molecule_chembl_id |
structure |
assay_type |
relation |
values |
units |
mol_wt |
smiles |
organism |
assay_chembl_id |
bao_label |
CHEMBL4077433 |
|
IC50 |
= |
0.7 |
nM |
432.59 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCN1CCNCC1 |
Homo sapiens |
CHEMBL4009736 |
single protein format |
CHEMBL4525926 |
OBDepict
H
3
C
O
O
N
CH
3
HN
S
N
F
N
H
3
C
|
IC50 |
= |
1.3 |
nM |
442.56 |
COc1ccc(N(Cc2ccc(F)cc2)C(=S)NCCCn2cncc2C)cc1OC |
Homo sapiens |
CHEMBL4376103 |
cell-based format |
CHEMBL4445407 |
OBDepict
NH
2
N
H
N
N
N
H
O
O
O
CH
3
CH
3
N
N
H
3
C
|
IC50 |
= |
1.6 |
nM |
509.66 |
COc1ccc(N(CCCCc2ccnc(NCCN)c2)C(=O)NCCCn2cncc2C)cc1OC |
Homo sapiens |
CHEMBL4376103 |
cell-based format |
CHEMBL4204093 |
OBDepict
NH
2
HN
N
O
O
CH
3
N
H
N
H
S
N
N
H
3
C
|
IC50 |
= |
1.8 |
nM |
511.7 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCCCc1ccnc(NCCN)c1 |
Homo sapiens |
CHEMBL4188043 |
single protein format |
CHEMBL583368 |
OBDepict
CH
3
O
O
H
3
C
N
H
S
N
N
CH
3
|
Ki |
= |
2.6 |
nM |
359.5 |
COc1ccc(C2(C(=S)NCCCn3cncc3C)CC2)cc1OC |
Homo sapiens |
CHEMBL1057686 |
assay format |
CHEMBL4464130 |
OBDepict
CH
3
O
O
N
CH
3
HN
S
CH
3
H
3
C
N
N
H
3
C
|
IC50 |
= |
2.8 |
nM |
376.53 |
COc1ccc(N(C(=S)NCCCn2cncc2C)C(C)C)cc1OC |
Homo sapiens |
CHEMBL4376103 |
cell-based format |
CHEMBL3677287 |
OBDepict
CH
3
O
HO
N
O
NH
O
N
N
H
|
IC50 |
= |
3.08 |
nM |
338.32 |
COc1ccc(C2C(=O)NC(=O)N2c2ccc3[nH]cnc3c2)cc1O |
Homo sapiens |
CHEMBL3705923 |
single protein format |
CHEMBL3677287 |
OBDepict
CH
3
O
HO
N
O
NH
O
N
N
H
|
Ki |
= |
3.24 |
nM |
338.32 |
COc1ccc(C2C(=O)NC(=O)N2c2ccc3[nH]cnc3c2)cc1O |
Homo sapiens |
CHEMBL3705923 |
single protein format |
CHEMBL4539841 |
OBDepict
H
3
C
O
O
N
CH
3
N
H
S
F
N
N
CH
3
|
IC50 |
= |
3.4 |
nM |
442.56 |
COc1ccc(N(Cc2cccc(F)c2)C(=S)NCCCn2cncc2C)cc1OC |
Homo sapiens |
CHEMBL4376103 |
cell-based format |
CHEMBL4586501 |
OBDepict
H
3
C
O
O
N
CH
3
N
H
S
Cl
N
N
CH
3
|
IC50 |
= |
3.5 |
nM |
459.02 |
COc1ccc(N(Cc2cccc(Cl)c2)C(=S)NCCCn2cncc2C)cc1OC |
Homo sapiens |
CHEMBL4376103 |
cell-based format |
CHEMBL4547037 |
OBDepict
CH
3
O
O
N
CH
3
N
H
O
N
N
CH
3
N
NH
2
|
IC50 |
= |
3.6 |
nM |
466.59 |
COc1ccc(N(CCCCc2ccnc(N)c2)C(=O)NCCCn2cncc2C)cc1OC |
Homo sapiens |
CHEMBL4376103 |
cell-based format |
CHEMBL4208618 |
OBDepict
H
2
N
O
N
N
O
O
H
3
C
N
H
N
H
S
N
N
CH
3
|
IC50 |
= |
3.6 |
nM |
519.72 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCN1CCN(CCOCCN)CC1 |
Homo sapiens |
CHEMBL4188043 |
single protein format |
CHEMBL4070663 |
OBDepict
H
3
C
O
O
NH
NH
S
N
CH
3
H
3
C
N
N
CH
3
|
IC50 |
= |
