HOME LIGAND hPROTEOME OTHERS DOCUMENT

Q13546 | RIPK1_HUMAN | Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)

3D structures mapped by conservation among orthologs

[ Domain: "DEATH domain" // Death ]

download pymol session

[ Domain: "Protein kinase" // Pkinase_Tyr ]

download pymol session



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4067372 OBDepict O N H N O H O O N H 3 C IC50 = 0.05 nM 377.4 CN1C(=O)[C@@H](NC(=O)c2ncc(Cc3ccccc3)o2)COc2ccccc21 Homo sapiens CHEMBL3999296 cell-based format
CHEMBL4093220 OBDepict O N H N N N N H O O N H 3 C IC50 = 0.079 nM 378.39 CN1C(=O)[C@@H](NC(=O)c2nnn(Cc3ccccc3)n2)COc2ccccc21 Homo sapiens CHEMBL3999296 cell-based format
CHEMBL3786997 OBDepict O N H N O H O N CH 3 IC50 = 0.2 nM 375.43 CN1C(=O)[C@@H](NC(=O)c2cc(Cc3ccccc3)on2)CCc2ccccc21 Homo sapiens CHEMBL3789114 single protein format
CHEMBL4068954 OBDepict H 3 C N H O N O H 3 C O H N H O N O IC50 = 0.32 nM 434.45 CC(=O)Nc1ccc2c(c1)N(C)C(=O)[C@@H](NC(=O)c1cc(Cc3ccccc3)on1)CO2 Homo sapiens CHEMBL3999296 cell-based format
CHEMBL4096224 OBDepict H 3 C O N H O N O H 3 C O H N H O N O IC50 = 0.32 nM 450.45 COC(=O)Nc1ccc2c(c1)N(C)C(=O)[C@@H](NC(=O)c1cc(Cc3ccccc3)on1)CO2 Homo sapiens CHEMBL3999296 cell-based format
CHEMBL4069318 OBDepict O N H N N H O O N CH 3 IC50 = 0.4 nM 376.42 CN1C(=O)[C@@H](NC(=O)c2cn(Cc3ccccc3)cn2)COc2ccccc21 Homo sapiens CHEMBL3999296 cell-based format
CHEMBL4060644 OBDepict O N H N N H CH 3 O O N H 3 C IC50 = 0.4 nM 390.44 CN1C(=O)[C@@H](NC(=O)c2cc(Cc3ccccc3)n(C)n2)COc2ccccc21 Homo sapiens CHEMBL3999296 cell-based format
CHEMBL4452233 OBDepict O N H H N H F O N N F N H IC50 = 0.4 nM 397.39 O=C(N[C@H]1CCc2cc(F)cc(F)c2NC1=O)c1n[nH]c(Cc2ccccc2)n1 Homo sapiens CHEMBL4305913 single protein format
CHEMBL3785482 OBDepict O N H N N H H O O N H 3 C IC50 = 0.4 nM 376.42 CN1C(=O)[C@@H](NC(=O)c2cc(Cc3ccccc3)[nH]n2)COc2ccccc21 Homo sapiens CHEMBL3789114 single protein format
CHEMBL4089558 OBDepict O N H 3 C H N H O O N O N O N O H IC50 = 0.5 nM 461.43 CN1C(=O)[C@@H](NC(=O)c2cc(Cc3ccccc3)on2)COc2ccc(-c3n[nH]c(=O)o3)cc21 Homo sapiens CHEMBL3999296 cell-based format
CHEMBL4099004 OBDepict O N H N N O H O O N H 3 C IC50 = 0.5 nM 378.39 CN1C(=O)[C@@H](NC(=O)c2noc(Cc3ccccc3)n2)COc2ccccc21 Homo sapiens CHEMBL3999296 cell-based format
CHEMBL4081685 OBDepict O N CH 3 H N H O O NH N S O O O H 3 C IC50 = 0.63 nM 470.51 CN1C(=O)[C@@H](NC(=O)c2cc(Cc3ccccc3)on2)COc2ccc(NS(C)(=O)=O)cc21 Homo sapiens CHEMBL3999296 cell-based format
CHEMBL4065561 OBDepict O N H N N N H O O N H 3 C IC50 = 0.63 nM 377.4 CN1C(=O)[C@@H](NC(=O)c2ncn(Cc3ccccc3)n2)COc2ccccc21 Homo sapiens CHEMBL3999296 cell-based format
