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Q15418 | KS6A1_HUMAN | Ribosomal protein S6 kinase alpha-1 (RPS6KA1)

3D structures mapped by conservation among orthologs

[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4855542 OBDepict NH 2 N S N O NH IC50 = -7700.0 nM 372.45 Nc1ncc(-c2cccc3ncsc23)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804489 cell-based format
CHEMBL4867931 OBDepict H 3 C O N H S N O O H 2 N O HN IC50 = -1400.0 nM 464.55 COc1cc(NS(=O)(=O)C2CC2)ccc1-c1cnc(N)c(-c2ccc3c(c2)CCNC3=O)c1 Homo sapiens CHEMBL4804489 cell-based format
CHEMBL4868141 OBDepict H 2 N N O O HN NH S O O IC50 = -700.0 nM 532.67 Nc1ncc(-c2ccc(NS(=O)(=O)C3CC3)cc2OC2CCCCC2)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804489 cell-based format
CHEMBL3975634 OBDepict CH 3 O H O N H N H H 3 C N N HO IC50 = 0.19 nM 452.51 CN[C@H]1CC2OC([C@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(O)=NC4 Homo sapiens CHEMBL3707977 single protein format
CHEMBL3218297 OBDepict CH 3 S O O HO O N H N H S N OH N IC50 < 1.0 nM 422.49 CS(=O)(=O)O.O=C(NCc1cccc(O)c1)Nc1nc(-c2ccncc2)cs1 Homo sapiens CHEMBL3224499 single protein format
CHEMBL523523 OBDepict NH 2 O N N N H 3 C N O H 2 N N HO IC50 = 1.0 nM 357.37 CCn1c(-c2nonc2N)nc2c(C#CCO)ncc(OCCCN)c21 Homo sapiens CHEMBL1028103 single protein format
CHEMBL388978 OBDepict CH 3 HN H H O H O N H 3 C H 3 C N O N H IC50 = 1.2 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL3807893 single protein format
CHEMBL4062453 OBDepict CH 3 N CH 3 N N N N O O NH 2 F IC50 = 5.4 nM 498.56 CN(C)CCn1cc(-c2ccn3c(-c4ccc(C(N)=O)c(OCc5cccc(F)c5)c4)cnc3c2)cn1 Homo sapiens CHEMBL4003702 single protein format
CHEMBL3964006 OBDepict CH 3 O H N H N H H 3 C O N HN N CH 3 N CH 3 IC50 = 5.47 nM 470.58 COc1ccc([C@@H]2CN(C)C[C@H]2NC(=O)c2ccc3cnc(Nc4cc(C)nn4C)cc3c2)cc1 Homo sapiens CHEMBL3888723 cell-based format
CHEMBL4112587 OBDepict CH 3 NH H O F N O CH 3 N HN O IC50 = 5.96 nM 438.5 CC[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)cc2n1)c1ccc(OC)c(F)c1 Homo sapiens CHEMBL3888723 cell-based format
CHEMBL493875 OBDepict NH 2 O N N N H 3 C N O H 2 N N OH IC50 = 6.0 nM 371.4 CCn1c(-c2nonc2N)nc2c(C#CCCO)ncc(OCCCN)c21 Homo sapiens CHEMBL1028103 single protein format
CHEMBL3604794 OBDepict OH F F N N O IC50 = 6.0 nM 368.38 Oc1c(F)cc(-c2cnccc2-c2ccc(N3CCOCC3)cc2)cc1F Homo sapiens CHEMBL4623001 single protein format
