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Q16665 | HIF1A_HUMAN | Hypoxia-inducible factor 1-alpha (HIF1A)

3D structures mapped by conservation among orthologs

[ Domain: "sensor domains" // PAS_11 ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL380456 OBDepict HO HO O O CH 3 CH 3 OH IC50 = 0.65 nM 326.35 CC1(C)Oc2cc3oc(-c4cc(O)cc(O)c4)cc3cc2CC1O Homo sapiens CHEMBL3399575 cell-based format
CHEMBL1795446 OBDepict HO O O H OH CH 3 H 3 C IC50 = 1.0 nM 310.35 CC(C)(O)[C@H]1Cc2cc3cc(-c4ccc(O)cc4)oc3cc2O1 Homo sapiens CHEMBL1799182 cell-based format
CHEMBL283631 OBDepict H 3 C O OH O H CH 3 H O O H O H N H O + N O _ O IC50 = 1.0 nM 520.49 COc1cc([C@@H]2c3cc4c(cc3[C@@H](Nc3ccc([N+](=O)[O-])cc3)[C@H]3COC(=O)[C@@H]32)OCO4)cc(OC)c1O Homo sapiens CHEMBL4396991 cell-based format
CHEMBL2205734 OBDepict CH 3 N N CH 3 N N H Cl IC50 = 3.0 nM 412.92 Cc1ccc(Cn2nc(-c3nc4ccc(-c5ccc(Cl)cc5)cc4[nH]3)cc2C)cc1 Homo sapiens CHEMBL2212528 cell-based format
CHEMBL1795435 OBDepict HO O O OH CH 3 CH 3 IC50 = 4.2 nM 310.35 CC(C)(O)C1Cc2cc3cc(-c4ccc(O)cc4)oc3cc2O1 Homo sapiens CHEMBL1799182 cell-based format
CHEMBL205924 OBDepict HO HO O O OH CH 3 CH 3 IC50 = 6.76 nM 326.35 CC(C)(O)C1Cc2cc3cc(-c4cc(O)cc(O)c4)oc3cc2O1 Homo sapiens CHEMBL1799182 cell-based format
CHEMBL1795432 OBDepict HO HO O O H OH CH 3 H 3 C IC50 = 6.76 nM 326.35 CC(C)(O)[C@H]1Cc2cc3cc(-c4cc(O)cc(O)c4)oc3cc2O1 Homo sapiens CHEMBL1799182 cell-based format
CHEMBL1795439 OBDepict CH 3 O O O HO H 3 C CH 3 IC50 = 7.0 nM 324.38 COc1cccc(-c2cc3cc4c(cc3o2)OC(C(C)(C)O)C4)c1 Homo sapiens CHEMBL1799182 cell-based format
CHEMBL1795433 OBDepict CH 3 O O CH 3 O O HO H 3 C CH 3 IC50 = 10.0 nM 354.4 COc1cc(OC)cc(-c2cc3cc4c(cc3o2)OC(C(C)(C)O)C4)c1 Homo sapiens CHEMBL1799182 cell-based format
CHEMBL561971 OBDepict HO HO O O CH 3 CH 3 H OH IC50 = 10.7 nM 326.35 CC1(C)Oc2cc3oc(-c4cc(O)cc(O)c4)cc3cc2C[C@H]1O Homo sapiens CHEMBL1799182 cell-based format
CHEMBL2323956 OBDepict H N N N H O O IC50 = 14.0 nM 305.34 c1ccc2c(c1)Cc1c(Nc3ccc4c(c3)OCCO4)n[nH]c1-2 Homo sapiens CHEMBL2327238 cell-based format
CHEMBL3105545 OBDepict CH 3 O O H O CH 3 H H CH 3 HO H H H CH 3 O O O CH 3 O CH 3 CH 3 CH 3 IC50 = 20.0 nM 552.66 COc1ccc([C@H]2O[C@H](c3ccc(O[C@H](C)[C@H](O)c4ccc(OC)c(OC)c4)c(OC)c3)[C@H](C)[C@H]2C)cc1OC Homo sapiens CHEMBL4344026 cell-based format
