HOME LIGAND hPROTEOME OTHERS DOCUMENT

Q07889 | SOS1_HUMAN | Son of sevenless homolog 1 (SOS1)

3D structures mapped by conservation among orthologs

[ Domain: "Ras GEF" // RasGEF ]

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[ Domain: "DBL homology domain (DH-domain)" // RhoGEF ]

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[ Domain: "Histone" // Histone_1 ]

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[ Domain: "PH domain-like" // PH_10 ]

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[ Domain: pdbs with more than 2 multi-domains ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4442809 OBDepict CH 3 N H CH 3 H N CH 3 N N O N O CH 3 H 3 C IC50 = 1.0 nM 455.56 Cc1cccc([C@@H](C)Nc2nc(C)nc3ccc(-c4ccn(CC(=O)N(C)C)c(=O)c4)cc23)c1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4449786 OBDepict H 3 C O N O O H 3 C N N H N H 3 C H 3 C H F F OH IC50 = 2.0 nM 526.58 COCC(=O)N1CC=C(c2cc3c(N[C@H](C)c4cccc(C(F)(F)CO)c4)nc(C)nc3cc2OC)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4469357 OBDepict CH 3 O N O N N N H CH 3 CH 3 H H 2 N F F F IC50 = 2.0 nM 501.55 COCC(=O)N1CCC(c2ccc3nc(C)nc(N[C@H](C)c4cc(N)cc(C(F)(F)F)c4)c3c2)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4554249 OBDepict H 2 N N H H 3 C H F F F N CH 3 N CH 3 H H N O H 3 C H 3 C IC50 = 2.0 nM 513.61 Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@H](C(=O)N(C)C)CC3)c(C)cc2n1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4550769 OBDepict CH 3 O N N O H H N N NH H 3 C H 3 C H H 2 N F F F IC50 = 2.0 nM 598.71 COCCN1CCN(C(=O)[C@H]2CC[C@H](c3ccc4nc(C)nc(N[C@H](C)c5cc(N)cc(C(F)(F)F)c5)c4c3)CC2)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4449981 OBDepict CH 3 O N H CH 3 N N H H CH 3 H N O CH 3 CH 3 F H 2 N F F F IC50 = 2.0 nM 547.6 COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3F)c2cc1[C@H]1CC[C@H](C(=O)N(C)C)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4436505 OBDepict CH 3 O N H CH 3 N N H H CH 3 H N O CH 3 CH 3 CH 3 H 2 N F F F IC50 = 2.0 nM 543.63 COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3C)c2cc1[C@H]1CC[C@H](C(=O)N(C)C)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4474160 OBDepict CH 3 O N H 3 C O H H N N N H CH 3 CH 3 H H 2 N F F F IC50 = 2.0 nM 543.63 COCCN(C)C(=O)[C@H]1CC[C@H](c2ccc3nc(C)nc(N[C@H](C)c4cc(N)cc(C(F)(F)F)c4)c3c2)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4471555 OBDepict OH F F HN CH 3 H N CH 3 N O CH 3 N O H 3 C IC50 = 2.0 nM 498.57 COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)CO)c3)c2cc1C1CCN(C(C)=O)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4465802 OBDepict CH 3 O N H CH 3 N N H H CH 3 H N O H 2 N O F F F IC50 = 2.0 nM 571.64 COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3)c2cc1[C@H]1CC[C@H](C(=O)N2CCOCC2)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4456066 OBDepict H 3 C O N O O H 3 C N N H N H 3 C H 3 C H F F OH IC50 = 2.0 nM 528.6 COCC(=O)N1CCC(c2cc3c(N[C@H](C)c4cccc(C(F)(F)CO)c4)nc(C)nc3cc2OC)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4557641 OBDepict CH 3 O N H CH 3 N N H H CH 3 H N O H 2 N N F F F CH 3 IC50 = 2.0 nM 584.69 COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3)c2cc1[C@H]1CC[C@H](C(=O)N2CCN(C)CC2)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4555192 