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Q13936 | CAC1C_HUMAN | Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C)

3D structures mapped by conservation among orthologs

[ Domain: "Voltage gated calcium channel IQ domain" // Ca_chan_IQ ]

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[ Domain: "Voltage gated calcium channel IQ domain" // UNK_F_TYPE ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL475534 OBDepict CH 3 O O H 3 C HN CH 3 O O + N CH 3 O _ O Ki = 0.25 nM 360.37 CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cccc([N+](=O)[O-])c1 Homo sapiens CHEMBL664887 assay format
CHEMBL193 OBDepict H 3 C O O CH 3 HN H 3 C O O + N CH 3 O _ O Ki = 1.0 nM 346.34 COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-] Homo sapiens CHEMBL664887 assay format
CHEMBL159854 OBDepict CH 3 O OH CH 3 N H 3 C O O S CH 3 + N H 3 C O _ O Ki = 1.0 nM 420.49 CCOC(=O)C1=C(C)N=C(C)/C(=C(/O)OCC)C1c1cccc([N+](=O)[O-])c1SC Homo sapiens CHEMBL664887 assay format
CHEMBL104455 OBDepict H 3 C O HO CH 3 N H 3 C O O CH 3 N O H 3 C Ki = 4.11 nM 488.58 CCOC(=O)C1=C(C)N=C(C)/C(=C(/O)OCC)C1c1c(C)noc1CCc1cccc2ccccc12 Homo sapiens CHEMBL653732 cell membrane format
CHEMBL325811 OBDepict H 3 C O OH H 3 C N CH 3 O O O N CH 3 Br Ki = 6.89 nM 579.49 CCOC(=O)C1=C(C)N=C(C)/C(=C(/O)OCC)C1c1c(-c2ccccc2)noc1CCc1cccc(Br)c1 Homo sapiens CHEMBL653732 cell membrane format
CHEMBL305903 OBDepict CH 3 O HO CH 3 N CH 3 O O CH 3 O N H 3 C Ki = 13.9 nM 410.47 CCOC(=O)C1=C(C)N=C(C)/C(=C(/O)OCC)C1c1c(-c2ccccc2)noc1C Homo sapiens CHEMBL659866 cell membrane format
CHEMBL104082 OBDepict CH 3 O OH CH 3 N H 3 C O O CH 3 N O H 3 C Ki = 18.2 nM 514.62 CCOC(=O)C1=C(C)N=C(C)/C(=C(/O)OCC)C1c1c(C)noc1CCc1ccc(-c2ccccc2)cc1 Homo sapiens CHEMBL653732 cell membrane format
CHEMBL317651 OBDepict CH 3 O OH H 3 C N CH 3 O O H 3 C N O CH 3 Ki = 20.2 nM 488.58 CCOC(=O)C1=C(C)N=C(C)/C(=C(/O)OCC)C1c1c(C)noc1CCc1ccc2ccccc2c1 Homo sapiens CHEMBL653732 cell membrane format
CHEMBL323782 OBDepict CH 3 O OH H 3 C N CH 3 O O H 3 C N O CH 3 Ki = 22.9 nM 438.52 CCOC(=O)C1=C(C)N=C(C)/C(=C(/O)OCC)C1c1c(C)noc1CCc1ccccc1 Homo sapiens CHEMBL653732 cell membrane format
CHEMBL74944 OBDepict CH 3 O OH H 3 C N H 3 C O O H 3 C N H 3 C O H 3 C Ki = 27.1 nM 348.4 CCOC(=O)C1=C(C)N=C(C)/C(=C(/O)OCC)C1c1c(C)noc1C Homo sapiens CHEMBL659866 cell membrane format
CHEMBL2114104 OBDepict CH 3 O O CH 3 HN D H 3 C O O H 3 C N H 3 C O H 3 C Ki = 28.5 nM 349.41 [2H]C1(c2c(C)noc2C)C(C(=O)OCC)=C(C)NC(C)=C1C(=O)OCC Homo sapiens CHEMBL653733 cell membrane format
