O)c1ccc(SCc2ccc3ncnc(O)c3c2)cc1)C(=O)O Homo sapiens CHEMBL678792 assay format
CHEMBL335629 OBDepict H 2 N N H O OH O N H Cl N OH N H 2 N Ki = 500.0 nM 458.91 NCCCC(NC(=O)c1ccc(CNc2ccc3nc(N)nc(O)c3c2Cl)cc1)C(=O)O Homo sapiens CHEMBL679521 assay format
CHEMBL340993 OBDepict H 2 N N H O OH O N H F N OH N H 2 N Ki = 900.0 nM 442.45 NCCCC(NC(=O)c1ccc(CNc2ccc3nc(N)nc(O)c3c2F)cc1)C(=O)O Homo sapiens CHEMBL679521 assay format