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Q70CQ3 | UBP30_HUMAN | Ubiquitin carboxyl-terminal hydrolase 30 (USP30)

3D structures mapped by conservation among orthologs

[ Domain: "Cysteine proteinases" // UCH ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4584791 OBDepict N N H N H O N O N IC50 = 1.0 nM 321.34 N#Cc1cccc(-c2cc(NC(=O)C[C@H]3CCN(C#N)C3)no2)c1 Homo sapiens CHEMBL4418459 assay format
CHEMBL4544816 OBDepict N N H N H O N N N IC50 = 1.0 nM 332.37 N#Cc1ccnc(-c2ccc(N3CCO[C@H]4CN(C#N)C[C@H]43)nc2)c1 Homo sapiens CHEMBL4418460 assay format
CHEMBL4467425 OBDepict N N H N H O N N N IC50 = 1.0 nM 332.37 N#Cc1cccc(-c2cnc(N3CCO[C@H]4CN(C#N)C[C@H]43)nc2)c1 Homo sapiens CHEMBL4418460 assay format
CHEMBL4455275 OBDepict N N H N H O N N IC50 = 1.0 nM 331.38 N#Cc1cccc(-c2ccc(N3CCO[C@H]4CN(C#N)C[C@H]43)nc2)c1 Homo sapiens CHEMBL4418460 assay format
CHEMBL4559084 OBDepict N N H N H O N N N IC50 = 1.0 nM 332.37 N#Cc1cc(-c2ccc(N3CCO[C@@H]4CN(C#N)C[C@@H]43)nc2)ccn1 Homo sapiens CHEMBL4418460 assay format
CHEMBL4541601 OBDepict N N H N H O O N O F F F IC50 = 1.0 nM 380.33 N#CN1CC[C@H](CC(=O)Nc2cc(-c3cccc(OC(F)(F)F)c3)no2)C1 Homo sapiens CHEMBL4418459 assay format
CHEMBL4443477 OBDepict N N H N H O O N N IC50 = 1.0 nM 321.34 N#Cc1cccc(-c2cc(NC(=O)C[C@H]3CCN(C#N)C3)on2)c1 Homo sapiens CHEMBL4418459 assay format
CHEMBL4474904 OBDepict N N H H 3 C H N H O O N Cl IC50 = 1.0 nM 344.8 C[C@H](C(=O)Nc1cc(-c2cccc(Cl)c2)no1)[C@@H]1CCN(C#N)C1 Homo sapiens CHEMBL4418459 assay format
CHEMBL4565384 OBDepict N N H N H O O N Cl IC50 = 1.0 nM 330.77 N#CN1CC[C@H](CC(=O)Nc2cc(-c3cccc(Cl)c3)no2)C1 Homo sapiens CHEMBL4418459 assay format
CHEMBL4525477 OBDepict N N H N H O N N N IC50 = 1.0 nM 332.37 N#Cc1cccc(-c2cnc(N3CCO[C@H]4CN(C#N)C[C@H]43)cn2)c1 Homo sapiens CHEMBL4418460 assay format
CHEMBL4459141 OBDepict N N H N H O N N N IC50 = 10.0 nM 332.37 N#Cc1cc(-c2ccc(N3CCO[C@H]4CN(C#N)C[C@H]43)nc2)ccn1 Homo sapiens CHEMBL4418460 assay format
CHEMBL4467362 OBDepict N N H N O H 3 C N IC50 = 10.0 nM 308.39 Cc1cc(C2CN(C(=O)C[C@@H]3CCN(C#N)C3)C2)ccc1C#N Homo sapiens CHEMBL4418459 assay format
CHEMBL4444397 OBDepict N N H N H O O N O H 3 C IC50 = 10.0 nM 326.36 COc1cccc(-c2cc(NC(=O)C[C@H]3CCN(C#N)C3)on2)c1 Homo sapiens CHEMBL4418459 assay format
CHEMBL4459110 OBDepict N N H N H O O N Cl IC50 = 10.0 nM 330.77 N#CN1CC[C@@H](CC(=O)Nc2cc(-c3cccc(Cl)c3)no2)C1 Homo sapiens CHEMBL4418459 assay format