3.7 |
nM |
419.6 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCCCN(C)C |
Homo sapiens |
CHEMBL4009736 |
single protein format |
CHEMBL4212160 |
OBDepict
NH
2
N
N
O
O
CH
3
N
H
N
H
S
N
N
H
3
C
|
IC50 |
= |
3.8 |
nM |
489.69 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCCN1CCN(CCN)CC1 |
Homo sapiens |
CHEMBL4188043 |
single protein format |
CHEMBL3677285 |
OBDepict
CH
3
O
N
O
NH
O
N
N
H
|
Ki |
= |
3.8 |
nM |
350.38 |
CCCOc1ccc(C2C(=O)NC(=O)N2c2ccc3[nH]cnc3c2)cc1 |
Homo sapiens |
CHEMBL3705923 |
single protein format |
CHEMBL4448303 |
OBDepict
H
3
C
O
O
N
CH
3
HN
O
N
F
N
H
3
C
|
IC50 |
= |
3.9 |
nM |
426.49 |
COc1ccc(N(Cc2ccc(F)cc2)C(=O)NCCCn2cncc2C)cc1OC |
Homo sapiens |
CHEMBL4376103 |
cell-based format |
CHEMBL4445143 |
OBDepict
CH
3
O
O
N
CH
3
N
H
S
N
N
CH
3
|
IC50 |
= |
4.1 |
nM |
416.59 |
COc1ccc(N(CC2CCCC2)C(=S)NCCCn2cncc2C)cc1OC |
Homo sapiens |
CHEMBL4376103 |
cell-based format |
CHEMBL3677288 |
OBDepict
O
N
H
N
O
N
N
H
|
Ki |
= |
4.13 |
nM |
368.4 |
O=C1NC(=O)N(c2ccc3[nH]cnc3c2)C1c1ccc(-c2ccccc2)cc1 |
Homo sapiens |
CHEMBL3705923 |
single protein format |
CHEMBL3674614 |
OBDepict
CH
3
O
N
O
N
N
N
H
S
O
O
|
Ki |
= |
4.4 |
nM |
438.51 |
COC1=CC(=O)N(c2ccc3nc[nH]c3c2)C1c1ccc(N2CCS(=O)(=O)CC2)cc1 |
Homo sapiens |
CHEMBL3705340 |
single protein format |
CHEMBL4097599 |
OBDepict
CH
3
O
O
N
H
N
H
S
N
N
NH
2
N
H
3
C
|
IC50 |
= |
4.5 |
nM |
468.63 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCCCc1ccnc(N)c1 |
Homo sapiens |
CHEMBL4009736 |
single protein format |
CHEMBL4205777 |
OBDepict
NH
2
N
N
H
O
O
O
CH
3
N
H
N
H
S
N
N
H
3
C
|
IC50 |
= |
4.5 |
nM |
503.67 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCC(=O)NC1CCN(CCN)CC1 |
Homo sapiens |
CHEMBL4188043 |
single protein format |
CHEMBL4549443 |
OBDepict
H
3
C
O
O
N
H
3
C
NH
O
N
N
CH
3
|
IC50 |
= |
4.5 |
nM |
400.52 |
COc1ccc(N(C(=O)NCCCn2cncc2C)C2CCCCC2)cc1OC |
Homo sapiens |
CHEMBL4376103 |
cell-based format |
CHEMBL4093071 |
OBDepict
CH
3
O
O
N
H
N
H
S
N
N
CH
3
N
H
3
C
|
IC50 |
= |
4.6 |
nM |
445.63 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCC1CCN(C)CC1 |
Homo sapiens |
CHEMBL4009736 |
single protein format |
CHEMBL4459792 |
OBDepict
H
3
C
O
O
N
CH
3
HN
S
N
N
H
3
C
|
IC50 |
= |
4.6 |
nM |
424.57 |
COc1ccc(N(Cc2ccccc2)C(=S)NCCCn2cncc2C)cc1OC |
Homo sapiens |
CHEMBL4376103 |
cell-based format |
CHEMBL3674615 |
OBDepict
O
N
N
N
N
H
N
O
|
Ki |
= |
4.6 |
nM |
443.55 |
O=C1C=C(N2CCCCC2)C(c2ccc(N3CCOCC3)cc2)N1c1ccc2nc[nH]c2c1 |
Homo sapiens |
CHEMBL3705340 |
single protein format |
CHEMBL4462968 |
OBDepict
H
3
C
