HOME LIGAND hPROTEOME OTHERS DOCUMENT

Q13002 | GRIK2_HUMAN | "Glutamate receptor ionotropic, kainate 2" (GRIK2)

3D structures mapped by conservation among orthologs

[ Domain: "Periplasmic binding protein-like II" // Lig_chan_1 ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL221142 OBDepict H 3 C N H H H HO H O O H O OH H 2 N H O OH Ki = 1.2 nM 304.3 CN[C@@H]1[C@H](O)CO[C@@H]2C[C@](C[C@H](N)C(=O)O)(C(=O)O)O[C@@H]21 Homo sapiens CHEMBL3864490 cell-based format
CHEMBL288166 OBDepict OH O H 3 C H NH 2 H O HO Ki = 10.0 nM 161.16 C[C@H](C[C@H](N)C(=O)O)C(=O)O Homo sapiens CHEMBL701166 cell-based format
CHEMBL420720 OBDepict H 3 C N H H 2 C OH CH 2 OH CH 3 H CH 2 HO Ki = 18.3 nM 291.39 C=C(O)C1NCC(/C(C)=C/C=C/[C@@H](C)C(=C)O)C1C(=C)O Homo sapiens CHEMBL699991 single protein format
CHEMBL121741 OBDepict OH O H H H NH CH 2 O OH Ki = 29.8 nM 275.3 C=C(c1ccccc1)[C@H]1CN[C@H](C(=O)O)[C@H]1CC(=O)O Homo sapiens CHEMBL699991 single protein format
CHEMBL431839 OBDepict HO O H H H HN CH 2 O HO Cl Ki = 31.7 nM 309.75 C=C(c1ccc(Cl)cc1)[C@H]1CN[C@H](C(=O)O)[C@H]1CC(=O)O Homo sapiens CHEMBL699991 single protein format
CHEMBL120003 OBDepict HO O H H H HN CH 2 O HO F Ki = 38.4 nM 293.29 C=C(c1ccc(F)cc1)[C@H]1CN[C@H](C(=O)O)[C@H]1CC(=O)O Homo sapiens CHEMBL699991 single protein format
CHEMBL332334 OBDepict HO O H H H HN CH 2 O HO CH 3 Ki = 41.1 nM 289.33 C=C(c1ccc(C)cc1)[C@H]1CN[C@H](C(=O)O)[C@H]1CC(=O)O Homo sapiens CHEMBL699991 single protein format
CHEMBL59284 OBDepict CH 3 O H O HO H 2 N H O HO Ki = 48.0 nM 293.32 COc1ccccc1/C=C/C[C@H](C[C@H](N)C(=O)O)C(=O)O Homo sapiens CHEMBL699992 cell-based format
CHEMBL1234118 OBDepict OH O H HN H H H N H F F O OH Ki = 50.0 nM 346.37 O=C(O)[C@@H]1C[C@H]2C[C@@H](CN3CC(F)(F)C[C@H]3C(=O)O)CC[C@H]2CN1 Homo sapiens CHEMBL3864794 cell-based format
CHEMBL275040 OBDepict OH O H H H HN CH 2 CH 3 O HO Ki = 53.0 nM 213.23 C=C(C)[C@H]1CN[C@H](C(=O)O)[C@H]1CC(=O)O Homo sapiens CHEMBL699991 single protein format
CHEMBL120785 OBDepict HO O H H H HN CH 2 O HO CH 3 F Ki = 54.3 nM 307.32 C=C(c1ccc(F)c(C)c1)[C@H]1CN[C@H](C(=O)O)[C@H]1CC(=O)O Homo sapiens CHEMBL699991 single protein format
CHEMBL333015 OBDepict CH 3 O CH 2 H N H H H O OH O HO Ki = 57.4 nM 305.33 C=C(c1ccc(OC)cc1)[C@H]1CN[C@H](C(=O)O)[C@H]1CC(=O)O Homo sapiens CHEMBL699991 single protein format