CHEMBL4454465 OBDepict N N H N H O N N N IC50 = 10.0 nM 332.37 N#Cc1cccc(-c2ccc(N3CCO[C@H]4CN(C#N)C[C@H]43)nc2)n1 Homo sapiens CHEMBL4418460 assay format
CHEMBL4445598 OBDepict N N H N O O N CH 3 H 3 C N IC50 = 10.0 nM 379.46 COc1ccc(C2CN(C(=O)C[C@@H]3CCN(C#N)C3)C2)cc1-c1ccnn1C Homo sapiens CHEMBL4418459 assay format
CHEMBL4581658 OBDepict N N H H 3 C H N H O O N Cl IC50 = 10.0 nM 344.8 C[C@@H](C(=O)Nc1cc(-c2cccc(Cl)c2)no1)[C@@H]1CCN(C#N)C1 Homo sapiens CHEMBL4418459 assay format
CHEMBL4460685 OBDepict N N H N O O CH 3 IC50 = 10.0 nM 299.37 COc1ccc(C2CN(C(=O)C[C@@H]3CCN(C#N)C3)C2)cc1 Homo sapiens CHEMBL4418459 assay format
CHEMBL4444321 OBDepict N N H N O O N CH 3 H N IC50 = 10.0 nM 365.44 COc1ccc(C2CN(C(=O)C[C@@H]3CCN(C#N)C3)C2)cc1-c1ccn[nH]1 Homo sapiens CHEMBL4418459 assay format
CHEMBL4566816 OBDepict N N H N O F O CH 3 IC50 = 10.0 nM 317.36 COc1cccc(C2CN(C(=O)C[C@@H]3CCN(C#N)C3)C2)c1F Homo sapiens CHEMBL4418459 assay format
CHEMBL4458543 OBDepict N N H H N N N H O Cl F F IC50 = 10.0 nM 353.76 N#CN1C[C@H]2CCN(c3nc4ccc(OC(F)(F)Cl)cc4[nH]3)[C@H]2C1 Homo sapiens CHEMBL4418460 assay format
CHEMBL4588648 OBDepict N N N H O O IC50 = 10.0 nM 319.36 N#CN1CCC(=CC(=O)Nc2ccc(Oc3ccccc3)cc2)C1 Homo sapiens CHEMBL4418459 assay format
CHEMBL4569335 OBDepict N N H N H O N N N N IC50 = 10.0 nM 333.36 N#Cc1cc(-c2ccc(N3CCO[C@H]4CN(C#N)C[C@H]43)nn2)ccn1 Homo sapiens CHEMBL4418460 assay format
CHEMBL4538624 OBDepict N N H N O O CH 3 N N CH 3 IC50 = 10.0 nM 379.46 COc1ccc(C2CN(C(=O)C[C@@H]3CCN(C#N)C3)C2)cc1-c1cnn(C)c1 Homo sapiens CHEMBL4418459 assay format
CHEMBL4462205 OBDepict O N H HN H O N S HN O O CH 3 CH 3 CH 3 F IC50 = 16.0 nM 498.58 CC(C)(C)NS(=O)(=O)c1ccc(NC(=O)[C@H](Cc2cccnc2)NC(=O)c2ccc(F)cc2)cc1 Homo sapiens CHEMBL4418477 single protein format
CHEMBL4525652 OBDepict O N H HN H O S HN O O CH 3 CH 3 CH 3 F IC50 = 17.0 nM 497.59 CC(C)(C)NS(=O)(=O)c1ccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2ccc(F)cc2)cc1 Homo sapiens CHEMBL4418477 single protein format
CHEMBL4534346 OBDepict O N H NH H O S S HN O O CH 3 CH 3 CH 3 F IC50 = 19.0 nM 503.62 CC(C)(C)NS(=O)(=O)c1ccc(NC(=O)[C@H](Cc2cccs2)NC(=O)c2ccc(F)cc2)cc1 Homo sapiens CHEMBL4418477 single protein format
CHEMBL4443856 OBDepict O N H HN H O N S HN O O CH 3 CH 3 CH 3 F IC50 = 20.0 nM 498.58 CC(C)(C)NS(=O)(=O)c1ccc(NC(=O)[C@H](Cc2ccncc2)NC(=O)c2ccc(F)cc2)cc1 Homo sapiens CHEMBL4418477 single protein format