CHEMBL4434875 OBDepict H 3 C O O H H 3 C H N OH H O O O H 3 C O H 3 C H 3 C CH 3 IC50 = 22.8 nM 523.63 COc1ccc([C@@H](O)[C@@H](C)Oc2ccc([C@@H]3CCN(c4ccc(OC)c(OC)c4)C3)cc2OC)cc1OC Homo sapiens CHEMBL4344026 cell-based format
CHEMBL2323957 OBDepict CH 3 O N N H N H O O IC50 = 34.0 nM 335.36 COc1cccc2c1Cc1c(Nc3ccc4c(c3)OCCO4)n[nH]c1-2 Homo sapiens CHEMBL2327238 cell-based format
CHEMBL1337170 OBDepict _ O + N O S O O IC50 = 43.0 nM 211.2 O=[N+]([O-])c1ccc2c(c1)S(=O)(=O)C=C2 Homo sapiens CHEMBL4481809 single protein format
CHEMBL1795434 OBDepict OH O O HO H 3 C CH 3 IC50 = 46.0 nM 310.35 CC(C)(O)C1Cc2cc3cc(-c4cccc(O)c4)oc3cc2O1 Homo sapiens CHEMBL1799182 cell-based format
CHEMBL1795436 OBDepict CH 3 O O O O O HO H 3 C CH 3 IC50 = 54.0 nM 396.44 CCOC(=O)COc1ccc(-c2cc3cc4c(cc3o2)OC(C(C)(C)O)C4)cc1 Homo sapiens CHEMBL1799182 cell-based format
CHEMBL1795441 OBDepict CH 3 OH CH 3 O O IC50 = 54.0 nM 294.35 CC(C)(O)C1Cc2cc3cc(-c4ccccc4)oc3cc2O1 Homo sapiens CHEMBL1799182 cell-based format
CHEMBL84 OBDepict CH 3 HO O O N O N HO N CH 3 CH 3 IC50 = 60.0 nM 421.45 CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3c(CN(C)C)c(O)ccc3nc2-1 Homo sapiens CHEMBL1272616 cell-based format
CHEMBL4849133 OBDepict O N H O N O O CH 3 CH 3 H CH 3 H 3 C CH 3 H 3 C O CH 3 OH IC50 = 70.0 nM 588.75 CC1=C(O)C(=O)C=C2C1=CC=C1[C@@]3(C)CC[C@@]4(C)CC[C@@](C)(C(=O)OCC(=O)Nc5cc(C)on5)C[C@H]4[C@]3(C)CC[C@@]21C Homo sapiens CHEMBL4837973 cell-based format
CHEMBL1836238 OBDepict CH 3 O N N O N NH IC50 = 90.0 nM 364.45 CCOc1ccccc1-n1c(CN2CCNCC2)nc2ccccc2c1=O Homo sapiens CHEMBL1837625 cell-based format
CHEMBL4209785 OBDepict H 3 C O O O CH 3 CH 3 F IC50 = 100.0 nM 326.37 COc1c(C(=O)Cc2ccccc2F)ccc2c1C=CC(C)(C)O2 Homo sapiens CHEMBL4202196 cell-based format
CHEMBL1795440 OBDepict CH 3 O O O HO H 3 C CH 3 IC50 = 110.0 nM 324.38 COc1ccc(-c2cc3cc4c(cc3o2)OC(C(C)(C)O)C4)cc1 Homo sapiens CHEMBL1799182 cell-based format
CHEMBL2178399 OBDepict O NH O O O N O IC50 = 120.0 nM 530.67 O=C(/C=C/Oc1ccc(C23CC4CC(CC(C4)C2)C3)cc1)Nc1cccc(C(=O)OCCN2CCOCC2)c1 Homo sapiens CHEMBL2183271 cell-based format