O
O
N
H
3
C
NH
S
N
N
CH
3
|
IC50 |
= |
4.7 |
nM |
416.59 |
COc1ccc(N(C(=S)NCCCn2cncc2C)C2CCCCC2)cc1OC |
Homo sapiens |
CHEMBL4376103 |
cell-based format |
CHEMBL4099813 |
OBDepict
CH
3
O
O
N
H
N
H
S
N
N
NH
N
H
3
C
|
IC50 |
= |
4.8 |
nM |
460.65 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCCCN1CCNCC1 |
Homo sapiens |
CHEMBL4009736 |
single protein format |
CHEMBL4216611 |
OBDepict
HO
N
N
O
O
H
3
C
N
H
N
H
S
N
N
CH
3
|
IC50 |
= |
4.8 |
nM |
504.7 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCCCN1CCN(CCO)CC1 |
Homo sapiens |
CHEMBL4188043 |
single protein format |
CHEMBL4590359 |
OBDepict
H
3
C
O
O
N
CH
3
HN
S
N
Cl
N
H
3
C
|
IC50 |
= |
5.2 |
nM |
459.02 |
COc1ccc(N(Cc2ccc(Cl)cc2)C(=S)NCCCn2cncc2C)cc1OC |
Homo sapiens |
CHEMBL4376103 |
cell-based format |
CHEMBL4082916 |
OBDepict
NH
2
O
O
CH
3
HN
HN
S
N
N
H
3
C
|
IC50 |
= |
5.3 |
nM |
377.51 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCCN |
Homo sapiens |
CHEMBL4009736 |
single protein format |
CHEMBL4472311 |
OBDepict
H
3
C
O
O
N
CH
3
HN
S
N
N
N
H
3
C
|
IC50 |
= |
5.4 |
nM |
425.56 |
COc1ccc(N(Cc2cccnc2)C(=S)NCCCn2cncc2C)cc1OC |
Homo sapiens |
CHEMBL4376103 |
cell-based format |
CHEMBL4074799 |
OBDepict
CH
3
O
O
N
H
N
H
S
N
NH
2
N
N
H
3
C
|
IC50 |
= |
5.5 |
nM |
440.57 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCc1ccnc(N)c1 |
Homo sapiens |
CHEMBL4009736 |
single protein format |
CHEMBL4205893 |
OBDepict
H
3
C
O
O
N
H
N
H
S
NH
O
N
HN
N
CH
3
|
IC50 |
= |
5.5 |
nM |
474.63 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCC(=O)NC1CCNCC1 |
Homo sapiens |
CHEMBL4188043 |
single protein format |
CHEMBL4459555 |
OBDepict
H
3
C
O
O
N
CH
3
HN
S
N
N
N
H
3
C
|
IC50 |
= |
5.6 |
nM |
425.56 |
COc1ccc(N(Cc2ccncc2)C(=S)NCCCn2cncc2C)cc1OC |
Homo sapiens |
CHEMBL4376103 |
cell-based format |
CHEMBL4075925 |
OBDepict
H
3
C
O
O
NH
N
H
S
N
H
N
N
N
N
H
3
C
|
IC50 |
= |
5.7 |
nM |
469.62 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCCCNc1ncccn1 |
Homo sapiens |
CHEMBL4009736 |
single protein format |
CHEMBL4202790 |
OBDepict
H
3
C
O
O
N
H
N
H
S
N
CH
3
HN
N
N
CH
3
|
IC50 |
= |
5.8 |
nM |
446.62 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCN1CCNCC1C |
Homo sapiens |
CHEMBL4188043 |
single protein format |
CHEMBL3677280 |
OBDepict
O
N
H
N
O
N
N
N
H
N
S
|
Ki |
= |
6.07 |
nM |
350.36 |
O=C1NC(=O)N(c2ccc3[nH]cnc3c2)C1c1ccc2nsnc2c1 |
Homo sapiens |
CHEMBL3705923 |
single protein format |
CHEMBL4589039 |
OBDepict
H
3
C
O
O
N
H
3
C
NH
O
N
H
3
C
N
N
CH
3
|
IC50 |
= |
6.1 |
nM |
415.54 |
COc1ccc(N(C(=O)NCCCn2cncc2C)C2CCN(C)CC2)cc1OC |