CHEMBL4546127 OBDepict CH 3 O HN H N H O O S F NH O O H 3 C H 3 C CH 3 IC50 = 22.0 nM 527.62 COc1ccc(C[C@H](NC(=O)c2ccc(F)cc2)C(=O)Nc2ccc(S(=O)(=O)NC(C)(C)C)cc2)cc1 Homo sapiens CHEMBL4418477 single protein format
CHEMBL4446528 OBDepict O N H HN H O S HN O O CH 3 CH 3 CH 3 F IC50 = 23.0 nM 503.64 CC(C)(C)NS(=O)(=O)c1ccc(NC(=O)[C@H](CC2CCCCC2)NC(=O)c2ccc(F)cc2)cc1 Homo sapiens CHEMBL4418477 single protein format
CHEMBL4447784 OBDepict O N H HN H O S F HN O O CH 3 CH 3 CH 3 F IC50 = 26.0 nM 515.58 CC(C)(C)NS(=O)(=O)c1ccc(NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)c2ccc(F)cc2)cc1 Homo sapiens CHEMBL4418477 single protein format
CHEMBL4463590 OBDepict O N H NH H S O S HN O O CH 3 CH 3 CH 3 IC50 = 28.0 nM 491.68 CC(C)(C)NS(=O)(=O)c1ccc(NC(=O)[C@H](Cc2cccs2)NC(=O)C2CCCCC2)cc1 Homo sapiens CHEMBL4418477 single protein format
CHEMBL4449181 OBDepict O N H N H H O S HN O O CH 3 CH 3 CH 3 IC50 = 28.0 nM 485.65 CC(C)(C)NS(=O)(=O)c1ccc(NC(=O)[C@@H](Cc2ccccc2)NC(=O)C2CCCCC2)cc1 Homo sapiens CHEMBL4418477 single protein format
CHEMBL4584029 OBDepict O N H HN H O S F HN O O CH 3 CH 3 CH 3 F IC50 = 31.0 nM 521.63 CC(C)(C)NS(=O)(=O)c1ccc(NC(=O)[C@H](CC2CCCCC2)NC(=O)c2ccc(F)c(F)c2)cc1 Homo sapiens CHEMBL4418477 single protein format
CHEMBL4442098 OBDepict N NH H N H O O S HN O O CH 3 CH 3 CH 3 IC50 = 41.0 nM 510.66 CC(C)(C)NS(=O)(=O)c1ccc(NC(=O)[C@H](Cc2cccc(C#N)c2)NC(=O)C2CCCCC2)cc1 Homo sapiens CHEMBL4418477 single protein format
CHEMBL4550326 OBDepict O N H HN H O N S HN O O CH 3 CH 3 CH 3 F IC50 = 48.0 nM 498.58 CC(C)(C)NS(=O)(=O)c1ccc(NC(=O)[C@H](Cc2ccccn2)NC(=O)c2ccc(F)cc2)cc1 Homo sapiens CHEMBL4418477 single protein format
CHEMBL4568841 OBDepict O N H HN H O S HN O O CH 3 CH 3 CH 3 F IC50 = 49.0 nM 547.65 CC(C)(C)NS(=O)(=O)c1cccc2c(NC(=O)[C@H](Cc3ccccc3)NC(=O)c3ccc(F)cc3)cccc12 Homo sapiens CHEMBL4418477 single protein format
CHEMBL4448706 OBDepict O N H HN H O S F HN O O CH 3 CH 3 CH 3 IC50 = 57.0 nM 503.64 CC(C)(C)NS(=O)(=O)c1ccc(NC(=O)[C@H](CC2CCCCC2)NC(=O)c2cccc(F)c2)cc1 Homo sapiens CHEMBL4418477 single protein format
CHEMBL4463355 OBDepict O N H N H H O S HN O O CH 3 CH 3 CH 3 IC50 = 59.0 nM 485.65 CC(C)(C)NS(=O)(=O)c1ccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2CCCCC2)cc1 Homo sapiens CHEMBL4418477 single protein format
