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Q13370 | PDE3B_HUMAN | "cGMP-inhibited 3',5'-cyclic phosphodiesterase B" (PDE3B)

3D structures mapped by conservation among orthologs

[ Domain: "HD-domain/PDEase-like" // PDEase_I ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL338860 OBDepict O N H N H H 3 C N H O + N O _ O IC50 = 0.049 nM 508.58 C[C@@H]1CC(=O)NN=C1c1ccc(NC2=C(Cc3ccccc3-c3cccc([N+](=O)[O-])c3)C(=O)CCC2)cc1 Homo sapiens CHEMBL761482 assay format
CHEMBL339210 OBDepict O N H N H H 3 C N H O S IC50 = 0.068 nM 469.61 C[C@@H]1CC(=O)NN=C1c1ccc(NC2=C(Cc3ccccc3-c3ccsc3)C(=O)CCC2)cc1 Homo sapiens CHEMBL761482 assay format
CHEMBL131355 OBDepict O NH N H 3 C N H O I IC50 = 0.11 nM 513.38 CC1CC(=O)NN=C1c1ccc(NC2=C(Cc3cccc(I)c3)C(=O)CCC2)cc1 Homo sapiens CHEMBL761482 assay format
CHEMBL129668 OBDepict O NH Cl Cl F N HN CH 3 CH 3 O IC50 = 0.13 nM 474.36 CC1(C)C(=O)NN=C1c1ccc(NC2=C(Cc3c(Cl)cccc3Cl)C(=O)CCC2)cc1F Homo sapiens CHEMBL761482 assay format
CHEMBL131111 OBDepict CH 3 O O N H N HN CH 3 O IC50 = 0.13 nM 417.51 COc1ccccc1CC1=C(Nc2ccc(C3=NNC(=O)CC3C)cc2)CCCC1=O Homo sapiens CHEMBL761482 assay format
CHEMBL128456 OBDepict O NH N H H 3 C NH O IC50 = 0.19 nM 387.48 C[C@@H]1CC(=O)NN=C1c1ccc(NC2=C(Cc3ccccc3)C(=O)CCC2)cc1 Homo sapiens CHEMBL761482 assay format
CHEMBL338179 OBDepict O NH N H 3 C F N H O IC50 = 0.24 nM 405.47 CC1CC(=O)NN=C1c1ccc(NC2=C(Cc3ccccc3)C(=O)CCC2)cc1F Homo sapiens CHEMBL761482 assay format
CHEMBL128391 OBDepict O N H N CH 3 F N HO IC50 = 0.26 nM 405.47 CC1CC(=O)NN=C1c1ccc(/N=C2CCCC(O)=C2Cc2ccccc2)c(F)c1 Homo sapiens CHEMBL761482 assay format
CHEMBL128621 OBDepict O NH N H 3 C N H O Br IC50 = 0.3 nM 466.38 CC1CC(=O)NN=C1c1ccc(NC2=C(Cc3cccc(Br)c3)C(=O)CCC2)cc1 Homo sapiens CHEMBL761482 assay format
CHEMBL129283 OBDepict N OH N F F N HN CH 3 CH 3 O IC50 = 0.33 nM 448.47 CC1(C)C(=O)NN=C1c1ccc(/N=C2CCCC(O)=C2Cc2cccc(C#N)c2)c(F)c1F Homo sapiens CHEMBL761482 assay format
CHEMBL338381 OBDepict O N H N CH 3 N H O F F F IC50 = 0.35 nM 455.48 CC1CC(=O)NN=C1c1ccc(NC2=C(Cc3ccccc3C(F)(F)F)C(=O)CCC2)cc1 Homo sapiens CHEMBL761482 assay format
CHEMBL130081 OBDepict O HN Cl F N NH H 3 C H 3 C O IC50 = 0.53 nM 439.92 CC1(C)C(=O)NN=C1c1ccc(NC2=C(Cc3ccccc3Cl)C(=O)CCC2)cc1F Homo sapiens CHEMBL761482 assay format
CHEMBL131939 OBDepict O NH N H 3 C CH 3 N HO IC50 = 0.61 nM 401.51 Cc1cc(C2=NNC(=O)CC2C)ccc1/N=C1CCCC(O)=C1Cc1ccccc1 Homo sapiens CHEMBL761482 assay format