Homo sapiens |
CHEMBL4376103 |
cell-based format |
CHEMBL4446821 |
OBDepict
CH
3
O
O
N
CH
3
N
H
O
N
N
CH
3
|
IC50 |
= |
6.2 |
nM |
400.52 |
COc1ccc(N(CC2CCCC2)C(=O)NCCCn2cncc2C)cc1OC |
Homo sapiens |
CHEMBL4376103 |
cell-based format |
CHEMBL4213886 |
OBDepict
CH
3
O
O
HN
N
H
S
N
N
CH
3
NH
|
IC50 |
= |
6.2 |
nM |
493.68 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCc1ccc(C2CCNCC2)cc1 |
Homo sapiens |
CHEMBL4188043 |
single protein format |
CHEMBL566563 |
OBDepict
H
3
C
O
O
NH
CH
3
NH
S
N
N
CH
3
|
Ki |
= |
6.3 |
nM |
334.45 |
COc1ccc(NC(=S)NCCCn2cncc2C)cc1OC |
Homo sapiens |
CHEMBL1057686 |
assay format |
CHEMBL4127764 |
OBDepict
NH
2
N
N
O
N
H
N
H
S
N
N
CH
3
|
IC50 |
= |
6.4 |
nM |
455.63 |
Cc1cncn1CCCNC(=S)Nc1ccc(/C=C/C(=O)N2CCN(CCN)CC2)cc1 |
Homo sapiens |
CHEMBL4122308 |
single protein format |
CHEMBL3677297 |
OBDepict
Br
F
N
S
NH
O
N
N
H
|
Ki |
= |
6.49 |
nM |
405.25 |
O=C1NC(=S)C(c2ccc(Br)cc2F)N1c1ccc2nc[nH]c2c1 |
Homo sapiens |
CHEMBL3705923 |
single protein format |
CHEMBL4582369 |
OBDepict
CH
3
O
O
N
CH
3
HN
S
N
N
H
3
C
|
IC50 |
= |
6.5 |
nM |
402.56 |
COc1ccc(N(C(=S)NCCCn2cncc2C)C2CCCC2)cc1OC |
Homo sapiens |
CHEMBL4376103 |
cell-based format |
CHEMBL4520303 |
OBDepict
H
3
C
O
O
N
CH
3
HN
S
CH
3
H
3
C
N
N
H
3
C
|
IC50 |
= |
6.8 |
nM |
390.55 |
COc1ccc(N(CC(C)C)C(=S)NCCCn2cncc2C)cc1OC |
Homo sapiens |
CHEMBL4376103 |
cell-based format |
CHEMBL4088456 |
OBDepict
CH
3
HN
O
O
H
3
C
NH
NH
S
N
N
CH
3
|
IC50 |
= |
6.9 |
nM |
391.54 |
CNCCCOc1ccc(NC(=S)NCCCn2cncc2C)cc1OC |
Homo sapiens |
CHEMBL4009736 |
single protein format |
CHEMBL4206718 |
OBDepict
H
3
C
O
O
N
H
N
H
S
N
O
N
HN
N
CH
3
|
IC50 |
= |
7.0 |
nM |
474.63 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCCC(=O)N1CCNCC1 |
Homo sapiens |
CHEMBL4188043 |
single protein format |
CHEMBL4073599 |
OBDepict
CH
3
O
O
N
H
N
H
S
N
NH
N
H
3
C
|
IC50 |
= |
7.2 |
nM |
445.63 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCCC1CCNCC1 |
Homo sapiens |
CHEMBL4009736 |
single protein format |
CHEMBL4130158 |
OBDepict
CH
3
O
O
NH
NH
S
HN
N
N
CH
3
|
IC50 |
= |
7.3 |
nM |
431.61 |
COc1ccc(NC(=S)NCCCn2cncc2C)cc1OCCC1CCNCC1 |
Homo sapiens |
CHEMBL4122308 |
single protein format |
CHEMBL4071297 |
OBDepict
CH
3
O
O
N
H
N
H
S
N
N
N
CH
3
N
H
3
C
|
IC50 |
= |
7.3 |
nM |
446.62 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCN1CCN(C)CC1 |
Homo sapiens |
CHEMBL4009736 |
single protein format |
CHEMBL4204419 |
OBDepict
HO
N
N
O
O
H
3
C
N
H
N
H
S
N
N
CH
3
|
IC50 |
= |
7.4 |
nM |
476.65 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCN1CCN(CCO)CC1 |