CHEMBL3786078 OBDepict O N H N O H N H O N CH 3 IC50 = 0.79 nM 376.42 CN1C(=O)[C@@H](NC(=O)c2cc(Cc3ccccc3)on2)CNc2ccccc21 Homo sapiens CHEMBL3789105 single protein format
CHEMBL4088857 OBDepict O N H N O N H O O N H 3 C IC50 = 0.79 nM 378.39 CN1C(=O)[C@@H](NC(=O)c2nnc(Cc3ccccc3)o2)COc2ccccc21 Homo sapiens CHEMBL3999296 cell-based format
CHEMBL3785703 OBDepict O N H N O H O O N CH 3 Ki = 0.8 nM 377.4 CN1C(=O)[C@@H](NC(=O)c2cc(Cc3ccccc3)on2)COc2ccccc21 Homo sapiens CHEMBL3789111 single protein format
CHEMBL4439913 OBDepict H 3 C NH O N N O O H 3 C H 3 C CH 3 IC50 = 0.9 nM 365.43 CNC(=O)c1ccc2c(c1)ncn2-c1ccc(CC(=O)OC(C)(C)C)cc1 Homo sapiens CHEMBL4378744 single protein format
CHEMBL3785745 OBDepict O N H N O H S O N CH 3 IC50 = 0.94 nM 393.47 CN1C(=O)[C@@H](NC(=O)c2cc(Cc3ccccc3)on2)CSc2ccccc21 Homo sapiens CHEMBL3789105 single protein format
CHEMBL4080978 OBDepict O N H N N N H O O N CH 3 IC50 = 1.0 nM 377.4 CN1C(=O)[C@@H](NC(=O)c2cn(Cc3ccccc3)nn2)COc2ccccc21 Homo sapiens CHEMBL3999296 cell-based format
CHEMBL4099698 OBDepict O N H 3 C H N H O O N N O N H IC50 = 1.0 nM 443.46 CN1C(=O)[C@@H](NC(=O)c2cc(Cc3ccccc3)on2)COc2ccc(-c3cc[nH]n3)cc21 Homo sapiens CHEMBL3999296 cell-based format
CHEMBL4071864 OBDepict O N H N N N H H O O N H 3 C IC50 = 1.0 nM 377.4 CN1C(=O)[C@@H](NC(=O)c2n[nH]c(Cc3ccccc3)n2)COc2ccccc21 Homo sapiens CHEMBL3999296 cell-based format
CHEMBL4100398 OBDepict N O N H 3 C O H N O N N Cl IC50 = 1.3 nM 461.91 CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Cl)C2=O)COc2cc(C#N)ccc21 Homo sapiens CHEMBL4024006 cell-based format
CHEMBL4469781 OBDepict H 3 C S CH 3 O O N N H S N IC50 = 1.8 nM 383.5 CC(C)S(=O)(=O)c1ccc2nccc(Nc3ccc4ncsc4c3)c2c1 Homo sapiens CHEMBL4378744 single protein format
CHEMBL4071080 OBDepict O N H N H O O N CH 3 IC50 = 2.0 nM 387.44 CN1C(=O)[C@@H](NC(=O)c2cc(Cc3ccccc3)ccn2)COc2ccccc21 Homo sapiens CHEMBL3999296 cell-based format
CHEMBL3785703 OBDepict O N H N O H O O N CH 3 IC50 = 2.8 nM 377.4 CN1C(=O)[C@@H](NC(=O)c2cc(Cc3ccccc3)on2)COc2ccccc21 Homo sapiens CHEMBL3789354 cell-based format
CHEMBL3787689 OBDepict O N H N O H NH O N H IC50 = 3.2 nM 362.39 O=C(N[C@H]1CNc2ccccc2NC1=O)c1cc(Cc2ccccc2)on1 Homo sapiens CHEMBL3789105 single protein format
CHEMBL4554676 OBDepict O N H N N N H H O N H 3 C IC50 = 5.0 nM 375.43 CN1C(=O)[C@@H](NC(=O)c2n[nH]c(Cc3ccccc3)n2)CCc2ccccc21 Homo sapiens CHEMBL4305904 cell-based format
CHEMBL4069959 OBDepict O N H N O H N O N H 3 C CH 3 IC50 = 5.0 nM 390.44 CN1C[C@H](NC(=O)c2cc(Cc3ccccc3)on2)C(=O)N(C)c2ccccc21 Homo sapiens CHEMBL3999296 cell-based format
CHEMBL3109209 OBDepict O N H N H F F F F N H N N IC50 = 6.3 nM 491.45 O=C(Nc1cccc(-c2c[nH]c3ncc(-c4cccnc4)cc23)c1)Nc1cc(C(F)(F)F)ccc1F Homo sapiens CHEMBL3110728 cell-based format