CHEMBL130026 OBDepict O N H N CH 3 F F N H O IC50 = 0.62 nM 423.46 CC1CC(=O)NN=C1c1cc(F)c(NC2=C(Cc3ccccc3)C(=O)CCC2)cc1F Homo sapiens CHEMBL761482 assay format
CHEMBL129255 OBDepict H 3 C O O NH N N H CH 3 O IC50 = 0.7 nM 417.51 COc1ccc(CC2=C(Nc3ccc(C4=NNC(=O)CC4C)cc3)CCCC2=O)cc1 Homo sapiens CHEMBL761482 assay format
CHEMBL341231 OBDepict O NH N H 3 C N H O F IC50 = 0.7 nM 405.47 CC1CC(=O)NN=C1c1ccc(NC2=C(Cc3cccc(F)c3)C(=O)CCC2)cc1 Homo sapiens CHEMBL761482 assay format
CHEMBL341354 OBDepict O HN N CH 3 N H O + N O _ O IC50 = 0.94 nM 432.48 CC1CC(=O)NN=C1c1ccc(NC2=C(Cc3cccc([N+](=O)[O-])c3)C(=O)CCC2)cc1 Homo sapiens CHEMBL761482 assay format
CHEMBL129692 OBDepict CH 3 N O HN HN O O IC50 = 1.0 nM 337.38 CC1CC(=O)NN=C1c1ccc(NC(=O)OCc2ccccc2)cc1 Homo sapiens CHEMBL761482 assay format
CHEMBL131672 OBDepict O HN F F N NH H 3 C H 3 C O IC50 = 1.1 nM 423.46 CC1(C)C(=O)NN=C1c1ccc(NC2=C(Cc3ccccc3F)C(=O)CCC2)cc1F Homo sapiens CHEMBL761482 assay format
CHEMBL128485 OBDepict O N H F N NH H 3 C H 3 C O IC50 = 2.5 nM 405.47 CC1(C)C(=O)NN=C1c1ccc(NC2=C(Cc3ccccc3)C(=O)CCC2)cc1F Homo sapiens CHEMBL761482 assay format
CHEMBL421249 OBDepict O N H N CH 3 CH 3 N H O IC50 = 2.6 nM 401.51 Cc1cc(NC2=C(Cc3ccccc3)C(=O)CCC2)ccc1C1=NNC(=O)CC1C Homo sapiens CHEMBL761482 assay format
CHEMBL128263 OBDepict F O HN F N NH H 3 C H 3 C O IC50 = 3.1 nM 423.46 CC1(C)C(=O)NN=C1c1ccc(NC2=C(Cc3ccc(F)cc3)C(=O)CCC2)cc1F Homo sapiens CHEMBL761482 assay format
CHEMBL128877 OBDepict N O N H F N NH H 3 C H 3 C O IC50 = 3.2 nM 430.48 CC1(C)C(=O)NN=C1c1ccc(NC2=C(Cc3cccc(C#N)c3)C(=O)CCC2)cc1F Homo sapiens CHEMBL761482 assay format
CHEMBL129600 OBDepict O HN + N O _ O F N NH H 3 C H 3 C O IC50 = 4.5 nM 450.47 CC1(C)C(=O)NN=C1c1ccc(NC2=C(Cc3cccc([N+](=O)[O-])c3)C(=O)CCC2)cc1F Homo sapiens CHEMBL761482 assay format
CHEMBL128783 OBDepict O NH N H 3 C Cl N H O IC50 = 4.8 nM 421.93 CC1CC(=O)NN=C1c1ccc(NC2=C(Cc3ccccc3)C(=O)CCC2)cc1Cl Homo sapiens CHEMBL761482 assay format
CHEMBL129689 OBDepict O N H CH 3 N N H CH 3 H 3 C O IC50 = 4.8 nM 401.51 Cc1cc(NC2=C(Cc3ccccc3)C(=O)CCC2)ccc1C1=NNC(=O)C1(C)C Homo sapiens CHEMBL761482 assay format
CHEMBL4877229 OBDepict CH 3 O F F F N N H H H 3 C O O IC50 = 5.0 nM 316.28 CCCOc1ccc(C2=NNC(=O)O[C@H]2C)cc1C(F)(F)F Homo sapiens CHEMBL4827629 cell-based format
CHEMBL4876937 OBDepict O N H O N H H 3 C O F F F F F F IC50 = 5.0 nM 370.25 C[C@@H]1OC(=O)NN=C1c1ccc(OCCC(F)(F)F)c(C(F)(F)F)c1 Homo sapiens CHEMBL4827629 cell-based format