CHEMBL3604793 OBDepict CH 3 N N N F F OH IC50 = 6.0 nM 381.43 CN1CCN(c2ccc(-c3ccncc3-c3cc(F)c(O)c(F)c3)cc2)CC1 Homo sapiens CHEMBL4841338 assay format
CHEMBL4115564 OBDepict H 3 C NH H O F Cl N HN O IC50 = 8.5 nM 441.93 CC[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)cc2c1)c1ccc(Cl)c(F)c1 Homo sapiens CHEMBL3888723 cell-based format
CHEMBL4108790 OBDepict OH N H H O F N Cl N N H N CH 3 N IC50 = 9.84 nM 440.87 Cn1nccc1Nc1cc2nc(C(=O)N[C@H](CO)c3ccc(Cl)c(F)c3)ccc2cn1 Homo sapiens CHEMBL3888723 cell-based format
CHEMBL3976074 OBDepict CH 3 N N N H H O F Cl N N H N CH 3 N IC50 = 9.97 nM 489.94 Cn1cc([C@@H](NC(=O)c2ccc3cnc(Nc4ccnn4C)cc3c2)c2ccc(Cl)c(F)c2)cn1 Homo sapiens CHEMBL3888723 cell-based format
CHEMBL493251 OBDepict NH 2 O N N N H 3 C N N H O H 2 N N IC50 = 13.0 nM 368.4 CCn1c(-c2nonc2N)nc2c(-c3ccc[nH]3)ncc(OCCCN)c21 Homo sapiens CHEMBL1028103 single protein format
CHEMBL4113272 OBDepict OH N H H O F Cl N HN O IC50 = 14.8 nM 443.91 O=C(N[C@H](CO)c1ccc(Cl)c(F)c1)c1ccc2cnc(NC3CCOCC3)cc2c1 Homo sapiens CHEMBL3888723 cell-based format
CHEMBL4108819 OBDepict H 3 C NH H O F Cl N N H N H 3 C N H 3 C IC50 = 15.7 nM 451.93 CC[C@@H](NC(=O)c1ccc2cnc(Nc3cc(C)nn3C)cc2c1)c1ccc(Cl)c(F)c1 Homo sapiens CHEMBL3888723 cell-based format
CHEMBL4112022 OBDepict OH N H H O F N Cl N HN O IC50 = 16.3 nM 444.89 O=C(N[C@H](CO)c1ccc(Cl)c(F)c1)c1ccc2cnc(NC3CCOCC3)cc2n1 Homo sapiens CHEMBL3888723 cell-based format
CHEMBL3920757 OBDepict CH 3 O F NH H N N O H 3 C N N NH O IC50 = 18.7 nM 490.54 COc1ccc([C@H](NC(=O)c2ccc3cnc(NC4CCOCC4)cc3n2)c2cnn(C)c2)cc1F Homo sapiens CHEMBL3888723 cell-based format
CHEMBL4128457 OBDepict O NH N H H 3 C N N N N N F F F F IC50 = 20.0 nM 571.62 C[C@@H]1CC(=O)Nc2ncnc(N3CCC(c4nc(-c5ccc(F)c(C(F)(F)F)c5)cn4CCN4CCCC4)CC3)c21 Homo sapiens CHEMBL4121778 single protein format
CHEMBL3969698 OBDepict CH 3 O F NH H N N O CH 3 N N H N H 3 C N H 3 C IC50 = 30.4 nM 499.55 COc1ccc([C@H](NC(=O)c2ccc3cnc(Nc4cc(C)nn4C)cc3c2)c2cnn(C)c2)cc1F Homo sapiens CHEMBL3888723 cell-based format
CHEMBL573107 OBDepict H 3 C CH 3 N H 3 C N O N CH 3 N N H F F OH IC50 = 31.0 nM 391.42 CC(C)CCN1c2nc(Nc3cc(F)c(O)c(F)c3)ncc2N(C)C(=O)C1C Homo sapiens CHEMBL4623010 single protein format
CHEMBL4441825 OBDepict HO H N H H H N H O F O F Cl N Cl CH 3 N IC50 = 32.0 nM 499.35 Cn1ncc(Cl)c1-c1cc(C(=O)N[C@@H]2CN[C@H](CCO)C[C@H]2c2ccc(F)c(F)c2)oc1Cl Homo sapiens CHEMBL4407369 single protein format
