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Q06418 | TYRO3_HUMAN | Tyrosine-protein kinase receptor TYRO3 (TYRO3)

3D structures mapped by conservation among orthologs

[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_2 ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4855730 OBDepict F NH S N O O H 2 N O HN IC50 = -11000.0 nM 452.51 Nc1ncc(-c2ccc(NS(=O)(=O)C3CC3)cc2F)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804745 cell-based format
CHEMBL4867931 OBDepict H 3 C O N H S N O O H 2 N O HN IC50 = -2000.0 nM 464.55 COc1cc(NS(=O)(=O)C2CC2)ccc1-c1cnc(N)c(-c2ccc3c(c2)CCNC3=O)c1 Homo sapiens CHEMBL4804745 cell-based format
CHEMBL2312654 OBDepict CH 3 N H 3 C NH N N N H O N CH 3 Cl Cl IC50 = 0.7 nM 461.4 Cc1cc(-c2cnc(Nc3cc(Cl)cc(Cl)c3)nc2NC2CCC(N(C)C)CC2)on1 Homo sapiens CHEMBL2318063 single protein format
CHEMBL4873571 OBDepict O N H N O F NH O N O N CH 3 H 3 C O F IC50 = 1.0 nM 561.55 CC(C)n1cc(C(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O Homo sapiens CHEMBL4823597 single protein format
CHEMBL2312649 OBDepict CH 3 N HN O N NH N N H N Cl Cl CH 3 H 3 C IC50 = 2.0 nM 520.51 CN1CCC(NC(=O)c2cnc(Nc3cc(Cl)cc(Cl)c3)nc2NC2CCC(N(C)C)CC2)CC1 Homo sapiens CHEMBL2318063 single protein format
CHEMBL2036806 OBDepict H 3 C N H N N N N H N H H 2 N NH IC50 = 2.9 nM 462.65 CCCCNc1ncc2c(-c3ccc(N4CCNCC4)cc3)nn(C[C@H]3CC[C@H](N)CC3)c2n1 Homo sapiens CHEMBL2037932 single protein format
CHEMBL2311550 OBDepict H 3 C HN H OH N N N H N H O Cl Cl N H 3 C IC50 = 3.0 nM 467.4 CC[C@@H](CO)Nc1nc(Nc2cc(Cl)cc(Cl)c2)ncc1C(=O)NC1CCN(C)CC1 Homo sapiens CHEMBL2318063 single protein format
CHEMBL4283353 OBDepict CH 3 N H H 3 C H N N N H H OH N N H 3 C IC50 = 3.1 nM 504.72 CCC[C@H](C)Nc1ncc2c(-c3ccc(CN4CCCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL4276359 assay format
CHEMBL4286701 OBDepict H 3 C HN CH 3 H N N N H H HO N IC50 = 3.4 nM 487.69 CCC[C@H](C)Nc1ncc2c(-c3ccc(CN4C5CCC4CC5)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL4276334 single protein format
CHEMBL4283353 OBDepict CH 3 N H H 3 C H N N N H H OH N N H 3 C Ki = 3.87 nM 504.72 CCC[C@H](C)Nc1ncc2c(-c3ccc(CN4CCCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL4276334 single protein format
CHEMBL4753082 OBDepict H 3 C O N N H O O F F O Cl N NH 2 IC50 = 4.3 nM 498.87 COc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc(N)c2Cl)c(F)c1 Homo sapiens CHEMBL4686592 single protein format
CHEMBL460702 OBDepict CH 3 O N N H O O F F O Cl N NH 2 IC50 = 4.3 nM 512.9 CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc(N)c2Cl)c(F)c1 Homo sapiens CHEMBL957101 single protein format
CHEMBL4280761 OBDepict H 3 C N H CH 3 H N N N H H HO N N CH 3 IC50 = 4.3 nM 504.72 CCCC[C@H](C)Nc1ncc2c(-c3ccc(CN4CCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL4276334 single protein format