CHEMBL332467 OBDepict CH 3 CH 2 H N H H H O OH O HO Ki = 82.2 nM 303.36 C=C(c1ccc(CC)cc1)[C@H]1CN[C@H](C(=O)O)[C@H]1CC(=O)O Homo sapiens CHEMBL699991 single protein format
CHEMBL121113 OBDepict HO O H H H N H H 2 C O OH Ki = 90.6 nM 351.4 C=C(c1cccc(-c2ccccc2)c1)[C@H]1CN[C@H](C(=O)O)[C@H]1CC(=O)O Homo sapiens CHEMBL699991 single protein format
CHEMBL332168 OBDepict H 3 C O CH 2 H N H H H O HO O OH Ki = 93.5 nM 305.33 C=C(c1cccc(OC)c1)[C@H]1CN[C@H](C(=O)O)[C@H]1CC(=O)O Homo sapiens CHEMBL699991 single protein format
CHEMBL334119 OBDepict HO O H H H HN CH 2 O HO CH 3 CH 3 Ki = 107.8 nM 303.36 C=C(c1ccc(C)c(C)c1)[C@H]1CN[C@H](C(=O)O)[C@H]1CC(=O)O Homo sapiens CHEMBL699991 single protein format
CHEMBL332818 OBDepict HO O H H H HN CH 2 O HO CH 3 Ki = 122.5 nM 289.33 C=C(c1cccc(C)c1)[C@H]1CN[C@H](C(=O)O)[C@H]1CC(=O)O Homo sapiens CHEMBL699991 single protein format
CHEMBL332114 OBDepict HO O H H H N H H 2 C O OH O Ki = 126.2 nM 395.46 C=C(c1ccc(OCCc2ccccc2)cc1)[C@H]1CN[C@H](C(=O)O)[C@H]1CC(=O)O Homo sapiens CHEMBL699991 single protein format
CHEMBL121514 OBDepict OH O H H H N H CH 2 O HO H 3 C O Ki = 129.3 nM 409.48 C=C(c1ccc(OCCc2ccccc2)c(C)c1)[C@H]1CN[C@H](C(=O)O)[C@H]1CC(=O)O Homo sapiens CHEMBL699991 single protein format
CHEMBL333790 OBDepict OH O H H H NH CH 2 O OH Ki = 130.6 nM 351.4 C=C(c1ccc(-c2ccccc2)cc1)[C@H]1CN[C@H](C(=O)O)[C@H]1CC(=O)O Homo sapiens CHEMBL699991 single protein format
CHEMBL120753 OBDepict HO O H H H HN CH 2 O HO CH 2 CH 3 Ki = 131.5 nM 315.37 C=C(C)c1ccc(C(=C)[C@H]2CN[C@H](C(=O)O)[C@H]2CC(=O)O)cc1 Homo sapiens CHEMBL699991 single protein format
CHEMBL120450 OBDepict CH 3 CH 2 H N H H H O OH O HO Ki = 145.6 nM 331.41 C=C(c1ccc(CCCC)cc1)[C@H]1CN[C@H](C(=O)O)[C@H]1CC(=O)O Homo sapiens CHEMBL699991 single protein format
CHEMBL122507 OBDepict CH 3 O CH 2 H N H H H O OH O HO Ki = 146.6 nM 347.41 C=C(c1ccc(OCCCC)cc1)[C@H]1CN[C@H](C(=O)O)[C@H]1CC(=O)O Homo sapiens CHEMBL699991 single protein format
CHEMBL120288 OBDepict CH 3 CH 2 H N H H H O OH O HO Ki = 146.8 nM 317.39 C=C(c1ccc(CCC)cc1)[C@H]1CN[C@H](C(=O)O)[C@H]1CC(=O)O Homo sapiens CHEMBL699991 single protein format
CHEMBL59551 OBDepict H O OH CH NH 2 H O HO Ki = 160.0 nM 185.18 C#CC[C@H](C[C@H](N)C(=O)O)C(=O)O Homo sapiens CHEMBL701166 cell-based format
CHEMBL121461 OBDepict OH O H H H NH CH 2 O OH H 3 C CH 3 Ki = 169.3 nM 303.36 C=C(c1cc(C)cc(C)c1)[C@H]1CN[C@H](C(=O)O)[C@H]1CC(=O)O Homo sapiens CHEMBL699991 single protein format
