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Q13255 | GRM1_HUMAN | Metabotropic glutamate receptor 1 (GRM1)

3D structures mapped by conservation among orthologs

[ Domain: "Periplasmic binding protein-like I" // ANF_receptor_2nd_1 ]

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[ Domain: "Family A G protein-coupled receptor-like" // 7tm_3 ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL174588 OBDepict CH 3 O H H O N O Ki = 0.34 nM 325.41 CO[C@H]1CC[C@@H](C(=O)c2ccc3nc4c(cc3c2)CCCO4)CC1 Homo sapiens CHEMBL1647365 single protein format
CHEMBL1645349 OBDepict H 3 C N O N N H 3 C N F N Ki = 0.4 nM 350.39 CCCN1Cc2cc(-c3nnn(-c4cccnc4[18F])c3C)ccc2C1=O Homo sapiens CHEMBL1647365 single protein format
CHEMBL174588 OBDepict CH 3 O H H O N O IC50 = 0.55 nM 325.41 CO[C@H]1CC[C@@H](C(=O)c2ccc3nc4c(cc3c2)CCCO4)CC1 Homo sapiens CHEMBL874546 single protein format
CHEMBL178690 OBDepict CH 3 O H H O N IC50 = 0.56 nM 309.41 CO[C@H]1CC[C@@H](C(=O)c2ccc3nc4c(cc3c2)CCC4)CC1 Homo sapiens CHEMBL874546 single protein format
CHEMBL1645348 OBDepict H 3 C O H H O N CH 3 H H H Ki = 0.87 nM 310.43 CCc1cc2cc(C(=O)[C@H]3CC[C@@H](OC)CC3)ccc2nc1[11CH3] Homo sapiens CHEMBL1647365 single protein format
CHEMBL2112967 OBDepict CH 3 O H H O N H 2 N H 3 C IC50 = 1.0 nM 312.41 CCc1cc2cc(C(=O)[C@H]3CC[C@@H](OC)CC3)ccc2nc1N Homo sapiens CHEMBL874546 single protein format
CHEMBL175463 OBDepict CH 3 O H H O N S IC50 = 2.0 nM 327.45 CO[C@H]1CC[C@@H](C(=O)c2ccc3nc4c(cc3c2)CCS4)CC1 Homo sapiens CHEMBL874546 single protein format
CHEMBL176279 OBDepict CH 3 N O H H O H 3 C IC50 = 3.0 nM 311.43 CCCc1ccc2cc(C(=O)[C@H]3CC[C@@H](OC)CC3)ccc2n1 Homo sapiens CHEMBL874546 single protein format
CHEMBL1645352 OBDepict H 3 C N N N F N N IC50 = 3.6 nM 305.32 Cc1c(-c2ccc3ncccc3c2)nnn1-c1cccnc1F Homo sapiens CHEMBL1647364 single protein format
CHEMBL1645350 OBDepict CH 3 N H 3 C H 3 C N O N N CH 3 N F N Ki = 3.9 nM 357.42 Cc1c(C2=CCN(C(=O)N(C)C(C)C)CC2)nnn1-c1cccnc1[18F] Homo sapiens CHEMBL1647365 single protein format
CHEMBL178592 OBDepict H 3 C O O N Cl CH 3 IC50 = 4.0 nM 331.84 CCc1cc2cc(C(=O)C3CCC(OC)CC3)ccc2nc1Cl Homo sapiens CHEMBL874546 single protein format
CHEMBL1645351 OBDepict CH 3 O N H H H N N S N O H 3 C Ki = 4.8 nM 413.58 COCCN([11CH3])Cc1ccc2nc3sc(C(=O)N(C)C4CCCCC4)cn3c2c1 Homo sapiens CHEMBL1647365 single protein format
CHEMBL1771388 OBDepict CH 3 O N CH 3 N N S N O H H H Ki = 4.8 nM 413.58 COCCN(C)Cc1ccc2nc3sc(C(=O)N([11CH3])C4CCCCC4)cn3c2c1 Homo sapiens CHEMBL1772533 single protein format
CHEMBL360728 OBDepict CH 3 H 3 C N O H H O H 3 C IC50 = 6.0 nM 325.45 CCCc1cc2cc(C(=O)[C@H]3CC[C@@H](OC)CC3)ccc2nc1C Homo sapiens CHEMBL874546 single protein format
CHEMBL177519 OBDepict CH 3 H 3 C N O O O IC50 = 7.0 nM 333.39 CCc1cc2cc(C(=O)C3COc4ccccc4O3)ccc2nc1C Homo sapiens CHEMBL874546 single protein format
CHEMBL175377 OBDepict CH 3 O O N CH 3 H 3 C IC50 = 8.0 nM 325.45 CCc1cc2cc(C(=O)C3CCC(OC)CC3)ccc2nc1CC Homo sapiens CHEMBL874546 single protein format
