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Q13188 | STK3_HUMAN | Serine/threonine-protein kinase 3 (STK3)

3D structures mapped by conservation among orthologs

[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Domain: "NAP-like" // Mst1_SARAH ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL388978 OBDepict CH 3 HN H H O H O N H 3 C H 3 C N O N H IC50 = 0.41 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL973450 single protein format
CHEMBL2010872 OBDepict CH 3 H 3 C N N H N H N N O N N CH 3 IC50 = 21.0 nM 477.57 CC(C)Cn1c2ccc(Nc3ncccn3)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3 Homo sapiens CHEMBL2016115 single protein format
CHEMBL3393348 OBDepict N N H N N N O IC50 = 22.0 nM 305.34 N#Cc1cccc(-c2c[nH]c3ncnc(N4CCOCC4)c23)c1 Homo sapiens CHEMBL3395732 single protein format
CHEMBL4860789 OBDepict NH 2 N S O NH N H O O IC50 = 40.0 nM 434.52 Nc1ncc(-c2cccc(S(=O)(=O)NC3CC3)c2)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804308 single protein format
CHEMBL4874241 OBDepict NH 2 N F + N O NH O _ O IC50 = 40.0 nM 378.36 Nc1ncc(-c2cc([N+](=O)[O-])ccc2F)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804308 single protein format
CHEMBL4859660 OBDepict NH 2 N F + N O NH O _ O IC50 < 40.0 nM 378.36 Nc1ncc(-c2cccc([N+](=O)[O-])c2F)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804308 single protein format
CHEMBL4855188 OBDepict F S N O O CH 3 N H 2 N N H O IC50 < 40.0 nM 452.51 CN(C1CC1)S(=O)(=O)c1ccc(-c2cnc(N)c(-c3ccc4c(c3)CNC4=O)c2)c(F)c1 Homo sapiens CHEMBL4804308 single protein format
CHEMBL4865313 OBDepict H 3 C O S N O O CH 3 N H 2 N O N H IC50 < 40.0 nM 478.57 COc1cc(S(=O)(=O)N(C)C2CC2)ccc1-c1cnc(N)c(-c2ccc3c(c2)CCNC3=O)c1 Homo sapiens CHEMBL4804308 single protein format
CHEMBL4860979 OBDepict F S N O O CH 3 N H 2 N O N H IC50 < 40.0 nM 466.54 CN(C1CC1)S(=O)(=O)c1ccc(-c2cnc(N)c(-c3ccc4c(c3)CCNC4=O)c2)c(F)c1 Homo sapiens CHEMBL4804308 single protein format
CHEMBL4868315 OBDepict NH 2 N S Cl N O NH IC50 = 40.0 nM 356.84 Nc1ncc(-c2scnc2Cl)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804308 single protein format
CHEMBL4879343 OBDepict N N H 2 N O HN IC50 = 40.0 nM 340.39 N#Cc1cccc(-c2cnc(N)c(-c3ccc4c(c3)CCNC4=O)c2)c1 Homo sapiens CHEMBL4804308 single protein format
CHEMBL4849739 OBDepict O N H O F N NH 2 O NH IC50 = 40.0 nM 404.4 Nc1ncc(-c2cc3c(cc2F)OCC(=O)N3)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804308 single protein format
CHEMBL4869774 OBDepict NH 2 N F + N O NH O _ O Cl IC50 = 40.0 nM 412.81 Nc1ncc(-c2cc([N+](=O)[O-])c(Cl)cc2F)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804308 single protein format
CHEMBL4855542 OBDepict NH 2 N S N O NH IC50 = 40.0 nM 372.45 Nc1ncc(-c2cccc3ncsc23)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804308 single protein format
CHEMBL4281823 OBDepict CH 3 N N N NH 2 N O O F F F IC50 = 50.0 nM 481.48 CCn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 Homo sapiens CHEMBL4261441 single protein format
CHEMBL605003 OBDepict O HN N H S N O O H 3 C CH 3 IC50 = 110.0 nM 371.46 CN(C)S(=O)(=O)c1ccc2c(c1)/C(=C/c1cc3c([nH]1)CCCC3)C(=O)N2 Homo sapiens CHEMBL1061941 single protein format
CHEMBL3393444 OBDepict N N H N N N O H H 3 C IC50 = 179.0 nM 319.37 C[C@H]1CN(c2ncnc3[nH]cc(-c4cccc(C#N)c4)c23)CCO1 Homo sapiens CHEMBL3395732 single protein format
CHEMBL3393446 OBDepict N O N N N N H N IC50 = 196.0 nM 344.38 N#CCC1CN(c2ncnc3[nH]cc(-c4cccc(C#N)c4)c23)CCO1 Homo sapiens CHEMBL3395732 single protein format
CHEMBL3393445 OBDepict N O N N N N H N IC50 = 288.0 nM 330.35 N#Cc1cccc(-c2c[nH]c3ncnc(N4CCOC(C#N)C4)c23)c1 Homo sapiens CHEMBL3395732 single protein format
CHEMBL2312654 OBDepict CH 3 N H 3 C NH N N N H O N CH 3 Cl Cl IC50 = 470.0 nM 461.4 Cc1cc(-c2cnc(Nc3cc(Cl)cc(Cl)c3)nc2NC2CCC(N(C)C)CC2)on1 Homo sapiens CHEMBL2319694 single protein format
CHEMBL590109 OBDepict H 2 N N N N NH 2 N N S H IC50 = 570.0 nM 425.52 NCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 Homo sapiens CHEMBL1072673 single protein format
CHEMBL3393453 OBDepict N N H N N N O IC50 = 626.0 nM 331.38 N#Cc1cccc(-c2c[nH]c3ncnc(N4CC5CCOC5C4)c23)c1 Homo sapiens CHEMBL3395732 single protein format
CHEMBL1090360 OBDepict O N H N N S N N HN N O IC50 = 650.0 nM 587.71 O=C(Cc1ccccc1)Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3cccc(N4CCOCC4)c3)n2)c1 Homo sapiens CHEMBL1109700 single protein format
CHEMBL3393449 OBDepict N N H N N N O H N N O H 3 C IC50 = 795.0 nM 387.4 Cc1nc([C@@H]2CN(c3ncnc4[nH]cc(-c5cccc(C#N)c5)c34)CCO2)no1 Homo sapiens CHEMBL3395732 single protein format