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Q13164 | MK07_HUMAN | Mitogen-activated protein kinase 7 (MAPK7)

3D structures mapped by conservation among orthologs

[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4855730 OBDepict F NH S N O O H 2 N O HN IC50 = -13200.0 nM 452.51 Nc1ncc(-c2ccc(NS(=O)(=O)C3CC3)cc2F)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804719 cell-based format
CHEMBL4868141 OBDepict H 2 N N O O HN NH S O O IC50 = -6500.0 nM 532.67 Nc1ncc(-c2ccc(NS(=O)(=O)C3CC3)cc2OC2CCCCC2)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804719 cell-based format
CHEMBL4867931 OBDepict H 3 C O N H S N O O H 2 N O HN IC50 = -2800.0 nM 464.55 COc1cc(NS(=O)(=O)C2CC2)ccc1-c1cnc(N)c(-c2ccc3c(c2)CCNC3=O)c1 Homo sapiens CHEMBL4804719 cell-based format
CHEMBL4757477 OBDepict CH 3 O HN N O N N N H 3 C N CH 3 O IC50 = 11.0 nM 554.7 CCOc1cc(C(=O)N2CCC(N3CCCC3)CC2)ccc1Nc1cc2c(cn1)N(C)C(=O)c1ccccc1N2C Homo sapiens CHEMBL4724823 single protein format
CHEMBL4438379 OBDepict O N O N F F F N N N O IC50 = 17.0 nM 487.48 O=C(c1ccc(OC(F)(F)F)cc1)N1CCC(c2ncnc3cc(N4CCOCC4)cnc23)CC1 Homo sapiens CHEMBL4332025 assay format
CHEMBL4445670 OBDepict CH 3 N N N N N N O NH 2 O F F F IC50 = 35.0 nM 515.54 CN1CCN(c2cnc3c(C4CCN(C(=O)c5ccc(OC(F)(F)F)cc5N)CC4)ncnc3c2)CC1 Homo sapiens CHEMBL4332025 assay format
CHEMBL4469661 OBDepict CH 3 O N N N O H 2 N O F F F IC50 = 51.0 nM 446.43 COc1ccc2c(C3CCN(C(=O)c4ccc(OC(F)(F)F)cc4N)CC3)ncnc2c1 Homo sapiens CHEMBL4332025 assay format
CHEMBL4550589 OBDepict H 3 C N N N N N N O O F F F IC50 = 54.0 nM 500.53 CN1CCN(c2cnc3c(C4CCN(C(=O)c5ccc(OC(F)(F)F)cc5)CC4)ncnc3c2)CC1 Homo sapiens CHEMBL4332025 assay format
CHEMBL2381342 OBDepict CH 3 N CH 3 N H O N H N O CH 3 H 3 C IC50 = 59.0 nM 440.55 CN(C)Cc1cccc(N/C(=C2C(=O)Nc3cc(C(=O)N(C)C)ccc32)c2ccccc2)c1 Homo sapiens CHEMBL2384568 cell-based format
CHEMBL4542723 OBDepict CH 3 N CH 3 N N N N N O O F F F IC50 = 64.0 nM 514.55 CN(C)C1CCN(c2cnc3c(C4CCN(C(=O)c5ccc(OC(F)(F)F)cc5)CC4)ncnc3c2)C1 Homo sapiens CHEMBL4332025 assay format
CHEMBL4526317 OBDepict O N O N F F F N N N CH 3 OH IC50 = 68.0 nM 501.51 CC1(O)CCN(c2cnc3c(C4CCN(C(=O)c5ccc(OC(F)(F)F)cc5)CC4)ncnc3c2)C1 Homo sapiens CHEMBL4332025 assay format
CHEMBL4636072 OBDepict H 3 C O N H N N N N N H 3 C N CH 3 O IC50 = 79.0 nM 499.62 COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(C1CCC1)c1ccccc1C(=O)N2C Homo sapiens CHEMBL4612964 cell-based format
CHEMBL4800629 OBDepict CH 3 O H H N H N N N CH 3 CH 3 O IC50 = 81.0 nM 380.49 CCO[C@H]1CC[C@H](Nc2cc3c(cn2)N(C)C(=O)c2ccccc2N3C)CC1 Homo sapiens CHEMBL4724828 single protein format