CHEMBL1836239 OBDepict CH 3 O N N O N N H IC50 = 160.0 nM 378.48 CCOc1ccccc1-n1c(CN2CCCNCC2)nc2ccccc2c1=O Homo sapiens CHEMBL1837625 cell-based format
CHEMBL1836179 OBDepict CH 3 O N N O F F F N HN IC50 = 200.0 nM 418.42 COc1ccc(C(F)(F)F)cc1-n1c(CN2CCNCC2)nc2ccccc2c1=O Homo sapiens CHEMBL1837625 cell-based format
CHEMBL253429 OBDepict O HN N H O N NH 2 N H O O IC50 = 214.0 nM 439.43 Nc1ccc(NC(=O)Nc2cccc3c2C(=O)c2c-3n[nH]c2-c2ccc3c(c2)OCO3)cc1 Homo sapiens CHEMBL2327238 cell-based format
CHEMBL301982 OBDepict O OH H 3 C CH 3 H 3 C CH 3 H H 3 C CH 3 O HO IC50 = 250.0 nM 450.62 CC1=C(O)C(=O)C=C2C1=CC=C1[C@@]3(C)CC[C@@]4(C)CC[C@@](C)(C(=O)O)C[C@H]4[C@]3(C)CC[C@@]21C Homo sapiens CHEMBL4837973 cell-based format
CHEMBL2323955 OBDepict H N N N H O O IC50 = 270.0 nM 291.31 c1ccc2c(c1)Cc1c(Nc3ccc4c(c3)OCO4)n[nH]c1-2 Homo sapiens CHEMBL2327238 cell-based format
CHEMBL1795442 OBDepict CH 3 O O HO H 3 C CH 3 IC50 = 310.0 nM 308.38 Cc1ccc(-c2cc3cc4c(cc3o2)OC(C(C)(C)O)C4)cc1 Homo sapiens CHEMBL1799182 cell-based format
CHEMBL4447149 OBDepict CH 3 O N NH O F IC50 = 320.0 nM 350.39 COc1ccccc1-c1ccc(C(=O)NCCc2ccccc2F)nc1 Homo sapiens CHEMBL4356100 assay format
CHEMBL1795443 OBDepict F F O O OH CH 3 CH 3 IC50 = 360.0 nM 330.33 CC(C)(O)C1Cc2cc3cc(-c4cc(F)cc(F)c4)oc3cc2O1 Homo sapiens CHEMBL1799182 cell-based format
CHEMBL4214693 OBDepict CH 3 O O O H 3 C H 3 C F IC50 = 360.0 nM 326.37 COc1c(C(=O)Cc2cccc(F)c2)ccc2c1C=CC(C)(C)O2 Homo sapiens CHEMBL4202196 cell-based format
CHEMBL4643958 OBDepict OH N N O IC50 = 390.0 nM 262.27 O=C1c2ccccc2-c2cnn(-c3ccc(O)cc3)c21 Homo sapiens CHEMBL4614037 cell-based format
CHEMBL219673 OBDepict O N H O O OH IC50 = 400.0 nM 405.49 O=C(COc1ccc(C23CC4CC(CC(C4)C2)C3)cc1)Nc1cccc(C(=O)O)c1 Homo sapiens CHEMBL924307 cell-based format
CHEMBL1345685 OBDepict CH 3 O N N O N N O O IC50 = 430.0 nM 458.52 CCOc1ccccc1-n1c(CN2CCN(C(=O)c3ccco3)CC2)nc2ccccc2c1=O Homo sapiens CHEMBL1837625 cell-based format
CHEMBL1836233 OBDepict CH 3 O N N O N N O CH 3 IC50 = 470.0 nM 406.49 CCOc1ccccc1-n1c(CN2CCN(C(C)=O)CC2)nc2ccccc2c1=O Homo sapiens CHEMBL1837625 cell-based format
CHEMBL1795437 OBDepict CH 3 OH CH 3 O O O IC50 = 490.0 nM 400.47 CC(C)(O)C1Cc2cc3cc(-c4ccc(OCc5ccccc5)cc4)oc3cc2O1 Homo sapiens CHEMBL1799182 cell-based format
