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Q13627 | DYR1A_HUMAN | Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A)

3D structures mapped by conservation among orthologs

[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL2386744 OBDepict CH 3 O HN N S N N H N F Br IC50 = 0.16 nM 432.28 COC(=N)c1nc2ccc3ncnc(Nc4ccc(Br)cc4F)c3c2s1 Homo sapiens CHEMBL2388921 single protein format
CHEMBL2386747 OBDepict CH 3 O HN N S N N H N Cl Cl IC50 = 0.22 nM 404.28 COC(=N)c1nc2ccc3ncnc(Nc4ccc(Cl)cc4Cl)c3c2s1 Homo sapiens CHEMBL2388921 single protein format
CHEMBL2386745 OBDepict H 3 C O NH N S N N H N O H 3 C F IC50 = 0.36 nM 383.41 COC(=N)c1nc2ccc3ncnc(Nc4ccc(F)cc4OC)c3c2s1 Homo sapiens CHEMBL2388921 single protein format
CHEMBL3894571 OBDepict CH 3 O F N H N N S N O NH CH 3 IC50 = 0.36 nM 383.41 COC(=N)c1nc2ccc3ncnc(Nc4ccc(OC)cc4F)c3c2s1 Homo sapiens CHEMBL3889022 single protein format
CHEMBL2386748 OBDepict CH 3 O HN N S N N H N F F IC50 = 0.94 nM 371.37 COC(=N)c1nc2ccc3ncnc(Nc4ccc(F)cc4F)c3c2s1 Homo sapiens CHEMBL2388921 single protein format
CHEMBL2386764 OBDepict CH 3 O HN N S N N H N CH 3 IC50 = 0.98 nM 349.42 COC(=N)c1nc2ccc3ncnc(Nc4ccc(C)cc4)c3c2s1 Homo sapiens CHEMBL2388921 single protein format
CHEMBL2386746 OBDepict CH 3 O HN N S N N H N Cl F IC50 = 0.99 nM 387.83 COC(=N)c1nc2ccc3ncnc(Nc4ccc(F)cc4Cl)c3c2s1 Homo sapiens CHEMBL2388921 single protein format
CHEMBL3971170 OBDepict CH 3 O HN N S N N H N F Cl IC50 = 0.99 nM 387.83 COC(=N)c1nc2ccc3ncnc(Nc4ccc(Cl)cc4F)c3c2s1 Homo sapiens CHEMBL3889022 single protein format
CHEMBL4079572 OBDepict NH 2 N N N H N IC50 = 1.0 nM 211.23 Nc1nccc(-c2c[nH]c3cnccc23)n1 Homo sapiens CHEMBL4034241 assay format
CHEMBL4084955 OBDepict H N N N IC50 = 1.0 nM 195.22 c1cc(-c2c[nH]c3cnccc23)ccn1 Homo sapiens CHEMBL4034241 assay format
CHEMBL2386762 OBDepict CH 3 O HN N S N N H N Cl IC50 = 1.13 nM 369.84 COC(=N)c1nc2ccc3ncnc(Nc4ccc(Cl)cc4)c3c2s1 Homo sapiens CHEMBL2388921 single protein format
CHEMBL2386753 OBDepict H 3 C O NH N S N N H N O O IC50 = 1.65 nM 379.4 COC(=N)c1nc2ccc3ncnc(Nc4ccc5c(c4)OCO5)c3c2s1 Homo sapiens CHEMBL2388921 single protein format
CHEMBL2386763 OBDepict H 3 C O NH N S N N H N IC50 = 1.81 nM 335.39 COC(=N)c1nc2ccc3ncnc(Nc4ccccc4)c3c2s1 Homo sapiens CHEMBL2388921 single protein format
CHEMBL4294976 OBDepict CH 3 O N H N CH 3 N N H N NH 2 IC50 = 2.1 nM 374.45 CCOc1ccccc1CNc1nc(C)nc2[nH]cc(-c3ccnc(N)c3)c12 Homo sapiens CHEMBL4266666 assay format