CHEMBL4453758 OBDepict F F N H 3 C H N H O O N N N H IC50 = 6.3 nM 411.41 CN1C(=O)[C@@H](NC(=O)c2n[nH]c(Cc3ccccc3)n2)CCc2cc(F)cc(F)c21 Homo sapiens CHEMBL4305905 cell-based format
CHEMBL4441118 OBDepict CH 3 N N H 3 C N S H 2 N N S IC50 = 8.6 nM 377.5 Cc1cc(-c2cnc(N)c3c(-c4ccc5scnc5c4)csc23)n(C)n1 Homo sapiens CHEMBL4378744 single protein format
CHEMBL4474301 OBDepict O N N O IC50 = 10.0 nM 258.32 O=C(C1CCOCC1)N1N=CCC1c1ccccc1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4454462 OBDepict O N N H N N IC50 = 10.0 nM 334.42 O=C(C1CCN(c2ccccn2)CC1)N1N=CC[C@H]1c1ccccc1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4471642 OBDepict O N N IC50 = 10.0 nM 256.35 O=C(C1CCCCC1)N1N=CCC1c1ccccc1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4457026 OBDepict O N N IC50 = 10.0 nM 242.32 O=C(C1CCCC1)N1N=CCC1c1ccccc1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4436215 OBDepict CH 3 N N O CH 3 CH 3 H 3 C IC50 = 10.0 nM 244.34 Cc1ccc(C2CC=NN2C(=O)C(C)(C)C)cc1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4593226 OBDepict O N H 3 C CH 3 H 3 C N F F IC50 = 10.0 nM 266.29 CC(C)(C)C(=O)N1N=CCC1c1cc(F)cc(F)c1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4545939 OBDepict F F H N N O N N O N CH 3 IC50 = 10.0 nM 375.38 Cc1nnc(N2CCC(C(=O)N3N=CC[C@H]3c3cc(F)cc(F)c3)CC2)o1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4279118 OBDepict O N O N F F F N H 3 C NH 2 N N IC50 = 10.0 nM 468.44 Cn1nc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 Homo sapiens CHEMBL4261372 single protein format
CHEMBL4436131 OBDepict O N N IC50 = 10.0 nM 228.29 O=C(C1CCC1)N1N=CCC1c1ccccc1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4594130 OBDepict O N N H N IC50 = 10.0 nM 333.44 O=C(C1CCN(c2ccccc2)CC1)N1N=CC[C@H]1c1ccccc1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4514271 OBDepict N N N N N O N H F F IC50 = 10.0 nM 396.4 N#Cc1cc(N2CCC(C(=O)N3N=CC[C@H]3c3cc(F)cc(F)c3)CC2)ncn1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4544356 OBDepict O N H 3 C H 3 C CH 3 N N IC50 = 10.0 nM 231.3 CC(C)(C)C(=O)N1N=CCC1c1ccccn1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4446523 OBDepict O N H 3 C H 3 C CH 3 N N IC50 = 10.0 nM 231.3 CC(C)(C)C(=O)N1N=CCC1c1cccnc1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4556131 OBDepict Cl N N O CH 3 H 3 C CH 3 IC50 = 10.0 nM 264.76 CC(C)(C)C(=O)N1N=CCC1c1cccc(Cl)c1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4448908 OBDepict O N H 3 C H 3 C CH 3 N N IC50 = 10.0 nM 231.3 CC(C)(C)C(=O)N1N=CCC1c1ccncc1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4446758 OBDepict O N CH 3 CH 3 CH 3 N N N H IC50 = 10.0 nM 220.28 CC(C)(C)C(=O)N1N=CCC1c1cc[nH]n1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4446928 OBDepict O N CH 3 