OBDepict CH 3 O N HO CH 3 N N H N CH 3 H O H 3 C F F F F IC50 = 2.0 nM 520.53 COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)F)c3F)c2cc1C1(O)CCN(C(C)=O)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4476562 OBDepict OH F F HN CH 3 H N CH 3 N O CH 3 N O H 3 C IC50 = 2.0 nM 496.56 COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)CO)c3)c2cc1C1=CCN(C(C)=O)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4540213 OBDepict NH 2 HN CH 3 H F F F N CH 3 N H H N O O IC50 = 2.0 nM 541.62 Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@H](C(=O)N4CCOCC4)CC3)ccc2n1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4515975 OBDepict CH 3 O N H CH 3 N N H H CH 3 H N O CH 3 CH 3 H 2 N F F F IC50 = 2.0 nM 529.61 COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3)c2cc1[C@H]1CC[C@H](C(=O)N(C)C)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4593376 OBDepict H 2 N N H H 3 C H F F F N CH 3 N H H N O H 3 C HO CH 3 H IC50 = 2.0 nM 543.63 Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@H](C(=O)N(C)C[C@H](C)O)CC3)ccc2n1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4588008 OBDepict HO N CH 3 O H H O H 3 C N N H N CH 3 H 3 C H H 3 C NH 2 F F F IC50 = 2.0 nM 573.66 COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3C)c2cc1[C@H]1CC[C@H](C(=O)N(C)CCO)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4586874 OBDepict HO N CH 3 O H H O H 3 C N N H N CH 3 H 3 C H H 3 C NH 2 F F F IC50 = 2.0 nM 573.66 COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3C)c2cc1[C@H]1CC[C@@H](C(=O)N(C)CCO)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4519925 OBDepict H 3 C O N H CH 3 N N H H H 3 C H N O H 3 C H 3 C NH 2 HO CH 3 H F F F IC50 = 2.0 nM 587.69 COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3C)c2cc1[C@H]1CC[C@H](C(=O)N(C)C[C@@H](C)O)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4532163 OBDepict CH 3 O N CH 3 N N H N CH 3 H O H 3 C H 2 N F F F IC50 = 2.0 nM 501.55 COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3)c2cc1C1CCN(C(C)=O)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4475551 OBDepict CH 3 O N CH 3 N N H N CH 3 H O H 3 C F H 2 N F F F IC50 = 2.0 nM 519.54 COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3F)c2cc1C1CCN(C(C)=O)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4529467 OBDepict OH F F HN CH 3 H N CH 3 N O CH 3 N O CH 3 CH 3 IC50 = 2.0 nM 524.61 COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)CO)c3)c2cc1C1=CCC(C(=O)N(C)C)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4435672 OBDepict CH 3 O O N H CH 3 N N H N H 3 C H O CH 3 NH 2 F F F IC50 = 3.0 nM 503.53 COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3)c2cc1O[C@H]1CCN(C(C)=O)C1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4582516 OBDepict H 3 C O N O O H 3 C N N N H H 3 C H 3 C H NH 2 F F F IC50 = 3.0 nM 531.58 COCC(=O)N1CCC(c2cc3c(N[C@H](C)c4cc(N)cc(C(F)(F)F)c4)nc(C)nc3cc2OC)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4442848 OBDepict H 3 C N O H O CH 3 N N N H CH 3 CH 3 H H 2 N F F F IC50 = 3.0 nM 501.55 CCC(=O)N1CC[C@H](Oc2cc3c(N[C@H](C)c4cc(N)cc(C(F)(F)F)c4)nc(C)nc3cc2C)C1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4551407 