CHEMBL4463406 OBDepict OH N O N N O N N O F F F IC50 = 550.0 nM 579.58 OC1CCN(CCOc2cccc(Cn3nc(-c4nc(-c5ccc(OC(F)(F)F)cc5)no4)c4ccccc43)c2)CC1 Homo sapiens CHEMBL4344027 single protein format
CHEMBL1795438 OBDepict CH 3 O O O HO H 3 C CH 3 IC50 = 580.0 nM 324.38 COc1ccccc1-c1cc2cc3c(cc2o1)OC(C(C)(C)O)C3 Homo sapiens CHEMBL1799182 cell-based format
CHEMBL249027 OBDepict O HN O N O H 2 N IC50 = 600.0 nM 405.5 NC(=O)c1ccnc(NC(=O)COc2ccc(C34CC5CC(CC(C5)C3)C4)cc2)c1 Homo sapiens CHEMBL924306 cell-based format
CHEMBL4090212 OBDepict CH 3 O N O O H 3 C O O Cl IC50 = 600.0 nM 439.9 CO/N=C(/C(=O)OC)c1ccccc1COc1cccc(OCc2ccc(Cl)cc2)c1 Homo sapiens CHEMBL4036023 cell-based format
CHEMBL4215206 OBDepict N N H O CH 3 O CH 3 O O H 3 C H 3 C IC50 = 600.0 nM 430.5 COc1ccc(C(C)C(=O)c2ccc(NCc3ccc(C#N)cc3)cc2OC)cc1OC Homo sapiens CHEMBL4202196 cell-based format
CHEMBL4645257 OBDepict CH 3 O N N O IC50 = 610.0 nM 276.3 COc1ccc(-n2ncc3c2C(=O)c2ccccc2-3)cc1 Homo sapiens CHEMBL4614037 cell-based format
CHEMBL4435719 OBDepict CH 3 N N O N N O N N O F F F IC50 = 620.0 nM 578.6 CN1CCN(CCOc2cccc(Cn3nc(-c4nc(-c5ccc(OC(F)(F)F)cc5)no4)c4ccccc43)c2)CC1 Homo sapiens CHEMBL4344027 single protein format
CHEMBL373396 OBDepict H 3 C O O N H O O IC50 = 700.0 nM 419.52 COC(=O)c1cccc(NC(=O)COc2ccc(C34CC5CC(CC(C5)C3)C4)cc2)c1 Homo sapiens CHEMBL924308 cell-based format
CHEMBL1194747 OBDepict H N O N H + N H S H H HO O IC50 = 730.0 nM 352.4 O=C1C2=C3C4=[N+](CCc5c[nH]c1c54)[C@@H]1C(=O)C=C4S[C@@H](C[C@@]43[C@H]1O)N2 Homo sapiens CHEMBL3854200 single protein format
CHEMBL2178407 OBDepict H 3 C O O N H O O IC50 = 740.0 nM 431.53 COC(=O)c1cccc(NC(=O)/C=C/Oc2ccc(C34CC5CC(CC(C5)C3)C4)cc2)c1 Homo sapiens CHEMBL2183271 cell-based format
CHEMBL4635527 OBDepict H 3 C N N O IC50 = 790.0 nM 260.3 Cc1ccc(-n2ncc3c2C(=O)c2ccccc2-3)cc1 Homo sapiens CHEMBL4614037 cell-based format
CHEMBL4206967 OBDepict H 3 C O O O CH 3 CH 3 OH IC50 = 790.0 nM 324.38 COc1c(C(=O)Cc2ccc(O)cc2)ccc2c1C=CC(C)(C)O2 Homo sapiens CHEMBL4202196 cell-based format
CHEMBL1271866 OBDepict Cl N H O N N N OH F F F IC50 = 800.0 nM 332.67 O=C(CCl)Nc1ccc(-c2nc(O)cc(C(F)(F)F)n2)nc1 Homo sapiens CHEMBL1272616 cell-based format