CHEMBL2110302 OBDepict H 3 C O HO CH 3 N H H CH 3 S O O + N O _ O CH 3 Ki = 30.0 nM 406.46 CCOC(=O)[C@@H]1[C@H]2/C(=C(O)OCC)C(C)=N[C@]1(C)Sc1ccc([N+](=O)[O-])cc12 Homo sapiens CHEMBL664887 assay format
CHEMBL539426 OBDepict H 3 C O OH H 3 C N CH 3 O O O N CH 3 O CH 3 Ki = 39.5 nM 530.62 CCOC(=O)C1=C(C)N=C(C)/C(=C(/O)OCC)C1c1c(-c2ccccc2)noc1CCc1cccc(OC)c1 Homo sapiens CHEMBL653732 cell membrane format
CHEMBL72620 OBDepict CH 3 O OH H 3 C N H 3 C O O H 3 C N O CH 3 H 3 C Ki = 52.0 nM 362.43 CCOC(=O)C1=C(C)N=C(C)/C(=C(/O)OCC)C1c1c(C)noc1CC Homo sapiens CHEMBL659866 cell membrane format
CHEMBL107213 OBDepict H 3 C O OH H 3 C N CH 3 O O O N CH 3 Ki = 72.9 nM 500.6 CCOC(=O)C1=C(C)N=C(C)/C(=C(/O)OCC)C1c1c(-c2ccccc2)noc1CCc1ccccc1 Homo sapiens CHEMBL653732 cell membrane format
CHEMBL72717 OBDepict CH 3 O N O OH H 3 C N O O CH 3 CH 3 CH 3 Ki = 79.0 nM 466.58 CCCCCc1onc(-c2ccccc2)c1C1C(C(=O)OCC)=C(C)N=C(C)/C1=C(/O)OCC Homo sapiens CHEMBL659866 cell membrane format
CHEMBL161165 OBDepict CH 3 O OH H 3 C N CH 3 O O S + N CH 3 CH 3 O _ O Ki = 80.0 nM 420.49 CCOC(=O)C1=C(C)N=C(C)/C(=C(/O)OCC)C1c1cc([N+](=O)[O-])ccc1SC Homo sapiens CHEMBL664887 assay format
CHEMBL105893 OBDepict H 3 C O HO CH 3 N CH 3 O O CH 3 N O CH 3 Ki = 91.1 nM 514.62 CCOC(=O)C1=C(C)N=C(C)/C(=C(/O)OCC)C1c1c(C)noc1CCc1ccccc1-c1ccccc1 Homo sapiens CHEMBL653732 cell membrane format
CHEMBL3392230 OBDepict CH 3 O O H 3 C HN H H 3 C N N IC50 = 100.0 nM 409.49 CCOC(=O)C1=C(C)NC(C)=C(C#N)[C@@H]1c1cnccc1-c1ccc2ccccc2c1 Homo sapiens CHEMBL660543 single protein format
CHEMBL73647 OBDepict CH 3 O OH H 3 C N H 3 C O O H 3 C N H 3 C O CH 3 Ki = 122.0 nM 320.35 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1c(C)noc1C Homo sapiens CHEMBL659866 cell membrane format
CHEMBL3608946 OBDepict CH 3 N O H N N O H H IC50 = 140.0 nM 457.62 CN(CCCc1nc2ccccc2[nH]1)CC[C@@]1(OC(=O)C2CC2)C[C@@H]2CC[C@H]1c1ccccc12 Homo sapiens CHEMBL3611367 cell-based format
CHEMBL6966 OBDepict CH 3 O O H 3 C N H 3 C H 3 C H 3 C N O O CH 3 H 3 C IC50 = 150.0 nM 454.61 COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC Homo sapiens CHEMBL656260 cell membrane format
CHEMBL3608941 OBDepict CH 3 N O H N N O H O CH 3 H 3 C H CH 3 H 3 C F IC50 = 156.0 nM 599.79 CC(C)C(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)C[C@@H](OCc2ccccc2)c2cc(F)ccc2[C@@H]1C(C)C Homo sapiens CHEMBL3611367 cell-based format
