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Q13177 | PAK2_HUMAN | Serine/threonine-protein kinase PAK 2 (PAK2)

3D structures mapped by conservation among orthologs



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4855730 OBDepict F NH S N O O H 2 N O HN IC50 = -14000.0 nM 452.51 Nc1ncc(-c2ccc(NS(=O)(=O)C3CC3)cc2F)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804749 cell-based format
CHEMBL388978 OBDepict CH 3 HN H H O H O N H 3 C H 3 C N O N H IC50 = 1.0 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL1021076 single protein format
CHEMBL3818265 OBDepict CH 3 N H N N N O F Cl N H 3 C N O H 3 C Ki = 2.0 nM 508.99 CNc1ncc2cc(-c3ccc(-n4cccc(C)c4=O)cc3Cl)c(=O)n(CCC3(F)CN(C)C3)c2n1 Homo sapiens CHEMBL3820957 single protein format
CHEMBL3818479 OBDepict Cl N O N O N H 3 C N N N H F F HN O Ki = 4.6 nM 570.0 Cc1nccn(-c2ccc(-c3cc4cnc(NC5COC5)nc4n(CC4CCNCC4(F)F)c3=O)c(Cl)c2)c1=O Homo sapiens CHEMBL3820957 single protein format
CHEMBL3819118 OBDepict H 3 C O N Cl O N N N H O N H N H CH 3 Ki = 9.5 nM 506.99 CCc1cccn(-c2ccc(-c3cc4cnc(NC)nc4n(C[C@H]4CNCCO4)c3=O)c(Cl)c2)c1=O Homo sapiens CHEMBL3820957 single protein format
CHEMBL3770443 OBDepict CH 3 HN N N N O H O O Cl H H 2 N N CH 3 IC50 = 11.0 nM 492.97 CNc1ncc2cc(-c3ccc(-c4cccc(C)n4)cc3Cl)c(=O)n(C[C@H]3OC[C@H](N)CO3)c2n1 Homo sapiens CHEMBL3772532 single protein format
CHEMBL3770443 OBDepict CH 3 HN N N N O H O O Cl H H 2 N N CH 3 Ki = 11.0 nM 492.97 CNc1ncc2cc(-c3ccc(-c4cccc(C)n4)cc3Cl)c(=O)n(C[C@H]3OC[C@H](N)CO3)c2n1 Homo sapiens CHEMBL3820957 single protein format
CHEMBL3609327 OBDepict CH 3 N N O N N H Cl S N N N H 3 C IC50 = 12.8 nM 558.11 CCn1c(=O)c(-c2ccc(-c3cncs3)cc2Cl)cc2cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc21 Homo sapiens CHEMBL3611427 single protein format
CHEMBL3817984 OBDepict CH 3 N O N N N H Cl N O O H 3 C Ki = 21.0 nM 463.93 CCn1c(=O)c(-c2ccc(-n3cccc(C)c3=O)cc2Cl)cc2cnc(NC3COC3)nc21 Homo sapiens CHEMBL3820957 single protein format
CHEMBL3819447 OBDepict CH 3 O N O N N H N Cl CH 3 N N O H 3 C Ki = 39.0 nM 452.9 CNc1ncc2cc(-c3ccc(-n4cncc(C)c4=O)cc3Cl)c(=O)n(CCOC)c2n1 Homo sapiens CHEMBL3820957 single protein format
CHEMBL3609326 OBDepict CH 3 N N O N N H Cl Cl F N NH IC50 = 39.5 nM 513.4 CCn1c(=O)c(-c2ccc(Cl)cc2Cl)cc2cnc(Nc3ccc(N4CCNCC4)c(F)c3)nc21 Homo sapiens CHEMBL3611546 single protein format
CHEMBL3770186 OBDepict CH 3 N N O NH N Cl N N N H 3 C CH 3 Ki = 48.0 nM 518.07 CCn1c(=O)c(-c2ccc(-c3cncc(C)n3)cc2Cl)cc2cnc(NCCC3CCN(C)CC3)nc21 Homo sapiens CHEMBL3820957 single protein format
CHEMBL2386715 OBDepict H 3 C O N N N NH F N N N H N H IC50 = 64.1 nM 422.47 COCCN(Cc1cc(F)cc2[nH]ncc12)c1nccc(Nc2cc(C3CC3)[nH]n2)n1 Homo sapiens CHEMBL2388904 cell-based format
CHEMBL2386717 OBDepict OH N H 3 C N N HN F N N N H N H IC50 = 70.8 nM 422.47 CC(CO)N(Cc1cc(F)cc2[nH]ncc12)c1nccc(Nc2cc(C3CC3)[nH]n2)n1 Homo sapiens CHEMBL2388904 cell-based format
CHEMBL2386716 OBDepict H N N N H N N N H H 3 C H N H IC50 = 133.0 nM 373.46 C[C@H](Nc1nccc(Nc2cc(C3CCC3)[nH]n2)n1)c1ccc2[nH]ccc2c1 Homo sapiens CHEMBL2388904 cell-based format
CHEMBL3128043 OBDepict H 3 C N CH 3 N H H N O CH 3 H 3 C N HN N H N S CH 3 N IC50 = 190.0 nM 490.64 Cc1nc(Nc2[nH]nc3c2CN(C(=O)N[C@H](CN(C)C)c2ccccc2)C3(C)C)c2sccc2n1 Homo sapiens CHEMBL3611421 single protein format
CHEMBL2386718 OBDepict H N N N H F F N N N H CH 3 H N N H IC50 = 244.0 nM 396.41 C[C@H](Nc1nccc(Nc2cc(C3CC3(F)F)[nH]n2)n1)c1ccc2[nH]cnc2c1 Homo sapiens CHEMBL2388904 cell-based format
CHEMBL3819371 OBDepict CH 3 N N Cl O N N N H H H 2 N Ki = 940.0 nM 460.97 Cc1cncc(-c2ccc(-c3cc4cncnc4n(C[C@H]4CC[C@H](N)CC4)c3=O)c(Cl)c2)n1 Homo sapiens CHEMBL3820957 single protein format
CHEMBL3128042 OBDepict H 3 C O N H N N N N NH 2 HO IC50 = 970.0 nM 406.49 COCCNc1nc2ccc(C#CC3(O)CCCCC3)cc2n1-c1ccnc(N)n1 Homo sapiens CHEMBL3129190 single protein format