CHEMBL128017 OBDepict O N H N H H 3 C N H O F F F IC50 = 5.0 nM 375.35 C[C@@H]1CC(=O)NN=C1c1ccc(NC(=O)c2ccccc2C(F)(F)F)cc1 Homo sapiens CHEMBL761482 assay format
CHEMBL128338 OBDepict O NH N H 3 C N H O + N O _ O IC50 = 5.5 nM 432.48 CC1CC(=O)NN=C1c1ccc(NC2=C(Cc3ccc([N+](=O)[O-])cc3)C(=O)CCC2)cc1 Homo sapiens CHEMBL761482 assay format
CHEMBL129407 OBDepict F O N H F N NH H 3 C H 3 C O IC50 = 5.6 nM 423.46 CC1(C)C(=O)NN=C1c1ccc(NC2=C(Cc3cccc(F)c3)C(=O)CCC2)cc1F Homo sapiens CHEMBL761482 assay format
CHEMBL340118 OBDepict O HN Cl Cl N NH H 3 C H 3 C O IC50 = 6.3 nM 456.37 CC1(C)C(=O)NN=C1c1ccc(NC2=C(Cc3ccccc3Cl)C(=O)CCC2)cc1Cl Homo sapiens CHEMBL761482 assay format
CHEMBL4862024 OBDepict CH 3 O F F F N N H H H 3 C O O IC50 = 7.0 nM 302.25 CCOc1ccc(C2=NNC(=O)O[C@H]2C)cc1C(F)(F)F Homo sapiens CHEMBL4827629 cell-based format
CHEMBL129691 OBDepict H 3 C O NH O N HN H CH 3 O IC50 = 8.5 nM 275.31 CCOC(=O)Nc1ccc(C2=NNC(=O)C[C@H]2C)cc1 Homo sapiens CHEMBL761482 assay format
CHEMBL341327 OBDepict O HN N H CH 3 N H CH 3 O IC50 = 8.8 nM 311.39 CC1=C(Nc2ccc(C3=NNC(=O)C[C@H]3C)cc2)CCCC1=O Homo sapiens CHEMBL761482 assay format
CHEMBL4853029 OBDepict O N H O N H H 3 C O F F F F CH 3 H IC50 = 9.0 nM 334.27 C[C@@H]1OC(=O)NN=C1c1ccc(OC[C@@H](C)F)c(C(F)(F)F)c1 Homo sapiens CHEMBL4827629 cell-based format
CHEMBL128619 OBDepict O N H N NH H 3 C H 3 C O IC50 = 10.0 nM 387.48 CC1(C)C(=O)NN=C1c1ccc(NC2=C(Cc3ccccc3)C(=O)CCC2)cc1 Homo sapiens CHEMBL761482 assay format
CHEMBL341160 OBDepict N O N H CH 3 N N H CH 3 H 3 C O IC50 = 10.0 nM 426.52 Cc1cc(NC2=C(Cc3cccc(C#N)c3)C(=O)CCC2)ccc1C1=NNC(=O)C1(C)C Homo sapiens CHEMBL761482 assay format
CHEMBL34431 OBDepict O N CH 3 O N HO IC50 = 18.0 nM 342.44 CN(C(=O)CCCOc1ccc2nc(O)ccc2c1)C1CCCCC1 Homo sapiens CHEMBL761482 assay format
CHEMBL131118 OBDepict CH 3 N H N N H CH 3 O O IC50 = 21.0 nM 415.54 CCc1cc(NC2=C(Cc3ccccc3)C(=O)CCC2)ccc1C1=NNC(=O)CC1C Homo sapiens CHEMBL761482 assay format
CHEMBL273816 OBDepict O HN + N O _ O Cl N NH H 3 C H 3 C O IC50 = 30.0 nM 466.93 CC1(C)C(=O)NN=C1c1ccc(NC2=C(Cc3cccc([N+](=O)[O-])c3)C(=O)CCC2)cc1Cl Homo sapiens CHEMBL761482 assay format
CHEMBL340785 OBDepict CH 3 N H O N N H H H 3 C O IC50 = 37.0 nM 245.28 CC(=O)Nc1ccc(C2=NNC(=O)C[C@H]2C)cc1 Homo sapiens CHEMBL761482 assay format
