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Q14832 | GRM3_HUMAN | Metabotropic glutamate receptor 3 (GRM3)

3D structures mapped by conservation among orthologs

[ Domain: "Periplasmic binding protein-like I" // ANF_receptor_2nd_1 ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL218710 OBDepict OH O H 2 N + S H _ O H H O OH Ki = 0.17 nM 219.22 N[C@@]1(C(=O)O)C[S+]([O-])[C@H]2[C@H](C(=O)O)[C@H]21 Homo sapiens CHEMBL910532 cell-based format
CHEMBL4071962 OBDepict Cl N H O H H NH 2 H H O OH O HO Ki = 0.47 nM 338.75 N[C@@]1(C(=O)O)C[C@H](NC(=O)c2cccc(Cl)c2)[C@H]2[C@H](C(=O)O)[C@H]21 Homo sapiens CHEMBL4023218 cell-based format
CHEMBL4081453 OBDepict CH 3 O N H O H H H 2 N H H O OH O OH Ki = 0.927 nM 334.33 COc1cccc(C(=O)N[C@H]2C[C@@](N)(C(=O)O)[C@@H]3[C@@H](C(=O)O)[C@H]23)c1 Homo sapiens CHEMBL4023218 cell-based format
CHEMBL432038 OBDepict OH O H H NH 2 O OH O Ki = 1.3 nM 353.37 N[C@](CC1c2ccccc2Oc2ccccc21)(C(=O)O)[C@H]1C[C@@H]1C(=O)O Homo sapiens CHEMBL4719948 cell membrane format
CHEMBL4068189 OBDepict O NH OH H H H 2 N H H O OH O HO Ki = 1.79 nM 320.3 N[C@@]1(C(=O)O)C[C@H](NC(=O)c2ccccc2O)[C@H]2[C@H](C(=O)O)[C@H]21 Homo sapiens CHEMBL4023218 cell-based format
CHEMBL4091203 OBDepict F N H O H H NH 2 H H O OH O HO Ki = 2.11 nM 322.29 N[C@@]1(C(=O)O)C[C@H](NC(=O)c2cccc(F)c2)[C@H]2[C@H](C(=O)O)[C@H]21 Homo sapiens CHEMBL4023218 cell-based format
CHEMBL4091735 OBDepict OH N H O H H NH 2 H H O OH O HO Ki = 2.27 nM 320.3 N[C@@]1(C(=O)O)C[C@H](NC(=O)c2cccc(O)c2)[C@H]2[C@H](C(=O)O)[C@H]21 Homo sapiens CHEMBL4023218 cell-based format
CHEMBL4095567 OBDepict Cl N H O H H H 2 N H H O HO O OH Ki = 2.29 nM 338.75 N[C@@]1(C(=O)O)C[C@H](NC(=O)c2ccc(Cl)cc2)[C@H]2[C@H](C(=O)O)[C@H]21 Homo sapiens CHEMBL4023218 cell-based format
CHEMBL4751065 OBDepict F F S H H 2 N H HO O OH H H H O OH ClH Ki = 2.5 nM 395.81 Cl.N[C@@]1(C(=O)O)[C@H](CSc2ccc(F)c(F)c2)[C@@H](O)[C@@H]2[C@H]1[C@H]2C(=O)O Homo sapiens CHEMBL4719948 cell membrane format
CHEMBL3969063 OBDepict H N N N S H H H O H H H 2 N O OH O OH Cl Cl Ki = 2.7 nM 459.31 N[C@@]1(C(=O)O)[C@H](OCc2ccc(Cl)c(Cl)c2)[C@@H](Sc2nc[nH]n2)[C@H]2[C@H](C(=O)O)[C@H]21 Homo sapiens CHEMBL3869614 cell-based format
