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Q14703 | MBTP1_HUMAN | Membrane-bound transcription factor site-1 protease (MBTPS1)

3D structures mapped by conservation among orthologs



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL391935 OBDepict O N HN Cl N H 3 C IC50 = 8.0 nM 516.13 Cc1ccccc1C1CCCN(Cc2ccc(C(=O)N(CCc3ccccc3Cl)C3CCNC3)cc2)C1 Homo sapiens CHEMBL896780 cell-based format
CHEMBL233987 OBDepict H 3 C O N O N H N IC50 = 29.0 nM 447.62 COc1ccccc1CCN(C(=O)c1ccc(CN2CC3CCCC2C3)cc1)C1CCNC1 Homo sapiens CHEMBL896780 cell-based format
CHEMBL233799 OBDepict CH 3 O N O N H N CH 3 IC50 = 37.0 nM 511.71 COc1ccccc1CCN(C(=O)c1ccc(CN2CCCC(c3ccccc3C)C2)cc1)C1CCNC1 Homo sapiens CHEMBL896780 cell-based format
CHEMBL233421 OBDepict H 3 C O N O NH N IC50 = 95.0 nM 433.6 COc1ccccc1CCN(C(=O)c1ccc(CN2CC3CCC2C3)cc1)C1CCNC1 Homo sapiens CHEMBL896780 cell-based format
CHEMBL233422 OBDepict CH 3 O N O N H N H H H OH IC50 = 100.0 nM 451.61 COc1ccccc1CCN(C(=O)c1ccc(CN[C@H]2CCCC[C@@H]2O)cc1)C1CCNC1 Homo sapiens CHEMBL896780 cell-based format
CHEMBL233609 OBDepict CH 3 O H N N O N H O H 3 C IC50 = 140.0 nM 451.61 COC[C@@H]1CCCN1Cc1ccc(C(=O)N(CCc2ccccc2OC)C2CCNC2)cc1 Homo sapiens CHEMBL896780 cell-based format
CHEMBL233610 OBDepict CH 3 O N O N H N O H 2 N IC50 = 160.0 nM 464.61 COc1ccccc1CCN(C(=O)c1ccc(CN2CCCC(C(N)=O)C2)cc1)C1CCNC1 Homo sapiens CHEMBL896780 cell-based format
CHEMBL233611 OBDepict CH 3 N CH 3 N O H NH O H 3 C IC50 = 170.0 nM 409.57 CCN(CC)Cc1ccc(C(=O)N(CCc2ccccc2OC)[C@@H]2CCNC2)cc1 Homo sapiens CHEMBL896780 cell-based format
CHEMBL394028 OBDepict CH 3 O N O N H N IC50 = 250.0 nM 421.59 COc1ccccc1CCN(C(=O)c1ccc(CN2CCCCC2)cc1)C1CCNC1 Homo sapiens CHEMBL896780 cell-based format
CHEMBL393989 OBDepict CH 3 O N O N H O IC50 = 310.0 nM 430.55 COc1ccccc1CCN(C(=O)c1ccc(OCc2ccccc2)cc1)C1CCNC1 Homo sapiens CHEMBL896780 cell-based format
CHEMBL232587 OBDepict CH 3 N CH 3 N O N H Cl Cl IC50 = 430.0 nM 448.44 CCN(CC)Cc1ccc(C(=O)N(CCc2c(Cl)cccc2Cl)C2CCNC2)cc1 Homo sapiens CHEMBL896780 cell-based format
CHEMBL232777 OBDepict Cl N O N H O IC50 = 510.0 nM 434.97 O=C(c1ccc(OCc2ccccc2)cc1)N(CCc1cccc(Cl)c1)C1CCNC1 Homo sapiens CHEMBL896780 cell-based format
CHEMBL231776 OBDepict CH 3 N CH 3 N O N H O H 3 C IC50 = 540.0 nM 409.57 CCN(CC)Cc1ccc(C(=O)N(CCc2ccccc2OC)C2CCNC2)cc1 Homo sapiens CHEMBL896780 cell-based format
CHEMBL233573 OBDepict O N N H O Cl IC50 = 590.0 nM 434.97 O=C(c1ccc(OCc2ccccc2)cc1)N(CCc1ccccc1Cl)C1CCNC1 Homo sapiens CHEMBL896780 cell-based format
CHEMBL233572 OBDepict CH 3 N CH 3 N O N H Cl IC50 = 840.0 nM 413.99 CCN(CC)Cc1ccc(C(=O)N(CCc2ccccc2Cl)C2CCNC2)cc1 Homo sapiens CHEMBL896780 cell-based format
CHEMBL394029 OBDepict CH 3 N CH 3 N O H NH O H 3 C IC50 = 970.0 nM 409.57 CCN(CC)Cc1ccc(C(=O)N(CCc2ccccc2OC)[C@H]2CCNC2)cc1 Homo sapiens CHEMBL896780 cell-based format