CHEMBL263642 OBDepict CH 3 O O CH 3 N N N H O Ki = 56.0 nM 401.47 COc1cc2ncnc(N3CC[C@@H](Oc4cccc5ccccc45)C3)c2cc1OC Homo sapiens CHEMBL909388 cell-based format
CHEMBL4751598 OBDepict O N S N N N F F IC50 = 78.0 nM 416.5 O=C(c1cc2c(s1)CCCC2)N1CCCC(c2cc(C(F)F)nc3ccnn23)C1 Homo sapiens CHEMBL4672635 cell-based format
CHEMBL219451 OBDepict CH 3 O O H N N N O CH 3 O CH 3 Ki = 88.0 nM 395.46 CCOc1cccc(O[C@@H]2CCN(c3ncnc4cc(OC)c(OC)cc34)C2)c1 Homo sapiens CHEMBL909388 cell-based format
CHEMBL2431826 OBDepict N N N N N H 3 C H N IC50 = 88.0 nM 376.42 C[C@@H](c1ccc2ncccc2c1)c1nnc2ccc(-c3cccc(C#N)c3)nn12 Homo sapiens CHEMBL2433333 single protein format
CHEMBL1683806 OBDepict CH 3 S N H O O N CH 3 N H CH 3 CH 3 O IC50 = 88.4 nM 371.46 C/C(=NNS(=O)(=O)c1ccc(C)cc1)c1ccc2c(c1)C(C)(C)C(=O)N2 Homo sapiens CHEMBL1685984 single protein format
CHEMBL262088 OBDepict CH 3 O O CH 3 N N N H O CH 3 Ki < 100.0 nM 365.43 COc1cc2ncnc(N3CC[C@@H](Oc4ccccc4C)C3)c2cc1OC Homo sapiens CHEMBL909388 cell-based format
CHEMBL409484 OBDepict CH 3 O O CH 3 N N N H O N Ki < 100.0 nM 376.42 COc1cc2ncnc(N3CC[C@@H](Oc4ccccc4C#N)C3)c2cc1OC Homo sapiens CHEMBL909388 cell-based format
CHEMBL408978 OBDepict CH 3 O O CH 3 N N N H O Cl Ki < 100.0 nM 385.85 COc1cc2ncnc(N3CC[C@@H](Oc4ccccc4Cl)C3)c2cc1OC Homo sapiens CHEMBL909388 cell-based format
CHEMBL2431822 OBDepict F F N N N N CH 3 H N IC50 = 107.0 nM 387.39 C[C@@H](c1ccc2ncccc2c1)c1nnc2ccc(-c3ccc(F)c(F)c3)nn12 Homo sapiens CHEMBL2433333 single protein format
CHEMBL4746828 OBDepict CH 3 O N N N N N O S IC50 = 115.0 nM 397.5 COc1cc(C2CCCN(C(=O)c3cc4c(s3)CCCC4)C2)n2ncnc2n1 Homo sapiens CHEMBL4672635 cell-based format
CHEMBL2431819 OBDepict H 3 C N N N N N N H 3 C H N IC50 = 150.0 nM 355.41 C[C@@H](c1ccc2ncccc2c1)c1nnc2ccc(-c3cnn(C)c3)nn12 Homo sapiens CHEMBL2433333 single protein format
CHEMBL4282274 OBDepict CH 3 O O CH 3 N N N H O F F F N IC50 = 169.0 nM 404.35 COc1ccc(-c2nc(C(F)(F)F)ncc2C(=O)Nc2ccncc2)cc1OC Homo sapiens CHEMBL4255147 cell-based format
CHEMBL220185 OBDepict CH 3 O O CH 3 N N N H O N Ki = 196.0 nM 402.45 COc1cc2ncnc(N3CC[C@@H](Oc4cc5ccccc5cn4)C3)c2cc1OC Homo sapiens CHEMBL909388 cell-based format
CHEMBL263641 OBDepict CH 3 O O CH 3 N N N H O N Ki = 201.0 nM 402.45 COc1cc2ncnc(N3CC[C@@H](Oc4ccc5ncccc5c4)C3)c2cc1OC Homo sapiens CHEMBL909388 cell-based format
CHEMBL260006 OBDepict CH 3 O O CH 3 N N N H O N Ki = 207.0 nM 352.39 COc1cc2ncnc(N3CC[C@@H](Oc4ccccn4)C3)c2cc1OC Homo sapiens CHEMBL909388 cell-based format