CHEMBL3915647 OBDepict H 3 C O NH S N N N H N Br O O IC50 = 2.76 nM 458.3 COC(=N)c1nc2ccc3ncnc(Nc4cc(Br)c5c(c4)OCO5)c3c2s1 Homo sapiens CHEMBL3889022 single protein format
CHEMBL4640031 OBDepict O N NH N H CH 3 O H H 3 C N H N CH 3 OH IC50 = 3.0 nM 463.58 C[C@H]1CN(C(=O)Nc2cc(-c3cn([C@H]4CC[C@@](C)(O)CC4)c4cnccc34)ccn2)C[C@@H](C)O1 Homo sapiens CHEMBL4604967 cell-based format
CHEMBL4568087 OBDepict H 3 C N N N N N S N H O H H H 2 N IC50 = 3.2 nM 421.53 Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 Homo sapiens CHEMBL4479714 assay format
CHEMBL4283503 OBDepict O N H N S N IC50 = 3.2 nM 321.41 O=C(Nc1cncc(-c2cc(-c3cccnc3)cs2)c1)C1CC1 Homo sapiens CHEMBL4275965 assay format
CHEMBL2386770 OBDepict CH 3 O HN N S N N H N Br F IC50 = 3.6 nM 432.28 COC(=N)c1nc2ccc3ncnc(Nc4ccc(F)cc4Br)c3c2s1 Homo sapiens CHEMBL2388921 single protein format
CHEMBL2386766 OBDepict CH 3 O HN N S N N H N N IC50 = 3.89 nM 360.4 COC(=N)c1nc2ccc3ncnc(Nc4ccc(C#N)cc4)c3c2s1 Homo sapiens CHEMBL2388921 single protein format
CHEMBL4284240 OBDepict CH 3 O N CH 3 N N H 2 N N NH 2 IC50 = 4.0 nM 386.46 COc1ccc2c(c1)CC(n1c(C)nc3ccc(-c4cc(N)nc(N)c4)nc31)C2 Homo sapiens CHEMBL4266666 assay format
CHEMBL4285678 OBDepict O N H O N N H O H 3 C H OH H HO H HO IC50 = 4.0 nM 469.45 C[C@]12O[C@H]([C@H](O)[C@H](O)[C@H]1O)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4=O Homo sapiens CHEMBL4266655 single protein format
CHEMBL3905538 OBDepict H 3 C O NH S N N N H N HO O H 3 C IC50 = 4.25 nM 381.42 COC(=N)c1nc2ccc3ncnc(Nc4ccc(OC)c(O)c4)c3c2s1 Homo sapiens CHEMBL3889022 single protein format
CHEMBL3983413 OBDepict H 3 C O NH N S N N H N N N H IC50 = 4.44 nM 375.42 COC(=N)c1nc2ccc3ncnc(Nc4ccc5nc[nH]c5c4)c3c2s1 Homo sapiens CHEMBL3889022 single protein format
CHEMBL4282315 OBDepict NH 2 N H S O N H Cl O O N H N O CH 3 ClH IC50 = 4.6 nM 548.45 COc1cc2[nH]c(=O)c(C(=O)Nc3cc(C(=O)NC(CCN)c4ccsc4)ccc3Cl)cc2cn1.Cl Homo sapiens CHEMBL4266674 assay format
CHEMBL2386749 OBDepict H 3 C O NH N S N N H N + N HO O _ O IC50 = 4.91 nM 396.39 COC(=N)c1nc2ccc3ncnc(Nc4ccc(O)c([N+](=O)[O-])c4)c3c2s1 Homo sapiens CHEMBL2388921 single protein format
CHEMBL4856089 OBDepict OH N N N H HO IC50 = 5.0 nM 303.32 Oc1ccc(-c2cnc3[nH]nc(-c4ccc(O)cc4)c3c2)cc1 Homo sapiens CHEMBL4823189 single protein format
CHEMBL495696 OBDepict N NH N N N N N IC50 = 5.0 nM 313.32 N#Cc1cccc(Nc2nccc(-c3cnn4ncccc34)n2)c1 Homo sapiens CHEMBL4622607 assay format