CHEMBL3609824 OBDepict CH 3 H O H F N O CH 3 H 3 C H 3 C O H 3 C N N H IC50 = 173.0 nM 551.75 CCCC[C@@H]1C[C@@](CCN(C)CCCc2nc3ccccc3[nH]2)(OC(=O)COC)[C@@H](C(C)C)c2ccc(F)cc21 Homo sapiens CHEMBL3611367 cell-based format
CHEMBL45816 OBDepict CH 3 O O O H N CH 3 CH 3 H 3 C F N N H IC50 = 202.0 nM 495.64 COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C Homo sapiens CHEMBL3611367 cell-based format
CHEMBL3608316 OBDepict CH 3 N O H N N O H O CH 3 H 3 C H CH 3 H 3 C F IC50 = 225.0 nM 599.79 CC(C)C(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)C[C@H](OCc2ccccc2)c2cc(F)ccc2[C@@H]1C(C)C Homo sapiens CHEMBL3611367 cell-based format
CHEMBL2110168 OBDepict H 3 C O HO CH 3 N H H CH 3 S O O + N O _ O CH 3 Ki = 250.0 nM 406.46 CCOC(=O)[C@H]1[C@H]2/C(=C(O)OCC)C(C)=N[C@]1(C)Sc1c2cccc1[N+](=O)[O-] Homo sapiens CHEMBL664887 assay format
CHEMBL3392227 OBDepict H 3 C O O H 3 C HN H H 3 C N N IC50 = 250.0 nM 359.43 CCOC(=O)C1=C(C)NC(C)=C(C#N)[C@@H]1c1cnccc1-c1ccccc1 Homo sapiens CHEMBL660543 single protein format
CHEMBL3392229 OBDepict CH 3 O O CH 3 NH H CH 3 N N IC50 = 270.0 nM 409.49 CCOC(=O)C1=C(C)NC(C)=C(C#N)[C@@H]1c1cnccc1-c1cccc2ccccc12 Homo sapiens CHEMBL660543 single protein format
CHEMBL3609822 OBDepict H 3 C N O H N N O H 3 C CH 3 H H 3 C CH 3 F IC50 = 347.0 nM 493.67 CC(C)C(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C Homo sapiens CHEMBL3611367 cell-based format
CHEMBL3609819 OBDepict CH 3 O N N H N H 3 C O H O H CH 3 H 3 C IC50 = 387.0 nM 503.69 COc1cccc2nc(CCCN(C)CC[C@]3(OC(=O)C(C)C)C[C@H]4CCC[C@@H]3c3ccccc34)[nH]c12 Homo sapiens CHEMBL3611367 cell-based format
CHEMBL138302 OBDepict CH 3 O O CH 3 N CH 3 CH 3 CH 3 N O O H 3 C H 3 C IC50 = 390.0 nM 494.68 COc1ccc(CCN(C)C2CCCC(C(C#N)(c3ccc(OC)c(OC)c3)C(C)C)C2)cc1OC Homo sapiens CHEMBL656260 cell membrane format
CHEMBL3608940 OBDepict H 3 C O H O H F N O CH 3 H 3 C H 3 C H 3 C H 3 C N N H IC50 = 403.0 nM 523.69 CO[C@H]1C[C@@](CCN(C)CCCc2nc3ccccc3[nH]2)(OC(=O)C(C)C)[C@@H](C(C)C)c2ccc(F)cc21 Homo sapiens CHEMBL3611367 cell-based format
CHEMBL75770 OBDepict CH 3 O HO CH 3 N CH 3 O O O N CH 3 H 3 C H 3 C Ki = 417.0 nM 438.52 CCOC(=O)C1=C(C)N=C(C)/C(=C(/O)OCC)C1c1c(-c2ccccc2)noc1C(C)C Homo sapiens CHEMBL659866 cell membrane format
CHEMBL3609817 OBDepict CH 3 N O H N N O H H H 3 C H 3 C IC50 = 424.0 nM 459.63 CC(C)C(=O)O[C@@]1(CCN(C)CCCc2nc3ccccc3[nH]2)C[C@H]2CC[C@@H]1c1ccccc12 Homo sapiens CHEMBL3611367 cell-based format