CHEMBL140197 OBDepict HO O NH 2 H H H OH H O HO Ki = 3.0 nM 175.14 N[C@H](C(=O)O)[C@H]1[C@@H](O)[C@@H]1C(=O)O Homo sapiens CHEMBL714802 single protein format
CHEMBL4063336 OBDepict F N H O H H H 2 N H H O HO O OH Ki = 4.34 nM 322.29 N[C@@]1(C(=O)O)C[C@H](NC(=O)c2ccc(F)cc2)[C@H]2[C@H](C(=O)O)[C@H]21 Homo sapiens CHEMBL4023218 cell-based format
CHEMBL4759992 OBDepict H N N N S H H H H H S NH 2 O HO O HO CH 3 F ClH Ki = 4.5 nM 474.97 Cc1cc(SC[C@@H]2[C@@H](Sc3nc[nH]n3)[C@H]3[C@H](C(=O)O)[C@H]3[C@]2(N)C(=O)O)ccc1F.Cl Homo sapiens CHEMBL4719948 cell membrane format
CHEMBL186453 OBDepict Cl Cl O H H 2 N H O OH H F O OH Ki = 4.5 nM 378.18 N[C@@]1(C(=O)O)[C@H](OCc2ccc(Cl)c(Cl)c2)C[C@@H]2[C@H]1[C@@]2(F)C(=O)O Homo sapiens CHEMBL2182978 single protein format
CHEMBL4061162 OBDepict H 3 C O N H O H H NH 2 H H O HO O HO Ki = 4.56 nM 334.33 COc1ccc(C(=O)N[C@H]2C[C@@](N)(C(=O)O)[C@@H]3[C@@H](C(=O)O)[C@H]23)cc1 Homo sapiens CHEMBL4023218 cell-based format
CHEMBL4090293 OBDepict O NH F H H H 2 N H H O OH O HO Ki = 5.79 nM 322.29 N[C@@]1(C(=O)O)C[C@H](NC(=O)c2ccccc2F)[C@H]2[C@H](C(=O)O)[C@H]21 Homo sapiens CHEMBL4023218 cell-based format
CHEMBL275079 OBDepict OH O H 2 N O H H H O OH Ki = 5.8 nM 187.15 N[C@@]1(C(=O)O)CO[C@@H]2[C@H]1[C@H]2C(=O)O Homo sapiens CHEMBL717237 cell-based format
CHEMBL4780402 OBDepict CH 3 F S H NH 2 H OH O HO H H H O OH ClH Ki = 5.9 nM 391.85 Cc1cc(SC[C@@H]2[C@@H](O)[C@@H]3[C@@H]([C@H]3C(=O)O)[C@]2(N)C(=O)O)ccc1F.Cl Homo sapiens CHEMBL4719948 cell membrane format
CHEMBL2381643 OBDepict OH O H 2 N H H OH H H O OH IC50 = 6.3 nM 201.18 N[C@@]1(C(=O)O)C[C@H](O)[C@@H]2[C@H]1[C@H]2C(=O)O Homo sapiens CHEMBL4719944 single protein format
CHEMBL4095995 OBDepict O NH H H H 2 N H H O OH O HO Ki = 6.75 nM 304.3 N[C@@]1(C(=O)O)C[C@H](NC(=O)c2ccccc2)[C@H]2[C@H](C(=O)O)[C@H]21 Homo sapiens CHEMBL4023218 cell-based format
CHEMBL4776989 OBDepict F S H NH 2 H OH O HO H H H O OH ClH Ki = 6.8 nM 377.82 Cl.N[C@@]1(C(=O)O)[C@H](CSc2ccc(F)cc2)[C@@H](O)[C@@H]2[C@H]1[C@H]2C(=O)O Homo sapiens CHEMBL4719948 cell membrane format
CHEMBL4746125 OBDepict CH 3 HN O H H H H H S H 2 N O OH O OH H 3 C F ClH Ki = 7.7 nM 432.9 CC(=O)N[C@H]1[C@H]2[C@H](C(=O)O)[C@H]2[C@](N)(C(=O)O)[C@@H]1CSc1ccc(F)c(C)c1.Cl Homo sapiens CHEMBL4719948 cell membrane format