Homo sapiens |
CHEMBL4188043 |
single protein format |
CHEMBL4448862 |
OBDepict
H
3
C
O
O
N
CH
3
N
H
O
N
N
N
H
3
C
|
IC50 |
= |
7.5 |
nM |
491.64 |
COc1ccc(N(C(=O)NCCCn2cncc2C)C2CCN(Cc3ccccc3)CC2)cc1OC |
Homo sapiens |
CHEMBL4376103 |
cell-based format |
CHEMBL4213750 |
OBDepict
H
2
N
N
N
O
O
H
3
C
N
H
N
H
S
N
N
CH
3
|
IC50 |
= |
7.5 |
nM |
475.66 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCN1CCN(CCN)CC1 |
Homo sapiens |
CHEMBL4188043 |
single protein format |
CHEMBL4578714 |
OBDepict
H
3
C
O
O
N
CH
3
HN
O
CH
3
H
3
C
N
N
H
3
C
|
IC50 |
= |
7.6 |
nM |
374.49 |
COc1ccc(N(CC(C)C)C(=O)NCCCn2cncc2C)cc1OC |
Homo sapiens |
CHEMBL4376103 |
cell-based format |
CHEMBL4206893 |
OBDepict
H
3
C
O
O
N
H
N
H
S
N
O
N
N
H
N
CH
3
|
IC50 |
= |
7.7 |
nM |
460.6 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCC(=O)N1CCNCC1 |
Homo sapiens |
CHEMBL4188043 |
single protein format |
CHEMBL4099260 |
OBDepict
CH
3
O
O
N
H
N
H
S
N
NH
2
N
H
3
C
|
IC50 |
= |
7.7 |
nM |
439.59 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCc1ccc(N)cc1 |
Homo sapiens |
CHEMBL4009736 |
single protein format |
CHEMBL4082802 |
OBDepict
CH
3
O
O
N
H
N
H
S
N
NH
N
H
3
C
|
IC50 |
= |
7.8 |
nM |
459.66 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCCCC1CCNCC1 |
Homo sapiens |
CHEMBL4009736 |
single protein format |
CHEMBL4216476 |
OBDepict
NH
2
N
N
O
O
O
CH
3
N
H
N
H
S
N
N
H
3
C
|
IC50 |
= |
7.8 |
nM |
489.65 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCC(=O)N1CCN(CCN)CC1 |
Homo sapiens |
CHEMBL4188043 |
single protein format |
CHEMBL4127037 |
OBDepict
H
2
N
O
O
NH
CH
3
NH
S
N
N
CH
3
|
IC50 |
= |
7.9 |
nM |
363.49 |
COc1ccc(NC(=S)NCCCn2cncc2C)cc1OCCN |
Homo sapiens |
CHEMBL4122308 |
single protein format |
CHEMBL4130012 |
OBDepict
CH
3
O
O
HN
HN
S
N
NH
N
H
3
C
|
IC50 |
= |
7.9 |
nM |
459.66 |
COc1ccc(NC(=S)NCCCn2cncc2C)cc1OCCCCC1CCNCC1 |
Homo sapiens |
CHEMBL4122308 |
single protein format |
CHEMBL4130218 |
OBDepict
NH
2
N
N
H
O
O
N
H
HN
S
N
N
H
3
C
|
IC50 |
= |
7.9 |
nM |
473.65 |
Cc1cncn1CCCNC(=S)Nc1ccc(OCC(=O)NC2CCN(CCN)CC2)cc1 |
Homo sapiens |
CHEMBL4122308 |
single protein format |
CHEMBL4471709 |
OBDepict
H
3
C
O
O
N
H
3
C
NH
O
HN
N
N
CH
3
|
IC50 |
= |
8.2 |
nM |
401.51 |
COc1ccc(N(C(=O)NCCCn2cncc2C)C2CCNCC2)cc1OC |
Homo sapiens |
CHEMBL4376103 |
cell-based format |
CHEMBL4062645 |
OBDepict
CH
3
O
O
N
H
N
H
S
N
N
N
N
H
3
C
CH
3
|
IC50 |
= |
8.2 |
nM |
474.68 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCCCN1CCN(C)CC1 |
Homo sapiens |
CHEMBL4009736 |
single protein format |