OBDepict OH F F HN CH 3 H N CH 3 N O O H CH 3 O IC50 = 3.0 nM 459.49 COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)CO)c3)c2cc1O[C@H]1CCOC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4462383 OBDepict CH 3 N CH 3 O H H N N N H CH 3 H 3 C H NH 2 F F F IC50 = 3.0 nM 513.61 CCN(C)C(=O)[C@H]1CC[C@H](c2ccc3nc(C)nc(N[C@H](C)c4cc(N)cc(C(F)(F)F)c4)c3c2)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4571098 OBDepict OH F F HN CH 3 H N CH 3 N O CH 3 O IC50 = 3.0 nM 457.52 COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)CO)c3)c2cc1C1CCOCC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4456153 OBDepict H 2 N N H H 3 C H F F F N CH 3 N H H N O H 3 C HO H 3 C CH 3 IC50 = 3.0 nM 557.66 Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@H](C(=O)N(C)CC(C)(C)O)CC3)ccc2n1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4545778 OBDepict H 2 N N H H 3 C H F F F N CH 3 N H H N O H 3 C HO CH 3 H IC50 = 3.0 nM 543.63 Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@H](C(=O)N(C)C[C@@H](C)O)CC3)ccc2n1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4552956 OBDepict OH N H 3 C O H H N N N H CH 3 H 3 C H NH 2 F F F IC50 = 3.0 nM 529.61 Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@H](C(=O)N(C)CCO)CC3)ccc2n1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4585988 OBDepict CH 3 O N O O CH 3 N N H N CH 3 CH 3 H F H 2 N F F F IC50 = 3.0 nM 549.57 COCC(=O)N1CCC(c2cc3c(N[C@H](C)c4cc(N)cc(C(F)(F)F)c4F)nc(C)nc3cc2OC)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4534957 OBDepict CH 3 O N O N N N H CH 3 CH 3 H H 2 N F F F IC50 = 3.0 nM 499.54 COCC(=O)N1CC=C(c2ccc3nc(C)nc(N[C@H](C)c4cc(N)cc(C(F)(F)F)c4)c3c2)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4441565 OBDepict NH 2 N H CH 3 H F F F N CH 3 N H H N O CH 3 CH 3 IC50 = 3.0 nM 499.58 Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@H](C(=O)N(C)C)CC3)ccc2n1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4441648 OBDepict NH 2 NH H 3 C H F F F N CH 3 N O H 3 C H N O H 3 C IC50 = 3.0 nM 487.53 CC(=O)N1CC[C@H](Oc2cc3c(N[C@H](C)c4cc(N)cc(C(F)(F)F)c4)nc(C)nc3cc2C)C1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4540709 OBDepict OH F F HN CH 3 H N CH 3 N O O H CH 3 O IC50 = 3.0 nM 459.49 COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)CO)c3)c2cc1O[C@@H]1CCOC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4513254 OBDepict H 3 C O N CH 3 O H H O CH 3 N N HN CH 3 CH 3 H NH 2 F F F IC50 = 3.0 nM 573.66 COCCN(C)C(=O)[C@H]1CC[C@H](c2cc3c(N[C@H](C)c4cc(N)cc(C(F)(F)F)c4)nc(C)nc3cc2OC)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4474479 OBDepict CH 3 O N O H 3 C N N NH CH 3 H 3 C H NH 2 F F F IC50 = 3.0 nM 515.58 COCC(=O)N1CCC(c2cc3c(N[C@H](C)c4cc(N)cc(C(F)(F)F)c4)nc(C)nc3cc2C)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4539190 OBDepict CH 3 N CH 3 N O N N HN CH 3 CH 3 H NH 2 F F F IC50 = 3.0 nM 514.6 Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc(C3CCN(C(=O)CN(C)C)CC3)ccc2n1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4449118 OBDepict H 2 N N H H 3 C H F F F N CH 3 N CH 3 S O O IC50 = 3.0 nM 492.57 Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc(C3CCS(=O)(=O)CC3)c(C)cc2n1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4476263 