CH 3 CH 3 N N N H IC50 = 10.0 nM 220.28 CC(C)(C)C(=O)N1N=CCC1c1c[nH]cn1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4440532 OBDepict O N H 3 C H 3 C H 3 C N N O IC50 = 10.0 nM 221.26 CC(C)(C)C(=O)N1N=CCC1c1cocn1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4576386 OBDepict O N H 3 C CH 3 H 3 C N Cl IC50 = 10.0 nM 264.76 CC(C)(C)C(=O)N1N=CCC1c1ccc(Cl)cc1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4292454 OBDepict O N O F F F N H 2 N N N CH 3 H 3 C IC50 = 10.0 nM 495.51 CC(C)n1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 Homo sapiens CHEMBL4261372 single protein format
CHEMBL4590117 OBDepict O N H 3 C H 3 C CH 3 N IC50 = 10.0 nM 236.36 CC(C)(C)C(=O)N1N=CCC1C1CCCCC1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4290735 OBDepict H 3 C N N N H 2 N N O O F F F IC50 = 10.0 nM 509.53 CCCCn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 Homo sapiens CHEMBL4261372 single protein format
CHEMBL4467752 OBDepict O N H 3 C H 3 C H 3 C N IC50 = 10.0 nM 222.33 CC(C)(C)C(=O)N1N=CCC1C1CCCC1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4472572 OBDepict O N H 3 C H 3 C CH 3 N O IC50 = 10.0 nM 238.33 CC(C)(C)C(=O)N1N=CCC1C1CCOCC1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4452768 OBDepict CH 3 N N N O CH 3 CH 3 H 3 C IC50 = 10.0 nM 251.37 CN1CCC(C2CC=NN2C(=O)C(C)(C)C)CC1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4519627 OBDepict CH 3 H 3 C N O N IC50 = 10.0 nM 216.28 CC(C)C(=O)N1N=CCC1c1ccccc1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4437098 OBDepict NH 2 H 3 C CH 3 N O N IC50 = 10.0 nM 245.33 CC(C)(CN)C(=O)N1N=CCC1c1ccccc1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4451628 OBDepict OH H 3 C CH 3 N O N IC50 = 10.0 nM 246.31 CC(C)(CO)C(=O)N1N=CCC1c1ccccc1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4541955 OBDepict N N N N N O N H F F IC50 = 10.0 nM 396.4 N#Cc1nccc(N2CCC(C(=O)N3N=CC[C@H]3c3cc(F)cc(F)c3)CC2)n1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4436896 OBDepict O N H 3 C H 3 C H 3 C N S O O CH 3 IC50 = 10.0 nM 308.4 CC(C)(C)C(=O)N1N=CCC1c1ccc(S(C)(=O)=O)cc1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4552893 OBDepict O N N H N O N S IC50 = 10.0 nM 368.46 O=C(c1cscn1)N1CCC(C(=O)N2N=CC[C@H]2c2ccccc2)CC1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4465743 OBDepict O N N N O N N N H IC50 = 10.0 nM 352.4 O=C(c1c[nH]nn1)N1CCC(C(=O)N2N=CCC2c2ccccc2)CC1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4524420 OBDepict O N N N O N N H IC50 = 10.0 nM 351.41 O=C(c1cn[nH]c1)N1CCC(C(=O)N2N=CCC2c2ccccc2)CC1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4583157 OBDepict O N N N O N N H IC50 = 10.0 nM 351.41 