CHEMBL4456872 OBDepict O N H NH H O S HN O O CH 3 CH 3 CH 3 IC50 = 71.0 nM 471.62 CC(C)(C)NS(=O)(=O)c1ccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2CCCC2)cc1 Homo sapiens CHEMBL4418477 single protein format
CHEMBL4444845 OBDepict O N H HN H O O S HN O O CH 3 CH 3 CH 3 IC50 = 71.0 nM 493.67 CC(C)(C)NS(=O)(=O)c1ccc(NC(=O)[C@H](CC2CCOCC2)NC(=O)C2CCCCC2)cc1 Homo sapiens CHEMBL4418477 single protein format
CHEMBL4463218 OBDepict O N H HN H O S HN O O CH 3 CH 3 CH 3 IC50 = 83.0 nM 491.7 CC(C)(C)NS(=O)(=O)c1ccc(NC(=O)[C@H](CC2CCCCC2)NC(=O)C2CCCCC2)cc1 Homo sapiens CHEMBL4418477 single protein format
CHEMBL4437658 OBDepict CH 3 O HN H N H O O S NH O O H 3 C H 3 C CH 3 IC50 = 89.0 nM 559.69 COc1ccc(C[C@H](NC(=O)c2ccccc2)C(=O)Nc2cccc3c(S(=O)(=O)NC(C)(C)C)cccc23)cc1 Homo sapiens CHEMBL4418477 single protein format
CHEMBL4592783 OBDepict O N H N H H O S HN O O CH 3 CH 3 CH 3 F F IC50 = 98.0 nM 571.69 CC(C)(C)NS(=O)(=O)c1cccc2c(NC(=O)[C@H](Cc3ccccc3)NC(=O)C3CCC(F)(F)CC3)cccc12 Homo sapiens CHEMBL4418477 single protein format
CHEMBL4466906 OBDepict N N F N H O N N N IC50 = 100.0 nM 314.32 N#CN1CCC[C@](F)(C(=O)Nc2ccc(-n3cccn3)cn2)C1 Homo sapiens CHEMBL4418461 assay format
CHEMBL4537237 OBDepict N N F N H O N N N IC50 = 100.0 nM 338.35 N#Cc1cccc(-n2cnc(NC(=O)[C@@]3(F)CCCN(C#N)C3)c2)c1 Homo sapiens CHEMBL4418461 assay format
CHEMBL4470670 OBDepict N N F N H O N N F F F IC50 = 100.0 nM 381.33 N#CN1CCC[C@](F)(C(=O)Nc2cn(-c3cccc(C(F)(F)F)c3)cn2)C1 Homo sapiens CHEMBL4418461 assay format
CHEMBL4448068 OBDepict N N F N H O N N O F F F IC50 = 100.0 nM 397.33 N#CN1CCC[C@](F)(C(=O)Nc2cn(-c3cccc(OC(F)(F)F)c3)cn2)C1 Homo sapiens CHEMBL4418461 assay format
CHEMBL4527072 OBDepict N N N O H 3 C N IC50 = 100.0 nM 324.43 CN(Cc1ccc(N2CCCC2)cc1)C(=O)C=C1CCN(C#N)C1 Homo sapiens CHEMBL4418459 assay format
CHEMBL4571972 OBDepict N N F N H O N N N N IC50 = 100.0 nM 339.33 N#Cc1cccc(-n2cnc(NC(=O)[C@@]3(F)CCCN(C#N)C3)n2)c1 Homo sapiens CHEMBL4418461 assay format
CHEMBL4459707 OBDepict N N F N H O N N N N H IC50 = 100.0 nM 365.37 N#CN1CCC[C@](F)(C(=O)Nc2ccc(-c3ccnc4[nH]ncc34)cn2)C1 Homo sapiens CHEMBL4418461 assay format
CHEMBL4563261 OBDepict N N N H O Cl CH 3 IC50 = 100.0 nM 275.74 Cc1ccc(NC(=O)C=C2CCN(C#N)C2)cc1Cl Homo sapiens CHEMBL4418459 assay format
CHEMBL4443135 OBDepict N N H HN O Cl N IC50 < 100.0 nM 326.79 N#CN1CC[C@@H](NC(=O)c2ccc(-c3ccncc3Cl)cc2)C1 Homo sapiens CHEMBL4418408 assay format
CHEMBL4588955 OBDepict N N N H O CH 3 F F F IC50 = 100.0 nM 309.29 Cc1ccc(NC(=O)C=C2CCN(C#N)C2)cc1C(F)(F)F Homo sapiens CHEMBL4418459 assay format
