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Q13564 | ULA1_HUMAN | NEDD8-activating enzyme E1 regulatory subunit (NAE1)

3D structures mapped by conservation among orthologs

[ Domain: "Activating enzymes of the ubiquitin-like proteins" // ThiF_2,APPBP1_RUB ]

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[ Domain: "Activating enzymes of the ubiquitin-like proteins" // ThiF_3 ]

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[ Domain: "Catalytic cysteine domain in ubiquitin-activating enzyme" // APPBP1_RUB ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL2322194 OBDepict NH 2 S O O O H H OH H N N N N H H IC50 = 4.7 nM 445.55 NS(=O)(=O)OC[C@@H]1C[C@@H](N2CCc3c(N[C@H]4CCc5ccccc54)ncnc32)C[C@@H]1O Homo sapiens CHEMBL2328919 single protein format
CHEMBL2017005 OBDepict NH 2 S O O O H O H OH H N H HO N N N N H H IC50 = 10.0 nM 462.49 NS(=O)(=O)OC[C@H]1O[C@@H](n2cnc3c(N[C@H]4CCc5ccccc54)ncnc32)[C@H](O)[C@@H]1O Homo sapiens CHEMBL2328930 single protein format
CHEMBL1231160 OBDepict NH 2 S O O O H H OH H N N N N H H IC50 = 180.0 nM 443.53 NS(=O)(=O)OC[C@@H]1C[C@@H](n2ccc3c(N[C@H]4CCc5ccccc54)ncnc32)C[C@@H]1O Homo sapiens CHEMBL4733963 single protein format
CHEMBL4282603 OBDepict NH 2 S O O O H H OH H N N N N H H IC50 = 260.0 nM 443.53 NS(=O)(=O)OC[C@@H]1C[C@@H](n2ccc3c(N[C@@H]4CCc5ccccc54)ncnc32)C[C@@H]1O Homo sapiens CHEMBL4830933 single protein format
CHEMBL2322197 OBDepict O HN O N H O N O N O OH IC50 = 800.0 nM 374.35 O=C(O)CNC(=O)CNC(=O)COc1ccc2nc3n(c(=O)c2c1)CCC3 Homo sapiens CHEMBL2328914 single protein format