CHEMBL4288045 OBDepict NH 2 N H H O NH Cl O O N H O O CH 3 H 3 C IC50 = 5.0 nM 563.05 COCCc1cc2cc(C(=O)Nc3cc(C(=O)N[C@H](CCN)c4ccccc4)ccc3Cl)c(=O)[nH]c2cc1OC Homo sapiens CHEMBL4266674 assay format
CHEMBL4873449 OBDepict OH N N H N OH HO IC50 = 5.0 nM 319.32 Oc1ccc(-c2n[nH]c3ncc(-c4ccc(O)c(O)c4)cc23)cc1 Homo sapiens CHEMBL4823189 single protein format
CHEMBL3094437 OBDepict H 2 N HN O N H Cl O O N H N N N O IC50 = 5.0 nM 588.07 NCCC(NC(=O)c1ccc(Cl)c(NC(=O)c2cc3cnc(N4CC5CCC(C4)O5)nc3[nH]c2=O)c1)c1ccccc1 Homo sapiens CHEMBL3097668 single protein format
CHEMBL2386760 OBDepict CH 3 O O N S N N H N Cl Cl IC50 = 5.1 nM 405.27 COC(=O)c1nc2ccc3ncnc(Nc4ccc(Cl)cc4Cl)c3c2s1 Homo sapiens CHEMBL2388921 single protein format
CHEMBL4284572 OBDepict NH 2 HN N N N N H N N N H N O ClH IC50 = 5.9 nM 497.01 Cl.NCC(Nc1nccc(-c2n[nH]c3nc(NCCN4CCOCC4)ncc23)n1)c1ccccc1 Homo sapiens CHEMBL4266674 assay format
CHEMBL4647659 OBDepict CH 3 O CH 3 F N N H 2 N NH O N N H O OH IC50 = 6.0 nM 494.53 CC(C)Oc1ccc(F)c(-c2cnc(N)c(C(=O)Nc3cnccc3N3CCC[C@@H](C(=O)O)C3)n2)c1 Homo sapiens CHEMBL4604961 assay format
CHEMBL3589662 OBDepict OH O N N H I IC50 = 6.0 nM 388.16 O=C(O)c1nc2ccccc2c2[nH]c3c(I)cccc3c12 Homo sapiens CHEMBL3591177 assay format
CHEMBL4441878 OBDepict H 2 N N NH 2 N N N H 3 C CH 3 CH 3 IC50 = 6.0 nM 282.35 Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1C(C)C Homo sapiens CHEMBL4415166 single protein format
CHEMBL2386754 OBDepict CH 3 O NH N S N N H N O O IC50 = 6.02 nM 393.43 CCOC(=N)c1nc2ccc3ncnc(Nc4ccc5c(c4)OCO5)c3c2s1 Homo sapiens CHEMBL2388921 single protein format
CHEMBL2386765 OBDepict CH 3 O HN N S N N H N F IC50 = 6.06 nM 353.38 COC(=N)c1nc2ccc3ncnc(Nc4ccc(F)cc4)c3c2s1 Homo sapiens CHEMBL2388921 single protein format
CHEMBL4636064 OBDepict CH 3 N N N H O N N N O IC50 = 6.2 nM 434.54 CCN1CCN(C(=O)Nc2cc(-c3cn(C4CCOCC4)c4cnccc34)ccn2)CC1 Homo sapiens CHEMBL4604967 cell-based format
CHEMBL4062453 OBDepict CH 3 N CH 3 N N N N O O NH 2 F IC50 = 6.5 nM 498.56 CN(C)CCn1cc(-c2ccn3c(-c4ccc(C(N)=O)c(OCc5cccc(F)c5)c4)cnc3c2)cn1 Homo sapiens CHEMBL4003703 single protein format
CHEMBL4078550 OBDepict CH 3 NH O N N H HO IC50 = 6.6 nM 343.39 CC(=O)Nc1ccc(-c2cnc3[nH]cc(-c4ccc(O)cc4)c3c2)cc1 Homo sapiens CHEMBL4008895 single protein format
CHEMBL1230165 OBDepict Cl N H N N O HO IC50 = 6.8 nM 349.78 O=C(O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc12 Homo sapiens CHEMBL4266682 single protein format
