HOME LIGAND hPROTEOME OTHERS DOCUMENT

Q495T6 | MMEL1_HUMAN | Membrane metallo-endopeptidase-like 1 (MMEL1)

3D structures mapped by conservation among orthologs



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL3703477 OBDepict Cl NH H H 3 C H O O HO O N OH IC50 = 0.04 nM 428.87 C[C@H](C[C@@H](Cc1ccc(-c2cccc(Cl)c2)cc1)NC(=O)c1cc(O)no1)C(=O)O Homo sapiens CHEMBL3706305 cell-based format
CHEMBL3703472 OBDepict OH O N H H O HO O H 2 N Cl IC50 = 0.07 nM 402.83 NC(=O)/C=C(O)C(=O)N[C@@H](CC(=O)O)Cc1ccc(-c2cccc(Cl)c2)cc1 Homo sapiens CHEMBL3706305 cell-based format
CHEMBL3676152 OBDepict OH O NH H O O N OH Cl IC50 = 0.07 nM 400.82 O=C(O)C[C@@H](Cc1ccc(-c2cccc(Cl)c2)cc1)NC(=O)c1cc(O)no1 Homo sapiens CHEMBL3706013 cell-based format
CHEMBL3703478 OBDepict O NH HN H N N CH 3 H N H N O OH Cl IC50 = 0.09 nM 414.85 C[C@H](N[C@@H](Cc1ccc(-c2cccc(Cl)c2)cc1)C(=O)Nc1nnn[nH]1)C(=O)O Homo sapiens CHEMBL3706305 cell-based format
CHEMBL3703482 OBDepict Cl N H H N H O H N N O OH N H N IC50 = 0.2 nM 504.98 O=C(O)[C@H](CCc1ccccc1)N[C@@H](Cc1ccc(-c2cccc(Cl)c2)cc1)C(=O)Nc1nnn[nH]1 Homo sapiens CHEMBL3706305 cell-based format
CHEMBL3703475 OBDepict HO O N H H O O OH Cl Cl IC50 = 0.2 nM 424.28 O=C(O)CCC(=O)N[C@@H](CC(=O)O)Cc1ccc(-c2cc(Cl)ccc2Cl)cc1 Homo sapiens CHEMBL3706305 cell-based format
CHEMBL3703483 OBDepict CH 3 NH H O HO H N H O N N N H N Cl IC50 = 0.2 nM 428.88 CC[C@H](N[C@@H](Cc1ccc(-c2cccc(Cl)c2)cc1)C(=O)Nc1nnn[nH]1)C(=O)O Homo sapiens CHEMBL3706305 cell-based format
CHEMBL3703479 OBDepict O NH HN H N N CH 3 H N H N O OH Cl Cl IC50 = 0.3 nM 449.3 C[C@H](N[C@@H](Cc1ccc(-c2cc(Cl)ccc2Cl)cc1)C(=O)Nc1nnn[nH]1)C(=O)O Homo sapiens CHEMBL3706305 cell-based format
CHEMBL3677671 OBDepict Cl NH H H 3 C H O O HO O N OH IC50 = 0.3 nM 428.87 C[C@@H](C[C@@H](Cc1ccc(-c2cccc(Cl)c2)cc1)NC(=O)c1cc(O)no1)C(=O)O Homo sapiens CHEMBL3706305 cell-based format
CHEMBL3703484 OBDepict O NH H O OH CH 3 H O OH Cl IC50 = 0.3 nM 417.89 C[C@H](C[C@@H](Cc1ccc(-c2cccc(Cl)c2)cc1)NC(=O)CCC(=O)O)C(=O)O Homo sapiens CHEMBL3706305 cell-based format
CHEMBL3703473 OBDepict CH 3 N O N H O H O OH F Cl IC50 = 0.4 nM 430.86 CCc1ncc(C(=O)N[C@@H](CC(=O)O)Cc2ccc(-c3cc(Cl)ccc3F)cc2)o1 Homo sapiens CHEMBL3706305 cell-based format
CHEMBL3676145 OBDepict HO O N H H O N O N H O Cl IC50 = 0.5 nM 401.81 O=C(O)C[C@@H](Cc1ccc(-c2cccc(Cl)c2)cc1)NC(=O)c1n[nH]c(=O)o1 Homo sapiens CHEMBL3706013 cell-based format
CHEMBL3676151 OBDepict HO O N H H O F F F F O OH Cl IC50 = 0.5 nM 461.8 O=C(O)C[C@@H](Cc1ccc(-c2cccc(Cl)c2)cc1)NC(=O)C(F)(F)C(F)(F)C(=O)O Homo sapiens CHEMBL3706013 cell-based format
CHEMBL3676144 OBDepict CH 3 O Cl N H H O O OH O HO IC50 = 0.7 nM 419.86 COc1ccc(Cl)cc1-c1ccc(C[C@H](CC(=O)O)NC(=O)CCC(=O)O)cc1 Homo sapiens CHEMBL3706013 cell-based format