CHEMBL4277564 OBDepict H 3 C N H H 3 C H N N N H H HO HN N CH 3 CH 3 IC50 = 4.4 nM 506.74 CCC[C@H](C)Nc1ncc2c(-c3ccc(CNCCN(CC)CC)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL4276334 single protein format
CHEMBL2036807 OBDepict H N N H NH 2 N N H N N NH IC50 = 5.9 nM 524.72 N[C@H]1CC[C@H](Cn2nc(-c3ccc(N4CCNCC4)cc3)c3cnc(NCCCc4ccccc4)nc32)CC1 Homo sapiens CHEMBL2037932 single protein format
CHEMBL2312651 OBDepict CH 3 N HN O N N NH N H H O NH Cl Cl IC50 = 6.0 nM 506.44 CN1CCC(NC(=O)c2cnc(Nc3cc(Cl)cc(Cl)c3)nc2N[C@H]2CCCCNC2=O)CC1 Homo sapiens CHEMBL2318063 single protein format
CHEMBL4279154 OBDepict H 3 C N H H 3 C N N N H H HO N N CH 3 IC50 = 6.7 nM 504.72 CCC(CC)CNc1ncc2c(-c3ccc(CN4CCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL4276334 single protein format
CHEMBL4282624 OBDepict H 3 C N H CH 3 N N N H H HO N N CH 3 IC50 = 6.7 nM 490.7 CCCC(C)Nc1ncc2c(-c3ccc(CN4CCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL4276334 single protein format
CHEMBL4288009 OBDepict H 3 C N H CH 3 H N N N H H HO N N CH 3 IC50 = 6.9 nM 518.75 CCCCC[C@H](C)Nc1ncc2c(-c3ccc(CN4CCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL4276334 single protein format
CHEMBL3964573 OBDepict CH 3 N N N N N NH H H 2 N O HN IC50 = 7.5 nM 560.79 CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCCCCCNC(=O)[C@@H](N)CCCC4)cc2)CC1 Homo sapiens CHEMBL3865274 single protein format
CHEMBL2312650 OBDepict CH 3 N HN O N NH N N H O Cl Cl IC50 = 9.0 nM 479.41 CN1CCC(NC(=O)c2cnc(Nc3cc(Cl)cc(Cl)c3)nc2NC2CCOCC2)CC1 Homo sapiens CHEMBL2318063 single protein format
CHEMBL4289301 OBDepict CH 3 N H H 3 C H N N N H N N H OH HN IC50 = 9.0 nM 463.63 CCC[C@H](C)Nc1ncc2c(-c3ccnc(N4CCNCC4)c3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL4276334 single protein format
CHEMBL2312652 OBDepict H 3 C N NH O N N N H N H H O H OH Cl Cl IC50 = 10.0 nM 481.38 CN1CCC(NC(=O)c2cnc(Nc3cc(Cl)cc(Cl)c3)nc2N[C@@H]2COC[C@H]2O)CC1 Homo sapiens CHEMBL2318063 single protein format
CHEMBL4291202 OBDepict H 3 C N H CH 3 H N N N H H HO N O IC50 = 10.0 nM 477.65 CCC[C@H](C)Nc1ncc2c(-c3ccc(CN4CCOCC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL4276334 single protein format
CHEMBL4294601 OBDepict H 3 C N H CH 3 H N N N H H HO N H N H 3 C CH 3 IC50 = 11.0 nM 504.72 CCC[C@H](C)Nc1ncc2c(-c3ccc(CN4CC[C@H](N(C)C)C4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL4276334 single protein format
CHEMBL4287078 OBDepict CH 3 CH 3 N H N N N H H OH N N H 3 C IC50 = 12.0 nM 490.7 CCC(C)CNc1ncc2c(-c3ccc(CN4CCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL4276334 single protein format
CHEMBL4287582 OBDepict CH 3 N H H 3 C H N N N H H OH N N H 3 C IC50 = 12.0 nM 490.7 CCC[C@H](C)Nc1ncc2c(-c3ccc(CN4CCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL4276334 single protein format