CHEMBL4070866 OBDepict OH N H O H H H 2 N H H O HO O OH Ki = 9.34 nM 320.3 N[C@@]1(C(=O)O)C[C@H](NC(=O)c2ccc(O)cc2)[C@H]2[C@H](C(=O)O)[C@H]21 Homo sapiens CHEMBL4023218 cell-based format
CHEMBL8839 OBDepict OH O H 2 N S H H H O OH Ki = 9.4 nM 203.22 N[C@@]1(C(=O)O)CS[C@H]2[C@H](C(=O)O)[C@H]21 Homo sapiens CHEMBL717237 cell-based format
CHEMBL4748699 OBDepict Cl Cl S H H 2 N H HO O OH H H H O OH ClH Ki = 9.4 nM 428.72 Cl.N[C@@]1(C(=O)O)[C@H](CSc2ccc(Cl)c(Cl)c2)[C@@H](O)[C@@H]2[C@H]1[C@H]2C(=O)O Homo sapiens CHEMBL4719948 cell membrane format
CHEMBL2381642 OBDepict OH O H 2 N H H OH H H O OH IC50 = 11.2 nM 201.18 N[C@@]1(C(=O)O)C[C@@H](O)[C@@H]2[C@H]1[C@H]2C(=O)O Homo sapiens CHEMBL4719944 single protein format
CHEMBL4760856 OBDepict Cl Cl S H NH 2 H HO O OH H H H O HO ClH Ki = 16.3 nM 442.75 Cl.N[C@@]1(C(=O)O)[C@H](CSCc2ccc(Cl)c(Cl)c2)[C@@H](O)[C@@H]2[C@H]1[C@H]2C(=O)O Homo sapiens CHEMBL4719948 cell membrane format
CHEMBL4759209 OBDepict OH O H 2 N H H S H OH H H O OH ClH Ki = 19.2 nM 359.83 Cl.N[C@@]1(C(=O)O)[C@H](CSc2ccccc2)[C@@H](O)[C@@H]2[C@H]1[C@H]2C(=O)O Homo sapiens CHEMBL4719948 cell membrane format
CHEMBL4099470 OBDepict H 3 C O N H O H H NH 2 H H O HO O HO Ki = 23.2 nM 334.33 COc1ccccc1C(=O)N[C@H]1C[C@@](N)(C(=O)O)[C@@H]2[C@@H](C(=O)O)[C@H]12 Homo sapiens CHEMBL4023218 cell-based format
CHEMBL4784701 OBDepict F S H H 2 N H HO O OH H H H O OH ClH Ki = 25.1 nM 377.82 Cl.N[C@@]1(C(=O)O)[C@H](CSc2cccc(F)c2)[C@@H](O)[C@@H]2[C@H]1[C@H]2C(=O)O Homo sapiens CHEMBL4719948 cell membrane format
CHEMBL4781638 OBDepict OH O H 2 N H H S H OH H H O OH ClH Ki = 26.0 nM 359.83 Cl.N[C@@]1(C(=O)O)[C@H](CSc2ccccc2)[C@H](O)[C@@H]2[C@H]1[C@H]2C(=O)O Homo sapiens CHEMBL4719948 cell membrane format
CHEMBL4757159 OBDepict CH 3 CH 3 S H NH 2 H OH O HO H H H O OH ClH Ki = 26.0 nM 387.89 Cc1ccc(SC[C@@H]2[C@@H](O)[C@@H]3[C@@H]([C@H]3C(=O)O)[C@]2(N)C(=O)O)cc1C.Cl Homo sapiens CHEMBL4719948 cell membrane format
CHEMBL4098939 OBDepict O NH Cl H H H 2 N H H O OH O HO Ki = 27.4 nM 338.75 N[C@@]1(C(=O)O)C[C@H](NC(=O)c2ccccc2Cl)[C@H]2[C@H](C(=O)O)[C@H]21 Homo sapiens CHEMBL4023218 cell-based format