CHEMBL4084521 |
OBDepict
CH
3
O
O
N
H
N
H
S
N
N
H
3
C
NH
2
|
IC50 |
= |
8.3 |
nM |
467.64 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCCCc1ccc(N)cc1 |
Homo sapiens |
CHEMBL4009736 |
single protein format |
CHEMBL4215483 |
OBDepict
CH
3
O
O
N
H
N
H
S
N
N
NH
N
H
3
C
|
IC50 |
= |
8.5 |
nM |
480.64 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1Oc1ccc(N2CCNCC2)cc1 |
Homo sapiens |
CHEMBL4188043 |
single protein format |
CHEMBL4217140 |
OBDepict
H
2
N
N
N
O
O
H
3
C
N
H
N
H
S
N
N
CH
3
|
IC50 |
= |
8.6 |
nM |
503.72 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCCCN1CCN(CCN)CC1 |
Homo sapiens |
CHEMBL4188043 |
single protein format |
CHEMBL4434757 |
OBDepict
H
3
C
O
O
N
CH
3
NH
S
N
N
H
3
C
|
IC50 |
= |
8.6 |
nM |
388.54 |
COc1ccc(N(C(=S)NCCCn2cncc2C)C2CCC2)cc1OC |
Homo sapiens |
CHEMBL4376103 |
cell-based format |
CHEMBL4203546 |
OBDepict
OH
HN
N
O
O
CH
3
N
H
N
H
S
N
N
H
3
C
|
IC50 |
= |
8.7 |
nM |
512.68 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCCCc1ccnc(NCCO)c1 |
Homo sapiens |
CHEMBL4188043 |
single protein format |
CHEMBL4567619 |
OBDepict
H
3
C
O
O
N
CH
3
HN
O
N
N
N
H
3
C
|
IC50 |
= |
8.7 |
nM |
409.49 |
COc1ccc(N(Cc2cccnc2)C(=O)NCCCn2cncc2C)cc1OC |
Homo sapiens |
CHEMBL4376103 |
cell-based format |
CHEMBL4440547 |
OBDepict
CH
3
N
N
H
S
O
O
CH
3
CH
3
N
N
H
3
C
|
IC50 |
= |
8.8 |
nM |
362.5 |
CCN(C(=S)NCCCn1cncc1C)c1ccc(OC)c(OC)c1 |
Homo sapiens |
CHEMBL4376103 |
cell-based format |
CHEMBL4128529 |
OBDepict
NH
2
O
O
HN
CH
3
HN
S
N
N
H
3
C
|
IC50 |
= |
8.8 |
nM |
391.54 |
COc1ccc(NC(=S)NCCCn2cncc2C)cc1OCCCCN |
Homo sapiens |
CHEMBL4122308 |
single protein format |
CHEMBL4128801 |
OBDepict
CH
3
O
O
N
H
N
H
S
NH
N
N
H
3
C
|
IC50 |
= |
8.8 |
nM |
445.63 |
COc1ccc(NC(=S)NCCCn2cncc2C)cc1OCCCC1CCNCC1 |
Homo sapiens |
CHEMBL4122308 |
single protein format |
CHEMBL4215626 |
OBDepict
HO
N
O
O
H
3
C
N
H
N
H
S
N
N
CH
3
|
IC50 |
= |
9.0 |
nM |
475.66 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCC1CCN(CCO)CC1 |
Homo sapiens |
CHEMBL4188043 |
single protein format |
CHEMBL4129900 |
OBDepict
NH
2
O
O
HN
CH
3
HN
S
N
N
H
3
C
|
IC50 |
= |
9.0 |
nM |
377.51 |
COc1ccc(NC(=S)NCCCn2cncc2C)cc1OCCCN |
Homo sapiens |
CHEMBL4122308 |
single protein format |
CHEMBL4062842 |
OBDepict
H
3
C
O
O
N
H
N
H
S
N
H
2
N
N
CH
3
|
IC50 |
= |
9.0 |
nM |
453.61 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCCc1ccc(N)cc1 |
Homo sapiens |
CHEMBL4009736 |
single protein format |
CHEMBL4093243 |
OBDepict
CH
3
O
O
N
H
N
H
S
N
N
N
H
3
C
|
IC50 |
= |
9.1 |
nM |
453.61 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCCCc1ccncc1 |