CHEMBL3892515 OBDepict CH 3 N N N N N N H H H 2 N O NH IC50 = 13.0 nM 532.74 CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCCCNC(=O)[C@@H](N)CCCC4)cc2)CC1 Homo sapiens CHEMBL3865274 single protein format
CHEMBL4294819 OBDepict CH 3 N H H 3 C H N N N H H OH N N H 3 C IC50 = 13.0 nM 490.7 CCC[C@@H](C)Nc1ncc2c(-c3ccc(CN4CCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL4276334 single protein format
CHEMBL2036804 OBDepict H 3 C N H N N N N H N N H H 2 N NH IC50 = 14.0 nM 463.63 CCCCNc1ncc2c(-c3ccc(N4CCNCC4)nc3)nn(C[C@H]3CC[C@H](N)CC3)c2n1 Homo sapiens CHEMBL2037932 single protein format
CHEMBL2312657 OBDepict Cl N H Cl N N NH Br H O H OH IC50 = 15.0 nM 420.09 O[C@@H]1COC[C@H]1Nc1nc(Nc2cc(Cl)cc(Cl)c2)ncc1Br Homo sapiens CHEMBL2318063 single protein format
CHEMBL3326006 OBDepict CH 3 N H N N N H H OH N N H 3 C IC50 = 17.0 nM 476.67 CCCCNc1ncc2c(-c3ccc(CN4CCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL3363357 single protein format
CHEMBL3809489 OBDepict NH 2 N N N N H N N H N IC50 = 17.0 nM 506.66 Nc1nc(Nc2ccc3c(c2)CC[C@@H](N2CCCC2)CC3)nn1-c1cc2c(nn1)-c1ccccc1CCC2 Homo sapiens CHEMBL4188981 assay format
CHEMBL3326007 OBDepict CH 3 N N N N N H N H H HO IC50 = 17.0 nM 488.68 CN1CCN(Cc2ccc(-c3cn([C@H]4CC[C@H](O)CC4)c4nc(NCCC5CC5)ncc34)cc2)CC1 Homo sapiens CHEMBL3363357 single protein format
CHEMBL4847691 OBDepict CH 3 N H H 3 C H N N N H N H OH O H N CH 3 IC50 = 18.0 nM 510.73 CCC[C@H](C)Nc1ncc2c(C3CCN(C(=O)[C@H]4CCCN(C)C4)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL4838704 single protein format
CHEMBL2036803 OBDepict NH 2 N N N N H N IC50 = 18.0 nM 426.57 NC1CCC(Cn2nc(-c3ccccc3)c3cnc(NCCc4ccccc4)nc32)CC1 Homo sapiens CHEMBL2037932 single protein format
CHEMBL4877347 OBDepict CH 3 N H H 3 C H N N N H N H OH O H 3 C N CH 3 Ki = 19.1 nM 518.71 CCC[C@H](C)Nc1ncc2c(C3CCN(C(=O)c4cc(C)nc(C)c4)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL4838732 single protein format
CHEMBL2018145 OBDepict H 3 C N N N N NH 2 HN O H HO IC50 = 20.0 nM 444.54 Cn1cc(-c2cccc(-c3cnc(N)c(C(=O)N[C@H]4C5CC6CC4C[C@](O)(C6)C5)n3)c2)cn1 Homo sapiens CHEMBL2019768 single protein format
CHEMBL2018146 OBDepict H 3 C N N N N NH 2 N H O H HO IC50 = 20.0 nM 458.57 CCn1cc(-c2cccc(-c3cnc(N)c(C(=O)N[C@H]4C5CC6CC4C[C@](O)(C6)C5)n3)c2)cn1 Homo sapiens CHEMBL2019768 single protein format
CHEMBL4281432 OBDepict H 3 C N H CH 3 H N N N H N H HO N CH 3 IC50 = 21.0 nM 476.67 CCC[C@H](C)Nc1ncc2c(-c3cccc(N4CCN(C)CC4)c3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL4276334 single protein format
CHEMBL3092791 OBDepict H 3 C NH N N HN N H H OH N CH 3 H 3 C IC50 = 21.0 nM 398.56 CCCCNc1ncc(-c2ccc(CN(C)C)cn2)c(N[C@H]2CC[C@H](O)CC2)n1 Homo sapiens CHEMBL3097236 single protein format
CHEMBL3092797 OBDepict CH 3 HN N N NH N H H HO HN OH IC50 = 21.0 nM 414.55 CCCCNc1ncc(-c2ccc(CNCCO)cn2)c(N[C@H]2CC[C@H](O)CC2)n1 Homo sapiens CHEMBL3097236 single protein format