CHEMBL4788469 OBDepict H 3 C N N O N N H H 3 C H H HO IC50 = 89.0 nM 352.44 CN1C(=O)c2ccccc2N(C)c2cc(N[C@H]3CC[C@H](O)CC3)ncc21 Homo sapiens CHEMBL4724823 single protein format
CHEMBL4441182 OBDepict CH 3 O N N N N O O F F F IC50 = 98.0 nM 432.4 COc1cnc2c(C3CCN(C(=O)c4ccc(OC(F)(F)F)cc4)CC3)ncnc2c1 Homo sapiens CHEMBL4332025 assay format
CHEMBL4450479 OBDepict CH 3 O N N O O F F F IC50 = 110.0 nM 430.43 COc1ccc2c(C3CCN(C(=O)c4ccc(OC(F)(F)F)cc4)CC3)ccnc2c1 Homo sapiens CHEMBL4332025 assay format
CHEMBL388978 OBDepict CH 3 HN H H O H O N H 3 C H 3 C N O N H IC50 = 121.6 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL4145868 single protein format
CHEMBL1673049 OBDepict H 3 C O NH N O N N N N H 3 C N CH 3 O IC50 = 130.0 nM 541.66 COc1cc(C(=O)N2CCC(N3CCCC3)CC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C Homo sapiens CHEMBL1679302 cell-based format
CHEMBL4763016 OBDepict H N H N H HO O N H 3 C O F IC50 = 131.0 nM 357.39 CN1C(=O)c2c(F)cccc2Oc2cc(N[C@H]3CC[C@H](O)CC3)ncc21 Homo sapiens CHEMBL4724828 single protein format
CHEMBL4450712 OBDepict CH 3 O N N N O O F F F IC50 = 150.0 nM 431.41 COc1ccc2c(C3CCN(C(=O)c4ccc(OC(F)(F)F)cc4)CC3)ncnc2c1 Homo sapiens CHEMBL4332025 assay format
CHEMBL4544067 OBDepict CH 3 O N N N O NH 2 O F F F IC50 = 170.0 nM 446.43 COc1ccc2c(C3CCN(C(=O)c4ccc(OC(F)(F)F)c(N)c4)CC3)ncnc2c1 Homo sapiens CHEMBL4332025 assay format
CHEMBL1673039 OBDepict H 3 C O N H N N N N N H 3 C N H 3 C H 3 C O IC50 = 190.0 nM 459.55 COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C Homo sapiens CHEMBL1679302 cell-based format
CHEMBL1673051 OBDepict CH 3 O N H N N N N N H 3 C N CH 3 H 3 C O IC50 = 200.0 nM 473.58 CCN1c2ccccc2C(=O)N(C)c2cnc(Nc3ccc(N4CCN(C)CC4)cc3OC)nc21 Homo sapiens CHEMBL1679302 cell-based format
CHEMBL1673043 OBDepict H 3 C O N H N N N N N N H 3 C H 3 C O N H 3 C IC50 = 200.0 nM 542.69 COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C Homo sapiens CHEMBL1679302 cell-based format
CHEMBL1673053 OBDepict H 3 C O N H N N N N N H 3 C N CH 3 O IC50 = 200.0 nM 513.65 COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(C1CCCC1)c1ccccc1C(=O)N2C Homo sapiens CHEMBL1679302 cell-based format
CHEMBL4582824 OBDepict H 3 C N N N O O F F F IC50 = 210.0 nM 415.42 Cc1ccc2c(C3CCN(C(=O)c4ccc(OC(F)(F)F)cc4)CC3)ncnc2c1 Homo sapiens CHEMBL4332025 assay format
CHEMBL4745137 OBDepict H 3 C N O N O F N H F H H HO IC50 = 213.0 nM 375.38 CN1C(=O)c2c(F)ccc(F)c2Oc2cc(N[C@H]3CC[C@H](O)CC3)ncc21 Homo sapiens CHEMBL4724828 single protein format