CHEMBL4646866 OBDepict CH 3 N H N N N N N IC50 = 7.0 nM 302.34 Cc1cccc(Nc2nccc(-c3cnn4ncccc34)n2)c1 Homo sapiens CHEMBL4622607 assay format
CHEMBL1738733 OBDepict O N N N H O O IC50 = 7.6 nM 307.31 O=C1N=C(Nc2ccccc2)N=C1Cc1ccc2c(c1)OCO2 Homo sapiens CHEMBL4003376 single protein format
CHEMBL4283751 OBDepict NH N H S O O IC50 = 7.9 nM 246.29 N=C1NC(=O)/C(=C/c2ccc3c(c2)CCO3)S1 Homo sapiens CHEMBL4266663 assay format
CHEMBL3912295 OBDepict H 3 C O NH N S N N H N O O IC50 = 8.0 nM 393.43 COC(=N)c1nc2ccc3ncnc(Nc4ccc5c(c4)OCCO5)c3c2s1 Homo sapiens CHEMBL3889022 single protein format
CHEMBL3094454 OBDepict NH 2 N H O NH Cl O O N H N N O CH 3 IC50 = 8.0 nM 492.92 COc1ncc2cc(C(=O)Nc3cc(C(=O)NC(CN)c4ccccc4)ccc3Cl)c(=O)[nH]c2n1 Homo sapiens CHEMBL3097668 single protein format
CHEMBL4105629 OBDepict N N N IC50 = 8.0 nM 263.34 c1cc(-c2cn(CCC3CC3)c3cnccc23)ccn1 Homo sapiens CHEMBL4034241 assay format
CHEMBL4064316 OBDepict CH 3 N H 3 C N N IC50 = 8.0 nM 237.31 CC(C)n1cc(-c2ccncc2)c2ccncc21 Homo sapiens CHEMBL4034241 assay format
CHEMBL4872136 OBDepict CH 3 O N N H N HN O H 3 C IC50 = 8.0 nM 358.4 COc1ccc(-c2n[nH]c3ncc(-c4ccc(NC(C)=O)cc4)cc23)cc1 Homo sapiens CHEMBL4823189 single protein format
CHEMBL4575900 OBDepict NH 2 N H 2 N N N N H 3 C O CH 3 H IC50 = 8.0 nM 374.45 Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1C[C@@H](C)Oc1ccccc1 Homo sapiens CHEMBL4415166 single protein format
CHEMBL4747992 OBDepict O HN N S N O O H 2 N N F IC50 = 8.1 nM 537.66 NC(=O)c1sc(-c2ccnc(NC(=O)C3CC3)c2)nc1OCCCC1CCN(Cc2ccc(F)cc2)CC1 Homo sapiens CHEMBL4688580 single protein format
CHEMBL2386752 OBDepict CH 3 O HN N S N N H N F OH IC50 = 8.63 nM 369.38 COC(=N)c1nc2ccc3ncnc(Nc4ccc(O)c(F)c4)c3c2s1 Homo sapiens CHEMBL2388921 single protein format
CHEMBL4159941 OBDepict H 3 C O N H Cl N IC50 = 8.8 nM 232.67 COc1ccc2c(c1)[nH]c1c(Cl)nccc12 Homo sapiens CHEMBL4151434 single protein format
CHEMBL3094436 OBDepict NH 2 HN O N H Cl O O N H N N N NH 2 IC50 = 9.0 nM 575.07 NCCC(NC(=O)c1ccc(Cl)c(NC(=O)c2cc3cnc(N4CCC(N)CC4)nc3[nH]c2=O)c1)c1ccccc1 Homo sapiens CHEMBL3097668 single protein format
CHEMBL3094455 OBDepict NH 2 N H O N H Cl O O N H N N O CH 3 IC50 = 9.0 nM 506.95 COc1ncc2cc(C(=O)Nc3cc(C(=O)NC(CCN)c4ccccc4)ccc3Cl)c(=O)[nH]c2n1 Homo sapiens CHEMBL3097668 single protein format
CHEMBL3094460 OBDepict NH 2 N H H O NH Cl O O N H N N O CH 3 IC50 = 9.0 nM 506.95 COc1ncc2cc(C(=O)Nc3cc(C(=O)N[C@H](CCN)c4ccccc4)ccc3Cl)c(=O)[nH]c2n1 Homo sapiens CHEMBL3097668 single protein format
