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Q13224 | NMDE2_HUMAN | "Glutamate receptor ionotropic, NMDA 2B" (GRIN2B)

3D structures mapped by conservation among orthologs

[ Domain: "Periplasmic binding protein-like I" // ANF_receptor_3rd ]

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[ Domain: "Periplasmic binding protein-like I" // ANF_receptor_2nd ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL161180 OBDepict Cl Cl HN NH O F F F Ki = 0.6 nM 363.17 N=C(NCc1cc(Cl)cc(Cl)c1)c1ccc(OC(F)(F)F)cc1 Homo sapiens CHEMBL749675 cell-based format
CHEMBL158737 OBDepict CH 3 O N NH 2 Ki = 0.7 nM 266.34 COc1ccccc1C/N=C(N)/C=C/c1ccccc1 Homo sapiens CHEMBL749675 cell-based format
CHEMBL159744 OBDepict CH 3 CH 3 N NH 2 O F F F Ki = 1.2 nM 322.33 Cc1cc(C)cc(C/N=C(N)c2ccc(OC(F)(F)F)cc2)c1 Homo sapiens CHEMBL749675 cell-based format
CHEMBL3735947 OBDepict _ O + N O N H Ki = 1.6 nM 324.42 O=[N+]([O-])c1ccc2c(c1)CCC(NCCCc1ccccc1)CC2 Homo sapiens CHEMBL3737377 cell-based format
CHEMBL429656 OBDepict CH 3 CH 3 N HN O F F F Ki = 2.0 nM 334.34 Cc1cc(C)cc(CN2Cc3cc(OC(F)(F)F)ccc3C2=N)c1 Homo sapiens CHEMBL887786 single protein format
CHEMBL4637295 OBDepict Cl N H Ki = 2.1 nM 313.87 Clc1ccc2c(c1)CCC(NCCCc1ccccc1)CC2 Homo sapiens CHEMBL4610803 cell-based format
CHEMBL393670 OBDepict HN N O O F F F Ki = 2.2 nM 346.31 N=C1c2ccc(OC(F)(F)F)cc2CN1Cc1cccc2ccoc12 Homo sapiens CHEMBL887786 single protein format
CHEMBL3357791 OBDepict H N H H Ki = 2.3 nM 319.49 c1ccc([C@H]2CC[C@@H](NC3CCc4ccccc4CC3)CC2)cc1 Homo sapiens CHEMBL3390297 cell-based format
CHEMBL3357790 OBDepict N Ki = 2.9 nM 319.49 c1ccc(CC2CCN(C3CCc4ccccc4CC3)CC2)cc1 Homo sapiens CHEMBL3390297 cell-based format
CHEMBL4758763 OBDepict N Ki = 3.2 nM 291.44 c1ccc(CC2CCN(C3Cc4ccccc4C3)CC2)cc1 Homo sapiens CHEMBL4685218 cell membrane format
CHEMBL3735485 OBDepict _ O + N O N H Ki = 3.3 nM 310.4 O=[N+]([O-])c1ccc2c(c1)CCC(NCCc1ccccc1)CC2 Homo sapiens CHEMBL3737377 cell-based format
CHEMBL218713 OBDepict H 3 C O N O HN N N Ki = 3.4 nM 340.43 Cc1ccc(COC(=O)N2CCC(CNc3ncccn3)CC2)cc1 Homo sapiens CHEMBL856830 cell-based format
CHEMBL247323 OBDepict CH 3 O N NH O F F F Ki = 3.6 nM 336.31 COc1ccccc1CN1Cc2cc(OC(F)(F)F)ccc2C1=N Homo sapiens CHEMBL887786 single protein format
CHEMBL218211 OBDepict CH 3 O N O HN N N Ki = 3.7 nM 354.45 CCc1ccc(COC(=O)N2CCC(CNc3ncccn3)CC2)cc1 Homo sapiens CHEMBL856830 cell-based format