O=C(c1cc[nH]n1)N1CCC(C(=O)N2N=CCC2c2ccccc2)CC1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4548784 OBDepict O N N H N O O N IC50 = 10.0 nM 352.39 O=C(c1cnco1)N1CCC(C(=O)N2N=CC[C@H]2c2ccccc2)CC1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4584779 OBDepict O N N N O N O IC50 = 10.0 nM 352.39 O=C(c1cocn1)N1CCC(C(=O)N2N=CCC2c2ccccc2)CC1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4575848 OBDepict O N N N O N IC50 = 10.0 nM 362.43 O=C(c1ccccn1)N1CCC(C(=O)N2N=CCC2c2ccccc2)CC1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4548719 OBDepict O N N N O N IC50 = 10.0 nM 362.43 O=C(c1cccnc1)N1CCC(C(=O)N2N=CCC2c2ccccc2)CC1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4588685 OBDepict O N N N O IC50 = 10.0 nM 361.45 O=C(c1ccccc1)N1CCC(C(=O)N2N=CCC2c2ccccc2)CC1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4448942 OBDepict O N N N O IC50 = 10.0 nM 367.49 O=C(C1CCCCC1)N1CCC(C(=O)N2N=CCC2c2ccccc2)CC1 Homo sapiens CHEMBL4352155 assay format
CHEMBL3109198 OBDepict O N H HN F F F F N NH 2 IC50 = 10.0 nM 440.4 Nc1nccc2c(-c3ccc(NC(=O)Nc4ccc(F)c(C(F)(F)F)c4)cc3)cccc12 Homo sapiens CHEMBL3110729 cell-based format
CHEMBL4526661 OBDepict CH 3 N O N O N IC50 = 10.0 nM 313.4 CCC(=O)N1CCC(C(=O)N2N=CCC2c2ccccc2)CC1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4463322 OBDepict O N N N O F F F IC50 = 10.0 nM 353.34 O=C(C1CCN(C(=O)C(F)(F)F)CC1)N1N=CCC1c1ccccc1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4514028 OBDepict O N H 3 C H 3 C H 3 C N F CH 3 IC50 = 10.0 nM 262.33 Cc1ccc(C2CC=NN2C(=O)C(C)(C)C)cc1F Homo sapiens CHEMBL4352155 assay format
CHEMBL4455042 OBDepict O N N H N N N IC50 = 10.0 nM 335.41 O=C(C1CCN(c2ncccn2)CC1)N1N=CC[C@H]1c1ccccc1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4474320 OBDepict O N N H N O CH 3 IC50 = 10.0 nM 299.37 CC(=O)N1CCC(C(=O)N2N=CC[C@H]2c2ccccc2)CC1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4450890 OBDepict H N N O F F N N N N IC50 = 10.0 nM 396.4 N#Cc1cnc(N2CCC(C(=O)N3N=CC[C@H]3c3cc(F)cc(F)c3)CC2)cn1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4474937 OBDepict O N N O IC50 = 10.0 nM 244.29 O=C(C1CCOC1)N1N=CCC1c1ccccc1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4561445 OBDepict H N N O F F N N N N IC50 = 10.0 nM 396.4 N#Cc1ccc(N2CCC(C(=O)N3N=CC[C@H]3c3cc(F)cc(F)c3)CC2)nn1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4564157 OBDepict O N N IC50 = 10.0 nM 250.3 O=C(c1ccccc1)N1N=CCC1c1ccccc1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4452678 OBDepict O N N N IC50 = 10.0 nM 251.29 O=C(c1ccncc1)N1N=CCC1c1ccccc1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4537171 OBDepict F N N O CH 3 H 3 C CH 3 IC50 = 10.0 nM 248.3 CC(C)(C)C(=O)N1N=CCC1c1cccc(F)c1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4443534 