CHEMBL8759 OBDepict OH O H 2 N H H H O OH IC50 = 27.9 nM 185.18 N[C@@]1(C(=O)O)CC[C@H]2[C@H](C(=O)O)[C@H]21 Homo sapiens CHEMBL4719944 single protein format
CHEMBL4756556 OBDepict CH 3 F S H NH 2 H NH 2 O HO H H H O OH ClH Ki = 36.1 nM 390.86 Cc1cc(SC[C@@H]2[C@@H](N)[C@H]3[C@H](C(=O)O)[C@H]3[C@]2(N)C(=O)O)ccc1F.Cl Homo sapiens CHEMBL4719948 cell membrane format
CHEMBL3616856 OBDepict H N N S N F F F H H H 2 N H H O HO O OH Ki = 43.1 nM 352.29 N[C@@]1(C(=O)O)C[C@H](Sc2nnc(C(F)(F)F)[nH]2)[C@H]2[C@H](C(=O)O)[C@H]21 Homo sapiens CHEMBL3619270 cell-based format
CHEMBL3616849 OBDepict H N N S N F F F H H H 2 N H H O HO O OH Ki = 56.7 nM 352.29 N[C@@]1(C(=O)O)C[C@@H](Sc2nnc(C(F)(F)F)[nH]2)[C@H]2[C@H](C(=O)O)[C@H]21 Homo sapiens CHEMBL3619270 cell-based format
CHEMBL3616857 OBDepict F F N N N H S H H H 2 N H H O HO O OH Ki = 57.5 nM 334.3 N[C@@]1(C(=O)O)C[C@H](Sc2nnc(C(F)F)[nH]2)[C@H]2[C@H](C(=O)O)[C@H]21 Homo sapiens CHEMBL3619270 cell-based format
CHEMBL3616851 OBDepict H 2 N N N N H S H H NH 2 H H O HO O HO Ki = 58.3 nM 299.31 Nc1nnc(S[C@@H]2C[C@@](N)(C(=O)O)[C@@H]3[C@@H](C(=O)O)[C@H]23)[nH]1 Homo sapiens CHEMBL3619270 cell-based format
CHEMBL3616848 OBDepict H 3 C N N N H S H H NH 2 H H O HO O HO Ki = 62.4 nM 298.32 Cc1nnc(S[C@@H]2C[C@@](N)(C(=O)O)[C@@H]3[C@@H](C(=O)O)[C@H]23)[nH]1 Homo sapiens CHEMBL3619270 cell-based format
CHEMBL3616850 OBDepict F F N N N H S H H H 2 N H H O HO O OH Ki = 63.2 nM 334.3 N[C@@]1(C(=O)O)C[C@@H](Sc2nnc(C(F)F)[nH]2)[C@H]2[C@H](C(=O)O)[C@H]21 Homo sapiens CHEMBL3619270 cell-based format
CHEMBL3616860 OBDepict H N N N S H H H 2 N H H O HO O OH Ki = 65.1 nM 284.3 N[C@@]1(C(=O)O)C[C@H](Sc2c[nH]nn2)[C@H]2[C@H](C(=O)O)[C@H]21 Homo sapiens CHEMBL3619270 cell-based format
CHEMBL3616858 OBDepict H 2 N N N N H S H H NH 2 H H O HO O HO Ki = 69.0 nM 299.31 Nc1nnc(S[C@H]2C[C@@](N)(C(=O)O)[C@@H]3[C@@H](C(=O)O)[C@H]23)[nH]1 Homo sapiens CHEMBL3619270 cell-based format
CHEMBL3616855 OBDepict H 3 C N N N H S H H NH 2 H H O HO O HO Ki = 79.0 nM 298.32 Cc1nnc(S[C@H]2C[C@@](N)(C(=O)O)[C@@H]3[C@@H](C(=O)O)[C@H]23)[nH]1 Homo sapiens CHEMBL3619270 cell-based format