CHEMBL2386743 OBDepict CH 3 O O N H CH 3 N N S N O HN H 3 C IC50 = 9.53 nM 395.44 COC(=N)c1nc2ccc3ncnc(Nc4ccc(OC)cc4OC)c3c2s1 Homo sapiens CHEMBL2388921 single protein format
CHEMBL3301610 OBDepict H 3 C N N N N H N N F F N N H 3 C H 3 C H 3 C Ki < 10.0 nM 506.61 CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1 Homo sapiens CHEMBL4348741 assay format
CHEMBL4569508 OBDepict O N H S F F F N N N O N IC50 < 10.0 nM 529.59 O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1 Homo sapiens CHEMBL4479714 assay format
CHEMBL4786159 OBDepict H 2 N N H O N N H Cl N ClH IC50 < 10.0 nM 416.31 Cl.NCCCNC(=O)c1cnc2[nH]cc(-c3cc(Cl)c4ncccc4c3)c2c1 Homo sapiens CHEMBL4742492 cell-based format
CHEMBL4777649 OBDepict H 2 N N H O N N H F N ClH IC50 < 10.0 nM 399.86 Cl.NCCCNC(=O)c1cnc2[nH]cc(-c3cc(F)c4ncccc4c3)c2c1 Homo sapiens CHEMBL4742492 cell-based format
CHEMBL4782142 OBDepict H 3 C NH O N N H F N IC50 < 10.0 nM 424.48 CNC(=O)c1cnc2[nH]cc(-c3cc(F)c4nccc(CCc5ccccc5)c4c3)c2c1 Homo sapiens CHEMBL4742492 cell-based format
CHEMBL4530280 OBDepict N N H I IC50 = 10.0 nM 344.16 N#Cc1c(-c2ccccc2)[nH]c2c(I)cccc12 Homo sapiens CHEMBL4381019 assay format
CHEMBL4778365 OBDepict NH 2 O N N H F N IC50 < 10.0 nM 306.3 NC(=O)c1cnc2[nH]cc(-c3cc(F)c4ncccc4c3)c2c1 Homo sapiens CHEMBL4742492 cell-based format
CHEMBL4780889 OBDepict CH 2 N CH 3 O N N H F N N IC50 < 10.0 nM 437.48 C=CCN(C)C(=O)c1cnc2[nH]cc(-c3cc(F)c4nccc(-c5cccnc5)c4c3)c2c1 Homo sapiens CHEMBL4742492 cell-based format
CHEMBL4777524 OBDepict NH 2 N H O N N H F N N ClH IC50 < 10.0 nM 476.94 Cl.NCCCNC(=O)c1cnc2[nH]cc(-c3cc(F)c4nccc(-c5cccnc5)c4c3)c2c1 Homo sapiens CHEMBL4742492 cell-based format
CHEMBL4797371 OBDepict O NH N N H F N N IC50 < 10.0 nM 473.51 O=C(NCc1ccccc1)c1cnc2[nH]cc(-c3cc(F)c4nccc(-c5cccnc5)c4c3)c2c1 Homo sapiens CHEMBL4742492 cell-based format
CHEMBL4794147 OBDepict CH 3 N HN N N H N IC50 = 10.0 nM 357.46 CN1CCC(Nc2ccnc3ccc(-c4c[nH]c5ncccc45)cc23)CC1 Homo sapiens CHEMBL4742492 cell-based format
CHEMBL4787210 OBDepict CH 3 N N H N ClH IC50 = 10.0 nM 295.77 Cc1cc(-c2c[nH]c3ncccc23)cc2cccnc12.Cl Homo sapiens CHEMBL4742492 cell-based format
CHEMBL4798630 OBDepict H N N O N F F F IC50 = 10.0 nM 329.28 FC(F)(F)Oc1cc(-c2c[nH]c3ncccc23)cc2cccnc12 Homo sapiens CHEMBL4742492 cell-based format
CHEMBL4784397 OBDepict CH 3 O N N H N IC50 = 10.0 nM 275.31 COc1cc(-c2c[nH]c3ncccc23)cc2cccnc12 Homo sapiens CHEMBL4742492 cell-based format