CHEMBL4283152 OBDepict CH 3 N H N N N H H OH N N H 3 C IC50 = 22.0 nM 462.64 CCCCNc1ncc2c(-c3ccc(N4CCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL4276334 single protein format
CHEMBL2036805 OBDepict H N N H NH 2 N N H N N N NH IC50 = 22.0 nM 525.71 N[C@H]1CC[C@H](Cn2nc(-c3ccc(N4CCNCC4)nc3)c3cnc(NCCCc4ccccc4)nc32)CC1 Homo sapiens CHEMBL2037932 single protein format
CHEMBL3967759 OBDepict OH N N N H N N N CH 3 IC50 = 22.0 nM 518.75 CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCCCCCC(O)CCCC4)cc2)CC1 Homo sapiens CHEMBL3865274 single protein format
CHEMBL3092793 OBDepict H 3 C NH N N HN N H H OH NH O N H 3 C IC50 = 24.0 nM 481.65 CCCCNc1ncc(-c2ccc(C(=O)NC3CCN(C)CC3)cn2)c(N[C@H]2CC[C@H](O)CC2)n1 Homo sapiens CHEMBL3097236 single protein format
CHEMBL4293116 OBDepict H 3 C N H CH 3 H N N N H N N H HO NH IC50 = 24.0 nM 451.62 CCC[C@H](C)Nc1ncc2c(-c3cnn(C4CCNCC4)c3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL4276334 single protein format
CHEMBL3092795 OBDepict H 3 C NH N N HN N H H OH NH IC50 = 24.0 nM 452.65 CCCCNc1ncc(-c2ccc(CNC3CCCCC3)cn2)c(N[C@H]2CC[C@H](O)CC2)n1 Homo sapiens CHEMBL3097236 single protein format
CHEMBL3910520 OBDepict OH N N N H N N N CH 3 IC50 = 25.0 nM 490.7 CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCCCCC(O)CCC4)cc2)CC1 Homo sapiens CHEMBL3865274 single protein format
CHEMBL4295042 OBDepict H 3 C N H CH 3 H N N N H H HO N H NH IC50 = 26.0 nM 476.67 CCC[C@H](C)Nc1ncc2c(-c3ccc(NC4CCNCC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL4276334 single protein format
CHEMBL4284541 OBDepict H 3 C NH N N N H H OH N N CH 3 IC50 = 27.0 nM 502.71 CCCCNc1ncc2c(-c3ccc(C4(N5CCN(C)CC5)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL4276334 single protein format
CHEMBL3092792 OBDepict H 3 C N H N N HN N H S H OH N O O O IC50 = 28.0 nM 490.63 CCCCNc1ncc(-c2ccc(S(=O)(=O)N3CCOCC3)cn2)c(N[C@H]2CC[C@H](O)CC2)n1 Homo sapiens CHEMBL3097236 single protein format
CHEMBL2018015 OBDepict NH 2 N N N NH 2 N H O CH 3 H 3 C NH IC50 = 28.0 nM 431.54 CC(C)(NC(=O)c1nc(-c2cccc(-c3ccc(N)nc3)c2)cnc1N)C1CCNCC1 Homo sapiens CHEMBL2019768 single protein format
CHEMBL4288213 OBDepict CH 3 N H H 3 C H N N N H H OH N N H 3 C IC50 = 29.0 nM 490.7 CCC[C@H](C)Nc1ncc2c(-c3cccc(CN4CCN(C)CC4)c3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL4276334 single protein format
CHEMBL2018023 OBDepict H 3 C N N N N CH 3 NH 2 N H O H HO IC50 = 30.0 nM 458.57 Cc1cc(-c2cnn(C)c2)cc(-c2cnc(N)c(C(=O)N[C@H]3C4CC5CC3C[C@@](O)(C5)C4)n2)c1 Homo sapiens CHEMBL2019768 single protein format
CHEMBL2018025 OBDepict H 3 C N N N N NH 2 N H O H HO IC50 = 30.0 nM 458.57 CCn1cc(-c2cccc(-c3cnc(N)c(C(=O)N[C@H]4C5CC6CC4C[C@@](O)(C6)C5)n3)c2)cn1 Homo sapiens CHEMBL2019768 single protein format
CHEMBL3932614 OBDepict OH N N HN N N N H 3 C IC50 = 31.0 nM 504.72 CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCCCCC(O)CCCC4)cc2)CC1 Homo sapiens CHEMBL3865274 single protein format