OBDepict H 2 N N H H 3 C H F F F N CH 3 N S O O IC50 = 3.0 nM 478.54 Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc(C3CCS(=O)(=O)CC3)ccc2n1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4462950 OBDepict NH 2 N H CH 3 H F F F N CH 3 N H 3 C H H N O CH 3 CH 3 IC50 = 4.0 nM 513.61 Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@@H](C(=O)N(C)C)CC3)cc(C)c2n1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4441820 OBDepict NH 2 H 3 C N H CH 3 H F F F N CH 3 N S O O IC50 = 4.0 nM 492.57 Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2C)c2cc(C3CCS(=O)(=O)CC3)ccc2n1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4445163 OBDepict NH 2 N H CH 3 H F F F N CH 3 N O CH 3 H N O IC50 = 4.0 nM 513.56 Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc(O[C@H]3CCN(C(=O)C4CC4)C3)c(C)cc2n1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4461311 OBDepict NH 2 HN H 3 C H F F F N CH 3 N H H N O CH 3 H O IC50 = 4.0 nM 555.64 Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@H](C(=O)N(C)[C@H]4CCOC4)CC3)ccc2n1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4546191 OBDepict H 2 N N H H 3 C H F F F N CH 3 N CH 3 N H 3 C O IC50 = 4.0 nM 467.5 Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc(-c3ccc(=O)n(C)c3)c(C)cc2n1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4449483 OBDepict H 2 N N H H 3 C H F F F N CH 3 N F S O O IC50 = 4.0 nM 496.53 Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc(C3CCS(=O)(=O)CC3)c(F)cc2n1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4545944 OBDepict CH 3 O N HO CH 3 N N H N CH 3 H O H 3 C F F F IC50 = 4.0 nM 502.54 COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)F)c3)c2cc1C1(O)CCN(C(C)=O)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4448891 OBDepict CH 3 O O N H CH 3 N N H O CH 3 H CH 3 H 2 N F F F IC50 = 4.0 nM 476.5 COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3C)c2cc1O[C@H]1CCOC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4541922 OBDepict H 3 C O N O OH O CH 3 N N H N CH 3 CH 3 H F F F F IC50 = 4.0 nM 550.55 COCC(=O)N1CCC(O)(c2cc3c(N[C@H](C)c4cccc(C(F)(F)F)c4F)nc(C)nc3cc2OC)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4541237 OBDepict OH N H 3 C O N O CH 3 N N N H CH 3 CH 3 H H 2 N F F F IC50 = 4.0 nM 554.57 COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3)c2cc1-c1ccc(C(=O)N(C)CCO)nc1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4572076 OBDepict CH 3 O O N H CH 3 N N H O CH 3 H F H 2 N F F F IC50 = 5.0 nM 480.46 COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3F)c2cc1O[C@H]1CCOC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4519023 OBDepict CH 3 O O N H CH 3 N N H O CH 3 H H 2 N F F F IC50 = 5.0 nM 462.47 COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3)c2cc1O[C@H]1CCOC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4565777 OBDepict HO N CH 3 O H H O H 3 C N N H N CH 3 H 3 C H H 3 C F F F IC50 = 5.0 nM 558.65 COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)F)c3C)c2cc1[C@H]1CC[C@H](C(=O)N(C)CCO)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4551748 OBDepict CH 3 N O H 3 C N N N H CH 3 H 3 C H NH 2 F F F IC50 = 5.0 nM 481.52 CCn1ccc(-c2cc3c(N[C@H](C)c4cc(N)cc(C(F)(F)F)c4)nc(C)nc3cc2C)cc1=O Homo sapiens CHEMBL4421312 single protein format