CHEMBL3616859 OBDepict H 3 C H 3 C N N N H S H H NH 2 H H O HO O HO Ki = 82.7 nM 326.38 CC(C)c1nnc(S[C@H]2C[C@@](N)(C(=O)O)[C@@H]3[C@@H](C(=O)O)[C@H]23)[nH]1 Homo sapiens CHEMBL3619270 cell-based format
CHEMBL375611 OBDepict OH O H 2 N S H O O H H O OH Ki = 92.0 nM 235.22 N[C@@]1(C(=O)O)CS(=O)(=O)[C@H]2[C@H](C(=O)O)[C@H]21 Homo sapiens CHEMBL910532 cell-based format
CHEMBL8759 OBDepict OH O H 2 N H H H O OH Ki = 93.3 nM 185.18 N[C@@]1(C(=O)O)CC[C@H]2[C@H](C(=O)O)[C@H]21 Homo sapiens CHEMBL717237 cell-based format
CHEMBL3616854 OBDepict H N N N S H H NH 2 H H O OH O HO Ki = 126.0 nM 284.3 N[C@@]1(C(=O)O)C[C@H](Sc2nnc[nH]2)[C@H]2[C@H](C(=O)O)[C@H]21 Homo sapiens CHEMBL3619270 cell-based format
CHEMBL2381650 OBDepict OH O H 2 N H H S H H O OH Ki = 138.0 nM 293.34 N[C@@]1(C(=O)O)C[C@@H](Sc2ccccc2)[C@H]2[C@H](C(=O)O)[C@H]21 Homo sapiens CHEMBL3619270 cell-based format
CHEMBL192977 OBDepict OH O H H H NH 2 H H 3 C O HO Ki = 146.0 nM 199.21 C[C@@H]1C[C@H]2[C@H](C(=O)O)[C@H]2[C@]1(N)C(=O)O Homo sapiens CHEMBL839635 assay format
CHEMBL3616847 OBDepict H N N N S H H NH 2 H H O OH O HO Ki = 156.0 nM 284.3 N[C@@]1(C(=O)O)C[C@@H](Sc2nnc[nH]2)[C@H]2[C@H](C(=O)O)[C@H]21 Homo sapiens CHEMBL3619270 cell-based format
CHEMBL3616852 OBDepict H 3 C H 3 C N N N H S H H NH 2 H H O HO O HO Ki = 157.0 nM 326.38 CC(C)c1nnc(S[C@@H]2C[C@@](N)(C(=O)O)[C@@H]3[C@@H](C(=O)O)[C@H]23)[nH]1 Homo sapiens CHEMBL3619270 cell-based format
CHEMBL2381649 OBDepict CH 3 HN O H H H 2 N H H O OH O OH Ki = 177.0 nM 242.23 CC(=O)N[C@H]1C[C@@](N)(C(=O)O)[C@@H]2[C@@H](C(=O)O)[C@H]12 Homo sapiens CHEMBL4023218 cell-based format
CHEMBL2204436 OBDepict Cl Cl N H H N N N Br IC50 = 190.0 nM 402.12 Clc1ccc(CN[C@H]2CCN(c3ncc(Br)cn3)C2)c(Cl)c1 Homo sapiens CHEMBL2213651 cell-based format
CHEMBL4779554 OBDepict HO O NH 2 H H S H HO H H O OH ClH Ki = 238.0 nM 359.83 Cl.N[C@]1(C(=O)O)[C@@H]2[C@@H](C(=O)O)[C@@H]2[C@@H](O)[C@@H]1CSc1ccccc1 Homo sapiens CHEMBL4719948 cell membrane format
CHEMBL4778355 OBDepict HO O NH 2 H H S H HO H H O OH ClH Ki = 251.0 nM 359.83 Cl.N[C@]1(C(=O)O)[C@@H]2[C@@H](C(=O)O)[C@@H]2[C@H](O)[C@@H]1CSc1ccccc1 Homo sapiens CHEMBL4719948 cell membrane format
CHEMBL3616853 OBDepict H N N N S H H H 2 N H H O HO O OH Ki = 259.0 nM 284.3 N[C@@]1(C(=O)O)C[C@@H](Sc2c[nH]nn2)[C@H]2[C@H](C(=O)O)[C@H]21 Homo sapiens CHEMBL3619270 cell-based format
