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Q460N5 | PAR14_HUMAN | Protein mono-ADP-ribosyltransferase PARP14 (PARP14)

3D structures mapped by conservation among orthologs

[ Domain: "ADP-ribosylation" // PARP ]

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[ Domain: "Macro domain-like" // Macro ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4068366 OBDepict O NH N O O NH 2 N Cl IC50 = 160.0 nM 412.88 NC(=O)c1cccc(NC(=O)/C=CC(=O)N2CCN(c3ccc(Cl)cc3)CC2)c1 Homo sapiens CHEMBL4022061 assay format
CHEMBL4074448 OBDepict O NH N O O NH 2 F IC50 = 270.0 nM 395.43 NC(=O)c1cccc(NC(=O)/C=CC(=O)N2CCC(c3ccc(F)cc3)CC2)c1 Homo sapiens CHEMBL4022061 assay format
CHEMBL4104938 OBDepict O HN N O O NH 2 N O O CH 3 CH 3 H 3 C IC50 = 370.0 nM 402.45 CC(C)(C)OC(=O)N1CCN(C(=O)/C=CC(=O)Nc2cccc(C(N)=O)c2)CC1 Homo sapiens CHEMBL4022061 assay format
CHEMBL4079213 OBDepict O NH N O O NH 2 N F IC50 = 410.0 nM 396.42 NC(=O)c1cccc(NC(=O)/C=CC(=O)N2CCN(c3ccccc3F)CC2)c1 Homo sapiens CHEMBL4022061 assay format
CHEMBL4104503 OBDepict O HN N O O H 2 N IC50 = 450.0 nM 391.47 NC(=O)c1cccc(NC(=O)/C=CC(=O)N2CCC(Cc3ccccc3)CC2)c1 Homo sapiens CHEMBL4022061 assay format
CHEMBL4080281 OBDepict O NH N O O NH 2 IC50 = 650.0 nM 405.5 NC(=O)c1cccc(NC(=O)/C=CC(=O)N2CCC(CCc3ccccc3)CC2)c1 Homo sapiens CHEMBL4022061 assay format
CHEMBL4226482 OBDepict N S N H O O N H IC50 = 660.0 nM 437.52 N#Cc1cccc(CS(=O)(=O)Nc2ccccc2-c2cccc3c2[nH]c2ccccc23)c1 Homo sapiens CHEMBL4222715 assay format
CHEMBL4085694 OBDepict O HN N O O H 2 N IC50 = 690.0 nM 377.44 NC(=O)c1cccc(NC(=O)/C=CC(=O)N2CCCC(c3ccccc3)C2)c1 Homo sapiens CHEMBL4022061 assay format
CHEMBL4126260 OBDepict O N O N F F O NH 2 IC50 = 700.0 nM 437.45 NC(=O)c1ccc(Oc2cccc(C(=O)N3CCN(c4ccc(F)c(F)c4)CC3)c2)cc1 Homo sapiens CHEMBL4122799 assay format
CHEMBL4089522 OBDepict O NH N O O NH 2 N F IC50 = 700.0 nM 396.42 NC(=O)c1cccc(NC(=O)/C=CC(=O)N2CCN(c3ccc(F)cc3)CC2)c1 Homo sapiens CHEMBL4022061 assay format
CHEMBL4226393 OBDepict CH 3 HN O N H IC50 = 720.0 nM 300.36 CC(=O)Nc1ccccc1-c1cccc2c1[nH]c1ccccc12 Homo sapiens CHEMBL4222715 assay format
CHEMBL4129001 OBDepict F N N O O O NH 2 IC50 = 780.0 nM 419.46 NC(=O)c1ccc(Oc2cccc(C(=O)N3CCN(c4ccc(F)cc4)CC3)c2)cc1 Homo sapiens CHEMBL4122799 assay format
CHEMBL4087082 OBDepict O HN N O O H 2 N N IC50 = 900.0 nM 378.43 NC(=O)c1cccc(NC(=O)/C=CC(=O)N2CCN(c3ccccc3)CC2)c1 Homo sapiens CHEMBL4022061 assay format
CHEMBL4226081 OBDepict CH 3 NH O N H IC50 = 900.0 nM 328.42 CCCC(=O)Nc1ccccc1-c1cccc2c1[nH]c1ccccc12 Homo sapiens CHEMBL4222715 assay format
CHEMBL4228040 OBDepict H N N H S O O CH 3 IC50 = 900.0 nM 336.42 CS(=O)(=O)Nc1ccccc1-c1cccc2c1[nH]c1ccccc12 Homo sapiens CHEMBL4222715 assay format
CHEMBL4227680 OBDepict H 3 C NH O N H IC50 = 1000.0 nM 314.39 CCC(=O)Nc1ccccc1-c1cccc2c1[nH]c1ccccc12 Homo sapiens CHEMBL4222715 assay format
CHEMBL4229283 OBDepict CH 3 N N H O N H IC50 = 1000.0 nM 391.47 Cc1ccc(CC(=O)Nc2ccccc2-c2cccc3c2[nH]c2ccccc23)cn1 Homo sapiens CHEMBL4222715 assay format