CHEMBL3736502 OBDepict _ O + N O N H Ki = 3.8 nM 338.45 O=[N+]([O-])c1ccc2c(c1)CCC(NCCCCc1ccccc1)CC2 Homo sapiens CHEMBL3737377 cell-based format
CHEMBL162080 OBDepict NH 2 N F F F CH 3 CH 3 Ki = 3.9 nM 306.33 Cc1cc(C)cc(C/N=C(N)c2ccc(C(F)(F)F)cc2)c1 Homo sapiens CHEMBL749675 cell-based format
CHEMBL159560 OBDepict CH 3 O N NH 2 O F F F IC50 = 4.1 nM 324.3 COc1ccccc1C/N=C(N)c1ccc(OC(F)(F)F)cc1 Homo sapiens CHEMBL749390 single protein format
CHEMBL159744 OBDepict CH 3 CH 3 N NH 2 O F F F IC50 = 4.2 nM 322.33 Cc1cc(C)cc(C/N=C(N)c2ccc(OC(F)(F)F)cc2)c1 Homo sapiens CHEMBL749390 single protein format
CHEMBL4111330 OBDepict HO N H O N F IC50 = 4.2 nM 368.45 O=C1[C@H](N2CCC(c3ccc(O)cc3)CC2)CCN1Cc1ccc(F)cc1 Homo sapiens CHEMBL4149864 cell-based format
CHEMBL4745685 OBDepict N Ki = 4.5 nM 277.41 c1ccc(C2CCN(C3Cc4ccccc4C3)CC2)cc1 Homo sapiens CHEMBL4685218 cell membrane format
CHEMBL1289403 OBDepict H 3 C O HO N Ki = 5.4 nM 325.45 COc1ccc2c(c1)CCN(CCCCc1ccccc1)CC2O Homo sapiens CHEMBL3390297 cell-based format
CHEMBL3357792 OBDepict H N H H Ki = 5.7 nM 319.49 c1ccc([C@H]2CC[C@H](NC3CCc4ccccc4CC3)CC2)cc1 Homo sapiens CHEMBL3390297 cell-based format
CHEMBL159560 OBDepict CH 3 O N NH 2 O F F F Ki = 5.7 nM 324.3 COc1ccccc1C/N=C(N)c1ccc(OC(F)(F)F)cc1 Homo sapiens CHEMBL749675 cell-based format
CHEMBL493054 OBDepict OH HO H N CH 3 H Ki = 5.8 nM 325.45 C[C@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 Homo sapiens CHEMBL4713189 cell membrane format
CHEMBL4634358 OBDepict N H S Ki = 5.9 nM 285.46 c1ccc(CCCNC2CCc3ccsc3CC2)cc1 Homo sapiens CHEMBL4610803 cell-based format
CHEMBL4645707 OBDepict CH 3 N S Ki = 6.0 nM 299.48 CN(CCCc1ccccc1)C1CCc2ccsc2CC1 Homo sapiens CHEMBL4610803 cell-based format
CHEMBL3892956 OBDepict CH 3 N O H N H F H HO Ki = 6.3 nM 382.48 Cc1ccc(CN2CC[C@@H](N3CC[C@@H](c4ccc(O)cc4)[C@H](F)C3)C2=O)cc1 Homo sapiens CHEMBL4149901 assay format
CHEMBL3357788 OBDepict N Ki = 6.9 nM 305.46 c1ccc(C2CCN(C3CCc4ccccc4CC3)CC2)cc1 Homo sapiens CHEMBL3390297 cell-based format
CHEMBL3735173 OBDepict _ O + N O N H Ki = 7.6 nM 296.37 O=[N+]([O-])c1ccc2c(c1)CCC(NCc1ccccc1)CC2 Homo sapiens CHEMBL3737377 cell-based format
CHEMBL386184 OBDepict CH 3 CH 3 O N O HN N N Ki = 7.8 nM 368.48 CC(C)c1ccc(COC(=O)N2CCC(CNc3ncccn3)CC2)cc1 Homo sapiens CHEMBL856830 cell-based format
CHEMBL247718 OBDepict Cl N NH O F F F Ki = 8.0 nM 340.73 N=C1c2ccc(OC(F)(F)F)cc2CN1Cc1cccc(Cl)c1 Homo sapiens CHEMBL887786 single protein format