Homo sapiens |
CHEMBL4009736 |
single protein format |
CHEMBL4100758 |
OBDepict
CH
3
O
O
N
H
N
H
S
N
N
O
N
H
3
C
|
IC50 |
= |
9.2 |
nM |
461.63 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCCCN1CCOCC1 |
Homo sapiens |
CHEMBL4009736 |
single protein format |
CHEMBL4218344 |
OBDepict
CH
3
O
O
N
H
N
H
S
N
HN
N
CH
3
|
IC50 |
= |
9.4 |
nM |
477.63 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1Oc1ccc(C2=CCNCC2)cc1 |
Homo sapiens |
CHEMBL4188043 |
single protein format |
CHEMBL4214577 |
OBDepict
CH
3
O
O
N
H
N
H
S
N
NH
N
H
3
C
|
IC50 |
= |
9.9 |
nM |
479.65 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1Oc1ccc(C2CCNCC2)cc1 |
Homo sapiens |
CHEMBL4188043 |
single protein format |
CHEMBL4213555 |
OBDepict
CH
3
O
O
N
H
N
H
S
N
CH
3
NH
CH
3
N
N
H
3
C
|
IC50 |
= |
9.9 |
nM |
460.65 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCN1CC(C)NC(C)C1 |
Homo sapiens |
CHEMBL4188043 |
single protein format |
CHEMBL4205854 |
OBDepict
H
3
C
O
O
N
H
N
H
S
N
H
O
N
HN
N
CH
3
|
IC50 |
= |
10.3 |
nM |
460.6 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCC(=O)NC1CCNCC1 |
Homo sapiens |
CHEMBL4188043 |
single protein format |
CHEMBL4207248 |
OBDepict
H
2
N
N
O
O
H
3
C
N
H
N
H
S
N
N
CH
3
|
IC50 |
= |
10.6 |
nM |
474.68 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCC1CCN(CCN)CC1 |
Homo sapiens |
CHEMBL4188043 |
single protein format |
CHEMBL4074222 |
OBDepict
H
3
C
O
O
N
H
N
H
S
N
N
H
2
N
N
CH
3
|
IC50 |
= |
10.7 |
nM |
454.6 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCCc1ccnc(N)c1 |
Homo sapiens |
CHEMBL4009736 |
single protein format |
CHEMBL4464265 |
OBDepict
H
3
C
O
O
N
CH
3
HN
O
N
N
N
H
3
C
|
IC50 |
= |
11.0 |
nM |
409.49 |
COc1ccc(N(Cc2ccncc2)C(=O)NCCCn2cncc2C)cc1OC |
Homo sapiens |
CHEMBL4376103 |
cell-based format |
CHEMBL4126533 |
OBDepict
NH
2
N
N
H
O
N
H
HN
S
N
N
H
3
C
|
IC50 |
= |
11.2 |
nM |
469.66 |
Cc1cncn1CCCNC(=S)Nc1ccc(/C=C/C(=O)NC2CCN(CCN)CC2)cc1 |
Homo sapiens |
CHEMBL4122308 |
single protein format |
CHEMBL4081803 |
OBDepict
CH
3
O
O
N
H
N
H
S
N
N
NH
N
H
3
C
|
IC50 |
= |
11.4 |
nM |
446.62 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCCN1CCNCC1 |
Homo sapiens |
CHEMBL4009736 |
single protein format |
CHEMBL4130284 |
OBDepict
S
N
H
NH
N
O
N
H
3
C
N
O
N
H
|
IC50 |
= |
11.4 |
nM |
416.55 |
Cc1cncn1CCCNC(=S)Nc1ccc(OCC(=O)N2CCNCC2)cc1 |
Homo sapiens |
CHEMBL4122308 |
single protein format |
CHEMBL4206681 |
OBDepict
CH
3
O
O
HN
N
H
S
N
N
N
CH
3
NH
|
IC50 |
= |
11.5 |
nM |
494.67 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCc1ccc(N2CCNCC2)cc1 |
