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Q14397 | GCKR_HUMAN | Glucokinase regulatory protein (GCKR)

3D structures mapped by conservation among orthologs

[ Domain: "C-terminal lid domain of glucokinase regulatory protein" // murQ_2nd ]

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[ Domain: "Ribosomal protein S2/SIS domain" // PRK12570 ]

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[ Domain: "Ribosomal protein S2/SIS domain" // murQ_1st ]

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[ Domain: pdbs with more than 2 multi-domains ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL3746243 OBDepict Cl N F N H H NH 2 S S O O N OH CH 3 CH 3 IC50 = 3.8 nM 547.08 CC(C)(O)c1ccnc(-c2cccc3cc([C@H](NS(=O)(=O)C4CC4)c4c(Cl)cnc(N)c4F)sc23)c1 Homo sapiens CHEMBL3751192 single protein format
CHEMBL3114185 OBDepict CH 3 H N N S O O N NH 2 OH F F F F F F IC50 = 4.0 nM 522.47 CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1 Homo sapiens CHEMBL3240701 single protein format
CHEMBL3237987 OBDepict H 3 C H N N S O O N NH 2 OH F F F CH 3 IC50 = 5.0 nM 506.55 CC#CCC(O)(c1ccc(N2CCN(S(=O)(=O)c3ccc(N)nc3)C[C@@H]2C#CC)cc1)C(F)(F)F Homo sapiens CHEMBL3240701 single protein format
CHEMBL3745887 OBDepict NH 2 N Cl N H H S S O O N OH CH 3 CH 3 IC50 = 6.0 nM 529.09 CC(C)(O)c1ccnc(-c2cccc3cc([C@H](NS(=O)(=O)C4CC4)c4nc(N)ccc4Cl)sc23)c1 Homo sapiens CHEMBL3751192 single protein format
CHEMBL3237986 OBDepict CH OH F F F N H N S CH 3 O O N NH 2 IC50 = 6.0 nM 492.52 C#CCC(O)(c1ccc(N2CCN(S(=O)(=O)c3ccc(N)nc3)C[C@@H]2C#CC)cc1)C(F)(F)F Homo sapiens CHEMBL3240701 single protein format
CHEMBL3237981 OBDepict CH 3 H N N S O O N NH 2 OH F F F OH IC50 = 6.0 nM 484.5 CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc([C@@](O)(CO)C(F)(F)F)cc1 Homo sapiens CHEMBL3240701 single protein format
CHEMBL3114187 OBDepict CH 3 H N N S O O N NH 2 OH CH 3 F F F IC50 = 9.0 nM 468.5 CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc([C@@](C)(O)C(F)(F)F)cc1 Homo sapiens CHEMBL3240701 single protein format
CHEMBL3127349 OBDepict H N N N S H CH 3 O O S O OH F F F F F F IC50 = 9.7 nM 587.61 C[C@H]1COCCN1C[C@H]1CN(S(=O)(=O)c2cccs2)CCN1c1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1 Homo sapiens CHEMBL3131528 single protein format
CHEMBL3238310 OBDepict CH 3 H N N S N N O O N NH 2 OH F F F F F F IC50 = 10.0 nM 524.45 CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ncc(C(O)(C(F)(F)F)C(F)(F)F)cn1 Homo sapiens CHEMBL3240701 single protein format
CHEMBL3238309 OBDepict CH 3 H N N S N O O N NH 2 OH F F F F F F IC50 = 10.0 nM 523.46 CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc(C(O)(C(F)(F)F)C(F)(F)F)cn1 Homo sapiens CHEMBL3240701 single protein format
CHEMBL3746444 OBDepict Cl N F N H H H 2 N S S O O N HO H 3 C CH 3 IC50 = 11.0 nM 547.08 CC(C)(O)c1ccnc(-c2cccc3cc([C@H](NS(=O)(=O)C4CC4)c4nc(N)c(F)cc4Cl)sc23)c1 Homo sapiens CHEMBL3751192 single protein format
CHEMBL3127352 OBDepict H N N N S H CH 3 O O S O OH H 3 C F F F IC50 = 12.0 nM 533.64 C[C@H]1COCCN1C[C@H]1CN(S(=O)(=O)c2cccs2)CCN1c1ccc([C@](C)(O)C(F)(F)F)cc1 Homo sapiens CHEMBL3131528 single protein format
CHEMBL3238313 OBDepict CH 3 H N N S N O O N NH 2 OH F F F OH IC50 = 13.0 nM 485.49 CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc([C@](O)(CO)C(F)(F)F)cn1 Homo sapiens CHEMBL3240701 single protein format