CHEMBL4572414 OBDepict H 3 C N N O H H CH 3 N N HN CH 3 CH 3 H NH 2 F F F IC50 = 5.0 nM 568.69 Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@H](C(=O)N4CCN(C)CC4)CC3)cc(C)c2n1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4579770 OBDepict CH 3 O N O HO O H 3 C N N H N H 3 C H 3 C H F F F IC50 = 5.0 nM 532.56 COCC(=O)N1CCC(O)(c2cc3c(N[C@H](C)c4cccc(C(F)(F)F)c4)nc(C)nc3cc2OC)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4545115 OBDepict NH 2 HN H 3 C H F F F N CH 3 N H H N O CH 3 H O IC50 = 5.0 nM 555.64 Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@H](C(=O)N(C)[C@@H]4CCOC4)CC3)ccc2n1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4459389 OBDepict CH 3 O N HO CH 3 N N H CH 3 H N O CH 3 CH 3 F F F F IC50 = 5.0 nM 548.58 COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)F)c3F)c2cc1C1(O)CCC(C(=O)N(C)C)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4572787 OBDepict CH 3 O O N H CH 3 N N H O CH 3 H H 2 N F F F IC50 = 6.0 nM 462.47 COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3)c2cc1O[C@@H]1CCOC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4449876 OBDepict CH 3 N O H 3 C N N N H CH 3 H 3 C H NH 2 F F F IC50 = 6.0 nM 481.52 CCn1cc(-c2cc3c(N[C@H](C)c4cc(N)cc(C(F)(F)F)c4)nc(C)nc3cc2C)ccc1=O Homo sapiens CHEMBL4421312 single protein format
CHEMBL4517886 OBDepict CH 3 O N HO CH 3 N N H H OH CH 3 H F F F F IC50 = 6.0 nM 493.5 COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)F)c3F)c2cc1[C@]1(O)CC[C@@H](O)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4533406 OBDepict H 2 N N H H 3 C H F F F N CH 3 N N H 3 C O IC50 = 6.0 nM 453.47 Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc(-c3ccc(=O)n(C)c3)ccc2n1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4463205 OBDepict NH 2 NH H 3 C H F F F N CH 3 N O F H N O H 3 C IC50 = 6.0 nM 491.49 CC(=O)N1CC[C@H](Oc2cc3c(N[C@H](C)c4cc(N)cc(C(F)(F)F)c4)nc(C)nc3cc2F)C1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4436318 OBDepict CH 3 O N CH 3 N N H S O O CH 3 H F H 2 N F F F IC50 = 6.0 nM 526.56 COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3F)c2cc1C1CCS(=O)(=O)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4572664 OBDepict H 2 N N H H 3 C H F F F N CH 3 N CH 3 S O O IC50 = 6.0 nM 492.57 Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc(C3CCS(=O)(=O)CC3)cc(C)c2n1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4536359 OBDepict H 3 C O N N N CH 3 N N H H 3 C H N O CH 3 H 3 C NH 2 F F F IC50 = 6.0 nM 527.55 COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3)c2cc1-c1cnn(CC(=O)N(C)C)c1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4447334 OBDepict NH 2 N H H 3 C H F F F N CH 3 N O H 3 C H O IC50 = 7.0 nM 446.47 Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc(O[C@H]3CCOC3)c(C)cc2n1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4571606 OBDepict CH 3 O N N O H H N N NH H 3 C H 3 C H H 2 N F F F IC50 = 7.0 nM 598.71 COCCN1CCN(C(=O)[C@H]2CC[C@@H](c3ccc4nc(C)nc(N[C@H](C)c5cc(N)cc(C(F)(F)F)c5)c4c3)CC2)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4471328 OBDepict H 2 N N H H 3 C H F F F N CH 3 N H H N O H 3 C HO CH 3 H