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Q06330 | SUH_HUMAN | Recombining binding protein suppressor of hairless (RBPJ)

3D structures mapped by conservation among orthologs

[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // TIG_7 ]

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[ Domain: "Common fold of diphtheria toxin/transcription factors/cytochrome f" // LAG1-DNAbind ]

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[ Domain: "beta-Trefoil" // BTD ]

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[ Domain: pdbs with more than 2 multi-domains ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4111071 OBDepict F N H O N H HN O H H O NH 2 F F F F F IC50 = 1.4 nM 568.52 NC(=O)[C@@H](CC1CC(F)(F)C1)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(F)c2NC1=O Homo sapiens CHEMBL3888937 cell-based format
CHEMBL4114579 OBDepict H 3 C N H N H HN O F O H H O NH 2 F F F F F IC50 = 2.2 nM 582.55 Cc1cccc(C2=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CC3CC(F)(F)C3)C(N)=O)C(=O)Nc3c(F)cccc32)c1 Homo sapiens CHEMBL3888937 cell-based format
CHEMBL3921166 OBDepict F NH O N H NH O H H O H 2 N CH 3 H F F F F F F IC50 = 2.4 nM 574.5 C[C@@H](C[C@H](C(N)=O)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(F)c2NC1=O)C(F)(F)F Homo sapiens CHEMBL3888937 cell-based format
CHEMBL4111904 OBDepict H 3 C HN O N H N H O H H O NH 2 F F F F F IC50 = 2.4 nM 564.56 Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CC1CC(F)(F)C1)C(N)=O)N=C2c1ccccc1 Homo sapiens CHEMBL3888937 cell-based format
CHEMBL4114126 OBDepict Cl N H O N H HN O H H O NH 2 F F F F F IC50 = 2.4 nM 584.97 NC(=O)[C@@H](CC1CC(F)(F)C1)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(Cl)c2NC1=O Homo sapiens CHEMBL3888937 cell-based format
CHEMBL3896414 OBDepict Cl NH O N H NH O H H O H 2 N CH 3 H F F F F F F IC50 = 3.2 nM 590.95 C[C@@H](C[C@H](C(N)=O)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(Cl)c2NC1=O)C(F)(F)F Homo sapiens CHEMBL3888937 cell-based format
CHEMBL4107767 OBDepict F N H NH NH O CH 3 O H H O NH 2 F F F F F IC50 = 3.2 nM 582.55 Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CC1CC(F)(F)C1)C(N)=O)N=C2c1cccc(F)c1 Homo sapiens CHEMBL3888937 cell-based format
CHEMBL4107070 OBDepict O N H H N N H O H H O NH 2 F F F F F IC50 = 3.8 nM 550.53 NC(=O)[C@@H](CC1CC(F)(F)C1)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2NC1=O Homo sapiens CHEMBL3888937 cell-based format
CHEMBL4112577 OBDepict H 3 C O HN O N H N H O H H O NH 2 F F F F F IC50 = 4.0 nM 580.55 COc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CC1CC(F)(F)C1)C(N)=O)N=C2c1ccccc1 Homo sapiens CHEMBL3888937 cell-based format
CHEMBL4106629 OBDepict O N H H H H N O NH 2 O N H F F F F F IC50 = 4.3 nM 590.59 NC(=O)[C@@H](CC1CC(F)(F)C1)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(C3CC3)c2NC1=O Homo sapiens CHEMBL3888937 cell-based format
CHEMBL4109925 OBDepict H 3 C N H N H HN O Cl O H H O NH 2 F F F F F IC50 = 4.4 nM 599.0 Cc1cccc(C2=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CC3CC(F)(F)C3)C(N)=O)C(=O)Nc3c(Cl)cccc32)c1 Homo sapiens CHEMBL3888937 cell-based format