CHEMBL3238308 OBDepict CH 3 H N N S N O O N NH 2 OH CH 3 F F F IC50 = 13.0 nM 469.49 CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc([C@](C)(O)C(F)(F)F)cn1 Homo sapiens CHEMBL3240701 single protein format
CHEMBL3238307 OBDepict CH 3 H N N S N O O N NH 2 OH CH 3 F F F IC50 = 13.0 nM 469.49 CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc([C@@](C)(O)C(F)(F)F)cn1 Homo sapiens CHEMBL3240701 single protein format
CHEMBL3237985 OBDepict H 3 C O OH F F F N H N S CH 3 O O N NH 2 IC50 = 16.0 nM 498.53 CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc(C(O)(COC)C(F)(F)F)cc1 Homo sapiens CHEMBL3240701 single protein format
CHEMBL3746456 OBDepict Cl HN H S S O O O O IC50 = 17.0 nM 486.01 O=S(=O)(N[C@@H](c1cc2ccccc2s1)c1ccccc1Cl)c1ccc2c(c1)OCCCO2 Homo sapiens CHEMBL3751192 single protein format
CHEMBL3238303 OBDepict CH 3 H N N S O O N NH 2 S O NH F F F IC50 = 17.0 nM 487.53 CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc([S@](=N)(=O)C(F)(F)F)cc1 Homo sapiens CHEMBL3240701 single protein format
CHEMBL3746034 OBDepict NH 2 N N Cl N H H S S O O N OH CH 3 CH 3 IC50 = 18.0 nM 530.08 CC(C)(O)c1ccnc(-c2cccc3cc([C@H](NS(=O)(=O)C4CC4)c4nc(N)ncc4Cl)sc23)c1 Homo sapiens CHEMBL3751192 single protein format
CHEMBL3238306 OBDepict CH 3 H N N S N O O N NH 2 OH CH 3 F F F IC50 = 18.0 nM 469.49 CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc(C(C)(O)C(F)(F)F)cn1 Homo sapiens CHEMBL3240701 single protein format
CHEMBL3113979 OBDepict H N N N S H CH 3 O O S O OH H 3 C F F F IC50 = 21.0 nM 533.64 C[C@H]1COCCN1C[C@H]1CN(S(=O)(=O)c2cccs2)CCN1c1ccc([C@@](C)(O)C(F)(F)F)cc1 Homo sapiens CHEMBL3131528 single protein format
CHEMBL3238312 OBDepict CH 3 H N N S N O O N NH 2 OH F F F OH IC50 = 24.0 nM 485.49 CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc(C(O)(CO)C(F)(F)F)cn1 Homo sapiens CHEMBL3240701 single protein format
CHEMBL3746655 OBDepict NH 2 N Cl N H H S S O O N OH CH 3 CH 3 IC50 = 25.0 nM 529.09 CC(C)(O)c1ccnc(-c2cccc3cc([C@H](NS(=O)(=O)C4CC4)c4cc(N)ncc4Cl)sc23)c1 Homo sapiens CHEMBL3751192 single protein format
CHEMBL3237984 OBDepict N OH F F F N H N S CH 3 O O N NH 2 IC50 = 28.0 nM 493.51 CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc(C(O)(CC#N)C(F)(F)F)cc1 Homo sapiens CHEMBL3240701 single protein format
CHEMBL3237980 OBDepict CH 3 H N N S O O N NH 2 OH F F F OH IC50 = 28.0 nM 484.5 CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc([C@](O)(CO)C(F)(F)F)cc1 Homo sapiens CHEMBL3240701 single protein format
CHEMBL3237993 OBDepict CH 3 H N N S O O N NH 2 S NH O O H 3 C IC50 = 35.0 nM 449.56 CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc(S(=O)(=O)NC)cc1 Homo sapiens CHEMBL3240701 single protein format
CHEMBL3127348 OBDepict H N N N S O O S O OH F F F F F F IC50 = 36.0 nM 573.58 O=S(=O)(c1cccs1)N1CCN(c2ccc(C(O)(C(F)(F)F)C(F)(F)F)cc2)[C@@H](CN2CCOCC2)C1 Homo sapiens CHEMBL3131528 single protein format
CHEMBL3238301 OBDepict CH 3 H N N S O O N NH 2 S O NH F F F IC50 = 45.0 nM 487.53 CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc(S(=N)(=O)C(F)(F)F)cc1 Homo sapiens CHEMBL3240701 single protein format