CHEMBL3676147 OBDepict CH 3 O F N H H O O HO O N HO IC50 = 0.7 nM 414.39 COc1ccc(F)cc1-c1ccc(C[C@H](CC(=O)O)NC(=O)c2cc(O)no2)cc1 Homo sapiens CHEMBL3706013 cell-based format
CHEMBL3676153 OBDepict HO O N H H HN O O OH Cl IC50 = 0.8 nM 390.82 O=C(O)CNC(=O)N[C@@H](CC(=O)O)Cc1ccc(-c2cccc(Cl)c2)cc1 Homo sapiens CHEMBL3706013 cell-based format
CHEMBL3929999 OBDepict OH O H 3 C H NH H O N N O HO IC50 = 1.0 nM 433.46 C[C@@H](C[C@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)c1cc(C(=O)O)ncn1)C(=O)O Homo sapiens CHEMBL3706305 cell-based format
CHEMBL3676150 OBDepict HO O N H H O O OH Cl IC50 = 1.1 nM 389.83 O=C(O)CCC(=O)N[C@@H](CC(=O)O)Cc1ccc(-c2cccc(Cl)c2)cc1 Homo sapiens CHEMBL3706013 cell-based format
CHEMBL3676154 OBDepict OH O N H H O N N N N H Cl IC50 = 1.2 nM 385.81 O=C(O)C[C@@H](Cc1ccc(-c2cccc(Cl)c2)cc1)NC(=O)c1nn[nH]n1 Homo sapiens CHEMBL3706013 cell-based format
CHEMBL3676143 OBDepict CH 3 O F N H H O O OH O HO IC50 = 2.3 nM 403.41 COc1ccc(F)cc1-c1ccc(C[C@H](CC(=O)O)NC(=O)CCC(=O)O)cc1 Homo sapiens CHEMBL3706013 cell-based format
CHEMBL3695451 OBDepict Cl N H H HN O CH 3 H O O OH N OH IC50 = 2.4 nM 429.86 C[C@H](N[C@@H](Cc1ccc(-c2cccc(Cl)c2)cc1)C(=O)Nc1cc(O)no1)C(=O)O Homo sapiens CHEMBL3706305 cell-based format
CHEMBL3676146 OBDepict CH 3 N O N H O H O OH Cl IC50 = 2.7 nM 412.87 CCc1ncc(C(=O)N[C@@H](CC(=O)O)Cc2ccc(-c3cccc(Cl)c3)cc2)o1 Homo sapiens CHEMBL3706013 cell-based format
CHEMBL3639750 OBDepict OH O N H H O N N HO IC50 = 3.0 nM 377.4 O=C(O)C[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)c1cnc(O)nc1 Homo sapiens CHEMBL3706013 cell-based format
CHEMBL3676141 OBDepict CH 3 O N H H O O OH O HO IC50 = 4.0 nM 385.42 COc1ccccc1-c1ccc(C[C@H](CC(=O)O)NC(=O)CCC(=O)O)cc1 Homo sapiens CHEMBL3706013 cell-based format
CHEMBL3676140 OBDepict HO O N H H O O OH F IC50 = 7.0 nM 373.38 O=C(O)CCC(=O)N[C@@H](CC(=O)O)Cc1ccc(-c2cccc(F)c2)cc1 Homo sapiens CHEMBL3706013 cell-based format
CHEMBL3902042 OBDepict OH O H 3 C H NH H O N N H O OH IC50 = 7.3 nM 421.45 C[C@@H](C[C@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)c1c[nH]c(C(=O)O)n1)C(=O)O Homo sapiens CHEMBL3706305 cell-based format
CHEMBL3703480 OBDepict O HN NH H N N CH 3 H N H N O HO IC50 = 11.0 nM 380.41 C[C@H](N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(=O)Nc1nnn[nH]1)C(=O)O Homo sapiens CHEMBL3706305 cell-based format
CHEMBL3703476 OBDepict OH O H 3 C H NH H O N N N H N IC50 = 14.0 nM 379.42 C[C@H](C[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)c1nnn[nH]1)C(=O)O Homo sapiens CHEMBL3706305 cell-based format
CHEMBL3676138 OBDepict H 3 C O O N H O H O HO Cl IC50 = 15.0 nM 431.92 CCOC(=O)CCCC(=O)N[C@@H](CC(=O)O)Cc1ccc(-c2cccc(Cl)c2)cc1 Homo sapiens CHEMBL3706013 cell-based format