CHEMBL4787086 OBDepict CH 3 N H O N N H O H 3 C N IC50 = 10.0 nM 332.36 CNC(=O)c1cnc2[nH]cc(-c3cc(OC)c4ncccc4c3)c2c1 Homo sapiens CHEMBL4742492 cell-based format
CHEMBL4782598 OBDepict CH 3 N H O N N H H 3 C N N IC50 = 10.0 nM 393.45 CNC(=O)c1cnc2[nH]cc(-c3cc(C)c4nccc(-c5cccnc5)c4c3)c2c1 Homo sapiens CHEMBL4742492 cell-based format
CHEMBL4786897 OBDepict CH 3 O N N H N N O H 2 N IC50 = 10.0 nM 395.42 COc1cc(-c2c[nH]c3ncc(C(N)=O)cc23)cc2c(-c3cccnc3)ccnc12 Homo sapiens CHEMBL4742492 cell-based format
CHEMBL4799177 OBDepict O N H N N N H N HN + N H O _ O H H 2 N ClH IC50 = 10.0 nM 573.06 Cl.N[C@H]1CC[C@H](Nc2c([N+](=O)[O-])cnc3ccc(-c4c[nH]c5ncc(C(=O)NCc6cccnc6)cc45)cc23)CC1 Homo sapiens CHEMBL4742492 cell-based format
CHEMBL4796415 OBDepict N N HN N CH 3 N H N IC50 = 10.0 nM 382.47 CN1CCC(Nc2c(C#N)cnc3ccc(-c4c[nH]c5ncccc45)cc23)CC1 Homo sapiens CHEMBL4742492 cell-based format
CHEMBL4784584 OBDepict CH 3 N N H 3 C + N N O _ O N H N IC50 = 10.0 nM 416.49 CN1CCC(N(C)c2c([N+](=O)[O-])cnc3ccc(-c4c[nH]c5ncccc45)cc23)CC1 Homo sapiens CHEMBL4742492 cell-based format
CHEMBL4853178 OBDepict CH 3 O N H O N N N IC50 = 10.0 nM 408.46 COc1ccc(CNC(=O)c2cnc3ccc(-c4ccc5ncccc5c4)cn23)cc1 Homo sapiens CHEMBL4815946 single protein format
CHEMBL4795920 OBDepict H 3 C N H O N N H F N N H NH 2 ClH IC50 < 10.0 nM 454.94 CNC(=O)c1cnc2[nH]cc(-c3cc(F)c4nccc(N5CCC[C@H](N)C5)c4c3)c2c1.Cl Homo sapiens CHEMBL4742492 cell-based format
CHEMBL4785328 OBDepict H 3 C N N H N N IC50 = 10.0 nM 336.4 Cc1cc(-c2c[nH]c3ncccc23)cc2c(-c3cccnc3)ccnc12 Homo sapiens CHEMBL4742492 cell-based format
CHEMBL4798819 OBDepict CH 2 N HO H N N H N IC50 < 10.0 nM 410.52 C=CC1CN2CCC1CC2[C@H](O)c1ccnc2ccc(-c3c[nH]c4ncccc34)cc12 Homo sapiens CHEMBL4742492 cell-based format
CHEMBL4796652 OBDepict O HN N N H Cl N IC50 < 10.0 nM 412.88 O=C(NCc1ccccc1)c1cnc2[nH]cc(-c3cc(Cl)c4ncccc4c3)c2c1 Homo sapiens CHEMBL4742492 cell-based format
CHEMBL4783465 OBDepict O N H N N N H F N N H NH 2 ClH IC50 < 10.0 nM 532.02 Cl.N[C@@H]1CCCN(c2ccnc3c(F)cc(-c4c[nH]c5ncc(C(=O)NCc6cccnc6)cc45)cc23)C1 Homo sapiens CHEMBL4742492 cell-based format
CHEMBL4791911 OBDepict O NH N N N H F N N IC50 < 10.0 nM 474.5 O=C(NCc1cccnc1)c1cnc2[nH]cc(-c3cc(F)c4nccc(-c5cccnc5)c4c3)c2c1 Homo sapiens CHEMBL4742492 cell-based format