CHEMBL3237983 OBDepict CH 3 H N N S O O N NH 2 OH F F F NH 2 IC50 = 47.0 nM 483.52 CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc([C@@](O)(CN)C(F)(F)F)cc1 Homo sapiens CHEMBL3240701 single protein format
CHEMBL3238316 OBDepict CH 3 H N N S N S O O N NH 2 OH CH 3 F F F IC50 = 49.0 nM 475.52 CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ncc(C(C)(O)C(F)(F)F)s1 Homo sapiens CHEMBL3240701 single protein format
CHEMBL3747784 OBDepict Cl HN H O S O O O O IC50 = 52.0 nM 469.95 O=S(=O)(N[C@@H](c1cc2ccccc2o1)c1ccccc1Cl)c1ccc2c(c1)OCCCO2 Homo sapiens CHEMBL3751192 single protein format
CHEMBL3747365 OBDepict F Cl N H H S S O O N OH CH 3 CH 3 IC50 = 56.0 nM 531.07 CC(C)(O)c1ccnc(-c2cccc3cc([C@H](NS(=O)(=O)C4CC4)c4c(F)cccc4Cl)sc23)c1 Homo sapiens CHEMBL3751192 single protein format
CHEMBL3127347 OBDepict H N N S O O S O OH F F F F F F IC50 = 58.0 nM 572.59 O=S(=O)(c1cccs1)N1CCN(c2ccc(C(O)(C(F)(F)F)C(F)(F)F)cc2)[C@@H](CC2CCOCC2)C1 Homo sapiens CHEMBL3131528 single protein format
CHEMBL3237992 OBDepict CH 3 H N N S O O N NH 2 S O O NH 2 IC50 = 61.0 nM 435.53 CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc(S(N)(=O)=O)cc1 Homo sapiens CHEMBL3240701 single protein format
CHEMBL3238311 OBDepict CH 3 H N N S N O O N NH 2 S NH O O H 3 C IC50 = 68.0 nM 450.55 CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc(S(=O)(=O)NC)cn1 Homo sapiens CHEMBL3240701 single protein format
CHEMBL3238305 OBDepict CH 3 H N N S O O N NH 2 N OH CH 3 F F F IC50 = 69.0 nM 469.49 CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc(C(C)(O)C(F)(F)F)nc1 Homo sapiens CHEMBL3240701 single protein format
CHEMBL3238314 OBDepict CH 3 H N N S N O O N NH 2 OH F F F OH IC50 = 70.0 nM 485.49 CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc([C@@](O)(CO)C(F)(F)F)cn1 Homo sapiens CHEMBL3240701 single protein format
CHEMBL3746828 OBDepict F O O S HN O O H S Cl IC50 = 74.0 nM 504.0 O=S(=O)(N[C@@H](c1cc2ccccc2s1)c1ccccc1Cl)c1ccc2c(c1)OCC(F)CO2 Homo sapiens CHEMBL3751192 single protein format
CHEMBL3238315 OBDepict CH 3 H N N S N S O O N NH 2 OH F F F F F F IC50 = 81.0 nM 529.49 CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ncc(C(O)(C(F)(F)F)C(F)(F)F)s1 Homo sapiens CHEMBL3240701 single protein format
CHEMBL3127350 OBDepict H N N S O O S O OH H 3 C F F F IC50 = 95.0 nM 518.62 C[C@@](O)(c1ccc(N2CCN(S(=O)(=O)c3cccs3)C[C@@H]2CC2CCOCC2)cc1)C(F)(F)F Homo sapiens CHEMBL3131528 single protein format
CHEMBL3127351 OBDepict H N N S O O S O OH H 3 C F F F IC50 = 100.0 nM 518.62 C[C@](O)(c1ccc(N2CCN(S(=O)(=O)c3cccs3)C[C@@H]2CC2CCOCC2)cc1)C(F)(F)F Homo sapiens CHEMBL3131528 single protein format
CHEMBL3745736 OBDepict HO O O S HN O O H S Cl IC50 = 100.0 nM 502.01 O=S(=O)(N[C@@H](c1cc2ccccc2s1)c1ccccc1Cl)c1ccc2c(c1)OCC(O)CO2 Homo sapiens CHEMBL3751192 single protein format
CHEMBL3237994 OBDepict CH 3 H N N S O O N NH 2 S NH O O IC50 = 101.0 nM 475.6 CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc(S(=O)(=O)NC2CC2)cc1 Homo sapiens CHEMBL3240701 single protein format
CHEMBL3746320 OBDepict Cl N H H S S O O N HO H 3 C CH 3 IC50 = 110.0 nM 513.08 CC(C)(O)c1ccnc(-c2cccc3cc([C@H](NS(=O)(=O)C4CC4)c4ccccc4Cl)sc23)c1 Homo sapiens CHEMBL3751192 single protein format
CHEMBL3746391 OBDepict Cl HN H N S S O O O O N IC50 = 160.0 nM 487.99 O=S(=O)(N[C@@H](c1nc2cccnc2s1)c1ccccc1Cl)c1ccc2c(c1)OCCCO2 Homo sapiens CHEMBL3751192 single protein format
