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Q12851 | M4K2_HUMAN | Mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2)

3D structures mapped by conservation among orthologs



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4213673 OBDepict O N N CH 3 N CH 3 N N H N H O N CH 3 N CH 3 F F F IC50 = 5.0 nM 550.55 Cc1cc(Nc2ncc3c(n2)N(C)C(=O)N(c2cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc2C)C3)n(C)n1 Homo sapiens CHEMBL4201009 single protein format
CHEMBL4217421 OBDepict O N N CH 3 N CH 3 N N H N H O N N CH 3 F F F IC50 = 6.0 nM 536.52 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1N1Cc2cnc(Nc3cnn(C)c3)nc2N(C)C1=O Homo sapiens CHEMBL4201009 single protein format
CHEMBL1214141 OBDepict CH 3 N N H N N N CH 3 N O CH 3 NH O F F F IC50 = 8.0 nM 547.54 Cc1ccc(Nc2ncc3c(n2)N(C)C(=O)N(c2cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc2C)C3)cn1 Homo sapiens CHEMBL4201009 single protein format
CHEMBL288441 OBDepict CH 3 O O N N H N N Cl O H 3 C Cl N CH 3 IC50 = 9.9 nM 530.46 COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl Homo sapiens CHEMBL1244338 single protein format
CHEMBL1163016 OBDepict OH HN N N N N H O CH 3 CH 3 N H 3 C H 3 C . O IC50 = 24.0 nM 499.6 CC1(C)CC(NC(=O)c2cccc(-c3cc4nccc(Nc5cccc(O)c5)n4n3)c2)CC(C)(C)N1[O] Homo sapiens CHEMBL1046257 single protein format
CHEMBL459850 OBDepict O N N H 3 C N H 3 C N N H H 2 N O F F F IC50 = 28.0 nM 456.43 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1N1Cc2cnc(N)nc2N(C)C1=O Homo sapiens CHEMBL4201009 single protein format
CHEMBL4215989 OBDepict OH NH N N N CH 3 N O CH 3 N H O F F F IC50 = 33.0 nM 500.48 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1N1Cc2cnc(NCCO)nc2N(C)C1=O Homo sapiens CHEMBL4201009 single protein format
CHEMBL4203337 OBDepict H 3 C N N O N N N H CH 3 N H N O CH 3 CH 3 F F F IC50 = 34.0 nM 575.6 CCN1C(=O)N(c2cc(NC(=O)c3ccc(C)c(C(F)(F)F)c3)ccc2C)Cc2cnc(Nc3ccc(C)nc3)nc21 Homo sapiens CHEMBL4201009 single protein format
CHEMBL4212809 OBDepict CH 3 N N H N N N CH 3 N O CH 3 NH O H 3 C F F F IC50 = 39.0 nM 561.57 Cc1ccc(Nc2ncc3c(n2)N(C)C(=O)N(c2cc(NC(=O)c4ccc(C)c(C(F)(F)F)c4)ccc2C)C3)cn1 Homo sapiens CHEMBL4201009 single protein format
CHEMBL4210482 OBDepict O N N H 3 C N H 3 C N N H N H O F F F IC50 = 42.0 nM 496.49 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1N1Cc2cnc(NC3CC3)nc2N(C)C1=O Homo sapiens CHEMBL4201009 single protein format
CHEMBL1214142 OBDepict O N N CH 3 N CH 3 N N H N H O F F F IC50 = 47.0 nM 532.53 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1N1Cc2cnc(Nc3ccccc3)nc2N(C)C1=O Homo sapiens CHEMBL4201009 single protein format
CHEMBL2064666 OBDepict CH 3 O HN N N H N HN Cl H O H H O H 2 N H IC50 = 60.0 nM 539.08 COc1c(Nc2ncc(Cl)c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)n2)ccc2c1CC[C@@H](N1CCOCC1)CC2 Homo sapiens CHEMBL2067594 single protein format
CHEMBL4213945 OBDepict H 3 C N N H N N N N O H 3 C N H O CH 3 F F F IC50 = 63.0 nM 587.61 Cc1ccc(Nc2ncc3c(n2)N(C2CC2)C(=O)N(c2cc(NC(=O)c4ccc(C)c(C(F)(F)F)c4)ccc2C)C3)cn1 Homo sapiens CHEMBL4201009 single protein format
CHEMBL2006765 OBDepict CH 3 HN O N H N N HN N H F F F IC50 = 115.0 nM 392.39 CCCNC(=O)c1ccc(Nc2nc(NCC(F)(F)F)c3cc[nH]c3n2)cc1 Homo sapiens CHEMBL4007724 single protein format
CHEMBL584052 OBDepict OH O N H N H N Ki = 340.0 nM 341.37 O=C1Nc2ccccc2-c2ccnc3[nH]cc(c23)C1c1ccc(O)cc1 Homo sapiens CHEMBL1042397 single protein format
CHEMBL4281823 OBDepict CH 3 N N N NH 2 N O O F F F IC50 = 387.0 nM 481.48 CCn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 Homo sapiens CHEMBL4261417 single protein format
CHEMBL4564337 OBDepict H 3 C O Br N O H N N H IC50 = 600.0 nM 358.2 COc1cc2c(-c3cnc(-c4ccc[nH]4)o3)c[nH]c2cc1Br Homo sapiens CHEMBL4338193 single protein format
CHEMBL4211395 OBDepict O N N CH 3 N CH 3 N N H N H O F F F IC50 = 925.0 nM 538.57 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1N1Cc2cnc(NC3CCCCC3)nc2N(C)C1=O Homo sapiens CHEMBL4201009 single protein format