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Q15465 | SHH_HUMAN | Sonic hedgehog protein (SHH)

3D structures mapped by conservation among orthologs

[ Domain: "Hedgehog/DD-peptidase" // HH_signal ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL473417 OBDepict O N H Cl S O O CH 3 Cl N IC50 = 15.0 nM 421.31 CS(=O)(=O)c1ccc(C(=O)Nc2ccc(Cl)c(-c3ccccn3)c2)c(Cl)c1 Homo sapiens CHEMBL1776927 cell-based format
CHEMBL480889 OBDepict H 3 C O N H O N H H 3 C CH 3 H 3 C N O O N H O IC50 = 100.0 nM 550.7 COc1cccc(CN(C(=O)CC(C)(C)C)[C@H]2C[C@@H](C(=O)N3CCNCC3)N(Cc3ccc4c(c3)OCO4)C2)c1 Homo sapiens CHEMBL972423 cell-based format
CHEMBL473189 OBDepict CH 3 O N O N N O HN O O IC50 < 100.0 nM 520.63 COc1cccc(CN(C(=O)C2CC2)C2CC(C(=O)N3CCNCC3)N(Cc3ccc4c(c3)OCO4)C2)c1 Homo sapiens CHEMBL972423 cell-based format
CHEMBL515092 OBDepict CH 3 O N O CH 3 H 3 C N N O NH O O IC50 < 100.0 nM 522.65 COc1cccc(CN(C(=O)C(C)C)C2CC(C(=O)N3CCNCC3)N(Cc3ccc4c(c3)OCO4)C2)c1 Homo sapiens CHEMBL972423 cell-based format
CHEMBL186779 OBDepict CH 3 O O H H H 3 C H H H H N H CH 3 H CH 3 H HO IC50 = 500.0 nM 425.61 CC1=C2C(=O)[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@@]43C)[C@@H]2CC[C@]12O[C@@H]1C[C@H](C)CN[C@H]1[C@H]2C Homo sapiens CHEMBL972423 cell-based format
CHEMBL254129 OBDepict CH 3 O H H CH 3 H H H H N H H 3 C H H 3 C H OH IC50 = 600.0 nM 411.63 CC1=C2C[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@@]43C)[C@@H]2CC[C@]12O[C@@H]1C[C@H](C)CN[C@H]1[C@H]2C Homo sapiens CHEMBL2155375 single protein format