CHEMBL4878774 OBDepict H 3 C N H CH 3 H N N N H N H HO NH IC50 = 33.0 nM 482.72 CCC[C@H](C)Nc1ncc2c(C3CCN(CC4CCNCC4)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL4838704 single protein format
CHEMBL3326004 OBDepict CH 3 N H N N N H F H OH S N O O N CH 3 IC50 = 33.0 nM 544.7 CCCCNc1ncc2c(-c3ccc(S(=O)(=O)N4CCN(C)CC4)c(F)c3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL3363357 single protein format
CHEMBL4284392 OBDepict CH 3 N H H 3 C H N N N H F H OH S N O O N CH 3 IC50 = 33.0 nM 558.72 CCC[C@H](C)Nc1ncc2c(-c3ccc(S(=O)(=O)N4CCN(C)CC4)cc3F)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL4276334 single protein format
CHEMBL3092796 OBDepict CH 3 NH N N HN N H H OH HN IC50 = 33.0 nM 410.57 CCCCNc1ncc(-c2ccc(CNC3CC3)cn2)c(N[C@H]2CC[C@H](O)CC2)n1 Homo sapiens CHEMBL3097236 single protein format
CHEMBL4291006 OBDepict CH 3 N H N N N H H OH N H HN IC50 = 34.0 nM 462.64 CCCCNc1ncc2c(-c3ccc(NC4CCNCC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL4276334 single protein format
CHEMBL2018014 OBDepict CH 3 O N N N NH 2 HN O CH 3 CH 3 N H IC50 = 34.0 nM 446.56 COc1cncc(-c2cccc(-c3cnc(N)c(C(=O)NC(C)(C)C4CCNCC4)n3)c2)c1 Homo sapiens CHEMBL2019768 single protein format
CHEMBL2312292 OBDepict CH 3 O OH N H N N HN N H O N O IC50 = 35.0 nM 496.61 COc1cc(CCNc2ncc(C(=O)NCCCN3CCCC3=O)c(NC3CCCC3)n2)ccc1O Homo sapiens CHEMBL2319403 single protein format
CHEMBL3092790 OBDepict CH 3 N H N N HN N H H HO N F F IC50 = 36.0 nM 474.6 CCCCNc1ncc(-c2ccc(CN3CCC(F)(F)CC3)cn2)c(N[C@H]2CC[C@H](O)CC2)n1 Homo sapiens CHEMBL3097236 single protein format
CHEMBL2312318 OBDepict CH 3 O N H N N HN N H O N O IC50 = 37.0 nM 480.61 COc1cccc(CCNc2ncc(C(=O)NCCCN3CCCC3=O)c(NC3CCCC3)n2)c1 Homo sapiens CHEMBL2319403 single protein format
CHEMBL3946971 OBDepict HO N N N H N N N CH 3 IC50 = 38.0 nM 518.75 CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCCCCC(O)CCCCC4)cc2)CC1 Homo sapiens CHEMBL3865274 single protein format
CHEMBL3973561 OBDepict H 3 C N N N N N N H H NH 2 O NH IC50 = 39.0 nM 490.66 CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCNC(=O)[C@@H](N)CCC4)cc2)CC1 Homo sapiens CHEMBL3865274 single protein format
CHEMBL4850498 OBDepict CH 3 HN H 3 C H N N N H NH H HO IC50 = 39.0 nM 385.56 CCC[C@H](C)Nc1ncc2c(C3CCNCC3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL4838704 single protein format
CHEMBL2018022 OBDepict H 3 C N N N N NH 2 HN O H HO IC50 = 40.0 nM 444.54 Cn1cc(-c2cccc(-c3cnc(N)c(C(=O)N[C@H]4C5CC6CC4C[C@@](O)(C6)C5)n3)c2)cn1 Homo sapiens CHEMBL2019768 single protein format
CHEMBL1835071 OBDepict CH 3 NH N N N H O NH 2 H H NH 2 O IC50 = 40.0 nM 342.4 Cc1ccc(Nc2nc(N[C@@H]3CCOC[C@@H]3N)ncc2C(N)=O)cc1 Homo sapiens CHEMBL3705243 single protein format