CHEMBL3935675 OBDepict Cl NH O N H NH O H H O NH 2 F F F F F CH 3 IC50 = 5.4 nM 572.96 CC(F)(F)CC[C@H](C(N)=O)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(Cl)c2NC1=O Homo sapiens CHEMBL3888937 cell-based format
CHEMBL4115546 OBDepict H 3 C O N H O N H N H O H H O H 2 N F F F F F IC50 = 6.0 nM 594.58 COc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)C1CCC(F)(F)CC1)N=C2c1ccccc1 Homo sapiens CHEMBL3888937 cell-based format
CHEMBL4112450 OBDepict Cl HN O N H HN O H H O NH 2 F F F F F IC50 = 7.3 nM 599.0 NC(=O)[C@@H](C1CCC(F)(F)CC1)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(Cl)c2NC1=O Homo sapiens CHEMBL3888937 cell-based format
CHEMBL4108896 OBDepict Cl NH O N H NH O H H O H 2 N CH 3 H F F F F F F IC50 = 9.3 nM 590.95 C[C@H](C[C@H](C(N)=O)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(Cl)c2NC1=O)C(F)(F)F Homo sapiens CHEMBL3888937 cell-based format
CHEMBL4111709 OBDepict O HN H N HN O H H O NH 2 F F CH 3 F F F IC50 = 10.8 nM 524.49 CC(F)(F)C[C@H](C(N)=O)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2NC1=O Homo sapiens CHEMBL3888937 cell-based format
CHEMBL3958560 OBDepict F H H O NH 2 HN O H N F F F O HN O CH 3 IC50 = 11.0 nM 536.53 COc1ccc2c(c1)NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCCF)C(N)=O)N=C2c1ccccc1 Homo sapiens CHEMBL3888937 cell-based format
CHEMBL3957276 OBDepict CH 3 N O H N NH O H H O H 2 N H 3 C CH 3 CH 2 IC50 = 12.5 nM 488.63 C=CC[C@H](C(N)=O)[C@@H](CC(C)C)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(CCC)C1=O Homo sapiens CHEMBL3888078 cell-based format
CHEMBL3974604 OBDepict CH 3 H H O NH 2 N H O H 3 C CH 3 H N O N CH 3 Cl IC50 = 13.5 nM 511.07 CCCC[C@H](C(N)=O)[C@@H](CC(C)C)C(=O)N[C@H]1N=C(c2ccc(Cl)cc2)c2ccccc2N(C)C1=O Homo sapiens CHEMBL3888078 cell-based format
CHEMBL3890931 OBDepict CH 3 O NH O N H N H O H H O NH 2 F F F F F CH 3 IC50 = 13.8 nM 568.54 COc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(C)(F)F)C(N)=O)N=C2c1ccccc1 Homo sapiens CHEMBL3888937 cell-based format
CHEMBL3975558 OBDepict F H H O NH 2 HN O H N F F F O HN O H 2 N IC50 = 15.4 nM 537.51 NOc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCCF)C(N)=O)N=C2c1ccccc1 Homo sapiens CHEMBL3888937 cell-based format
CHEMBL3956533 OBDepict F H H O NH 2 HN O H N F F F O NH Cl IC50 = 16.5 nM 540.95 NC(=O)[C@@H](CCCF)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(Cl)c2NC1=O Homo sapiens CHEMBL3888937 cell-based format
CHEMBL4113103 OBDepict O N H H N N H O H H O H 2 N F F F F F IC50 = 18.9 nM 536.5 NC(=O)[C@@H](C1CC(F)(F)C1)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2NC1=O Homo sapiens CHEMBL3888937 cell-based format
CHEMBL4107530 OBDepict CH 3 N H O N H N H O H H O H 2 N F F F F IC50 = 20.1 nM 546.57 Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CC1(F)CCC1)C(N)=O)N=C2c1ccccc1 Homo sapiens CHEMBL3888937 cell-based format
CHEMBL429441 OBDepict H 3 C H H O NH 2 N H O H 3 C H 3 C H N O N CH 3 IC50 = 48.3 nM 462.59 CCC[C@H](C(N)=O)[C@@H](CC(C)C)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O Homo sapiens CHEMBL3888078 cell-based format
CHEMBL3945182 OBDepict H 2 C H H O NH 2 N H O H 3 C H 3 C H N O N CH 3 Cl IC50 = 74.5 nM 495.02 C=CC[C@H](C(N)=O)[C@@H](CC(C)C)C(=O)N[C@H]1N=C(c2ccccc2)c2cc(Cl)ccc2N(C)C1=O Homo sapiens CHEMBL3888078 cell-based format