OBDepict O N N H N N N IC50 = 10.0 nM 335.41 O=C(C1CCN(c2ccncn2)CC1)N1N=CC[C@H]1c1ccccc1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4554458 OBDepict O N N N IC50 = 10.0 nM 251.29 O=C(c1cccnc1)N1N=CCC1c1ccccc1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4527680 OBDepict CH 3 N N O N IC50 = 10.0 nM 271.36 CN1CCC(C(=O)N2N=CCC2c2ccccc2)CC1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4454881 OBDepict O N N H N N O N CH 3 IC50 = 10.0 nM 339.4 Cc1nnc(N2CCC(C(=O)N3N=CC[C@H]3c3ccccc3)CC2)o1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4556751 OBDepict O N N H N N N IC50 = 10.0 nM 335.41 O=C(C1CCN(c2cccnn2)CC1)N1N=CC[C@H]1c1ccccc1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4565985 OBDepict O N N N IC50 = 10.0 nM 333.44 O=C(C1CCN(c2ccccc2)CC1)N1N=CCC1c1ccccc1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4553214 OBDepict O N N N O H 3 C IC50 = 10.0 nM 299.37 CC(=O)N1CCC(C(=O)N2N=CCC2c2ccccc2)CC1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4519892 OBDepict O N N N IC50 = 10.0 nM 251.29 O=C(c1ccccn1)N1N=CCC1c1ccccc1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4533161 OBDepict O N H 3 C CH 3 H 3 C N H 3 C CH 3 H 3 C IC50 = 10.0 nM 286.42 CC(C)(C)C(=O)N1N=CCC1c1ccc(C(C)(C)C)cc1 Homo sapiens CHEMBL4352155 assay format
CHEMBL4281823 OBDepict CH 3 N N N NH 2 N O O F F F IC50 = 11.0 nM 481.48 CCn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 Homo sapiens CHEMBL4261372 single protein format
CHEMBL1171837 OBDepict H 3 C N N F F F N H O CH 3 N N N IC50 = 12.0 nM 532.57 Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 Homo sapiens CHEMBL4378729 cell-based format
CHEMBL4290948 OBDepict O N O F F F N H 3 C NH 2 N N IC50 = 13.0 nM 467.45 Cn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 Homo sapiens CHEMBL4261372 single protein format
CHEMBL4092421 OBDepict H 3 C CH 3 CH 3 N O HO IC50 = 13.0 nM 221.3 CCC(C)(C)C(=O)N(O)Cc1ccccc1 Homo sapiens CHEMBL3993114 single protein format
CHEMBL4289355 OBDepict O N F F F N N CH 3 H 2 N N N IC50 = 14.0 nM 452.44 Cn1nc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(C(F)(F)F)c2)c2c(N)ncnc21 Homo sapiens CHEMBL4261372 single protein format
CHEMBL3109213 OBDepict O N H N H F F F F N H N NH 2 IC50 = 16.0 nM 505.48 Nc1ccc(-c2cnc3[nH]cc(-c4cccc(NC(=O)Nc5cc(C(F)(F)F)ccc5F)c4)c3c2)cc1 Homo sapiens CHEMBL3110728 cell-based format
CHEMBL3109212 OBDepict O N H N H F F F F N H N NH 2 IC50 = 16.0 nM 505.48 Nc1cccc(-c2cnc3[nH]cc(-c4cccc(NC(=O)Nc5cc(C(F)(F)F)ccc5F)c4)c3c2)c1 Homo sapiens CHEMBL3110728 cell-based format
CHEMBL4521353 OBDepict H N N O H 3 C H 3 C CH 3 IC50 = 16.0 nM 230.31 CC(C)(C)C(=O)N1N=CC[C@H]1c1ccccc1 Homo sapiens CHEMBL4352155 assay format