HOME LIGAND hPROTEOME OTHERS DOCUMENT

Q14524 | SCN5A_HUMAN | Sodium channel protein type 5 subunit alpha (SCN5A)

3D structures mapped by conservation among orthologs

[ Domain: "EF-hand" // EF-hand_7_6 ]

download pymol session

[ Domain: "Voltage gated calcium channel IQ domain" // IQ_like ]

download pymol session



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL3617050 OBDepict OH N H O O N NH N H H H N H N O N HO OH HN O O H S H O O HO HO IC50 = 0.28 nM 552.48 N=C1N[C@@]23[C@H]([C@H]4NC(=N)N2C[C@](OS(=O)(=O)O)(C[C@H]2[C@@H](CO)CON2C4=O)C3(O)O)N1COC(=O)NO Homo sapiens CHEMBL3618799 cell-based format
CHEMBL4061793 OBDepict Cl N H S F HN O O N S N IC50 = 2.2 nM 430.96 O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCC23CCCN2CCC3)cc1F Homo sapiens CHEMBL4046487 cell-based format
CHEMBL3657939 OBDepict O N H S F N O O O O IC50 = 14.0 nM 492.61 O=C(NS(=O)(=O)N1CCOCC1)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F Homo sapiens CHEMBL3705543 cell-based format
CHEMBL3657952 OBDepict HO N H S N H O O O F O IC50 = 22.0 nM 480.6 O=C(NS(=O)(=O)NCCCO)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F Homo sapiens CHEMBL3705543 cell-based format
CHEMBL3657932 OBDepict O N H S F O O O IC50 = 26.0 nM 447.57 O=C(NS(=O)(=O)C1CC1)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F Homo sapiens CHEMBL3705543 cell-based format
CHEMBL3677849 OBDepict CH 3 N N F F F S NH O O N S N IC50 = 30.0 nM 515.54 Cn1nccc1-c1cc(C(F)(F)F)ccc1-c1cccc2cc(S(=O)(=O)Nc3ncns3)ccc12 Homo sapiens CHEMBL3705623 cell-based format
CHEMBL4864812 OBDepict F N HN S O O F F F O H H N F F F F F IC50 = 31.0 nM 599.48 O=S(=O)(Nc1cccc(F)n1)c1cc(F)c(O[C@H]2CCN(CC(F)(F)F)C[C@@H]2c2ccc(F)c(F)c2)c(F)c1F Homo sapiens CHEMBL4813111 single protein format
CHEMBL4075332 OBDepict Cl N H S F HN O O N S S O O IC50 = 37.0 nM 468.0 O=S1(=O)CCC(CCNc2cc(F)c(S(=O)(=O)Nc3nccs3)cc2Cl)CC1 Homo sapiens CHEMBL4046487 cell-based format
CHEMBL3662238 OBDepict F O N H O S N O O IC50 = 40.0 nM 410.51 O=C(NS(=O)(=O)N1CCC1)c1cc(C2CC2)c(OCC2CCCCC2)cc1F Homo sapiens CHEMBL3705543 cell-based format
CHEMBL3662190 OBDepict O N H S F O O O H 3 C IC50 = 50.0 nM 435.56 CC1(COc2cc(F)c(C(=O)NS(=O)(=O)C3CC3)cc2C2CC2)CCC2(CC1)CC2 Homo sapiens CHEMBL4321995 cell-based format
CHEMBL4094490 OBDepict Cl N H S F HN O O N S O IC50 = 50.0 nM 419.93 O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCCC2CCCOC2)cc1F Homo sapiens CHEMBL4046487 cell-based format
CHEMBL3657855 OBDepict F O N H O S N O O IC50 = 51.5 nM 462.59 O=C(NS(=O)(=O)N1CCC1)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F Homo sapiens CHEMBL3705543 cell-based format