CHEMBL4454291 OBDepict N N H N H O N N N N IC50 = 100.0 nM 333.36 N#Cc1cc(-c2ccc(N3CCO[C@@H]4CN(C#N)C[C@@H]43)nn2)ccn1 Homo sapiens CHEMBL4418460 assay format
CHEMBL4446162 OBDepict N N N H O N IC50 = 100.0 nM 278.32 N#CN1CCC(=CC(=O)Nc2cnc3ccccc3c2)C1 Homo sapiens CHEMBL4418459 assay format
CHEMBL4472040 OBDepict N N H N CH 3 N N H F F F IC50 = 100.0 nM 309.3 CN(c1nc2ccc(C(F)(F)F)cc2[nH]1)[C@@H]1CCN(C#N)C1 Homo sapiens CHEMBL4418460 assay format
CHEMBL4577951 OBDepict N N H H N N N H O CH 3 IC50 = 100.0 nM 283.34 COc1ccc2nc(N3CC[C@@H]4CN(C#N)C[C@@H]43)[nH]c2c1 Homo sapiens CHEMBL4418460 assay format
CHEMBL4437162 OBDepict N N H N H N N H N IC50 = 100.0 nM 278.32 N#Cc1ccc2nc(N3CC[C@@H]4CN(C#N)C[C@@H]43)[nH]c2c1 Homo sapiens CHEMBL4418460 assay format
CHEMBL4593035 OBDepict N N H O H N N S IC50 = 100.0 nM 312.4 N#CN1C[C@@H]2OCCN(c3ncc(-c4ccccc4)s3)[C@H]2C1 Homo sapiens CHEMBL4418460 assay format
CHEMBL4462084 OBDepict N N H O H N N S IC50 = 100.0 nM 312.4 N#CN1C[C@H]2[C@@H](C1)OCCN2c1ncc(-c2ccccc2)s1 Homo sapiens CHEMBL4418460 assay format
CHEMBL4435770 OBDepict N N H H N N S IC50 = 100.0 nM 296.4 N#CN1C[C@H]2CCN(c3ncc(-c4ccccc4)s3)[C@H]2C1 Homo sapiens CHEMBL4418460 assay format
CHEMBL4456889 OBDepict N N H O H N N N IC50 = 100.0 nM 307.36 N#CN1C[C@H]2[C@@H](C1)OCCN2c1nccc(-c2ccccc2)n1 Homo sapiens CHEMBL4418460 assay format
CHEMBL4452100 OBDepict N N H O H N N IC50 = 100.0 nM 306.37 N#CN1C[C@H]2[C@@H](C1)OCCN2c1cccc(-c2ccccc2)n1 Homo sapiens CHEMBL4418460 assay format
CHEMBL4584536 OBDepict N N H O H N N N IC50 = 100.0 nM 307.36 N#CN1C[C@H]2[C@@H](C1)OCCN2c1ccc(-c2ccccc2)nn1 Homo sapiens CHEMBL4418460 assay format
CHEMBL4517525 OBDepict N N N O IC50 = 100.0 nM 267.33 N#CN1CCC(=CC(=O)N2CC(c3ccccc3)C2)C1 Homo sapiens CHEMBL4418459 assay format
CHEMBL4581714 OBDepict N N H HN O O H 3 C Cl N IC50 < 100.0 nM 356.81 COc1cc(C(=O)N[C@@H]2CCN(C#N)C2)ccc1-c1ccncc1Cl Homo sapiens CHEMBL4418408 assay format
CHEMBL4526514 OBDepict N N H NH O N N CH 3 IC50 < 100.0 nM 295.35 Cn1cc(-c2ccc(C(=O)N[C@@H]3CCN(C#N)C3)cc2)cn1 Homo sapiens CHEMBL4418408 assay format
CHEMBL4557861 OBDepict N N H N S O O N N IC50 < 100.0 nM 369.45 N#CN1CC[C@H](N2CCN(c3cccc(-c4ccncc4)c3)S2(=O)=O)C1 Homo sapiens CHEMBL4418444 assay format
CHEMBL4550921 OBDepict N N H N S O O N IC50 < 100.0 nM 368.46 N#CN1CC[C@H](N2CCN(c3ccc(-c4ccccc4)cc3)S2(=O)=O)C1 Homo sapiens CHEMBL4418444 assay format