CHEMBL1956071 OBDepict H 3 C N N N O H 2 N N N N O H H 2 N IC50 = 35.0 nM 342.36 CCn1c(-c2nonc2N)nc2cncc(C(=O)N3CC[C@H](N)C3)c21 Homo sapiens CHEMBL1960789 single protein format
CHEMBL3953138 OBDepict CH 3 O F NH H N N O H 3 C N N NH H 3 C H HO IC50 = 37.8 nM 464.5 COc1ccc([C@H](NC(=O)c2ccc3cnc(N[C@@H](C)CO)cc3n2)c2cnn(C)c2)cc1F Homo sapiens CHEMBL3888723 cell-based format
CHEMBL493250 OBDepict NH 2 O N N N CH 3 N O H 2 N N IC50 = 44.0 nM 379.42 CCn1c(-c2nonc2N)nc2c(-c3ccccc3)ncc(OCCCN)c21 Homo sapiens CHEMBL1028103 single protein format
CHEMBL1092754 OBDepict OH N H O N N CH 3 O O OH IC50 = 45.9 nM 455.47 Cn1cc(/C=C2Oc3cccc(O)c3C2=O)c2c(-c3ccc(C(=O)NCCO)cc3)ccnc21 Homo sapiens CHEMBL1107911 single protein format
CHEMBL2064666 OBDepict CH 3 O HN N N H N HN Cl H O H H O H 2 N H IC50 = 61.0 nM 539.08 COc1c(Nc2ncc(Cl)c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)n2)ccc2c1CC[C@@H](N1CCOCC1)CC2 Homo sapiens CHEMBL2067596 single protein format
CHEMBL3925797 OBDepict HO NH H 3 C H N HN O N H F IC50 = 65.1 nM 392.43 C[C@@H](CO)Nc1cc2cc(C(=O)NCc3cc4c(F)cccc4[nH]3)ccc2cn1 Homo sapiens CHEMBL3888723 cell-based format
CHEMBL445180 OBDepict NH 2 O N N N H 3 C N O O H 2 N N IC50 = 71.0 nM 369.39 CCn1c(-c2nonc2N)nc2c(-c3ccoc3)ncc(OCCCN)c21 Homo sapiens CHEMBL1028103 single protein format
CHEMBL427058 OBDepict O N H CH 3 N H O F F F Cl N N H IC50 = 90.0 nM 448.83 CC1=C(C(=O)Nc2cc(Cl)c3[nH]ncc3c2)C(c2ccc(C(F)(F)F)cc2)CC(=O)N1 Homo sapiens CHEMBL911039 single protein format
CHEMBL3963644 OBDepict O N H N N N H F Cl O IC50 = 98.9 nM 414.87 O=C(NCc1ccc(Cl)c(F)c1)c1ccc2cnc(NC3CCOCC3)cc2n1 Homo sapiens CHEMBL3888723 cell-based format
CHEMBL4440965 OBDepict H 3 C NH O H HN H H NH O F O F Cl N Cl CH 3 N IC50 = 131.0 nM 526.37 CNC(=O)C[C@@H]1C[C@@H](c2ccc(F)c(F)c2)[C@H](NC(=O)c2cc(-c3c(Cl)cnn3C)c(Cl)o2)CN1 Homo sapiens CHEMBL4407369 single protein format
CHEMBL535 OBDepict H 3 C N CH 3 HN O H 3 C CH 3 N H O N H F IC50 = 131.3 nM 398.48 CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2C(=O)Nc3ccc(F)cc32)c1C Homo sapiens CHEMBL1913892 single protein format
CHEMBL220241 OBDepict H 3 C N N N O NH 2 N N O N H O O N O IC50 = 132.0 nM 570.61 CCn1c(-c2nonc2N)nc2cnc(Oc3cccc(NC(=O)c4ccc(OCCN5CCOCC5)cc4)c3)cc21 Homo sapiens CHEMBL1960789 single protein format