IC50 = 7.0 nM 543.63 Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@@H](C(=O)N(C)C[C@@H](C)O)CC3)ccc2n1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4546881 OBDepict CH 3 O N H CH 3 N N H H CH 3 H N O CH 3 CH 3 CH 3 F F F IC50 = 7.0 nM 528.62 COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)F)c3C)c2cc1[C@H]1CC[C@H](C(=O)N(C)C)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4466752 OBDepict HO N CH 3 O H H N N N H CH 3 CH 3 H H 2 N F F F IC50 = 7.0 nM 529.61 Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@@H](C(=O)N(C)CCO)CC3)ccc2n1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4469774 OBDepict O N H N N N N HN CH 3 CH 3 H NH 2 F F F IC50 = 7.0 nM 481.48 Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc(-c3cc4n(n3)CCC(=O)N4)ccc2n1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4445184 OBDepict H 2 N N H H 3 C H F F F N CH 3 N CH 3 N O CH 3 IC50 = 7.0 nM 467.5 Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc(-c3ccn(C)c(=O)c3)c(C)cc2n1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4467456 OBDepict CH 3 O CH 3 N OH CH 3 N N H N CH 3 H O CH 3 F F F F IC50 = 7.0 nM 534.55 COc1c(C2(O)CCN(C(C)=O)CC2)cc2c(N[C@H](C)c3cccc(C(F)(F)F)c3F)nc(C)nc2c1C Homo sapiens CHEMBL4421312 single protein format
CHEMBL4555880 OBDepict O N H CH 3 H 3 C H N N N H CH 3 H 3 C H F F F IC50 = 7.0 nM 484.57 Cc1nc(N[C@H](C)c2cccc(C(F)(F)F)c2)c2cc([C@H]3CC[C@H](C(=O)N(C)C)CC3)ccc2n1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4584919 OBDepict NH 2 F N H CH 3 H F F F N CH 3 N S O O IC50 = 7.0 nM 496.53 Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2F)c2cc(C3CCS(=O)(=O)CC3)ccc2n1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4464802 OBDepict HO N CH 3 O H OH O H 3 C N N H N CH 3 H 3 C H F F F IC50 = 7.0 nM 560.62 COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)F)c3)c2cc1[C@]1(O)CC[C@@H](C(=O)N(C)CCO)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4554806 OBDepict CH 3 N N N H CH 3 H F HO F F F H OH IC50 = 8.0 nM 463.48 Cc1nc(N[C@H](C)c2cccc(C(F)(F)F)c2F)c2cc([C@]3(O)CC[C@@H](O)CC3)ccc2n1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4517853 OBDepict CH 3 N O OH H 3 C N N N H CH 3 H 3 C H F F F IC50 = 8.0 nM 486.54 CC(=O)N1CCC(O)(c2cc(C)c3nc(C)nc(N[C@H](C)c4cccc(C(F)(F)F)c4)c3c2)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4464090 OBDepict CH 3 O NH O H 3 C CH 3 N N N H CH 3 CH 3 H F F F IC50 = 8.0 nM 460.5 CONC(=O)CC(C)c1cc2c(N[C@H](C)c3cccc(C(F)(F)F)c3)nc(C)nc2cc1C Homo sapiens CHEMBL4421312 single protein format
CHEMBL4582622 OBDepict NH 2 HN CH 3 H F F F N CH 3 N H H N O O IC50 = 8.0 nM 541.62 Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@@H](C(=O)N4CCOCC4)CC3)ccc2n1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4575386 OBDepict CH 3 O N N CH 3 N N H CH 3 O CH 3 H H 2 N F F F IC50 = 8.0 nM 483.49 COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3)c2cc1-c1ccc(=O)n(C)c1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4467079 OBDepict H 3 C N N O H H CH 3 N N HN CH 3 CH 3 H NH 2 F F F IC50 = 8.0 nM 568.69 Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@@H](C(=O)N4CCN(C)CC4)CC3)cc(C)c2n1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4435342 OBDepict CH 3 