Homo sapiens |
CHEMBL4188043 |
single protein format |
CHEMBL3703751 |
OBDepict
H
N
S
N
O
N
N
H
3
C
|
Ki |
= |
11.6 |
nM |
300.39 |
Cc1cncn1CCCn1c(=S)[nH]c2ccccc2c1=O |
Homo sapiens |
CHEMBL3705439 |
single protein format |
CHEMBL4098332 |
OBDepict
H
3
C
O
O
N
H
N
H
S
N
N
N
H
3
C
N
CH
3
|
IC50 |
= |
11.7 |
nM |
460.65 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCCN1CCN(C)CC1 |
Homo sapiens |
CHEMBL4009736 |
single protein format |
CHEMBL3674616 |
OBDepict
O
N
O
N
N
N
H
O
|
Ki |
= |
11.9 |
nM |
376.42 |
O=C1CC(=O)N(c2ccc3nc[nH]c3c2)C1c1ccc(N2CCOCC2)cc1 |
Homo sapiens |
CHEMBL3705340 |
single protein format |
CHEMBL4215098 |
OBDepict
H
3
C
O
O
NH
N
H
S
N
N
N
N
N
N
H
3
C
|
IC50 |
= |
12.0 |
nM |
510.67 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCN1CCN(c2ncccn2)CC1 |
Homo sapiens |
CHEMBL4188043 |
single protein format |
CHEMBL4212913 |
OBDepict
H
2
N
N
N
O
O
CH
3
N
H
N
H
S
N
N
CH
3
|
IC50 |
= |
12.0 |
nM |
523.71 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1Oc1ccc(N2CCN(CCN)CC2)cc1 |
Homo sapiens |
CHEMBL4188043 |
single protein format |
CHEMBL4102431 |
OBDepict
CH
3
O
O
N
H
N
H
S
N
N
N
H
3
C
CH
3
|
IC50 |
= |
12.3 |
nM |
473.69 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCCCC1CCN(C)CC1 |
Homo sapiens |
CHEMBL4009736 |
single protein format |
CHEMBL4586829 |
OBDepict
H
3
C
O
O
N
CH
3
H
3
C
HN
S
N
N
H
3
C
|
IC50 |
= |
12.4 |
nM |
348.47 |
COc1ccc(N(C)C(=S)NCCCn2cncc2C)cc1OC |
Homo sapiens |
CHEMBL4376103 |
cell-based format |
CHEMBL3659481 |
OBDepict
O
O
N
H
N
N
H
N
N
|
Ki |
= |
12.5 |
nM |
439.52 |
O=C1OC[C@H](c2ccc(N3CCN(c4ccccc4)CC3)cc2)N1c1ccc2nc[nH]c2c1 |
Homo sapiens |
CHEMBL3705266 |
single protein format |
CHEMBL4090828 |
OBDepict
CH
3
O
O
N
H
N
H
S
N
N
N
H
3
C
|
IC50 |
= |
12.5 |
nM |
459.66 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCCCN1CCCCC1 |
Homo sapiens |
CHEMBL4009736 |
single protein format |
CHEMBL4520053 |
OBDepict
H
3
C
O
O
N
CH
3
HN
O
N
Cl
N
H
3
C
|
IC50 |
= |
12.5 |
nM |
442.95 |
COc1ccc(N(Cc2ccc(Cl)cc2)C(=O)NCCCn2cncc2C)cc1OC |
Homo sapiens |
CHEMBL4376103 |
cell-based format |
CHEMBL4062616 |
OBDepict
CH
3
O
O
N
H
N
H
S
N
O
N
N
H
3
C
|
IC50 |
= |
12.5 |
nM |
433.58 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCN1CCOCC1 |
Homo sapiens |
CHEMBL4009736 |
single protein format |
CHEMBL4209874 |
OBDepict
H
3
C
O
O
NH
N
H
S
N
N
N
N
H
3
C
|
IC50 |
= |
12.7 |
nM |
522.72 |
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCN1CCN(Cc2ccccc2)CC1 |
Homo sapiens |
CHEMBL4188043 |
single protein format |