CHEMBL3238302 OBDepict CH 3 H N N S O O N NH 2 S O NH F F F IC50 = 182.0 nM 487.53 CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc([S@@](=N)(=O)C(F)(F)F)cc1 Homo sapiens CHEMBL3240701 single protein format
CHEMBL3747490 OBDepict Cl N H H S S O O N HO CH 3 F F F IC50 = 190.0 nM 567.05 C[C@](O)(c1ccnc(-c2cccc3cc([C@H](NS(=O)(=O)C4CC4)c4ccccc4Cl)sc23)c1)C(F)(F)F Homo sapiens CHEMBL3751192 single protein format
CHEMBL3127361 OBDepict OH N N S O O S OH F F F F F F IC50 = 215.0 nM 580.57 O=S(=O)(c1cccs1)N1CCN(c2ccc(C(O)(C(F)(F)F)C(F)(F)F)cc2)C(Cc2ccccc2O)C1 Homo sapiens CHEMBL3131528 single protein format
CHEMBL3238296 OBDepict CH 3 H N N S O O N NH 2 S HN O O CH 3 CH 3 IC50 = 235.0 nM 477.61 CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc(S(=O)(=O)NC(C)C)cc1 Homo sapiens CHEMBL3240701 single protein format
CHEMBL3238300 OBDepict CH 3 H N N S O O N NH 2 S O NH IC50 = 256.0 nM 459.6 CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc(S(=N)(=O)C2CC2)cc1 Homo sapiens CHEMBL3240701 single protein format
CHEMBL3238304 OBDepict CH 3 H N N S O O N NH 2 S N O F F F CH 3 IC50 = 266.0 nM 501.56 CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc(S(=O)(=NC)C(F)(F)F)cc1 Homo sapiens CHEMBL3240701 single protein format
CHEMBL3745752 OBDepict Cl N H H S S O O N HO CH 3 F F F IC50 = 300.0 nM 567.05 C[C@@](O)(c1ccnc(-c2cccc3cc([C@H](NS(=O)(=O)C4CC4)c4ccccc4Cl)sc23)c1)C(F)(F)F Homo sapiens CHEMBL3751192 single protein format
CHEMBL3127354 OBDepict H H 3 C N N S O O S OH F F F F F F IC50 = 300.0 nM 488.48 C[C@H]1CN(S(=O)(=O)c2cccs2)CCN1c1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1 Homo sapiens CHEMBL3131528 single protein format
CHEMBL3238299 OBDepict CH 3 H N N S O O N NH 2 S O NH CH 3 IC50 = 310.0 nM 433.56 CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc(S(C)(=N)=O)cc1 Homo sapiens CHEMBL3240701 single protein format
CHEMBL3238297 OBDepict CH 3 H N N S O O N NH 2 S NH O O IC50 = 320.0 nM 489.62 CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc(S(=O)(=O)NCC2CC2)cc1 Homo sapiens CHEMBL3240701 single protein format
CHEMBL3237982 OBDepict CH 3 H N N S O O N NH 2 OH F F F NH 2 IC50 = 374.0 nM 483.52 CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc([C@](O)(CN)C(F)(F)F)cc1 Homo sapiens CHEMBL3240701 single protein format
CHEMBL3237991 OBDepict CH 3 H N N S O O N NH 2 S O O CH 3 IC50 = 401.0 nM 434.54 CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc(S(C)(=O)=O)cc1 Homo sapiens CHEMBL3240701 single protein format
CHEMBL3127360 OBDepict H N N S O O S OH F F F F F F IC50 = 701.0 nM 564.57 O=S(=O)(c1cccs1)N1CCN(c2ccc(C(O)(C(F)(F)F)C(F)(F)F)cc2)[C@@H](Cc2ccccc2)C1 Homo sapiens CHEMBL3131528 single protein format
CHEMBL3747590 OBDepict Cl HN H S S O O O O F F IC50 = 810.0 nM 521.99 O=S(=O)(N[C@@H](c1cc2ccccc2s1)c1ccccc1Cl)c1ccc2c(c1)OCC(F)(F)CO2 Homo sapiens CHEMBL3751192 single protein format
CHEMBL3127341 OBDepict OH N N S O O S OH F F F F F F IC50 = 850.0 nM 580.57 O=S(=O)(c1cccs1)N1CCN(c2ccc(C(O)(C(F)(F)F)C(F)(F)F)cc2)C(Cc2ccc(O)cc2)C1 Homo sapiens CHEMBL3131528 single protein format
CHEMBL3746716 OBDepict O S N H O H O O O IC50 = 870.0 nM 435.5 O=S(=O)(N[C@H](c1ccccc1)c1cc2ccccc2o1)c1ccc2c(c1)OCCCO2 Homo sapiens CHEMBL3751192 single protein format