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Q6DWJ6 | GP139_HUMAN | Probable G-protein coupled receptor 139 (GPR139)

3D structures mapped by conservation among orthologs



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4777495 OBDepict CH 3 N H H 3 C H O N N N O CH 3 CH 3 Ki = 10.0 nM 350.42 Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cc(C)cc3c2=O)cc1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4799483 OBDepict H 3 C O N O N N N H O CH 3 H F F F F Ki = 11.0 nM 424.35 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3F)c(=O)c12 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4789720 OBDepict H 3 C O N O N N N H O CH 3 H F F F Ki = 26.0 nM 406.36 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)c(=O)c12 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4780038 OBDepict CH 3 N H H 3 C H O N N N O Cl Cl Ki = 26.0 nM 391.26 Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cc(Cl)cc3c2=O)cc1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4782204 OBDepict CH 3 O N O N N N H O H 3 C H F O F F F Ki = 33.0 nM 440.35 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3F)c(=O)c12 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4796493 OBDepict CH 3 O N O N N N H O H 3 C H O F F F Ki = 33.0 nM 422.36 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c12 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4776329 OBDepict O HN N CH 3 H N N O CH 3 H 3 C F Ki = 39.0 nM 354.39 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)c(C)c1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4776988 OBDepict O HN N CH 3 H N N O O F F F F Ki = 42.0 nM 410.33 C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)(F)F)cc1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4778172 OBDepict CH 3 O N O N N HN O CH 3 H CH 3 Ki = 48.0 nM 352.39 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c12 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4780801 OBDepict CH 3 O N O N N N H O CH 3 H H 3 C Ki = 58.0 nM 352.39 COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c2c1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4781729 OBDepict O HN N CH 3 H N N O CH 3 H 3 C Ki = 63.0 nM 336.4 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(C)c1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4789791 OBDepict CH 3 N H CH 3 H O N N N O H 3 C Ki = 72.0 nM 336.4 Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cccc3c2=O)cc1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4791752 OBDepict O HN N CH 3 H N N O F H 3 C F Ki = 77.0 nM 358.35 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)c(F)c1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4797410 OBDepict CH 3 N H H 3 C H O N N N O F CH 3 Ki = 85.0 nM 354.39 Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cc(C)cc3c2=O)cc1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4798933 OBDepict O NH N H 3 C H N N O CH 3 CH 3 Ki = 92.0 nM 336.4 Cc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(C)c3c2=O)cc1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4780121 OBDepict O HN N CH 3 H N N O F O F F F F Ki = 93.0 nM 428.32 C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)(F)F)cc1F Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4797857 OBDepict O NH N H 3 C H N N O F F F F Ki = 106.0 nM 394.33 C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(C(F)(F)F)cc1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4787761 OBDepict O NH N H 3 C H N N O CH 3 Cl Ki = 110.0 nM 356.81 Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cccc3c2=O)cc1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4794046 OBDepict CH 3 O N O N N N H O CH 3 H F F F Ki = 115.0 nM 406.36 COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)c(=O)c2c1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4779773 OBDepict O HN N CH 3 H N N O O F F F Ki = 119.0 nM 392.34 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4783626 OBDepict CH 3 O N O N N N H O H 3 C H O F F Ki = 120.0 nM 404.37 COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)F)cc3)c(=O)c12 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4785741 OBDepict O HN N CH 3 H N N O F O F F F Ki = 120.0 nM 410.33 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1F Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4788013 OBDepict CH 3 O N O N N N H O CH 3 H O F F F Ki = 128.0 nM 422.36 COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c2c1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4779855 OBDepict O NH N H 3 C H N N O F F F Ki = 148.0 nM 376.34 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4791792 OBDepict O NH N H 3 C H N N O F F F F Ki = 152.0 nM 394.33 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1F Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4789475 OBDepict O HN N CH 3 H N N O F H 3 C Ki = 171.0 nM 340.36 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(F)c1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4778124 OBDepict CH 3 N H CH 3 H O N N N O Cl Ki = 173.0 nM 356.81 Cc1ccc([C@H](C)NC(=O)Cn2nnc3cc(Cl)ccc3c2=O)cc1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4795005 OBDepict CH 3 O N H CH 3 H O N N N O CH 3 H 3 C Ki = 179.0 nM 366.42 COc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cc(C)cc3c2=O)cc1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4786722 OBDepict CH 3 N H CH 3 H O N N N O CH 3 Ki = 179.0 nM 336.4 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C)cc3c2=O)cc1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4777630 OBDepict