CHEMBL4556967 OBDepict N N H N S O O N IC50 < 100.0 nM 368.46 N#CN1CC[C@H](N2CCN(c3cccc(-c4ccccc4)c3)S2(=O)=O)C1 Homo sapiens CHEMBL4418444 assay format
CHEMBL4581232 OBDepict N N H N S O O N N IC50 < 100.0 nM 369.45 N#CN1CC[C@H](N2CCN(c3cccc(-c4ccccc4)n3)S2(=O)=O)C1 Homo sapiens CHEMBL4418444 assay format
CHEMBL4482891 OBDepict H N N S H CH 3 O O N N IC50 < 100.0 nM 382.49 C[C@H]1CN(C#N)C[C@@H]1N1CCN(c2ccc(-c3ccccc3)cc2)S1(=O)=O Homo sapiens CHEMBL4418444 assay format
CHEMBL4520781 OBDepict N N H N S O O N O H 3 C IC50 < 100.0 nM 398.49 COc1ccc(N2CCN([C@@H]3CCN(C#N)C3)S2(=O)=O)cc1-c1ccccc1 Homo sapiens CHEMBL4418444 assay format
CHEMBL4439978 OBDepict N N H N S O O N O CH 3 IC50 < 100.0 nM 398.49 COc1cc(N2CCN([C@@H]3CCN(C#N)C3)S2(=O)=O)ccc1-c1ccccc1 Homo sapiens CHEMBL4418444 assay format
CHEMBL4580700 OBDepict N N H N S O O N N H 3 C IC50 < 100.0 nM 395.49 Cn1c2ccccc2c2ccc(N3CCN([C@@H]4CCN(C#N)C4)S3(=O)=O)cc21 Homo sapiens CHEMBL4418444 assay format
CHEMBL4571894 OBDepict N N H N S O O N N N O IC50 < 100.0 nM 378.46 N#CN1CC[C@@H](N2CCN(c3ccnc(N4CCOCC4)c3)S2(=O)=O)C1 Homo sapiens CHEMBL4418444 assay format
CHEMBL4472476 OBDepict N N H N H O O N F F IC50 < 100.0 nM 318.28 N#CN1CC[C@@H](NC(=O)c2cc(-c3ccc(F)cc3F)no2)C1 Homo sapiens CHEMBL4418408 assay format
CHEMBL4588427 OBDepict N N H N H O O N CH 3 CH 3 IC50 < 100.0 nM 310.36 Cc1ccc(-c2cc(C(=O)N[C@@H]3CCN(C#N)C3)on2)cc1C Homo sapiens CHEMBL4418408 assay format
CHEMBL4568943 OBDepict N N H N H 3 C O N N H CH 3 N H 3 C O IC50 < 100.0 nM 364.41 Cc1noc(C)c1-c1ccc2nc(C(=O)N(C)[C@H]3CCN(C#N)C3)[nH]c2c1 Homo sapiens CHEMBL4418408 assay format
CHEMBL4572799 OBDepict N N H N S O O N N IC50 < 100.0 nM 369.45 N#CN1CC[C@H](N2CCN(c3ccc(-c4ccncc4)cc3)S2(=O)=O)C1 Homo sapiens CHEMBL4418444 assay format
CHEMBL4521293 OBDepict N N N CH 3 NH O IC50 < 100.0 nM 320.4 CN(C(=O)Nc1ccc(-c2ccccc2)cc1)C1CCN(C#N)C1 Homo sapiens CHEMBL4418408 assay format
CHEMBL4450486 OBDepict N N N H N H O O IC50 < 100.0 nM 322.37 N#CN1CCC(NC(=O)Nc2cccc(Oc3ccccc3)c2)C1 Homo sapiens CHEMBL4418408 assay format
CHEMBL4515227 OBDepict N N N H N H O IC50 < 100.0 nM 306.37 N#CN1CCC(NC(=O)Nc2ccc(-c3ccccc3)cc2)C1 Homo sapiens CHEMBL4418408 assay format
CHEMBL4527981 OBDepict N N H H N N H O N N CH 3 IC50 < 100.0 nM 348.41 Cc1cc(-c2ccc(NC(=O)N3CC[C@@H]4CN(C#N)C[C@@H]43)nc2)ccn1 Homo sapiens CHEMBL4418408 assay format