CHEMBL3735506 OBDepict H 3 C O N N H O N N H F F IC50 = 220.0 nM 428.48 COCCN1CCC(CNC(=O)c2n[nH]c3ccc(-c4cccc(F)c4F)cc23)CC1 Homo sapiens CHEMBL3736806 single protein format
CHEMBL4648947 OBDepict CH 3 N H 3 C N N O N N H H 3 C O CH 3 N N H 3 C IC50 = 222.0 nM 501.64 CCC(C)N1c2ccccc2C(=O)N(C)c2cnc(Nc3ccc(N4CCN(C)CC4)cc3OC)nc21 Homo sapiens CHEMBL4612964 cell-based format
CHEMBL1673042 OBDepict H 3 C O N H N N N HN N N H 3 C H 3 C O IC50 = 230.0 nM 445.53 COc1cc(N2CCNCC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C Homo sapiens CHEMBL1679302 cell-based format
CHEMBL1673052 OBDepict H 3 C O N H N N N N N H 3 C N H 3 C H 3 C CH 3 O IC50 = 230.0 nM 487.61 COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(C(C)C)c1ccccc1C(=O)N2C Homo sapiens CHEMBL1679302 cell-based format
CHEMBL1673050 OBDepict H 3 C O N H NH O N N N N N H 3 C CH 3 H 3 C H 3 C O IC50 = 240.0 nM 475.55 COc1cc(C(=O)NCCN(C)C)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C Homo sapiens CHEMBL1679302 cell-based format
CHEMBL1673046 OBDepict CH 3 O N H N N N N HO N H 3 C H 3 C O IC50 = 240.0 nM 474.57 CCOc1cc(N2CCC(O)CC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C Homo sapiens CHEMBL1679302 cell-based format
CHEMBL1673040 OBDepict H 3 C O N H N N N N HO N H 3 C H 3 C O IC50 = 240.0 nM 460.54 COc1cc(N2CCC(O)CC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C Homo sapiens CHEMBL1679302 cell-based format
CHEMBL1673041 OBDepict H 3 C O N H N N N O N N H 3 C H 3 C O IC50 = 260.0 nM 446.51 COc1cc(N2CCOCC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C Homo sapiens CHEMBL1679302 cell-based format
CHEMBL1673044 OBDepict H 3 C O N H N N N N H 3 C N H 3 C H 3 C O IC50 = 260.0 nM 458.57 COc1cc(C2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C Homo sapiens CHEMBL1679302 cell-based format
CHEMBL4796417 OBDepict H 3 C N O N O N H H H HO IC50 = 266.0 nM 339.4 CN1C(=O)c2ccccc2Oc2cc(N[C@H]3CC[C@H](O)CC3)ncc21 Homo sapiens CHEMBL4724828 single protein format
CHEMBL4535758 OBDepict CH 3 O O H 3 C N N N O O F F F IC50 = 270.0 nM 461.44 COc1cc2ncnc(C3CCN(C(=O)c4ccc(OC(F)(F)F)cc4)CC3)c2cc1OC Homo sapiens CHEMBL4332025 assay format
CHEMBL4636475 OBDepict H 3 C O N H HN S N N O O H 3 C N N H 3 C H 3 C O IC50 = 276.0 nM 454.51 COc1cc(NS(C)(=O)=O)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C Homo sapiens CHEMBL4612964 cell-based format
CHEMBL1673045 OBDepict H 3 C N N CH 3 N H N N N N H 3 C H 3 C O IC50 = 280.0 nM 443.56 Cc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C Homo sapiens CHEMBL1679302 cell-based format
CHEMBL1673047 OBDepict CH 3 N N N O N N H H 3 C S O O NH 2 IC50 = 310.0 nM 410.46 CN1C(=O)c2ccccc2N(C)c2nc(Nc3ccc(S(N)(=O)=O)cc3)ncc21 Homo sapiens CHEMBL1679302 cell-based format