CHEMBL4740593 OBDepict N Ki = 8.0 nM 305.46 c1ccc(CC2CCN(C3CCc4ccccc4C3)CC2)cc1 Homo sapiens CHEMBL4685218 cell membrane format
CHEMBL4746028 OBDepict N Ki = 8.4 nM 291.44 c1ccc(C2CCN(C3CCc4ccccc4C3)CC2)cc1 Homo sapiens CHEMBL4685218 cell membrane format
CHEMBL162080 OBDepict NH 2 N F F F CH 3 CH 3 IC50 = 8.7 nM 306.33 Cc1cc(C)cc(C/N=C(N)c2ccc(C(F)(F)F)cc2)c1 Homo sapiens CHEMBL749390 single protein format
CHEMBL4648500 OBDepict H 3 C N S Ki = 9.0 nM 313.51 CN(CCCCc1ccccc1)C1CCc2ccsc2CC1 Homo sapiens CHEMBL4610803 cell-based format
CHEMBL158874 OBDepict NH N H Ki = 9.0 nM 236.32 N=C(/C=C/c1ccccc1)NCc1ccccc1 Homo sapiens CHEMBL749675 cell-based format
CHEMBL305195 OBDepict HO HO H CH 3 H N IC50 = 9.0 nM 339.48 C[C@@H](CN1CCC(Cc2ccccc2)CC1)[C@@H](O)c1ccc(O)cc1 Homo sapiens CHEMBL4309004 cell-based format
CHEMBL349727 OBDepict CH 3 O N NH 2 O F F F IC50 = 9.7 nM 324.3 COc1cccc(C/N=C(N)c2ccc(OC(F)(F)F)cc2)c1 Homo sapiens CHEMBL749390 single protein format
CHEMBL3357784 OBDepict H 3 C O N H Ki = 10.0 nM 309.45 COc1ccc2c(c1)CCC(NCCCc1ccccc1)CC2 Homo sapiens CHEMBL3390297 cell-based format
CHEMBL319706 OBDepict OH HO H N CH 3 H Ki = 10.0 nM 325.45 C[C@@H]([C@@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 Homo sapiens CHEMBL3737377 cell-based format
CHEMBL305187 OBDepict OH OH N CH 3 Ki = 10.0 nM 325.45 CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 Homo sapiens CHEMBL3390297 cell-based format
CHEMBL113830 OBDepict OH HO H N CH 3 H Ki = 10.0 nM 325.45 C[C@H]([C@@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 Homo sapiens CHEMBL4349901 cell-based format
CHEMBL219060 OBDepict O N O HN N Ki = 10.6 nM 325.41 O=C(OCc1ccccc1)N1CCC(CNc2ccncc2)CC1 Homo sapiens CHEMBL856830 cell-based format
CHEMBL4646690 OBDepict HN S Ki = 11.0 nM 299.48 c1ccc(CCCCNC2CCc3ccsc3CC2)cc1 Homo sapiens CHEMBL4610803 cell-based format
CHEMBL161876 OBDepict NH N H Cl Cl O F F F Ki = 12.0 nM 363.17 N=C(NCc1ccccc1OC(F)(F)F)c1ccc(Cl)c(Cl)c1 Homo sapiens CHEMBL749675 cell-based format
CHEMBL3357789 OBDepict N N Ki = 12.0 nM 306.45 c1ccc(N2CCN(C3CCc4ccccc4CC3)CC2)cc1 Homo sapiens CHEMBL3390297 cell-based format
CHEMBL3545350 OBDepict F F F N N N CH 3 N IC50 = 12.0 nM 318.3 Cc1nccn1Cc1cc(-c2ccc(F)c(C(F)F)c2)cnn1 Homo sapiens CHEMBL4309004 cell-based format
CHEMBL4287203 OBDepict CH 3 O H OH H N H IC50 = 12.0 nM 325.45 COc1ccc2c(c1)CC[C@H](NCCCc1ccccc1)C[C@@H]2O Homo sapiens CHEMBL4261996 cell-based format
