HOME LIGAND hPROTEOME OTHERS DOCUMENT

Q6P179 | ERAP2_HUMAN | Endoplasmic reticulum aminopeptidase 2 (ERAP2)

3D structures mapped by conservation among orthologs

[ Domain: "ARM repeat" // ERAP1_C ]

download pymol session

[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // ERAP1_C ]

download pymol session

[ Domain: "Metalloproteases ("zincins") catalytic domain" // Peptidase_M1 ]

download pymol session

[ Domain: "Baculovirus p35 protein-related" // Peptidase_M1_2 ]

download pymol session

[ Domain: pdbs with more than 2 multi-domains ]

download pymol session



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL3416733 OBDepict H 3 C H 3 C H HN O P O OH H NH 2 H O NH 2 N H IC50 = 11.0 nM 512.59 CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O Homo sapiens CHEMBL3418221 cell-based format
CHEMBL4101200 OBDepict CH H NH O P O OH H NH 2 H O NH 2 IC50 = 37.0 nM 455.5 C#CC[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O Homo sapiens CHEMBL4024806 cell-based format
CHEMBL4097268 OBDepict CH 3 H 3 C H NH O P O OH H NH 2 H O H 2 N HO IC50 = 55.0 nM 489.55 CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O Homo sapiens CHEMBL4024806 cell-based format
CHEMBL4095882 OBDepict HO N O H N H O P O OH H NH 2 H O NH 2 IC50 = 56.0 nM 590.62 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cc(-c2ccc(O)cc2)no1)CP(=O)(O)[C@@H](N)CCc1ccccc1 Homo sapiens CHEMBL4024806 cell-based format
CHEMBL4077855 OBDepict OH N O H N H O P O OH H NH 2 H O NH 2 IC50 = 83.0 nM 590.62 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cc(-c2ccccc2O)no1)CP(=O)(O)[C@@H](N)CCc1ccccc1 Homo sapiens CHEMBL4024806 cell-based format
CHEMBL4091951 OBDepict CH 3 CH 3 H NH O P O OH H 3 C H NH 2 H O H 2 N IC50 = 96.0 nM 397.46 CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](C)C(N)=O Homo sapiens CHEMBL4024806 cell-based format
CHEMBL4099693 OBDepict CH 3 H 3 C H NH O P O OH H NH 2 H O H 2 N IC50 = 109.0 nM 473.55 CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O Homo sapiens CHEMBL4024806 cell-based format
CHEMBL4081682 OBDepict CH 3 CH 3 H NH O P O OH H NH 2 H O NH 2 H 3 C H 3 C IC50 = 118.0 nM 439.54 CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O Homo sapiens CHEMBL4024806 cell-based format
CHEMBL4066723 OBDepict H 3 C H 3 C H HN O P O OH H NH 2 H O NH 2 N N H IC50 = 128.0 nM 463.52 CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O Homo sapiens CHEMBL4024806 cell-based format
CHEMBL4070078 OBDepict OH HN H O H 2 N O H P O OH H 3 C CH 3 NH 2 H IC50 = 129.0 nM 413.46 CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](CO)C(N)=O Homo sapiens CHEMBL4024806 cell-based format
CHEMBL4089555 OBDepict H 3 C H 3 C H N O P O OH H NH 2 H O NH 2 IC50 = 144.0 nM 423.49 CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N1CCC[C@H]1C(N)=O Homo sapiens CHEMBL4024806 cell-based format
CHEMBL3355101 OBDepict OH O P O HO NH 2 + N O _ O Ki = 152.0 nM 406.38 NC(CCc1ccc([N+](=O)[O-])cc1)P(=O)(O)CC(Cc1ccccc1)C(=O)O Homo sapiens CHEMBL3829453 single protein format
CHEMBL3355104 OBDepict HO P NH 2 O OH O HO Ki = 185.0 nM 391.4 NC(CCc1ccc(CO)cc1)P(=O)(O)CC(Cc1ccccc1)C(=O)O Homo sapiens CHEMBL3829453 single protein format
CHEMBL4069425 OBDepict O N H H P H O OH O O NH 2 NH 2 H N IC50 = 190.0 nM 574.62 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cc(-c2ccccc2)no1)CP(=O)(O)[C@@H](N)CCc1ccccc1 Homo sapiens CHEMBL4024806 cell-based format
CHEMBL4065841 OBDepict O NH H P H O OH O NH 2 NH 2 H Ki = 200.0 nM 597.7 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(c1ccccc1)c1ccccc1)CP(=O)(O)[C@@H](N)CCc1ccccc1 Homo sapiens CHEMBL4011376 single protein format
CHEMBL3355105 OBDepict OH O P O HO NH 2 N Ki = 205.0 nM 362.37 NC(CCc1cccnc1)P(=O)(O)CC(Cc1ccccc1)C(=O)O Homo sapiens CHEMBL3829453 single protein format