CHEMBL3676139 OBDepict O NH O O O OH Cl IC50 = 15.0 nM 506.0 O=C(O)CC(Cc1ccc(-c2cccc(Cl)c2)cc1)NC(=O)CCC(=O)Oc1ccc2c(c1)CCC2 Homo sapiens CHEMBL3706013 cell-based format
CHEMBL3676137 OBDepict CH 3 O O N H O H O OH Cl IC50 = 18.0 nM 445.94 CCCCOC(=O)CCC(=O)N[C@@H](CC(=O)O)Cc1ccc(-c2cccc(Cl)c2)cc1 Homo sapiens CHEMBL3706013 cell-based format
CHEMBL3703474 OBDepict H 3 C O O N H H O N O O IC50 = 18.0 nM 528.65 CCOC(=O)C[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)CN1CCCC1C(=O)OCc1ccccc1 Homo sapiens CHEMBL3706305 cell-based format
CHEMBL3676155 OBDepict HO O N H H O O OH IC50 = 42.0 nM 355.39 O=C(O)CCC(=O)N[C@@H](CC(=O)O)Cc1ccc(-c2ccccc2)cc1 Homo sapiens CHEMBL3706013 cell-based format
CHEMBL3676149 OBDepict HO O N H H O N N N H N IC50 = 56.0 nM 351.37 O=C(O)C[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)c1nnn[nH]1 Homo sapiens CHEMBL3706013 cell-based format
CHEMBL3676142 OBDepict OH O HN H O N N O OH IC50 = 67.0 nM 405.41 O=C(O)C[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)c1cc(C(=O)O)ncn1 Homo sapiens CHEMBL3706013 cell-based format
CHEMBL3676148 OBDepict H N H O O HO O OH IC50 = 75.0 nM 355.39 O=C(O)CCNC(=O)[C@@H](CC(=O)O)Cc1ccc(-c2ccccc2)cc1 Homo sapiens CHEMBL3706013 cell-based format
CHEMBL3703481 OBDepict O NH HN H N N CH 3 H N CH 3 N O OH Cl IC50 = 91.0 nM 428.88 C[C@H](N[C@@H](Cc1ccc(-c2cccc(Cl)c2)cc1)C(=O)Nc1nnnn1C)C(=O)O Homo sapiens CHEMBL3706305 cell-based format
CHEMBL3677669 OBDepict H N H N H O H 3 C H O OH O HO IC50 = 93.0 nM 384.43 C[C@H](C[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)NCC(=O)O)C(=O)O Homo sapiens CHEMBL3706305 cell-based format
CHEMBL3677670 OBDepict OH O H 3 C H NH H N O N O OH IC50 = 142.0 nM 421.45 C[C@H](C[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)n1ccc(C(=O)O)n1)C(=O)O Homo sapiens CHEMBL3706305 cell-based format
CHEMBL3926616 OBDepict O N H H CH 3 H O HO S N H 3 C IC50 = 250.0 nM 500.66 Cc1nc2ccc(CCCC(=O)N[C@@H](Cc3ccc(-c4ccccc4)cc3)C[C@H](C)C(=O)O)cc2s1 Homo sapiens CHEMBL3706305 cell-based format
CHEMBL3677666 OBDepict H HN O CH 3 H O OH CH 3 CH 3 O OH IC50 = 267.0 nM 411.5 C[C@H](C[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)CC(C)(C)C(=O)O)C(=O)O Homo sapiens CHEMBL3706305 cell-based format
CHEMBL3677665 OBDepict HO O CH 3 H HN H O O HO IC50 = 283.0 nM 431.49 C[C@H](C[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)c1cccc(C(=O)O)c1)C(=O)O Homo sapiens CHEMBL3706305 cell-based format
CHEMBL3677667 OBDepict OH O H 3 C H NH H O O O O OH IC50 = 350.0 nM 449.46 C[C@H](C[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)c1cc(=O)cc(C(=O)O)o1)C(=O)O Homo sapiens CHEMBL3706305 cell-based format
CHEMBL3677668 OBDepict OH O H 3 C H NH H N O H O OH IC50 = 450.0 nM 424.5 C[C@H](C[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)N1CCC[C@H]1C(=O)O)C(=O)O Homo sapiens CHEMBL3706305 cell-based format