CHEMBL4632765 OBDepict Br S HN Ki = 13.0 nM 364.35 Brc1cc2c(s1)CCC(NCCCc1ccccc1)CC2 Homo sapiens CHEMBL4610803 cell-based format
CHEMBL28564 OBDepict F N HO Cl Ki = 13.0 nM 347.86 OC(CN1CCC(Cc2ccc(F)cc2)CC1)c1ccc(Cl)cc1 Homo sapiens CHEMBL3390297 cell-based format
CHEMBL220660 OBDepict O N O HN N N Ki = 14.0 nM 326.4 O=C(OCc1ccccc1)N1CCC(CNc2cnccn2)CC1 Homo sapiens CHEMBL856830 cell-based format
CHEMBL49623 OBDepict OH HO H N CH 3 H Ki = 14.4 nM 325.45 C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 Homo sapiens CHEMBL4713189 cell membrane format
CHEMBL4287203 OBDepict CH 3 O H OH H N H Ki = 16.0 nM 325.45 COc1ccc2c(c1)CC[C@H](NCCCc1ccccc1)C[C@@H]2O Homo sapiens CHEMBL4261991 cell-based format
CHEMBL4294561 OBDepict CH 3 O H OH H N H Ki = 16.0 nM 325.45 COc1ccc2c(c1)CC[C@@H](NCCCc1ccccc1)C[C@H]2O Homo sapiens CHEMBL4254520 cell-based format
CHEMBL159818 OBDepict Cl HN NH Cl Cl Ki = 16.0 nM 313.62 N=C(NCc1cccc(Cl)c1)c1ccc(Cl)c(Cl)c1 Homo sapiens CHEMBL749675 cell-based format
CHEMBL296601 OBDepict N H Ki = 16.0 nM 279.43 c1ccc(CCCNC2CCc3ccccc3CC2)cc1 Homo sapiens CHEMBL3390297 cell-based format
CHEMBL3357783 OBDepict H 3 C O HO N H Ki = 16.0 nM 325.45 COc1ccc2c(c1)CCC(NCCCc1ccccc1)CC2O Homo sapiens CHEMBL3390297 cell-based format
CHEMBL4283845 OBDepict F N H Ki = 17.0 nM 297.42 FC(CNC1CCc2ccccc2CC1)Cc1ccccc1 Homo sapiens CHEMBL4261991 cell-based format
CHEMBL3357787 OBDepict N H Ki = 17.0 nM 293.45 c1ccc(CCCCNC2CCc3ccccc3CC2)cc1 Homo sapiens CHEMBL3390297 cell-based format
CHEMBL218275 OBDepict F O N O NH N N Ki = 18.0 nM 344.39 O=C(OCc1ccc(F)cc1)N1CCC(CNc2ncccn2)CC1 Homo sapiens CHEMBL856830 cell-based format
CHEMBL221605 OBDepict O N O F N H N N Ki = 18.0 nM 344.39 O=C(OCc1ccccc1F)N1CCC(CNc2ncccn2)CC1 Homo sapiens CHEMBL856830 cell-based format
CHEMBL159558 OBDepict Cl HN NH F F F Ki = 20.0 nM 312.72 N=C(NCc1cccc(Cl)c1)c1ccc(C(F)(F)F)cc1 Homo sapiens CHEMBL749675 cell-based format
CHEMBL3357786 OBDepict N H Ki = 20.0 nM 265.4 c1ccc(CCNC2CCc3ccccc3CC2)cc1 Homo sapiens CHEMBL3390297 cell-based format
CHEMBL305187 OBDepict OH OH N CH 3 IC50 = 20.0 nM 325.45 CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 Homo sapiens CHEMBL3108300 single protein format
CHEMBL4284348 OBDepict OH N H Ki = 21.0 nM 309.45 Oc1ccc2c(c1)CCC(NCCCCc1ccccc1)CC2 Homo sapiens CHEMBL4254520 cell-based format
CHEMBL435316 OBDepict O N O HN N N Ki = 23.0 nM 326.4 O=C(OCc1ccccc1)N1CCC(CNc2ncccn2)CC1 Homo sapiens CHEMBL856830 cell-based format