CHEMBL478629 OBDepict N O N N N N IC50 = 210.0 nM 399.5 c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)ccn1 Homo sapiens CHEMBL1272386 single protein format
CHEMBL1271532 OBDepict H N N N N N O N O IC50 = 220.0 nM 390.45 c1cc(-c2cnc3c(-c4cn[nH]c4)cnn3c2)ccc1OCCN1CCOCC1 Homo sapiens CHEMBL1272386 single protein format
CHEMBL494882 OBDepict NH 2 O N N N CH 3 N O H 2 N N IC50 = 251.0 nM 367.41 CCn1c(-c2nonc2N)nc2c(C#CC3CC3)ncc(OCCCN)c21 Homo sapiens CHEMBL1028103 single protein format
CHEMBL1794064 OBDepict OH O F F F NH 2 O N N N H 3 C N O H 2 N N H 2 N IC50 = 251.0 nM 470.41 CCn1c(-c2nonc2N)nc2c(C#CCN)ncc(OCCCN)c21.O=C(O)C(F)(F)F Homo sapiens CHEMBL1028103 single protein format
CHEMBL4129817 OBDepict O HN N H CH 3 N N N N F F F N IC50 = 272.0 nM 477.54 C[C@@H]1CC(=O)Nc2ncnc(N3CCC(c4nc(C(F)(F)F)cn4CCN4CCCC4)CC3)c21 Homo sapiens CHEMBL4121778 single protein format
CHEMBL511410 OBDepict HO N H O H 2 N O HN O N IC50 = 290.0 nM 338.32 NC(=O)C(Nc1c(Nc2ccncc2)c(=O)c1=O)c1cccc(O)c1 Homo sapiens CHEMBL1011437 single protein format
CHEMBL3753341 OBDepict NH 2 N N N N N O H 3 C CH 3 IC50 = 311.0 nM 284.32 CC(C)n1nc(-c2cc(C3CC3)on2)c2c(N)ncnc21 Homo sapiens CHEMBL3756065 single protein format
CHEMBL3137336 OBDepict H 2 N N H H O O F Cl F N Cl H 3 C N IC50 = 339.0 nM 429.25 Cn1ncc(Cl)c1-c1cc(C(=O)N[C@H](CN)Cc2ccc(F)c(F)c2)oc1Cl Homo sapiens CHEMBL4407369 single protein format
CHEMBL521347 OBDepict Cl F N N H CH 3 N H O N Cl F N N H IC50 = 398.0 nM 513.34 CC1=C(C(=O)Nc2cc3cn[nH]c3cc2F)C(c2ccc(Cl)cc2F)N=C(c2ccnc(Cl)c2)N1 Homo sapiens CHEMBL987091 single protein format
CHEMBL3903344 OBDepict O N H N N N H F Cl O IC50 = 476.0 nM 428.9 O=C(NCCc1ccc(Cl)c(F)c1)c1ccc2cnc(NC3CCOCC3)cc2n1 Homo sapiens CHEMBL3888723 cell-based format
CHEMBL4742990 OBDepict CH 3 O N N O N N H IC50 = 483.0 nM 332.36 COc1cccc(Cn2cnc3ccc(-c4cn[nH]c4)cc3c2=O)c1 Homo sapiens CHEMBL4703627 single protein format
CHEMBL522351 OBDepict OH OH H HN O N N N H 3 C N O H 2 N N HO CH 3 CH 3 IC50 = 500.0 nM 459.51 CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)ncc(OCCCNC[C@H](O)CO)c21 Homo sapiens CHEMBL1028103 single protein format
CHEMBL453510 OBDepict H 2 N O N N N H 3 C N O NH 2 N OH H 3 C H 3 C IC50 = 500.0 nM 371.4 CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)ncc(OCCN)c21 Homo sapiens CHEMBL1028103 single protein format