CHEMBL1673048 OBDepict H 3 C O N H NH O N N N N H 3 C N H 3 C H 3 C O IC50 = 320.0 nM 501.59 COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C Homo sapiens CHEMBL1679302 cell-based format
CHEMBL4446192 OBDepict H 3 C O N O N N O CH 3 O H 3 C IC50 = 350.0 nM 407.47 COc1ccc(C(=O)N2CCC(c3ncnc4cc(OC)c(OC)cc34)CC2)cc1 Homo sapiens CHEMBL4332025 assay format
CHEMBL4466294 OBDepict H 3 C O N O N N O CH 3 O CH 3 IC50 = 380.0 nM 421.5 CCOc1ccc(C(=O)N2CCC(c3ncnc4cc(OC)c(OC)cc34)CC2)cc1 Homo sapiens CHEMBL4332025 assay format
CHEMBL4790464 OBDepict O N H 3 C O N F N H H H HO IC50 = 393.0 nM 357.39 CN1C(=O)c2cccc(F)c2Oc2cc(N[C@H]3CC[C@H](O)CC3)ncc21 Homo sapiens CHEMBL4724828 single protein format
CHEMBL4643632 OBDepict CH 3 O NH N H O N N N N CH 3 N CH 3 H 3 C O IC50 = 482.0 nM 515.62 CCN1C(=O)c2ccccc2N(C)c2nc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC)ncc21 Homo sapiens CHEMBL4612964 cell-based format
CHEMBL4565352 OBDepict CH 3 O O CH 3 N N N O F F F IC50 = 530.0 nM 445.44 COc1cc2ncnc(C3CCN(C(=O)c4ccc(C(F)(F)F)cc4)CC3)c2cc1OC Homo sapiens CHEMBL4332025 assay format
CHEMBL4453232 OBDepict F Cl O N H N H O N IC50 = 600.0 nM 343.75 O=C(Nc1cccnc1)c1cc(C(=O)c2c(F)cccc2Cl)c[nH]1 Homo sapiens CHEMBL4365545 cell-based format
CHEMBL4557683 OBDepict F Cl O N H N H O N IC50 = 600.0 nM 343.75 O=C(Nc1ccncc1)c1cc(C(=O)c2c(F)cccc2Cl)c[nH]1 Homo sapiens CHEMBL4365545 cell-based format
CHEMBL4527483 OBDepict F Br O N H N H O N IC50 = 700.0 nM 388.2 O=C(Nc1ccncc1)c1cc(C(=O)c2c(F)cccc2Br)c[nH]1 Homo sapiens CHEMBL4365545 cell-based format
CHEMBL4520598 OBDepict CH 3 N N N O O F F F IC50 = 760.0 nM 415.42 Cc1ccc2ncnc(C3CCN(C(=O)c4ccc(OC(F)(F)F)cc4)CC3)c2c1 Homo sapiens CHEMBL4332025 assay format
CHEMBL2381341 OBDepict H 3 C NH O N H O NH N CH 3 CH 3 IC50 = 810.0 nM 426.52 CNC(=O)c1ccc2c(c1)NC(=O)/C2=C(Nc1cccc(CN(C)C)c1)c1ccccc1 Homo sapiens CHEMBL2384568 cell-based format
CHEMBL4436895 OBDepict F Br O N H N H O N IC50 = 820.0 nM 388.2 O=C(Nc1cccnc1)c1cc(C(=O)c2c(F)cccc2Br)c[nH]1 Homo sapiens CHEMBL4365545 cell-based format
CHEMBL4443724 OBDepict O N H N H O N F F IC50 = 900.0 nM 327.29 O=C(Nc1ccncc1)c1cc(C(=O)c2c(F)cccc2F)c[nH]1 Homo sapiens CHEMBL4365545 cell-based format
CHEMBL4545407 OBDepict CH 3 O O CH 3 N N N O O H 3 C CH 3 IC50 = 920.0 nM 435.52 COc1cc2ncnc(C3CCN(C(=O)c4ccc(OC(C)C)cc4)CC3)c2cc1OC Homo sapiens CHEMBL4332025 assay format
CHEMBL4468045 OBDepict CH 3 O N N N O O F F F IC50 = 1000.0 nM 431.41 COc1ccc2ncnc(C3CCN(C(=O)c4ccc(OC(F)(F)F)cc4)CC3)c2c1 Homo sapiens CHEMBL4332025 assay format