CHEMBL221133 OBDepict O N O N H N N Ki = 23.0 nM 352.44 O=C(OC1Cc2ccccc2C1)N1CCC(CNc2ncccn2)CC1 Homo sapiens CHEMBL856830 cell-based format
CHEMBL349727 OBDepict CH 3 O N NH 2 O F F F Ki = 23.0 nM 324.3 COc1cccc(C/N=C(N)c2ccc(OC(F)(F)F)cc2)c1 Homo sapiens CHEMBL749675 cell-based format
CHEMBL4645300 OBDepict Br S N H Ki = 23.0 nM 378.38 Brc1cc2c(s1)CCC(NCCCCc1ccccc1)CC2 Homo sapiens CHEMBL4610803 cell-based format
CHEMBL3892956 OBDepict CH 3 N O H N H F H HO IC50 = 24.0 nM 382.48 Cc1ccc(CN2CC[C@@H](N3CC[C@@H](c4ccc(O)cc4)[C@H](F)C3)C2=O)cc1 Homo sapiens CHEMBL4149864 cell-based format
CHEMBL161180 OBDepict Cl Cl HN NH O F F F IC50 = 24.0 nM 363.17 N=C(NCc1cc(Cl)cc(Cl)c1)c1ccc(OC(F)(F)F)cc1 Homo sapiens CHEMBL749390 single protein format
CHEMBL4574247 OBDepict N H S Ki = 26.0 nM 257.4 c1ccc(CNC2CCc3ccsc3CC2)cc1 Homo sapiens CHEMBL4480642 cell-based format
CHEMBL4288292 OBDepict F N H Ki = 27.0 nM 311.44 FC(CCc1ccccc1)CNC1CCc2ccccc2CC1 Homo sapiens CHEMBL4261991 cell-based format
CHEMBL4286654 OBDepict OH N H Ki = 28.0 nM 295.43 Oc1ccc2c(c1)CCC(NCCCc1ccccc1)CC2 Homo sapiens CHEMBL4254520 cell-based format
CHEMBL219631 OBDepict F N + S _ O O N H O Ki = 30.0 nM 402.49 O=c1[nH]c2ccc([S+]([O-])CCN3CCC(Cc4ccc(F)cc4)CC3)cc2o1 Homo sapiens CHEMBL3804511 single protein format
CHEMBL4170858 OBDepict F H O N N Ki = 31.0 nM 414.61 FCC[C@H]1Cc2ccccc2C2(CCC(N3CCN(C4CCCCC4)CC3)CC2)O1 Homo sapiens CHEMBL4158754 cell-based format
CHEMBL159558 OBDepict Cl HN NH F F F IC50 = 32.0 nM 312.72 N=C(NCc1cccc(Cl)c1)c1ccc(C(F)(F)F)cc1 Homo sapiens CHEMBL749390 single protein format
CHEMBL4778291 OBDepict N Ki = 32.0 nM 293.45 c1ccc(CCCCN2CCCc3ccccc3CC2)cc1 Homo sapiens CHEMBL4685218 cell membrane format
CHEMBL4646841 OBDepict N H S Ki = 33.0 nM 271.43 c1ccc(CCNC2CCc3ccsc3CC2)cc1 Homo sapiens CHEMBL4610803 cell-based format
CHEMBL4641623 OBDepict H 3 C N S Ki = 33.0 nM 327.54 CCN(CCCCc1ccccc1)C1CCc2ccsc2CC1 Homo sapiens CHEMBL4610803 cell-based format
CHEMBL4169479 OBDepict H OH O N N Ki = 34.0 nM 384.56 O[C@H]1Cc2ccccc2C2(CCC(N3CCN(C4CCCCC4)CC3)CC2)O1 Homo sapiens CHEMBL4158754 cell-based format
CHEMBL4754021 OBDepict N Ki = 36.0 nM 279.43 c1ccc(CCCN2CCCc3ccccc3CC2)cc1 Homo sapiens CHEMBL4685218 cell membrane format
CHEMBL218017 OBDepict O N O HN N Ki = 37.0 nM 325.41 O=C(OCc1ccccc1)N1CCC(CNc2ccccn2)CC1 Homo sapiens CHEMBL856830 cell-based format