O N H CH 3 N N H H CH 3 H N O CH 3 CH 3 OH H 3 C H 3 C IC50 = 8.0 nM 504.68 COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(C)(C)O)c3)c2cc1[C@H]1CC[C@H](C(=O)N(C)C)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4563461 OBDepict H 2 N N H H 3 C H F F F N CH 3 N H H HO IC50 = 8.0 nM 444.5 Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@H](O)CC3)ccc2n1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4546387 OBDepict NH 2 N H CH 3 H F F F N CH 3 N N N N O H 3 C CH 3 IC50 = 8.0 nM 497.53 Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc(-c3cnn(CC(=O)N(C)C)c3)ccc2n1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4473906 OBDepict CH 3 O N N CH 3 N N H CH 3 O CH 3 H F H 2 N F F F IC50 = 8.0 nM 501.48 COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(C(F)(F)F)c3F)c2cc1-c1ccc(=O)n(C)c1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4541022 OBDepict H 2 N N H H 3 C H F F F N CH 3 N H H N O H 3 C HO CH 3 H IC50 = 8.0 nM 543.63 Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@@H](C(=O)N(C)C[C@H](C)O)CC3)ccc2n1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4455004 OBDepict H 3 C O N O HO N N N H CH 3 CH 3 H F F F IC50 = 9.0 nM 502.54 COCC(=O)N1CCC(O)(c2ccc3nc(C)nc(N[C@H](C)c4cccc(C(F)(F)F)c4)c3c2)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4456108 OBDepict CH 3 O N H CH 3 N N H H CH 3 H N O CH 3 CH 3 CH 3 IC50 = 9.0 nM 460.62 COc1cc2nc(C)nc(N[C@H](C)c3cccc(C)c3)c2cc1[C@H]1CC[C@H](C(=O)N(C)C)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4585263 OBDepict CH 3 O N H 3 C O H H N N N H CH 3 CH 3 H H 2 N F F F IC50 = 9.0 nM 543.63 COCCN(C)C(=O)[C@H]1CC[C@@H](c2ccc3nc(C)nc(N[C@H](C)c4cc(N)cc(C(F)(F)F)c4)c3c2)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4518543 OBDepict CH 3 O N CH 3 N N H N CH 3 H O H 3 C F F F IC50 = 9.0 nM 486.54 COc1cc2nc(C)nc(N[C@H](C)c3cccc(C(F)(F)F)c3)c2cc1C1CCN(C(C)=O)CC1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4557299 OBDepict H 2 N N H H 3 C H F F F N CH 3 N N H O IC50 = 9.0 nM 439.44 Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc(-c3ccc(=O)[nH]c3)ccc2n1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4557066 OBDepict NH 2 HN H 3 C H F F F N CH 3 N H H N O CH 3 H O IC50 = 9.0 nM 555.64 Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@@H](C(=O)N(C)[C@@H]4CCOC4)CC3)ccc2n1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4544247 OBDepict CH 3 O N N CH 3 N N H O CH 3 H 3 C H NH 2 F F F IC50 = 9.0 nM 497.52 CCn1cc(-c2cc3c(N[C@H](C)c4cc(N)cc(C(F)(F)F)c4)nc(C)nc3cc2OC)ccc1=O Homo sapiens CHEMBL4421312 single protein format
CHEMBL4460510 OBDepict CH 3 N N N H CH 3 H CH 3 HO F F F H OH IC50 = 9.0 nM 459.51 Cc1nc(N[C@H](C)c2cccc(C(F)(F)F)c2C)c2cc([C@]3(O)CC[C@@H](O)CC3)ccc2n1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4590891 OBDepict H 2 N N H H 3 C H F F F N CH 3 N H H N O H 3 C HO H 3 C CH 3 IC50 = 10.0 nM 557.66 Cc1nc(N[C@H](C)c2cc(N)cc(C(F)(F)F)c2)c2cc([C@H]3CC[C@@H](C(=O)N(C)CC(C)(C)O)CC3)ccc2n1 Homo sapiens CHEMBL4421312 single protein format
CHEMBL4436392 OBDepict CH 3 N N N H H 3 C H OH F F F H HO IC50 = 10.0 nM 445.49 Cc1nc(N[C@H](C)c2cccc(C(F)(F)F)c2)c2cc([C@]3(O)CC[C@@H](O)CC3)ccc2n1 Homo sapiens CHEMBL4421312 single protein format