CHEMBL4792646 OBDepict O N H N N N N H F N N H NH 2 ClH IC50 < 10.0 nM 533.01 Cl.N[C@@H]1CCCN(c2ccnc3c(F)cc(-c4c[nH]c5ncc(C(=O)NCc6cncnc6)cc45)cc23)C1 Homo sapiens CHEMBL4742492 cell-based format
CHEMBL4795553 OBDepict H N N F N H N N IC50 < 10.0 nM 459.53 Fc1cc(-c2c[nH]c3ncc(CNCc4ccccc4)cc23)cc2c(-c3cccnc3)ccnc12 Homo sapiens CHEMBL4742492 cell-based format
CHEMBL4782343 OBDepict CH 3 N H O N N H N N HN O Cl IC50 < 10.0 nM 527.03 CNC(=O)c1cnc2[nH]cc(-c3ccc4ncc(NCc5cccc(Cl)c5)c(N5CCOCC5)c4c3)c2c1 Homo sapiens CHEMBL4742492 cell-based format
CHEMBL4782648 OBDepict CH 2 N CH 3 N N H F N N IC50 < 10.0 nM 423.5 C=CCN(C)Cc1cnc2[nH]cc(-c3cc(F)c4nccc(-c5cccnc5)c4c3)c2c1 Homo sapiens CHEMBL4742492 cell-based format
CHEMBL4798075 OBDepict H N N N N IC50 < 10.0 nM 322.37 c1cnc2[nH]cc(-c3ccc4nccc(-c5ccncc5)c4c3)c2c1 Homo sapiens CHEMBL4742492 cell-based format
CHEMBL4799100 OBDepict CH 3 N O HN NH 2 N N H N IC50 < 10.0 nM 400.49 CC(=O)N1CCC(Nc2c(N)cnc3ccc(-c4c[nH]c5ncccc45)cc23)CC1 Homo sapiens CHEMBL4742492 cell-based format
CHEMBL4784265 OBDepict O N H N N N H N HN O IC50 < 10.0 nM 492.58 O=C(NCc1cccnc1)c1cnc2[nH]cc(-c3ccc4ncc(NCC5CCOCC5)cc4c3)c2c1 Homo sapiens CHEMBL4742492 cell-based format
CHEMBL4795136 OBDepict CH 3 N H O N N H N N H O N IC50 < 10.0 nM 436.48 CC(=O)Nc1cnc2ccc(-c3c[nH]c4ncc(C(=O)NCc5cccnc5)cc34)cc2c1 Homo sapiens CHEMBL4742492 cell-based format
CHEMBL4788819 OBDepict NH 2 N N H N NH O N IC50 < 10.0 nM 394.44 Nc1cnc2ccc(-c3c[nH]c4ncc(C(=O)NCc5cccnc5)cc34)cc2c1 Homo sapiens CHEMBL4742492 cell-based format
CHEMBL4091320 OBDepict H 3 C O N N N IC50 = 10.0 nM 253.31 COCCn1cc(-c2ccncc2)c2ccncc21 Homo sapiens CHEMBL4034241 assay format
CHEMBL4778932 OBDepict H N N F N H N N H NH 2 IC50 < 10.0 nM 480.59 N[C@@H]1CCCN(c2ccnc3c(F)cc(-c4c[nH]c5ncc(CNCc6ccccc6)cc45)cc23)C1 Homo sapiens CHEMBL4742492 cell-based format
CHEMBL4785301 OBDepict H N N N IC50 < 10.0 nM 321.38 c1ccc(-c2ccnc3ccc(-c4c[nH]c5ncccc45)cc23)cc1 Homo sapiens CHEMBL4742492 cell-based format
CHEMBL4785163 OBDepict CH 3 N H O N N H N N HN O O IC50 < 10.0 nM 500.6 CNC(=O)c1cnc2[nH]cc(-c3ccc4ncc(NCC5CCOCC5)c(N5CCOCC5)c4c3)c2c1 Homo sapiens CHEMBL4742492 cell-based format
CHEMBL4795260 OBDepict CH 3 N H O N N H N N NH O O CH 3 IC50 < 10.0 nM 444.5 CNC(=O)c1cnc2[nH]cc(-c3ccc4ncc(NC(C)=O)c(N5CCOCC5)c4c3)c2c1 Homo sapiens CHEMBL4742492 cell-based format
CHEMBL4794271 OBDepict H 3 C N H O N N H F N N IC50 < 10.0 nM 397.41 CC(=O)Nc1cnc2[nH]cc(-c3cc(F)c4nccc(-c5cccnc5)c4c3)c2c1 Homo sapiens CHEMBL4742492 cell-based format