CHEMBL2018027 OBDepict H 3 C N N N N H 2 N NH O H HO IC50 = 40.0 nM 472.59 CCCn1cc(-c2cccc(-c3cnc(N)c(C(=O)N[C@H]4C5CC6CC4C[C@@](O)(C6)C5)n3)c2)cn1 Homo sapiens CHEMBL2019768 single protein format
CHEMBL2018028 OBDepict O N H N H 2 N N H OH N N CH 3 H 3 C IC50 = 40.0 nM 472.59 CC(C)n1cc(-c2cccc(-c3cnc(N)c(C(=O)N[C@H]4C5CC6CC4C[C@@](O)(C6)C5)n3)c2)cn1 Homo sapiens CHEMBL2019768 single protein format
CHEMBL2018032 OBDepict H 2 N O N N N N H 2 N NH O H HO IC50 = 40.0 nM 487.56 NC(=O)Cn1cc(-c2cccc(-c3cnc(N)c(C(=O)N[C@H]4C5CC6CC4C[C@@](O)(C6)C5)n3)c2)cn1 Homo sapiens CHEMBL2019768 single protein format
CHEMBL2312648 OBDepict CH 3 N N H O N NH N N H N Cl CH 3 H 3 C Cl IC50 = 41.0 nM 534.54 CN1CCC(NC(=O)c2cnc(NCc3cc(Cl)ccc3Cl)nc2NC2CCC(N(C)C)CC2)CC1 Homo sapiens CHEMBL2318063 single protein format
CHEMBL4584949 OBDepict O N H N O F NH N N O CH 3 F IC50 = 41.1 nM 539.54 Cn1cc(-c2ccc(F)cc2)c(=O)c2c(Nc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)c(F)c3)nccc21 Homo sapiens CHEMBL4376522 assay format
CHEMBL2018013 OBDepict O N H N NH 2 N CH 3 CH 3 N H N H N IC50 = 42.0 nM 379.47 CC(C)(NC(=O)c1nc(-c2cccc3cn[nH]c23)cnc1N)C1CCNCC1 Homo sapiens CHEMBL2019768 single protein format
CHEMBL4877347 OBDepict CH 3 N H H 3 C H N N N H N H OH O H 3 C N CH 3 IC50 = 42.0 nM 518.71 CCC[C@H](C)Nc1ncc2c(C3CCN(C(=O)c4cc(C)nc(C)c4)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL4838704 single protein format
CHEMBL2312655 OBDepict Cl N H Cl N N HN H N O H OH IC50 = 44.0 nM 418.28 O[C@@H]1COC[C@H]1Nc1nc(Nc2cc(Cl)cc(Cl)c2)ncc1-c1cccnc1 Homo sapiens CHEMBL2318063 single protein format
CHEMBL3976261 OBDepict CH 3 N N N N N NH HO IC50 = 44.0 nM 504.72 CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCCCC(O)CCCCC4)cc2)CC1 Homo sapiens CHEMBL3865274 single protein format
CHEMBL3326005 OBDepict CH 3 N N S O O F N N N H HN H HO IC50 = 45.0 nM 556.71 CN1CCN(S(=O)(=O)c2ccc(-c3cn([C@H]4CC[C@H](O)CC4)c4nc(NCCC5CC5)ncc34)c(F)c2)CC1 Homo sapiens CHEMBL3363357 single protein format
CHEMBL4867544 OBDepict CH 3 N H H 3 C H N N N H N H OH O N IC50 = 46.0 nM 490.65 CCC[C@H](C)Nc1ncc2c(C3CCN(C(=O)c4ccncc4)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL4838704 single protein format
CHEMBL4877058 OBDepict CH 3 N H H 3 C H N N N H N H OH O N H 3 C IC50 = 48.0 nM 510.73 CCC[C@H](C)Nc1ncc2c(C3CCN(C(=O)C4CCN(C)CC4)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL4838704 single protein format
CHEMBL2036808 OBDepict CH 3 NH N N N N H F H NH 2 IC50 = 48.0 nM 396.51 CCCCNc1ncc2c(-c3ccc(F)cc3)nn(C[C@H]3CC[C@H](N)CC3)c2n1 Homo sapiens CHEMBL2037932 single protein format
CHEMBL388978 OBDepict CH 3 HN H H O H O N H 3 C H 3 C N O N H IC50 = 48.99 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL1211285 single protein format
CHEMBL3984314 OBDepict OH N N HN N N N H 3 C IC50 = 49.0 nM 532.78 CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCCCCCC(O)CCCCC4)cc2)CC1 Homo sapiens CHEMBL3865274 single protein format