O HN N CH 3 H N N O H 3 C F Ki = 182.0 nM 340.36 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)cc1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4783365 OBDepict CH 3 N H H O N O N N O F F F Ki = 183.0 nM 406.36 CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4778561 OBDepict O HN N CH 3 H N N O H 3 C Cl Ki = 189.0 nM 356.81 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(Cl)cc3c2=O)cc1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4784744 OBDepict CH 3 O N H CH 3 H O N N N O Cl Cl Ki = 190.0 nM 407.26 COc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cc(Cl)cc3c2=O)cc1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4781754 OBDepict CH 3 N H H O N N F F F N O Ki = 214.0 nM 390.37 CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4778354 OBDepict CH 3 O N N O N N H O CH 3 H O F F F Ki = 218.0 nM 422.36 COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nnc2c1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4798779 OBDepict O HN N CH 3 H N N O Cl Ki = 228.0 nM 342.79 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Cl)cc1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4779884 OBDepict CH 3 O N N N O N H O CH 3 H O F F F Ki = 240.0 nM 422.36 COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nnc12 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4782619 OBDepict O NH N H 3 C H N N O O F F F Ki = 282.0 nM 392.34 C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)F)cc1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4789079 OBDepict CH 3 N H CH 3 H O N N N O H 3 C Ki = 347.0 nM 336.4 Cc1ccc([C@H](C)NC(=O)Cn2nnc3cc(C)ccc3c2=O)cc1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4781805 OBDepict CH 3 O N N N O N H O CH 3 H F F F Ki = 352.0 nM 406.36 COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)nnc12 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4785980 OBDepict CH 3 O N N O N N H O H 3 C H F F F Ki = 375.0 nM 406.36 COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)nnc2c1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4797979 OBDepict O NH N H 3 C H N N O CH 3 F F F Ki = 435.0 nM 390.37 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C(F)(F)F)cc3c2=O)cc1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4783071 OBDepict CH 3 O N N O N N H O CH 3 H H 3 C Ki = 437.0 nM 352.39 COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc2c1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4778563 OBDepict O NH N H 3 C H N N O F CH 3 Ki = 459.0 nM 340.36 Cc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(F)c3c2=O)cc1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4798863 OBDepict O HN N CH 3 H N N O H 3 C Ki = 467.0 nM 322.37 Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4776509 OBDepict O HN N CH 3 H N N O Br Ki = 486.0 nM 387.24 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Br)cc1 Homo sapiens CHEMBL4810044 cell membrane format
CHEMBL4785669 OBDepict CH 3 O N H CH 3 H O N N N O CH 3 Ki = 526.0 nM 352.39 COc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cccc3c2=O)cc1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4792561 OBDepict CH 3 O N H CH 3 H O N N N O CH 3 Ki = 533.0 nM 352.39 COc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(C)c3c2=O)cc1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4796061 OBDepict CH 3 O N H CH 3 H O N N N O Cl Ki = 551.0 nM 372.81 COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(Cl)cc3c2=O)cc1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4794908 OBDepict CH 3 O N H CH 3 H O N N N O O H 3 C Ki = 619.0 nM 368.39 COc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(OC)c3c2=O)cc1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4790968 OBDepict O HN N CH 3 H N N O O F F Ki = 677.0 nM 374.35 C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)F)cc1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4779481 OBDepict O NH N H 3 C H N N O CH 3 F Ki = 708.0 nM 340.36 Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cccc3c2=O)cc1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4847108 OBDepict O N H N CH 3 N H 3 C H N O CH 3 Ki = 714.0 nM 336.4 Cc1ccc([C@H](C)NC(=O)C(C)n2nnc3ccccc3c2=O)cc1 Homo sapiens CHEMBL4810044 cell membrane format
CHEMBL4783106 OBDepict CH 3 O N N N O N H O CH 3 H H 3 C Ki = 791.0 nM 352.39 COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc12 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4873905 OBDepict CH 3 O N H CH 3 H O N N N O Ki = 802.0 nM 352.39 COc1ccc(C[C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 Homo sapiens CHEMBL4810044 cell membrane format
CHEMBL4788831 OBDepict CH 3 O N H CH 3 H O N N N O Cl Ki = 842.0 nM 372.81 COc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cccc3c2=O)cc1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4871506 OBDepict CH 3 O HN CH 3 H O N CH 3 N N O Ki = 869.0 nM 352.39 COc1ccc([C@H](C)NC(=O)C(C)n2nnc3ccccc3c2=O)cc1 Homo sapiens CHEMBL4810044 cell membrane format
CHEMBL4795372 OBDepict CH 3 O N H CH 3 H O N N N O F Ki = 909.0 nM 356.36 COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)cc1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4781651 OBDepict CH 3 O N H CH 3 H O N N N O H 3 C Ki = 915.0 nM 352.39 COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C)cc3c2=O)cc1 Homo sapiens CHEMBL4742408 cell membrane format
CHEMBL4783081 OBDepict CH 3 O N H H 3 C H O N N N O Ki = 953.0 nM 352.39 CCOc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 Homo sapiens CHEMBL4742408 cell membrane format