CHEMBL4102624 OBDepict O N H Cl F S HN O O N S IC50 = 52.0 nM 417.92 O=C1CCCC(CNc2cc(F)c(S(=O)(=O)Nc3nccs3)cc2Cl)C1 Homo sapiens CHEMBL4046487 cell-based format
CHEMBL3810248 OBDepict CH 3 Si CH 3 CH 3 N N N F F F IC50 = 59.0 nM 335.41 C[Si](C)(C)c1ccc(-c2ccc3nnc(C(F)(F)F)n3c2)cc1 Homo sapiens CHEMBL3811490 single protein format
CHEMBL3657838 OBDepict HO N S N H O O O F O IC50 = 60.6 nM 478.59 O=C(NS(=O)(=O)N1CC(O)C1)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F Homo sapiens CHEMBL3705543 cell-based format
CHEMBL4854735 OBDepict F N HN S O O F F O H H N F F F F F IC50 = 65.0 nM 581.49 O=S(=O)(Nc1cccc(F)n1)c1cc(F)c(O[C@H]2CCN(CC(F)(F)F)C[C@@H]2c2ccc(F)c(F)c2)c(F)c1 Homo sapiens CHEMBL4813111 single protein format
CHEMBL4087220 OBDepict Cl N H S F HN O O N S O O IC50 = 74.0 nM 407.88 O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCC2COCCO2)cc1F Homo sapiens CHEMBL4046487 cell-based format
CHEMBL4072883 OBDepict Cl N H S F HN O O N S H O IC50 = 76.0 nM 405.9 O=S(=O)(Nc1nccs1)c1cc(Cl)c(NC[C@H]2CCCOC2)cc1F Homo sapiens CHEMBL4046487 cell-based format
CHEMBL4102233 OBDepict Cl N H S F HN O O N S H H O IC50 = 77.0 nM 482.0 O=S(=O)(Nc1nccs1)c1cc(Cl)c(NC[C@H]2CCCO[C@@H]2c2ccccc2)cc1F Homo sapiens CHEMBL4046487 cell-based format
CHEMBL3707218 OBDepict O N O O O O F F F IC50 = 84.0 nM 429.35 O=C1N(Cc2ccc(C(F)(F)F)o2)c2ccccc2[C@]12COc1cc3c(cc12)OCO3 Homo sapiens CHEMBL4321995 cell-based format
CHEMBL3662081 OBDepict O HN S F N O O O F F F IC50 = 90.0 nM 464.48 O=C(NS(=O)(=O)N1CCC1)c1cc(C2CC2)c(OCC2(C(F)(F)F)CCCC2)cc1F Homo sapiens CHEMBL3705543 cell-based format
CHEMBL4100176 OBDepict H 3 C O N N H Cl F S NH O O N S IC50 = 94.0 nM 446.96 CON=C1CCC(CNc2cc(F)c(S(=O)(=O)Nc3nccs3)cc2Cl)CC1 Homo sapiens CHEMBL4046487 cell-based format
CHEMBL486495 OBDepict O N O N CH 3 CH 3 H 3 C IC50 = 100.0 nM 394.56 CC(C)(C)c1ccc(-c2ccc(C(=O)N3CCN(C4CCCCC4)CC3)o2)cc1 Homo sapiens CHEMBL954009 cell-based format
CHEMBL3657840 OBDepict H 3 C O S N H O O O F O IC50 = 101.0 nM 465.59 COCCS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F Homo sapiens CHEMBL3705543 cell-based format
CHEMBL3809404 OBDepict F O F F N N F F F IC50 = 102.0 nM 346.23 FC(F)(F)Oc1ccc(-c2ccc3cnc(C(F)(F)F)n3c2)cc1 Homo sapiens CHEMBL3811490 single protein format
CHEMBL4104727 OBDepict Cl HN S F NH O O N S H O O IC50 = 108.0 nM 433.91 O=S(=O)(Nc1nccs1)c1cc(Cl)c(NC[C@]23CCO[C@H]2OCC3)cc1F Homo sapiens CHEMBL4046487 cell-based format
CHEMBL3657931 OBDepict O N H S F N O O H HO O IC50 = 110.0 nM 492.61 O=C(NS(=O)(=O)N1CC[C@H](O)C1)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F Homo sapiens CHEMBL3705543 cell-based format