CHEMBL161421 OBDepict NH N H O F F F IC50 = 46.0 nM 294.28 N=C(NCc1ccccc1)c1ccc(OC(F)(F)F)cc1 Homo sapiens CHEMBL749390 single protein format
CHEMBL159279 OBDepict NH N H O F F F F F F IC50 = 47.0 nM 362.27 N=C(NCc1ccccc1C(F)(F)F)c1ccc(OC(F)(F)F)cc1 Homo sapiens CHEMBL749390 single protein format
CHEMBL421976 OBDepict NH N H Cl F F F IC50 = 48.0 nM 312.72 N=C(NCc1ccccc1Cl)c1ccc(C(F)(F)F)cc1 Homo sapiens CHEMBL749390 single protein format
CHEMBL4590193 OBDepict CH 3 O H OH H N H Ki = 48.0 nM 325.45 COc1ccc2c(c1)CC[C@H](NCCCc1ccccc1)C[C@H]2O Homo sapiens CHEMBL4480642 cell-based format
CHEMBL4648377 OBDepict CH 3 N S Ki = 51.0 nM 313.51 CCN(CCCc1ccccc1)C1CCc2ccsc2CC1 Homo sapiens CHEMBL4610803 cell-based format
CHEMBL4159233 OBDepict CH 3 O O H O N N Ki = 54.0 nM 454.66 CCOC(=O)C[C@H]1Cc2ccccc2C2(CCC(N3CCN(C4CCCCC4)CC3)CC2)O1 Homo sapiens CHEMBL4158754 cell-based format
CHEMBL421976 OBDepict NH N H Cl F F F Ki = 56.0 nM 312.72 N=C(NCc1ccccc1Cl)c1ccc(C(F)(F)F)cc1 Homo sapiens CHEMBL749675 cell-based format
CHEMBL161876 OBDepict NH N H Cl Cl O F F F IC50 = 57.0 nM 363.17 N=C(NCc1ccccc1OC(F)(F)F)c1ccc(Cl)c(Cl)c1 Homo sapiens CHEMBL749390 single protein format
CHEMBL3357785 OBDepict N H Ki = 57.0 nM 251.37 c1ccc(CNC2CCc3ccccc3CC2)cc1 Homo sapiens CHEMBL3390297 cell-based format
CHEMBL4643805 OBDepict CH 3 H 3 C N N O O Ki = 59.0 nM 362.47 Cc1ccc(CN2CCCN(C(=O)c3cc4ccccc4o3)CC2)c(C)c1 Homo sapiens CHEMBL4615566 cell-based format
CHEMBL4649725 OBDepict OH S N H Ki = 60.0 nM 377.55 Oc1ccc(-c2cc3c(s2)CCC(NCCCc2ccccc2)CC3)cc1 Homo sapiens CHEMBL4610803 cell-based format
CHEMBL4647186 OBDepict H 3 C N S Ki = 61.0 nM 285.46 CCN(Cc1ccccc1)C1CCc2ccsc2CC1 Homo sapiens CHEMBL4610803 cell-based format
CHEMBL161871 OBDepict Cl N H NH Cl Ki = 63.0 nM 279.17 N=C(NCc1cccc(Cl)c1)c1ccc(Cl)cc1 Homo sapiens CHEMBL749675 cell-based format
CHEMBL4170683 OBDepict F H O N N Ki = 65.0 nM 414.61 FCC[C@@H]1Cc2ccccc2C2(CCC(N3CCN(C4CCCCC4)CC3)CC2)O1 Homo sapiens CHEMBL4158754 cell-based format
CHEMBL429475 OBDepict Cl NH N Cl O F F F Ki = 66.0 nM 375.18 FC(F)(F)Oc1ccc(C2=NCC(c3cccc(Cl)c3)N2)cc1Cl Homo sapiens CHEMBL887786 single protein format
CHEMBL4800530 OBDepict NH Ki = 66.0 nM 265.4 c1ccc(CCCCNC2Cc3ccccc3C2)cc1 Homo sapiens CHEMBL4685218 cell membrane format
CHEMBL159279 OBDepict NH N H O F F F F F F Ki = 72.0 nM 362.27 N=C(NCc1ccccc1C(F)(F)F)c1ccc(OC(F)(F)F)cc1 Homo sapiens CHEMBL749675 cell-based format