CHEMBL2112964 OBDepict CH 3 O H H O N F H 3 C IC50 = 9.0 nM 315.39 CCc1cc2cc(C(=O)[C@H]3CC[C@@H](OC)CC3)ccc2nc1F Homo sapiens CHEMBL874546 single protein format
CHEMBL369459 OBDepict O N O IC50 = 14.0 nM 303.36 O=C(Cc1ccccc1)c1ccc2nc3c(cc2c1)CCCO3 Homo sapiens CHEMBL874546 single protein format
CHEMBL2112048 OBDepict O H H CH 3 N IC50 = 16.0 nM 321.46 C[C@H]1CC[C@@H](C(=O)c2ccc3nc4c(cc3c2)CCCCC4)CC1 Homo sapiens CHEMBL874546 single protein format
CHEMBL178741 OBDepict CH 3 O H H O N IC50 = 18.0 nM 337.46 CO[C@H]1CC[C@@H](C(=O)c2ccc3nc4c(cc3c2)CCCCC4)CC1 Homo sapiens CHEMBL874546 single protein format
CHEMBL174216 OBDepict CH 3 O H H O N N H 3 C IC50 = 29.0 nM 338.45 CO[C@H]1CC[C@@H](C(=O)c2ccc3nc4c(cc3c2)CCCN4C)CC1 Homo sapiens CHEMBL874546 single protein format
CHEMBL177586 OBDepict CH 3 H 3 C N O IC50 = 51.0 nM 289.38 CCc1cc2cc(C(=O)Cc3ccccc3)ccc2nc1C Homo sapiens CHEMBL874546 single protein format
CHEMBL177043 OBDepict H 3 C O O N I CH 3 IC50 = 62.0 nM 423.29 CCc1cc2cc(C(=O)C3CCC(OC)CC3)ccc2nc1I Homo sapiens CHEMBL874546 single protein format
CHEMBL178742 OBDepict O S N O IC50 = 74.0 nM 309.39 O=C(Cc1ccsc1)c1ccc2nc3c(cc2c1)CCCO3 Homo sapiens CHEMBL874546 single protein format
CHEMBL177585 OBDepict CH 3 CH 3 N O HO IC50 = 80.0 nM 297.4 CCc1cc2cc(C(=O)C3CCC(O)CC3)ccc2nc1C Homo sapiens CHEMBL874546 single protein format
CHEMBL175699 OBDepict H 3 C O H H O N CH 3 CH 3 IC50 = 85.0 nM 325.45 CCc1cc2cc(C(=O)C[C@H]3CC[C@@H](OC)CC3)ccc2nc1C Homo sapiens CHEMBL874546 single protein format
CHEMBL441844 OBDepict H 3 C O O N OH CH 3 IC50 = 85.0 nM 313.4 CCc1cc2cc(C(=O)C3CCC(OC)CC3)ccc2nc1O Homo sapiens CHEMBL874546 single protein format
CHEMBL175643 OBDepict CH 3 O O N O CH 3 H 3 C IC50 = 94.0 nM 327.42 CCc1cc2cc(C(=O)C3CCC(OC)CC3)ccc2nc1OC Homo sapiens CHEMBL874546 single protein format
CHEMBL367227 OBDepict CH 3 O N H N CH 3 O O H 3 C IC50 = 105.0 nM 370.49 CCc1cc2cc(C(=O)C3CCC(OC)CC3)ccc2nc1NCCOC Homo sapiens CHEMBL874546 single protein format
CHEMBL556070 OBDepict O N N O Ki = 110.0 nM 366.51 O=C(C1CC1c1ccc(N2CCOCC2)nc1)C12CC3CC(CC(C3)C1)C2 Homo sapiens CHEMBL1063423 single protein format
CHEMBL353547 OBDepict O N O IC50 = 160.0 nM 317.39 O=C(CCc1ccccc1)c1ccc2nc3c(cc2c1)CCCO3 Homo sapiens CHEMBL874546 single protein format
CHEMBL2112963 OBDepict H 3 C O H H O N CH 3 N IC50 = 174.0 nM 322.41 CCc1cc2cc(C(=O)[C@H]3CC[C@@H](OC)CC3)ccc2nc1C#N Homo sapiens CHEMBL874546 single protein format
CHEMBL2112965 OBDepict H 3 C O H H O N H 3 C S IC50 = 191.0 nM 379.53 CCc1cc2cc(C(=O)[C@H]3CC[C@@H](OC)CC3)ccc2nc1-c1ccsc1 Homo sapiens CHEMBL874546 single protein format
CHEMBL575060 OBDepict OH O NH 2 H O OH Ki = 250.0 nM 147.13 N[C@@H](CCC(=O)O)C(=O)O Homo sapiens CHEMBL895144 cell-based format
CHEMBL176068 OBDepict H 3 C O H H O N N N N CH 3 IC50 = 450.0 nM 338.41 CCc1cc2cc(C(=O)[C@H]3CC[C@@H](OC)CC3)ccc2n2nnnc12 Homo sapiens CHEMBL874546 single protein format