CHEMBL1836236 OBDepict CH 3 O N N O N N H 3 C IC50 = 810.0 nM 378.48 CCOc1ccccc1-n1c(CN2CCN(C)CC2)nc2ccccc2c1=O Homo sapiens CHEMBL1837625 cell-based format
CHEMBL235553 OBDepict CH 3 H HO H H 3 C H H H 3 C O H CH 3 H 3 C IC50 = 820.0 nM 306.49 CC1=C[C@@H](O)[C@@H]([C@@H](C)CC[C@@H]2[C@@H](C)[C@@]3(C)CC[C@]2(C)O3)CC1 Homo sapiens CHEMBL901549 cell-based format
CHEMBL4211498 OBDepict CH 3 O O O H 3 C H 3 C O CH 3 IC50 = 820.0 nM 338.4 COc1cccc(CC(=O)c2ccc3c(c2OC)C=CC(C)(C)O3)c1 Homo sapiens CHEMBL4202196 cell-based format
CHEMBL2178416 OBDepict CH 3 O O N H O O IC50 = 820.0 nM 445.56 CCOC(=O)c1cccc(NC(=O)/C=C/Oc2ccc(C34CC5CC(CC(C5)C3)C4)cc2)c1 Homo sapiens CHEMBL2183271 cell-based format
CHEMBL4074474 OBDepict H 3 C O N O O CH 3 O O CH 2 IC50 = 870.0 nM 431.49 C=Cc1ccc(COc2cccc(OCc3ccccc3/C(=NOC)C(=O)OC)c2)cc1 Homo sapiens CHEMBL4036023 cell-based format
CHEMBL4218467 OBDepict H 3 C O O O CH 3 CH 3 IC50 = 880.0 nM 308.38 COc1c(C(=O)Cc2ccccc2)ccc2c1C=CC(C)(C)O2 Homo sapiens CHEMBL4202196 cell-based format
CHEMBL401390 OBDepict O HN O N O H 2 N IC50 = 900.0 nM 405.5 NC(=O)c1cncc(NC(=O)COc2ccc(C34CC5CC(CC(C5)C3)C4)cc2)c1 Homo sapiens CHEMBL924308 cell-based format
CHEMBL403789 OBDepict O HN O N NH O N N IC50 = 900.0 nM 513.64 O=C(COc1ccc(C23CC4CC(CC(C4)C2)C3)cc1)Nc1cc(C(=O)NCCCn2ccnc2)ccn1 Homo sapiens CHEMBL924306 cell-based format
CHEMBL4556236 OBDepict O N H N F IC50 = 930.0 nM 320.37 O=C(NCCc1ccccc1F)c1ccc(-c2ccccc2)cn1 Homo sapiens CHEMBL4356100 assay format
CHEMBL4210297 OBDepict H 3 C O O O CH 3 CH 3 OH IC50 = 940.0 nM 324.38 COc1c(C(=O)Cc2ccccc2O)ccc2c1C=CC(C)(C)O2 Homo sapiens CHEMBL4202196 cell-based format
CHEMBL4101212 OBDepict H 3 C O N O O CH 3 O O F F F F F F IC50 = 940.0 nM 541.44 CO/N=C(/C(=O)OC)c1ccccc1COc1cccc(OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 Homo sapiens CHEMBL4036023 cell-based format
CHEMBL354349 OBDepict NH 2 + N CH 3 H 2 N _ Cl IC50 = 1000.0 nM 259.74 C[n+]1c2cc(N)ccc2cc2ccc(N)cc21.[Cl-] Homo sapiens CHEMBL4481808 cell-based format
CHEMBL430393 OBDepict O N H O N O HO IC50 = 1000.0 nM 406.48 O=C(COc1ccc(C23CC4CC(CC(C4)C2)C3)cc1)Nc1cc(C(=O)O)ccn1 Homo sapiens CHEMBL924307 cell-based format