CHEMBL368275 OBDepict HO O H H H N H H 2 C O OH O Ki = 209.6 nM 367.4 C=C(c1ccc(Oc2ccccc2)cc1)[C@H]1CN[C@H](C(=O)O)[C@H]1CC(=O)O Homo sapiens CHEMBL699991 single protein format
CHEMBL331339 OBDepict OH O H H H NH CH 2 O OH H 3 C H 3 C CH 3 Ki = 262.7 nM 331.41 C=C(c1ccc(C(C)(C)C)cc1)[C@H]1CN[C@H](C(=O)O)[C@H]1CC(=O)O Homo sapiens CHEMBL699991 single protein format
CHEMBL431657 OBDepict CH 3 O CH 2 H N H H H O HO O OH Ki = 275.3 nM 347.41 C=C(c1cccc(OCCCC)c1)[C@H]1CN[C@H](C(=O)O)[C@H]1CC(=O)O Homo sapiens CHEMBL699991 single protein format
CHEMBL118502 OBDepict H 3 C CH 2 CH 2 H N H H H O HO O OH Ki = 288.0 nM 329.4 C=C(CC)c1ccc(C(=C)[C@H]2CN[C@H](C(=O)O)[C@H]2CC(=O)O)cc1 Homo sapiens CHEMBL699991 single protein format
CHEMBL58808 OBDepict H O OH NH 2 H O OH Ki = 339.0 nM 263.29 N[C@@H](C[C@@H](C/C=Cc1ccccc1)C(=O)O)C(=O)O Homo sapiens CHEMBL701166 cell-based format
CHEMBL38499 OBDepict CH 2 O OH NH 2 H O HO Ki = 450.0 nM 159.14 C=C(C[C@H](N)C(=O)O)C(=O)O Homo sapiens CHEMBL699990 cell-based format
CHEMBL61697 OBDepict H O HO CH 3 NH 2 H O OH Ki = 500.0 nM 277.32 C/C(=Cc1ccccc1)C[C@H](C[C@H](N)C(=O)O)C(=O)O Homo sapiens CHEMBL701166 cell-based format
CHEMBL294683 OBDepict H O OH H 2 N H O HO F Ki = 559.0 nM 281.28 N[C@@H](C[C@@H](C/C=C/c1ccc(F)cc1)C(=O)O)C(=O)O Homo sapiens CHEMBL701166 cell-based format
CHEMBL13076 OBDepict O N H N H N + N O _ O N F F F N H O O O HO Ki = 610.0 nM 546.42 O=C(O)Cn1c(=O)c(=O)[nH]c2cc(C(F)(F)F)c(-n3ccc(CNC(=O)Nc4ccc([N+](=O)[O-])cc4)c3)cc21 Homo sapiens CHEMBL680879 cell-based format
CHEMBL123006 OBDepict CH 3 O H 3 C CH 2 H N H H H O OH O HO Ki = 663.3 nM 375.47 C=C(c1ccc(OCCCCC)c(C)c1)[C@H]1CN[C@H](C(=O)O)[C@H]1CC(=O)O Homo sapiens CHEMBL699991 single protein format
CHEMBL334024 OBDepict OH O H H H NH H 2 C O OH O Ki = 667.0 nM 395.46 C=C(c1cccc(OCCc2ccccc2)c1)[C@H]1CN[C@H](C(=O)O)[C@H]1CC(=O)O Homo sapiens CHEMBL699991 single protein format
CHEMBL3104225 OBDepict CH 3 O N CH 3 H 3 C O H 3 C IC50 = 700.0 nM 295.38 CCn1c(-c2ccc(OC)cc2)c(C)c2cc(OC)ccc21 Homo sapiens CHEMBL3107083 single protein format
CHEMBL58718 OBDepict H O OH CH NH 2 H O HO Ki = 823.0 nM 185.18 C#CC[C@@H](C[C@H](N)C(=O)O)C(=O)O Homo sapiens CHEMBL701166 cell-based format
CHEMBL59792 OBDepict H O HO NH 2 H O OH Ki = 1000.0 nM 261.28 N[C@@H](C[C@@H](CC#Cc1ccccc1)C(=O)O)C(=O)O Homo sapiens CHEMBL701166 cell-based format