CHEMBL409651 OBDepict CH 3 O O CH 3 N N N H O N H 3 C Ki = 223.0 nM 416.48 COc1cc2ncnc(N3CC[C@@H](Oc4ccc5nc(C)ccc5c4)C3)c2cc1OC Homo sapiens CHEMBL909388 cell-based format
CHEMBL408977 OBDepict CH 3 O O CH 3 N N N H O Ki = 237.0 nM 391.47 COc1cc2ncnc(N3CC[C@@H](Oc4ccc5c(c4)CCC5)C3)c2cc1OC Homo sapiens CHEMBL909388 cell-based format
CHEMBL409613 OBDepict CH 3 O O CH 3 N N N H O N Ki = 240.0 nM 402.45 COc1cc2ncnc(N3CC[C@@H](Oc4ccc5cccnc5c4)C3)c2cc1OC Homo sapiens CHEMBL909388 cell-based format
CHEMBL275084 OBDepict H 3 C CH 3 N O N N H 3 C H N O IC50 = 242.0 nM 222.25 CC(C)Cn1c(=O)n(C)c(=O)c2nc[nH]c21 Homo sapiens CHEMBL4425307 cell-based format
CHEMBL409862 OBDepict CH 3 O O CH 3 O H N N N O CH 3 O CH 3 Ki = 260.0 nM 411.46 COc1ccc(O[C@@H]2CCN(c3ncnc4cc(OC)c(OC)cc34)C2)cc1OC Homo sapiens CHEMBL909388 cell-based format
CHEMBL219445 OBDepict CH 3 O O CH 3 N N N H O N N Ki = 273.0 nM 403.44 COc1cc2ncnc(N3CC[C@@H](Oc4cnc5ccccc5n4)C3)c2cc1OC Homo sapiens CHEMBL909388 cell-based format
CHEMBL218855 OBDepict CH 3 O O CH 3 N N N H O Ki = 280.0 nM 427.5 COc1cc2ncnc(N3CC[C@@H](Oc4cccc(-c5ccccc5)c4)C3)c2cc1OC Homo sapiens CHEMBL909388 cell-based format
CHEMBL261711 OBDepict H 3 C O O H N N N O H 3 C O H 3 C Ki = 280.0 nM 431.49 COc1ccc2cc(O[C@@H]3CCN(c4ncnc5cc(OC)c(OC)cc45)C3)ccc2c1 Homo sapiens CHEMBL909388 cell-based format
CHEMBL189 OBDepict N O N H CH 3 N IC50 = 280.0 nM 211.22 Cc1[nH]c(=O)c(C#N)cc1-c1ccncc1 Homo sapiens CHEMBL761482 assay format
CHEMBL218955 OBDepict CH 3 O O H N N N O CH 3 O CH 3 Ki = 305.0 nM 431.49 COc1ccc2ccc(O[C@@H]3CCN(c4ncnc5cc(OC)c(OC)cc45)C3)cc2c1 Homo sapiens CHEMBL909388 cell-based format
CHEMBL4278921 OBDepict CH 3 O O CH 3 N N N H O F F F Cl Cl N IC50 = 321.0 nM 473.24 COc1ccc(-c2nc(C(F)(F)F)ncc2C(=O)Nc2c(Cl)cncc2Cl)cc1OC Homo sapiens CHEMBL4255147 cell-based format
CHEMBL375200 OBDepict H 3 C O O H N N N O CH 3 O CH 3 Ki = 328.0 nM 395.46 CCOc1ccc(O[C@@H]2CCN(c3ncnc4cc(OC)c(OC)cc34)C2)cc1 Homo sapiens CHEMBL909388 cell-based format
CHEMBL385754 OBDepict CH 3 O O CH 3 N N N H O N N Cl Ki = 332.0 nM 387.83 COc1cc2ncnc(N3CC[C@@H](Oc4ncc(Cl)cn4)C3)c2cc1OC Homo sapiens CHEMBL909388 cell-based format
CHEMBL4764226 OBDepict H 3 C N N N N O S IC50 = 347.0 nM 380.52 Cc1cc(C2CCCN(C(=O)c3cc4c(s3)CCCC4)C2)n2ccnc2n1 Homo sapiens CHEMBL4672635 cell-based format
CHEMBL19224 OBDepict CH 3 O O CH 3 N O CH 3 O CH 3 Ki = 417.0 nM 339.39 COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC Homo sapiens CHEMBL909388 cell-based format