CHEMBL520828 OBDepict H 3 C O N H N CH 3 N H O F Cl N N H IC50 = 510.0 nM 489.94 COc1ccc(C2=NC(c3ccc(Cl)cc3F)C(C(=O)Nc3ccc4[nH]ncc4c3)=C(C)N2)cc1 Homo sapiens CHEMBL987091 single protein format
CHEMBL4798527 OBDepict H 3 C N H N O N NH 2 N N H CH 3 F F F H HO IC50 = 559.0 nM 548.57 Cc1ccc(NC(=O)c2ccc(C)c(C(F)(F)F)c2)cc1C#Cc1nn([C@H]2CC[C@H](O)CC2)c2ncnc(N)c12 Homo sapiens CHEMBL4766186 single protein format
CHEMBL1271641 OBDepict HO HO N N N O N O IC50 = 560.0 nM 432.48 Oc1ccc(-c2cnn3cc(-c4ccc(OCCN5CCOCC5)cc4)cnc23)cc1O Homo sapiens CHEMBL1272386 single protein format
CHEMBL4129379 OBDepict O NH N H H 3 C N N N N N F F F IC50 = 568.0 nM 505.59 C[C@@H]1CC(=O)Nc2ncnc(N3CCC(c4nc(CCC(F)(F)F)cn4CCN4CCCC4)CC3)c21 Homo sapiens CHEMBL4121778 single protein format
CHEMBL374453 OBDepict O N H H 3 C N H O Cl Cl N N H IC50 = 620.0 nM 415.28 CC1=C(C(=O)Nc2ccc3[nH]ncc3c2)C(c2ccc(Cl)c(Cl)c2)CC(=O)N1 Homo sapiens CHEMBL911039 single protein format
CHEMBL4126067 OBDepict O HN N H CH 3 N N N N N O IC50 = 699.0 nM 493.66 C[C@@H]1CC(=O)Nc2ncnc(N3CCC(c4nc(C5CCOCC5)cn4CCN4CCCC4)CC3)c21 Homo sapiens CHEMBL4121778 single protein format
CHEMBL218719 OBDepict O N H CH 3 N H O F F F N N H IC50 = 740.0 nM 414.39 CC1=C(C(=O)Nc2ccc3[nH]ncc3c2)C(c2ccc(C(F)(F)F)cc2)CC(=O)N1 Homo sapiens CHEMBL911039 single protein format
CHEMBL4556790 OBDepict O N H F H NH H N CH 3 N F F ClH IC50 = 756.0 nM 450.89 Cl.Cn1nccc1-c1ccc(C(=O)N[C@@H]2CNCC[C@H]2c2ccc(F)c(F)c2)c(F)c1 Homo sapiens CHEMBL4830040 single protein format
CHEMBL467079 OBDepict O O N H HN O H 2 N N IC50 = 780.0 nM 322.32 NC(=O)C(Nc1c(Nc2ccncc2)c(=O)c1=O)c1ccccc1 Homo sapiens CHEMBL1011437 single protein format
CHEMBL375312 OBDepict O N H CH 3 N H O F F F F N N H IC50 = 780.0 nM 432.38 CC1=C(C(=O)Nc2cc3cn[nH]c3cc2F)C(c2ccc(C(F)(F)F)cc2)CC(=O)N1 Homo sapiens CHEMBL911039 single protein format
CHEMBL493269 OBDepict NH 2 O N N N CH 3 N O H 2 N N HO CH 3 CH 3 IC50 = 790.0 nM 399.46 CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)ncc(OCCCCN)c21 Homo sapiens CHEMBL1028103 single protein format
CHEMBL466496 OBDepict O O N H N H CH 3 H N IC50 = 810.0 nM 293.33 C[C@@H](Nc1c(Nc2ccncc2)c(=O)c1=O)c1ccccc1 Homo sapiens CHEMBL1011437 single protein format
CHEMBL4859660 OBDepict NH 2 N F + N O NH O _ O IC50 = 1000.0 nM 378.36 Nc1ncc(-c2cccc([N+](=O)[O-])c2F)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804489 cell-based format