CHEMBL3337595 OBDepict CH 3 O N H N N O N O H 3 C IC50 = 118.0 nM 472.59 COc1ccc2c(c1)NC1(CCN(C(=O)c3ccc(OC)c(N4CCCC4)c3)CC1)c1cccn1-2 Homo sapiens CHEMBL3387119 cell-based format
CHEMBL4064762 OBDepict Cl N H S F HN O O N S O IC50 = 120.0 nM 419.93 O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCCC2CCOCC2)cc1F Homo sapiens CHEMBL4046487 cell-based format
CHEMBL3809360 OBDepict CH 3 O N F F F N N F F F IC50 = 123.0 nM 361.25 Cc1cc(OC(F)(F)F)ccc1-c1ccc2nnc(C(F)(F)F)n2c1 Homo sapiens CHEMBL3811490 single protein format
CHEMBL4102647 OBDepict Cl N H S F HN O O N S O IC50 = 127.0 nM 405.9 O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCC2CCOCC2)cc1F Homo sapiens CHEMBL4046487 cell-based format
CHEMBL3657972 OBDepict O N H S F N O O O IC50 = 130.0 nM 462.59 O=C(NS(=O)(=O)N1CCC1)c1cc(C2CC2)c(OCC2C3CC4CC(C3)CC2C4)cc1F Homo sapiens CHEMBL3705543 cell-based format
CHEMBL3662090 OBDepict F O N H O S O O F F IC50 = 130.0 nM 483.55 O=C(NS(=O)(=O)C1CC1)c1cc(C2CC2)c(OCC23CC4CC(C2)C(F)(F)C(C4)C3)cc1F Homo sapiens CHEMBL3705543 cell-based format
CHEMBL4073353 OBDepict Cl N H S F HN O O N S O IC50 = 133.0 nM 419.93 O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCCCC2CCOC2)cc1F Homo sapiens CHEMBL4046487 cell-based format
CHEMBL3657967 OBDepict H 3 C O S N H O O O F O IC50 = 140.0 nM 413.51 COCCS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCCCC2)cc1F Homo sapiens CHEMBL3705543 cell-based format
CHEMBL4090259 OBDepict CH 3 O Cl H 2 N N N F S HN O O N O IC50 = 140.0 nM 525.95 COc1cc(-c2cccc(F)c2)c(Cl)cc1-c1c(N)nnc2cc(S(=O)(=O)Nc3ccon3)ccc12 Homo sapiens CHEMBL4012201 cell-based format
CHEMBL3657953 OBDepict CH 3 O N S N H O O O F O IC50 = 144.0 nM 492.61 COC1CN(S(=O)(=O)NC(=O)c2cc(C3CC3)c(OCC34CC5CC(CC(C5)C3)C4)cc2F)C1 Homo sapiens CHEMBL3705543 cell-based format
CHEMBL4073324 OBDepict O HN Cl F S N H O O N S IC50 = 150.0 nM 417.92 O=C1CCC(CNc2cc(F)c(S(=O)(=O)Nc3nccs3)cc2Cl)CC1 Homo sapiens CHEMBL4046487 cell-based format
CHEMBL4094879 OBDepict Cl N H S F HN O O N S H H HO IC50 = 151.0 nM 419.93 O=S(=O)(Nc1nccs1)c1cc(Cl)c(NC[C@H]2CCC[C@@H](O)C2)cc1F Homo sapiens CHEMBL4046487 cell-based format
CHEMBL4092435 OBDepict Cl N H S F HN O O N S H H HO IC50 = 156.0 nM 419.93 O=S(=O)(Nc1nccs1)c1cc(Cl)c(NC[C@H]2CC[C@H](O)CC2)cc1F Homo sapiens CHEMBL4046487 cell-based format
CHEMBL4064295 OBDepict Cl N H S F NH O O N S H H O CH 3 CH 3 H 3 C IC50 = 156.0 nM 462.01 CC(C)(C)[C@H]1OCCC[C@@H]1CNc1cc(F)c(S(=O)(=O)Nc2nccs2)cc1Cl Homo sapiens CHEMBL4046487 cell-based format