CHEMBL4077711 OBDepict CH 3 H 3 C H NH O P O OH H NH 2 H O H 2 N IC50 = 211.0 nM 473.55 CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(N)=O Homo sapiens CHEMBL4024806 cell-based format
CHEMBL3416727 OBDepict CH 3 H 2 N H NH O NH 2 NH O H O HO N H IC50 = 237.0 nM 451.53 CCCC[C@H](N)C(=O)Nc1ccc(C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)cc1N Homo sapiens CHEMBL3418221 cell-based format
CHEMBL3355106 OBDepict OH O P O HO NH 2 N Ki = 241.0 nM 362.37 NC(CCc1ccncc1)P(=O)(O)CC(Cc1ccccc1)C(=O)O Homo sapiens CHEMBL3829453 single protein format
CHEMBL4095735 OBDepict H N H O P O OH H 3 C CH 3 H NH 2 H O H 2 N O OH IC50 = 243.0 nM 455.49 CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](CCC(=O)O)C(N)=O Homo sapiens CHEMBL4024806 cell-based format
CHEMBL4069576 OBDepict CH 3 H 3 C NH H O NH 2 O H P O OH H 2 N H IC50 = 246.0 nM 563.68 CC(C)C[C@H](NC(=O)[C@H](CC(c1ccccc1)c1ccccc1)CP(=O)(O)[C@@H](N)CCc1ccccc1)C(N)=O Homo sapiens CHEMBL4024806 cell-based format
CHEMBL4088020 OBDepict H 2 N N H H O H 2 N O H P O OH H 3 C CH 3 NH 2 H IC50 = 271.0 nM 454.55 CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O Homo sapiens CHEMBL4024806 cell-based format
CHEMBL327844 OBDepict OH O P O HO NH 2 Ki = 350.0 nM 361.38 NC(CCc1ccccc1)P(=O)(O)CC(Cc1ccccc1)C(=O)O Homo sapiens CHEMBL3829453 single protein format
CHEMBL4074464 OBDepict O N H H P H O OH O H 2 N NH 2 H IC50 = 412.0 nM 565.69 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC12CC3CC(CC(C3)C1)C2)CP(=O)(O)[C@@H](N)CCc1ccccc1 Homo sapiens CHEMBL4024806 cell-based format
CHEMBL3416696 OBDepict CH 3 O O N H H O HN OH H 2 N O NH 2 H N H NH H 2 N IC50 = 518.0 nM 485.55 COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1ccc(N)c(NC(=O)[C@@H](N)CCCNC(=N)N)c1 Homo sapiens CHEMBL3418221 cell-based format
CHEMBL3827468 OBDepict CH 3 CH 3 H O H 2 N P O OH NH 2 H IC50 = 550.0 nM 326.38 CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(N)=O Homo sapiens CHEMBL3829451 single protein format
CHEMBL3416697 OBDepict H 2 N NH NH NH 2 H N H O NH 2 NH O H O HO N H IC50 = 589.0 nM 494.56 N=C(N)NCCC[C@H](N)C(=O)Nc1cc(C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)ccc1N Homo sapiens CHEMBL3418221 cell-based format
CHEMBL3804843 OBDepict H 2 N P O OH OH N Ki = 622.0 nM 208.2 NC(CN1CCCCC1)P(=O)(O)O Homo sapiens CHEMBL3829453 single protein format
CHEMBL3806247 OBDepict CH 3 N H P H 2 N O OH HO Ki = 632.0 nM 224.24 CCCCCCNCC(N)P(=O)(O)O Homo sapiens CHEMBL3829453 single protein format
CHEMBL4557197 OBDepict O HN N H O O O HO N H Ki = 700.0 nM 445.48 O=C(Cn1cccc(O)c1=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 Homo sapiens CHEMBL4410792 cell-based format
CHEMBL3416726 OBDepict H 3 C H 2 N H HN O H 2 N N H O H O O N H IC50 = 709.0 nM 541.65 CCCC[C@H](N)C(=O)Nc1ccc(C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)OCc2ccccc2)cc1N Homo sapiens CHEMBL3418221 cell-based format
CHEMBL4065841 OBDepict O NH H P H O OH O NH 2 NH 2 H IC50 = 740.0 nM 597.7 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(c1ccccc1)c1ccccc1)CP(=O)(O)[C@@H](N)CCc1ccccc1 Homo sapiens CHEMBL4024806 cell-based format
CHEMBL3416725 OBDepict CH 3 H 2 N H NH O NH 2 N H O H O O CH 3 OH IC50 = 755.0 nM 442.52 CCCC[C@H](N)C(=O)Nc1ccc(C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)OC)cc1N Homo sapiens CHEMBL3418221 cell-based format
CHEMBL4096656 OBDepict O N H H P H O OH O O NH 2 NH 2 H N IC50 = 878.0 nM 574.62 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cc(-c2ccccc2)no1)CP(=O)(O)[C@@H](N)CCc1ccccc1 Homo sapiens CHEMBL4024806 cell-based format
CHEMBL4854733 OBDepict H 3 C O O N H H O H N P H O OH H 3 C CH 3 NH 2 H IC50 = 900.0 nM 527.6 COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)CP(=O)(O)[C@@H](N)CCc1ccccc1 Homo sapiens CHEMBL4822043 single protein format