CHEMBL4467686 OBDepict N N H H N N H O N CH 3 IC50 < 100.0 nM 347.42 Cc1cc(-c2ccc(NC(=O)N3CC[C@@H]4CN(C#N)C[C@@H]43)cc2)ccn1 Homo sapiens CHEMBL4418408 assay format
CHEMBL4449699 OBDepict N N H H N N H O N CH 3 IC50 < 100.0 nM 347.42 Cc1cc(-c2cccc(NC(=O)N3CC[C@@H]4CN(C#N)C[C@@H]43)c2)ccn1 Homo sapiens CHEMBL4418408 assay format
CHEMBL4565842 OBDepict N N H N CH 3 O N N N IC50 < 100.0 nM 388.48 CN(C(=O)c1ccc2c(c1)CCN2c1nccc(C2CC2)n1)[C@@H]1CCN(C#N)C1 Homo sapiens CHEMBL4418408 assay format
CHEMBL4587360 OBDepict N N H N H O N N N IC50 < 100.0 nM 374.45 N#CN1CC[C@@H](NC(=O)c2ccc3c(c2)CCN3c2nccc(C3CC3)n2)C1 Homo sapiens CHEMBL4418408 assay format
CHEMBL4472801 OBDepict N N H NH N O O IC50 < 100.0 nM 376.46 N#CN1CC[C@@H](NC(=O)N2CC(OCc3ccccc3)(c3ccccc3)C2)C1 Homo sapiens CHEMBL4418408 assay format
CHEMBL4439776 OBDepict N N H N H N O N N Cl IC50 < 100.0 nM 382.86 N#CN1CC[C@@H](NC(=O)N2CC(c3ccnc(-c4ccc(Cl)cc4)n3)C2)C1 Homo sapiens CHEMBL4418408 assay format
CHEMBL4589299 OBDepict N N H N H N O N N IC50 < 100.0 nM 336.4 N#CN1CC[C@@H](NC(=O)N2CC(c3ccn(-c4ccccc4)n3)C2)C1 Homo sapiens CHEMBL4418408 assay format
CHEMBL4443562 OBDepict N N H N H O N F H 3 C N N CH 3 IC50 < 100.0 nM 366.4 Cn1cc(-c2ccc3c(c2)c(F)c(C(=O)N[C@@H]2CCN(C#N)C2)n3C)cn1 Homo sapiens CHEMBL4418408 assay format
CHEMBL4449533 OBDepict N N H N H O N H 3 C N N CH 3 IC50 < 100.0 nM 348.41 Cn1cc(-c2ccc3c(c2)cc(C(=O)N[C@@H]2CCN(C#N)C2)n3C)cn1 Homo sapiens CHEMBL4418408 assay format
CHEMBL4469578 OBDepict N N N CH 3 N H O O IC50 < 100.0 nM 336.4 CN(C(=O)Nc1cccc(Oc2ccccc2)c1)C1CCN(C#N)C1 Homo sapiens CHEMBL4418408 assay format
CHEMBL4592368 OBDepict N N H N S O O N N H N IC50 < 100.0 nM 358.43 N#CN1CC[C@@H](N2CCN(c3cc(-c4ccccc4)n[nH]3)S2(=O)=O)C1 Homo sapiens CHEMBL4418444 assay format
CHEMBL4445000 OBDepict N N H N S O O N O N IC50 < 100.0 nM 359.41 N#CN1CC[C@@H](N2CCN(c3cc(-c4ccccc4)no3)S2(=O)=O)C1 Homo sapiens CHEMBL4418444 assay format
CHEMBL4470939 OBDepict N N H N S O O N N O IC50 < 100.0 nM 377.47 N#CN1CC[C@@H](N2CCN(c3cccc(N4CCOCC4)c3)S2(=O)=O)C1 Homo sapiens CHEMBL4418444 assay format
CHEMBL4472293 OBDepict N N O H NH O N N IC50 < 100.0 nM 333.35 N#Cc1cccc(-c2ccnc(NC(=O)[C@H]3CN(C#N)CCO3)c2)c1 Homo sapiens CHEMBL4418461 assay format
CHEMBL4550169 OBDepict N N F N H O N O Cl IC50 < 100.0 nM 348.77 N#CN1CCC[C@](F)(C(=O)Nc2cc(-c3cccc(Cl)c3)on2)C1 Homo sapiens CHEMBL4418461 assay format