CHEMBL1629855 OBDepict O N H N H 3 C F F F CH 3 N CH 3 IC50 = 270.0 nM 423.44 Cc1cc(-c2cccc(C3=Nc4cc(C)c(C(F)(F)F)cc4NC(=O)C3)c2)cc(C)n1 Homo sapiens CHEMBL2213653 cell-based format
CHEMBL2381651 OBDepict OH O H 2 N H H S H H O OH Ki = 272.0 nM 293.34 N[C@@]1(C(=O)O)C[C@H](Sc2ccccc2)[C@H]2[C@H](C(=O)O)[C@H]21 Homo sapiens CHEMBL3619270 cell-based format
CHEMBL4069251 OBDepict O N H H H H 2 N H H O HO O OH Ki = 281.0 nM 332.36 N[C@@]1(C(=O)O)C[C@H](NC(=O)CCc2ccccc2)[C@H]2[C@H](C(=O)O)[C@H]21 Homo sapiens CHEMBL4023218 cell-based format
CHEMBL2381647 OBDepict HO O NH 2 H H H 2 N H H O OH Ki = 284.0 nM 200.19 N[C@H]1C[C@@](N)(C(=O)O)[C@@H]2[C@@H](C(=O)O)[C@H]12 Homo sapiens CHEMBL4023218 cell-based format
CHEMBL3401195 OBDepict F N O N N O IC50 = 290.0 nM 337.35 O=C1N(c2ccc(F)cc2)CCc2nc(COc3ccccc3)cn21 Homo sapiens CHEMBL3404398 single protein format
CHEMBL4755204 OBDepict F S H NH 2 H OH O HO H H H O OH ClH Ki = 369.0 nM 377.82 Cl.N[C@@]1(C(=O)O)[C@H](CSc2ccccc2F)[C@@H](O)[C@@H]2[C@H]1[C@H]2C(=O)O Homo sapiens CHEMBL4719948 cell membrane format
CHEMBL4093017 OBDepict O N H H H NH 2 H H O OH O HO Ki = 425.0 nM 324.38 N[C@@]1(C(=O)O)C[C@H](NC(=O)CC2CCCCC2)[C@H]2[C@H](C(=O)O)[C@H]21 Homo sapiens CHEMBL4023218 cell-based format
CHEMBL365368 OBDepict HO O NH 2 H H H 3 C H H O OH Ki = 511.0 nM 199.21 C[C@H]1C[C@@](N)(C(=O)O)[C@@H]2[C@@H](C(=O)O)[C@H]12 Homo sapiens CHEMBL839635 assay format
CHEMBL192051 OBDepict HO O NH 2 H H H 3 C H H O OH Ki = 570.0 nM 199.21 C[C@@H]1C[C@@](N)(C(=O)O)[C@@H]2[C@@H](C(=O)O)[C@@H]21 Homo sapiens CHEMBL839635 assay format
CHEMBL4749728 OBDepict CH 3 S CH 3 H NH 2 H OH O HO H H H O OH Ki = 614.0 nM 289.35 CC(C)SC[C@@H]1[C@@H](O)[C@@H]2[C@@H]([C@H]2C(=O)O)[C@]1(N)C(=O)O Homo sapiens CHEMBL4719948 cell membrane format
CHEMBL3401177 OBDepict F N O N N O IC50 = 630.0 nM 335.34 O=c1n(-c2ccc(F)cc2)ccc2nc(COc3ccccc3)cn12 Homo sapiens CHEMBL3404398 single protein format
CHEMBL4060567 OBDepict O NH H H H 2 N H H O OH O HO Ki = 757.0 nM 310.35 N[C@@]1(C(=O)O)C[C@H](NC(=O)C2CCCCC2)[C@H]2[C@H](C(=O)O)[C@H]21 Homo sapiens CHEMBL4023218 cell-based format