CHEMBL2431835 OBDepict HO N N N N N N N CH 3 H N IC50 = 420.0 nM 386.42 C[C@@H](c1ccc2ncccc2c1)n1nnc2ncc(-c3cnn(CCO)c3)nc21 Homo sapiens CHEMBL2433333 single protein format
CHEMBL410834 OBDepict CH 3 O O CH 3 N N N H O Ki = 463.0 nM 401.47 COc1cc2ncnc(N3CC[C@@H](Oc4ccc5ccccc5c4)C3)c2cc1OC Homo sapiens CHEMBL909388 cell-based format
CHEMBL441704 OBDepict CH 3 O O CH 3 N N N H O N Ki = 471.0 nM 376.42 COc1cc2ncnc(N3CC[C@@H](Oc4ccc(C#N)cc4)C3)c2cc1OC Homo sapiens CHEMBL909388 cell-based format
CHEMBL429686 OBDepict CH 3 O O CH 3 N N N H O CH 3 H 3 C Ki = 474.0 nM 393.49 COc1cc2ncnc(N3CC[C@@H](Oc4ccccc4C(C)C)C3)c2cc1OC Homo sapiens CHEMBL933709 single protein format
CHEMBL219123 OBDepict CH 3 O O CH 3 N N N H O CH 3 H 3 C Ki = 474.0 nM 393.49 COc1cc2ncnc(N3CC[C@@H](Oc4cccc(C(C)C)c4)C3)c2cc1OC Homo sapiens CHEMBL909388 cell-based format
CHEMBL4791830 OBDepict O N N N N N IC50 = 617.0 nM 313.41 O=C(C1CCCCC1)N1CCCC(c2ccnc3ncnn23)C1 Homo sapiens CHEMBL4672635 cell-based format
CHEMBL4761452 OBDepict N N N N N N O S IC50 = 676.0 nM 392.49 N#Cc1cc(C2CCCN(C(=O)c3cc4c(s3)CCCC4)C2)n2ncnc2n1 Homo sapiens CHEMBL4672635 cell-based format
CHEMBL259295 OBDepict CH 3 O O CH 3 N N N H O N Ki = 685.0 nM 352.39 COc1cc2ncnc(N3CC[C@@H](Oc4ccncc4)C3)c2cc1OC Homo sapiens CHEMBL909388 cell-based format
CHEMBL2431834 OBDepict H 3 C N N N N N N N H 3 C H N IC50 = 699.0 nM 356.39 C[C@@H](c1ccc2ncccc2c1)n1nnc2ncc(-c3cnn(C)c3)nc21 Homo sapiens CHEMBL2433333 single protein format
CHEMBL252387 OBDepict CH 3 O O N N CH 3 N N S O O H 3 C CH 3 IC50 = 720.0 nM 412.47 COc1ccc(OC)c(-c2nnc3n2N=C(c2ccc(OC)c(OC)c2)CS3)c1 Homo sapiens CHEMBL1036317 single protein format
CHEMBL374993 OBDepict CH 3 O O CH 3 N N N H O N Ki = 748.0 nM 352.39 COc1cc2ncnc(N3CC[C@@H](Oc4cccnc4)C3)c2cc1OC Homo sapiens CHEMBL909388 cell-based format
CHEMBL4284354 OBDepict CH 3 O O N H CH 3 O N N N S CH 3 O IC50 = 800.0 nM 390.47 COc1ccc(NC(=O)c2cnc(SC)nc2N2CCOCC2)cc1OC Homo sapiens CHEMBL4255147 cell-based format
CHEMBL592241 OBDepict OH N O O N CH 3 H O IC50 = 910.0 nM 392.46 Cc1cc(=O)[nH]c2ccc(OCc3cccc(C(=O)N4CCC(O)CC4)c3)cc12 Homo sapiens CHEMBL1065788 single protein format
CHEMBL4295242 OBDepict CH 3 O O N H CH 3 O N N N F F F O IC50 = 950.0 nM 412.37 COc1ccc(NC(=O)c2cnc(C(F)(F)F)nc2N2CCOCC2)cc1OC Homo sapiens CHEMBL4255147 cell-based format