CHEMBL3608943 OBDepict H 3 C N O H N N O H OH H 3 C CH 3 H CH 3 H 3 C F IC50 = 426.0 nM 509.67 CC(C)C(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)C[C@H](O)c2cc(F)ccc2[C@@H]1C(C)C Homo sapiens CHEMBL3611367 cell-based format
CHEMBL3609823 OBDepict CH 3 O O O H N H 3 C H 3 C CH 3 CH 3 H 3 C F N N H IC50 = 434.0 nM 523.69 COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CC(C)(C)c2cc(F)ccc2[C@@H]1C(C)C Homo sapiens CHEMBL3611367 cell-based format
CHEMBL3609818 OBDepict CH 3 N O H N N O H H CH 3 CH 3 IC50 = 455.0 nM 473.66 CC(C)C(=O)O[C@@]1(CCN(C)CCCc2nc3ccccc3[nH]2)C[C@H]2CCC[C@@H]1c1ccccc12 Homo sapiens CHEMBL3611367 cell-based format
CHEMBL2110303 OBDepict H 3 C O HO CH 3 N H H CH 3 S O O CH 3 Ki = 500.0 nM 361.46 CCOC(=O)[C@@H]1[C@H]2/C(=C(O)OCC)C(C)=N[C@]1(C)Sc1ccccc12 Homo sapiens CHEMBL664887 assay format
CHEMBL3608942 OBDepict H 3 C N O H N N O H OH H 3 C CH 3 H CH 3 H 3 C F IC50 = 504.0 nM 509.67 CC(C)C(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)C[C@@H](O)c2cc(F)ccc2[C@@H]1C(C)C Homo sapiens CHEMBL3611367 cell-based format
CHEMBL343771 OBDepict CH 3 O O CH 3 N H CH 3 H 3 C N O O CH 3 H 3 C IC50 = 540.0 nM 480.65 COc1ccc(CCNC2CCCC(C(C#N)(c3ccc(OC)c(OC)c3)C(C)C)C2)cc1OC Homo sapiens CHEMBL656260 cell membrane format
CHEMBL3609825 OBDepict H 3 C O H O H F N O CH 3 H 3 C H 3 C H 3 C H 3 C N N H IC50 = 588.0 nM 523.69 CO[C@@H]1C[C@@](CCN(C)CCCc2nc3ccccc3[nH]2)(OC(=O)C(C)C)[C@@H](C(C)C)c2ccc(F)cc21 Homo sapiens CHEMBL3611367 cell-based format
CHEMBL3608947 OBDepict CH 3 N O H N N O H H CH 3 CH 3 IC50 = 648.0 nM 473.66 CC(C)C(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)C[C@@H]2CCC[C@H]1c1ccccc12 Homo sapiens CHEMBL3611367 cell-based format
CHEMBL2110169 OBDepict H 3 C O HO CH 3 N H H CH 3 S O O + N O _ O CH 3 Ki = 650.0 nM 406.46 CCOC(=O)[C@H]1[C@H]2/C(=C(O)OCC)C(C)=N[C@]1(C)Sc1ccc([N+](=O)[O-])cc12 Homo sapiens CHEMBL664887 assay format
CHEMBL3608945 OBDepict CH 3 N O H N N O H H H 3 C H 3 C IC50 = 699.0 nM 459.63 CC(C)C(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)C[C@@H]2CC[C@H]1c1ccccc12 Homo sapiens CHEMBL3611367 cell-based format
CHEMBL3608944 OBDepict CH 3 O O O H N H CH 3 N N H IC50 = 748.0 nM 461.61 COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)C[C@@H]2CC[C@H]1c1ccccc12 Homo sapiens CHEMBL3611367 cell-based format
CHEMBL4209001 OBDepict H 3 C NH N N N H O O F F F IC50 = 860.0 nM 522.57 CCNCCc1c(C(=O)NCc2ccccc2OCC(F)(F)F)nn(-c2ccccc2)c1-c1ccccc1 Homo sapiens CHEMBL4180583 single protein format