CHEMBL4878118 OBDepict CH 3 N H CH 3 H N N N H N H OH HN IC50 = 50.0 nM 468.69 CCC[C@H](C)Nc1ncc2c(C3CCN(C4CCNCC4)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL4838704 single protein format
CHEMBL4284846 OBDepict H 3 C N H H 3 C H N N N H N H HO O O CH 3 IC50 = 50.0 nM 437.54 CCC[C@H](C)Nc1ncc2c(-c3ccnc(C(=O)OC)c3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL4276334 single protein format
CHEMBL4476226 OBDepict H 3 C N O N N H N N N F F F N S H 3 C O O H 3 C IC50 = 50.0 nM 589.64 CC(=O)N1CCN(c2ccc(Nc3ncc(C(F)(F)F)c(N4Cc5cccc(N(C)S(C)(=O)=O)c5C4)n3)cc2)CC1 Homo sapiens CHEMBL4326654 single protein format
CHEMBL2018026 OBDepict O N H N NH 2 N H OH N N F F F IC50 = 50.0 nM 512.54 Nc1ncc(-c2cccc(-c3cnn(CC(F)(F)F)c3)c2)nc1C(=O)N[C@H]1C2CC3CC1C[C@@](O)(C3)C2 Homo sapiens CHEMBL2019768 single protein format
CHEMBL2018024 OBDepict H 3 C O N N N N CH 3 NH 2 N H O H HO IC50 = 50.0 nM 474.57 COc1cc(-c2cnn(C)c2)cc(-c2cnc(N)c(C(=O)N[C@H]3C4CC5CC3C[C@@](O)(C5)C4)n2)c1 Homo sapiens CHEMBL2019768 single protein format
CHEMBL2018020 OBDepict H N N N N H 2 N NH O H HO IC50 = 50.0 nM 430.51 Nc1ncc(-c2cccc(-c3cn[nH]c3)c2)nc1C(=O)N[C@H]1C2CC3CC1C[C@@](O)(C3)C2 Homo sapiens CHEMBL2019768 single protein format
CHEMBL4857561 OBDepict H 3 C N H CH 3 H N N N H N H HO O H N H 3 C IC50 = 51.0 nM 510.73 CCC[C@H](C)Nc1ncc2c(C3CCN(C(=O)[C@@H]4CCCCN4C)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL4838704 single protein format
CHEMBL3951096 OBDepict HO N N H N N N N CH 3 IC50 = 53.0 nM 462.64 CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCCC(O)CCC4)cc2)CC1 Homo sapiens CHEMBL3865274 single protein format
CHEMBL4862333 OBDepict CH 3 N H H 3 C H N N N H N H OH O N CH 3 IC50 = 54.0 nM 504.68 CCC[C@H](C)Nc1ncc2c(C3CCN(C(=O)c4ccnc(C)c4)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL4838704 single protein format
CHEMBL3948030 OBDepict OH N N N H N N N CH 3 IC50 = 54.0 nM 504.72 CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCCCCCC(O)CCC4)cc2)CC1 Homo sapiens CHEMBL3865274 single protein format
CHEMBL3938180 OBDepict H 3 C N N N N N HN OH IC50 = 57.0 nM 490.7 CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCCC(O)CCCCC4)cc2)CC1 Homo sapiens CHEMBL3865274 single protein format
CHEMBL3092800 OBDepict H 3 C NH N N HN N H H H 2 N IC50 = 58.0 nM 354.5 CCCCNc1ncc(-c2ccccn2)c(N[C@H]2CC[C@H](CN)CC2)n1 Homo sapiens CHEMBL3097236 single protein format
CHEMBL4857351 OBDepict CH 3 H H N H N N N H N H OH O H 3 C N CH 3 IC50 = 59.0 nM 516.69 CC[C@H]1C[C@@H]1Nc1ncc2c(C3CCN(C(=O)c4cc(C)nc(C)c4)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL4838704 single protein format
CHEMBL2018147 OBDepict HO N N N N H 2 N NH O H OH IC50 = 60.0 nM 474.57 Nc1ncc(-c2cccc(-c3cnn(CCO)c3)c2)nc1C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 Homo sapiens CHEMBL2019768 single protein format