CHEMBL3657851 OBDepict O N H S F O O CH 3 O IC50 = 159.0 nM 421.53 CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F Homo sapiens CHEMBL3705543 cell-based format
CHEMBL3662229 OBDepict O N H S F O O O F F F IC50 = 160.0 nM 463.49 O=C(NS(=O)(=O)C1CC1)c1cc(C2CC2)c(OCC2(C(F)(F)F)CCCCC2)cc1F Homo sapiens CHEMBL3705543 cell-based format
CHEMBL3662093 OBDepict F O N H O S N O O IC50 = 160.0 nM 422.52 O=C(NS(=O)(=O)N1CCC1)c1cc(C2CC2)c(OCC23CCCCC2C3)cc1F Homo sapiens CHEMBL3705543 cell-based format
CHEMBL4074392 OBDepict Cl N H S F HN O O N S O O IC50 = 162.0 nM 461.97 O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCC2CCCC3(C2)OCCO3)cc1F Homo sapiens CHEMBL4046487 cell-based format
CHEMBL3810234 OBDepict CH 3 O F F F N N N F F F IC50 = 166.0 nM 361.25 Cc1cc(-c2ccc3nnc(C(F)(F)F)n3c2)ccc1OC(F)(F)F Homo sapiens CHEMBL3811490 single protein format
CHEMBL4071736 OBDepict Cl HN S F NH O O N S HO IC50 = 169.0 nM 445.97 O=S(=O)(Nc1nccs1)c1cc(Cl)c(NC[C@]23CCC[C@@]2(O)CCC3)cc1F Homo sapiens CHEMBL4046487 cell-based format
CHEMBL3337583 OBDepict CH 3 O N CH 3 CH 3 N O NH N O F F F IC50 = 181.0 nM 500.52 COc1ccc(C(=O)N2CCC3(CC2)Nc2cc(OC(F)(F)F)ccc2-n2cccc23)cc1N(C)C Homo sapiens CHEMBL3387119 cell-based format
CHEMBL3808867 OBDepict CH 3 H 3 C CH 3 N N N F F F IC50 = 182.0 nM 319.33 CC(C)(C)c1ccc(-c2ccc3nnc(C(F)(F)F)n3c2)cc1 Homo sapiens CHEMBL3811490 single protein format
CHEMBL4101414 OBDepict Cl N H S F HN O O N S O IC50 = 188.0 nM 391.88 O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCC2CCOC2)cc1F Homo sapiens CHEMBL4046487 cell-based format
CHEMBL4100208 OBDepict Cl N H S F HN O O N S O IC50 = 189.0 nM 391.88 O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCC2CCCO2)cc1F Homo sapiens CHEMBL4046487 cell-based format
CHEMBL3950353 OBDepict N N F F F O F S HN O O N S IC50 = 203.0 nM 484.46 N#Cc1cc(C(F)(F)F)ccc1N1CCOc2cc(S(=O)(=O)Nc3nccs3)c(F)cc21 Homo sapiens CHEMBL3888490 cell-based format
CHEMBL501134 OBDepict HN N H HN H N H NH OH HO O NH O H 2 N IC50 = 210.0 nM 299.29 N=C1N[C@H]2[C@H](COC(N)=O)NC(=N)N3CCC(O)(O)[C@]23N1 Homo sapiens CHEMBL4321995 cell-based format
CHEMBL3808645 OBDepict F F F N N N F F F IC50 = 211.0 nM 331.22 FC(F)(F)c1ccc(-c2ccc3nnc(C(F)(F)F)n3c2)cc1 Homo sapiens CHEMBL3811490 single protein format
CHEMBL3928707 OBDepict O S HN O N S O N N F F F O IC50 = 214.0 nM 524.55 O=S(=O)(Nc1ncns1)c1ccc2c(c1)OCCN2c1ccc(C(F)(F)F)cc1C1=CCOCC1 Homo sapiens CHEMBL3888490 cell-based format
CHEMBL3337585 OBDepict CH 3 O N CH 3 CH 3 N O NH N F F F IC50 = 217.0 nM 484.52 COc1ccc(C(=O)N2CCC3(CC2)Nc2cc(C(F)(F)F)ccc2-n2cccc23)cc1N(C)C Homo sapiens CHEMBL3387119 cell-based format
CHEMBL4076229 OBDepict Cl N H S F HN O O N S O IC50 = 221.0 nM 405.9 O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCCC2CCOC2)cc1F Homo sapiens CHEMBL4046487 cell-based format
CHEMBL3810347 OBDepict F O F F N N N N F F F IC50 = 223.0 nM 348.21 FC(F)(F)Oc1ccc(-c2ccc3nnc(C(F)(F)F)n3n2)cc1 Homo sapiens CHEMBL3811490 single protein format
CHEMBL3806065 OBDepict H 3 C HN N O O Cl F F S NH O O N S N IC50 = 230.0 nM 549.97 CNc1noc2ccc(-c3cc(Cl)ccc3Oc3cc(F)c(S(=O)(=O)Nc4ncns4)cc3F)cc12 Homo sapiens CHEMBL3806692 cell-based format
CHEMBL4092463 OBDepict Cl N H S F HN O O N S O IC50 = 237.0 nM 405.9 O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCC2CCCCO2)cc1F Homo sapiens CHEMBL4046487 cell-based format
CHEMBL841 OBDepict Cl OH N N O H 3 C CH 3 IC50 = 239.0 nM 477.05 CN(C)C(=O)C(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 Homo sapiens CHEMBL4184688 cell-based format
CHEMBL4849813 OBDepict F N HN S O O F F O N F F F F F IC50 = 240.0 nM 581.49 O=S(=O)(Nc1cccc(F)n1)c1cc(F)c(OC2CCN(CC(F)(F)F)CC2c2ccc(F)c(F)c2)cc1F Homo sapiens CHEMBL4813111 single protein format
CHEMBL4083744 OBDepict Cl N H S F HN O O N S O O IC50 = 242.0 nM 393.85 O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCC2OCCO2)cc1F Homo sapiens CHEMBL4046487 cell-based format
CHEMBL3929582 OBDepict O S HN O N S O N F F F N H IC50 = 254.0 nM 522.57 O=S(=O)(Nc1nccs1)c1ccc2c(c1)OCCN2c1ccc(C(F)(F)F)cc1C1=CCNCC1 Homo sapiens CHEMBL3888490 cell-based format
CHEMBL4061129 OBDepict Cl HN S F NH O O N S HO IC50 = 260.0 nM 472.01 O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCC23CC4CC(CC(O)(C4)C2)C3)cc1F Homo sapiens CHEMBL4046487 cell-based format
CHEMBL4863095 OBDepict F N HN S O O F F O H H N F F F F F IC50 = 260.0 nM 581.49 O=S(=O)(Nc1cccc(F)n1)c1cc(F)c(O[C@H]2CCN(CC(F)(F)F)C[C@@H]2c2ccc(F)c(F)c2)cc1F Homo sapiens CHEMBL4813111 single protein format
CHEMBL4082252 OBDepict Cl N H S F NH O O N S S O O IC50 = 266.0 nM 439.94 O=S1(=O)CCC(CNc2cc(F)c(S(=O)(=O)Nc3nccs3)cc2Cl)C1 Homo sapiens CHEMBL4046487 cell-based format
CHEMBL3809838 OBDepict F F F O N N N F F F IC50 = 281.0 nM 361.25 FC(F)(F)COc1ccc(-c2ccc3nnc(C(F)(F)F)n3c2)cc1 Homo sapiens CHEMBL3811490 single protein format
CHEMBL4084685 OBDepict Cl N H S F HN O O N S H H HO IC50 = 281.0 nM 419.93 O=S(=O)(Nc1nccs1)c1cc(Cl)c(NC[C@H]2CCC[C@H](O)C2)cc1F Homo sapiens CHEMBL4046487 cell-based format
CHEMBL1813050 OBDepict H 3 C NH O CH 3 N H N N N N O O F F F IC50 = 300.0 nM 502.5 CC(=O)Nc1cccc(Nc2ncnc(N3CCC(Oc4ccc(OC(F)(F)F)cc4)CC3)n2)c1C Homo sapiens CHEMBL1816131 cell-based format
CHEMBL3952945 OBDepict O S HN O N S O N N F F F N IC50 = 306.0 nM 519.53 O=S(=O)(Nc1ncns1)c1ccc2c(c1)OCCN2c1ccc(C(F)(F)F)cc1-c1ccncc1 Homo sapiens CHEMBL3888490 cell-based format
CHEMBL3657943 OBDepict O N H S F N O O F F O IC50 = 326.0 nM 498.57 O=C(NS(=O)(=O)N1CC(F)(F)C1)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F Homo sapiens CHEMBL3705543 cell-based format
CHEMBL4092025 OBDepict Cl N H S F HN O O N S H O IC50 = 328.0 nM 405.9 O=S(=O)(Nc1nccs1)c1cc(Cl)c(NC[C@@H]2CCCOC2)cc1F Homo sapiens CHEMBL4046487 cell-based format
CHEMBL3809595 OBDepict F O F F N N N F F F IC50 = 333.0 nM 347.22 FC(F)(F)Oc1ccc(-c2ccc3nnc(C(F)(F)F)n3c2)cc1 Homo sapiens CHEMBL3811490 single protein format
CHEMBL4062009 OBDepict Cl N H S F HN O O N S O IC50 = 336.0 nM 391.88 O=S(=O)(Nc1nccs1)c1cc(Cl)c(NC2CCOCC2)cc1F Homo sapiens CHEMBL4046487 cell-based format
CHEMBL3337584 OBDepict CH 3 O N CH 3 CH 3 N O NH N O F F IC50 = 340.0 nM 482.53 COc1ccc(C(=O)N2CCC3(CC2)Nc2cc(OC(F)F)ccc2-n2cccc23)cc1N(C)C Homo sapiens CHEMBL3387119 cell-based format
CHEMBL4098747 OBDepict Cl N H S F HN O O N S O O IC50 = 348.0 nM 476.0 O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCCC2CCC3(CC2)OCCO3)cc1F Homo sapiens CHEMBL4046487 cell-based format
CHEMBL3922400 OBDepict O S HN O N S O N N F F F N H IC50 = 349.0 nM 523.56 O=S(=O)(Nc1ncns1)c1ccc2c(c1)OCCN2c1ccc(C(F)(F)F)cc1C1=CCNCC1 Homo sapiens CHEMBL3888490 cell-based format
CHEMBL3658002 OBDepict F O N H O S N O O F F F IC50 = 350.0 nM 478.51 O=C(NS(=O)(=O)N1CCC1)c1cc(C2CC2)c(OCC2(C(F)(F)F)CCCCC2)cc1F Homo sapiens CHEMBL3705543 cell-based format
CHEMBL3809528 OBDepict F F N N N O F F F IC50 = 351.0 nM 329.23 FC(F)c1nnc2ccc(-c3ccc(OC(F)(F)F)cc3)cn12 Homo sapiens CHEMBL3811490 single protein format
CHEMBL3809853 OBDepict F O F F N N F F F IC50 = 353.0 nM 346.23 FC(F)(F)Oc1ccc(-c2ccc3ncc(C(F)(F)F)n3c2)cc1 Homo sapiens CHEMBL3811490 single protein format
CHEMBL3337587 OBDepict H 3 C O F NH N N O N O H 3 C CH 3 CH 3 IC50 = 358.0 nM 464.54 COc1cc2c(cc1F)-n1cccc1C1(CCN(C(=O)c3ccc(OC)c(N(C)C)c3)CC1)N2 Homo sapiens CHEMBL3387119 cell-based format
CHEMBL4854735 OBDepict F N HN S O O F F O H H N F F F F F Ki = 370.0 nM 581.49 O=S(=O)(Nc1cccc(F)n1)c1cc(F)c(O[C@H]2CCN(CC(F)(F)F)C[C@@H]2c2ccc(F)c(F)c2)c(F)c1 Homo sapiens CHEMBL4813156 single protein format
CHEMBL4068484 OBDepict Cl N H S F HN O O N S H H HO IC50 = 380.0 nM 419.93 O=S(=O)(Nc1nccs1)c1cc(Cl)c(NC[C@H]2CC[C@@H](O)CC2)cc1F Homo sapiens CHEMBL4046487 cell-based format
CHEMBL3948638 OBDepict N N F F F O F S HN O O N S IC50 = 385.0 nM 484.46 N#Cc1cc(C(F)(F)F)ccc1N1CCOc2cc(S(=O)(=O)Nc3nccs3)cc(F)c21 Homo sapiens CHEMBL3888490 cell-based format
CHEMBL3809777 OBDepict F F F N N N S F F F F F IC50 = 397.0 nM 389.27 FC(F)(F)c1nnc2ccc(-c3ccc(S(F)(F)(F)(F)F)cc3)cn12 Homo sapiens CHEMBL3811490 single protein format
CHEMBL4095822 OBDepict Cl N H S F HN O O N S O O IC50 = 407.0 nM 461.97 O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCC2CCC3(CC2)OCCO3)cc1F Homo sapiens CHEMBL4046487 cell-based format
CHEMBL4084268 OBDepict Cl N H S F NH O O N S H H O CH 3 CH 3 H 3 C IC50 = 415.0 nM 462.01 CC(C)(C)[C@@H]1OCCC[C@@H]1CNc1cc(F)c(S(=O)(=O)Nc2nccs2)cc1Cl Homo sapiens CHEMBL4046487 cell-based format
CHEMBL3809904 OBDepict F O F F N N F F F IC50 = 417.0 nM 346.23 FC(F)(F)Oc1ccc(-c2ccn3ncc(C(F)(F)F)c3c2)cc1 Homo sapiens CHEMBL3811490 single protein format
CHEMBL3337599 OBDepict CH 3 O N H N N O N IC50 = 419.0 nM 424.5 COc1ccc2c(c1)NC1(CCN(C(=O)c3ccc4ccccc4n3)CC1)c1cccn1-2 Homo sapiens CHEMBL3387119 cell-based format
CHEMBL3657934 OBDepict F N S N H O O O F O IC50 = 422.0 nM 480.58 O=C(NS(=O)(=O)N1CC(F)C1)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F Homo sapiens CHEMBL3705543 cell-based format
CHEMBL3809080 OBDepict F O F F N N IC50 = 425.0 nM 278.23 FC(F)(F)Oc1ccc(-c2ccn3nccc3c2)cc1 Homo sapiens CHEMBL3811490 single protein format
CHEMBL3657930 OBDepict Cl O F N H O S O O IC50 = 427.0 nM 441.95 O=C(NS(=O)(=O)C1CC1)c1cc(Cl)c(OCC23CC4CC(CC(C4)C2)C3)cc1F Homo sapiens CHEMBL3705543 cell-based format
CHEMBL3658014 OBDepict O N H S F O O O F F F IC50 = 430.0 nM 501.54 O=C(NS(=O)(=O)C1CC1)c1cc(C2CC2)c(OCC23CC4(F)CC(F)(CC(F)(C4)C2)C3)cc1F Homo sapiens CHEMBL3705543 cell-based format
CHEMBL4064737 OBDepict Cl NH S F N H O O N S N O IC50 = 444.0 nM 523.06 O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCC2CCC(=NOCc3ccccc3)CC2)cc1F Homo sapiens CHEMBL4046487 cell-based format
CHEMBL4853170 OBDepict F H N H O F F F F F S HN O O N F IC50 = 460.0 nM 563.5 O=S(=O)(Nc1cccc(F)n1)c1cc(F)c(O[C@H]2CCN(CC(F)(F)F)C[C@@H]2c2cccc(F)c2)cc1F Homo sapiens CHEMBL4813111 single protein format
CHEMBL4860097 OBDepict F F H N H O F F F F F S HN O O N F IC50 = 470.0 nM 581.49 O=S(=O)(Nc1cccc(F)n1)c1cc(F)c(O[C@H]2CCN(CC(F)(F)F)C[C@@H]2c2ccc(F)cc2F)cc1F Homo sapiens CHEMBL4813111 single protein format
CHEMBL3946486 OBDepict HO N F F F O S HN O O N S IC50 = 471.0 nM 485.51 O=S(=O)(Nc1nccs1)c1ccc2c(c1)OCCN2c1ccc(C(F)(F)F)cc1CCO Homo sapiens CHEMBL3888490 cell-based format
CHEMBL1627 OBDepict CH 3 NH O N HO Cl IC50 = 483.0 nM 463.02 CNC(=O)C(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 Homo sapiens CHEMBL4184688 cell-based format
CHEMBL3682649 OBDepict OH F F F S HN O O N S N IC50 = 490.0 nM 451.45 O=S(=O)(Nc1ncns1)c1ccc2c(-c3ccc(C(F)(F)F)cc3O)cccc2c1 Homo sapiens CHEMBL3705623 cell-based format